| Interacting proteins: P40189 and P08631 |
Pubmed |
SVM Score :0.86101589 |
| We also demonstrate a rapid and transient increase in Hck tyrosine kinase activity in parental ES cells stimulated by LIF and , finally , show that Hck is physically associated with gp 130 , an affinity converter and signal transducing component of the LIF receptor . 0.86101589^^^ |
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| Interacting proteins: P40189 and P08631 |
Pubmed |
SVM Score :0.0 |
| Functional involvement of Hck and p 21 ( ras ) activation in gp 130 mediated signaling is supported by the finding that the introduction of constitutively activated Hck or 5 Ha ras partially alleviates the requirement of ES cells for LIF to remain undifferentiated . ^^^ These results are consistent with the notion that gp 130 mediated suppression of ES cell differentiation depends on signaling through at least two cascades , namely a p 21 ( ras ) dependent pathway that possibly involves Hck , as well as a Jak kinase dependent pathway . . ^^^ |
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| Interacting proteins: P40189 and P08631 |
Pubmed |
SVM Score :0.0 |
| Coprecipitation experiments with anti Hck , anti Lyn , anti Fyn , and anti gp 130 antibodies revealed a physical association with gp 130 of p56 / 59Hck and p56Lyn , but not p59Fyn , in LP 1 cells . ^^^ |
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| Interacting proteins: P40189 and P08631 |
Pubmed |
SVM Score :0.0 |
| Signaling through a novel domain of gp 130 mediates cell proliferation and activation of Hck and Erk kinases . ^^^ Interleukin 6 ( IL 6 ) induces the activation of the Src family kinase Hck , which is associated with the IL 6 receptor beta chain , gp 130 . ^^^ Here we describe the identification of an `` acidic ' ' domain comprising amino acids 771 to 811 of gp 130 as a binding region for Hck , which mediates proliferative signaling . ^^^ The deletion of this region of gp 130 ( i . e . , in deletion mutant d 771 811 ) resulted in a significant reduction of Hck kinase activity and cell proliferation upon stimulation of gp 130 compared to wild type gp 130 . ^^^ Based on these findings , we propose a novel , acidic domain of gp 130 , which is responsible for the activation of Hck , Erk , and Pyk 2 and signals cell proliferation upon growth factor stimulation . . ^^^ |
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| Interacting proteins: P40189 and P08631 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P40189 and P08631 |
Pubmed |
SVM Score :0.0 |
| NA |
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