Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.55956024
Interleukin 6 only binds to gp 130 when complexed with the interleukin 6 receptor that exists as a membrane bound and soluble molecule . 0.55956024^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) exerts its action via a cell surface receptor composed of an 80 kDa IL 6 binding protein ( gp 80 ) and a 130 kDa polypeptide involved in signal transduction ( gp 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 signal transducer gp 130 mediates oncostatin M signaling . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The expression of 80 kDa interleukin 6 receptor ( IL 6R ) and the associated molecule gp 130 has been studied on human cell lines by FACS and Northern blot analysis . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The interleukin 6 signal transducer , gp 130 , functioning in immune , hematopoietic , and neural systems ] . ^^^ To understand the signaling mechanisms of such cytokines , we have proposed a two chain interleukin 6 receptor ( IL 6 R ) model : IL 6 triggers the association of a ligand binding chain ( IL 6 R ) and a non binding signal transducer ( gp 130 ) to form a high affinity receptor complex , causing transmission of the signal by the cytoplasmic portion of gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Up regulation of the interleukin 6 signal transducing protein ( gp 130 ) by interleukin 6 and dexamethasone in HepG 2 cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Differential regulation of interleukin 6 receptor and gp 130 gene expression in rat hepatocytes . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Critical cytoplasmic region of the interleukin 6 signal transducer gp 130 is conserved in the cytokine receptor family . ^^^ Interleukin 6 ( IL 6 ) signal is transduced through gp 130 that associates with a complex of IL 6 and IL 6 receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The overall structure of the beta chain ( gp 130 ) of the interleukin 6 receptor was found to be very similar to that of the G CSF receptor . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) signal is transduced through a membrane glycoprotein , gp 130 , which associates with IL 6 receptor ( IL 6 R ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) is a cytokine sharing structural and functional similarities with interleukin 6 ( IL 6 ) and other helical cytokines that utilize the common signalling chain gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Generation of interleukin 6 receptor antagonists by molecular modeling guided mutagenesis of residues important for gp 130 activation . ^^^ Interleukin 6 ( IL 6 ) drives the sequential assembly of a receptor complex formed by the IL 6 receptor ( IL 6R alpha ) and the signal transducing subunit , gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and interleukin 6 ( IL 6 ) compose a family of distantly related cytokines that initiate signaling by inducing either homodimerization of the `` beta ' ' signal transducing receptor component gp 130 ( in the case of IL 6 ) or heterodimerization between gp 130 and the gp 130 related LIFR beta ( in the case of CNTF , LIF , and OSM ) ; dimerization of beta receptor components in turn activates members of the Jak / Tyk family of receptor associated tyrosine kinases . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Association and activation of Btk and Tec tyrosine kinases by gp 130 , a signal transducer of the interleukin 6 family of cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells . gp 130 , a signal transducing receptor component of interleukin 6 ( IL 6 ) , associates with an IL 6 and IL 6 receptor ( IL 6 ) complex and transduces signals . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Activation of Fes tyrosine kinase by gp 130 , an interleukin 6 family cytokine signal transducer , and their association . gp 130 is a signal transducing subunit of receptors for the interleukin 6 ( IL 6 ) related cytokine subfamily including IL 6 , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotrophic factor , indicating that gp 130 mediated signals are involved in the immune response , hematopoiesis , inflammation , and endocrine and nervous system activity . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Continuous activation of gp 130 , a signal transducing receptor component for interleukin 6 related cytokines , causes myocardial hypertrophy in mice . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) interacts with a system of receptors , which include a 80 kDa IL 6 binding subunit ( IL 6R ) and a transducing element ( gp 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Functional distinction of two regions of human interleukin 6 important for signal transduction via gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
It is now recognized that the beta subunit of the interleukin 6 ( IL 6 ) receptor , also known as gp 130 , is a common signal transducer shared by other cytokines , including ciliary neurotrophic factor , leukemia inhibitor factor , oncostatin M , and IL 11 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor , oncostatin M , leukemia inhibitory factor , and interleukin 6 are related cytokines that initiate signaling by homodimerizing the signal transducing receptor component gp 130 or by heterodimerizing gp 130 with a gp 130 related receptor component . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 family of cytokines and gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A region within the cytoplasmic domain of the interleukin 6 signal transducer gp 130 important for ligand induced endocytosis of the IL 6 receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Members of the interleukin 6 family of cytokines bind to and activate receptors that contain a common subunit , gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The pleiotropic cytokine interleukin 6 ( IL 6 ) interacts with the specific ligand binding subunit ( IL 6R alpha ) of the IL 6 receptor , and this complex associates with the signal transducing subunit gp 130 ( IL 6R beta ) . ^^^ Combining two mutations of human interleukin 6 that affect gp 130 activation results in a potent interleukin 6 receptor antagonist on human myeloma cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Separate regulation of a membrane protein , gp 130 , present in receptor complex specific for interleukin 6 and other functionally related cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) antagonism by soluble IL 6 receptor alpha mutated in the predicted gp 130 binding interface . ^^^ Interleukin 6 ( IL 6 ) triggers the formation of a high affinity receptor complex constituted by the ligand binding subunit IL 6 receptor alpha ( IL 6R alpha ) and the signal transducing beta chain gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Separate signaling mechanisms are involved in the control of STAT protein activation and gene regulation via the interleukin 6 response element by the box 3 motif of gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Consistent with this prediction , the CNTF receptor complex is composed of the CNTF alpha receptor , the LIF beta receptor and gp 130 a signalling molecule for LIF and interleukin 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In addition to including a CNTF specific component , known as CNTFR alpha , the CNTF receptor complex utilizes two receptor components , gp 130 and LIFR beta , that are shared with members of a family of broadly acting cytokines , including leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Expression of the interleukin 6 ( IL 6 ) , IL 6 receptor , and gp 130 genes in acute leukemia . ^^^ Expression patterns of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , and gp 130 genes in 39 patients with acute myeloid leukemia ( AML ) , in 23 patients with acute lymphoblastic leukemia ( ALL ) , and in 7 patients with acute mixed lineage leukemia ( AMLL ) were studied by quantitative reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) mediates pleiotropic functions through specific receptors ( IL 6R ) composed of an 80 kDa binding protein , associated with a non ligand binding protein ( gp 130 ) which transduces the signal . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Biosynthesis and half life of the interleukin 6 receptor and its signal transducer gp 130 . ^^^ Interleukin 6 ( IL 6 ) exerts its action via a receptor complex composed of a ligand binding subunit ( gp 80 ) and a signal transducer ( gp 130 ) which both belong to the hematopoietic receptor super family . ^^^ Therefore , we studied the biosynthesis and maturation of the interleukin 6 receptor and its signaling subunit gp 130 by pulse chase experiments in stably transfected Madin Darby canine kidney cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Identification of a region within the cytoplasmic domain of the interleukin 6 ( IL 6 ) signal transducer gp 130 important for ligand induced endocytosis of the IL 6 receptor . ^^^ Interleukin 6 ( IL 6 ) exerts its action via a cell surface receptor complex consisting of two subunits , the IL 6 receptor and the signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) signal is transduced through a membrane glycoprotein gp 130 , which associates with the IL 6 receptor alpha chain ( IL 6R alpha ) in the presence of IL 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Recently , gp 130 , the signal transducer for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophice factor ( CNTF ) , was identified as the low affinity receptor for oncostatin M ( OM ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Signal transduction through gp 130 that is shared among the receptors for the interleukin 6 related cytokine subfamily . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , and oncostatin M , which all use gp 130 as a signal transducer , significantly inhibited mGHRF secretion by cultured placental cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Gp 130 is the signal transducing subunit of the interleukin 6 receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The JAK 2 tyrosine kinase is known to associate with the receptors for growth hormone ( GH ) and erythropoietin ( EPO ) and with the interleukin 6 receptor signal transducing protein , gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
High affinity interleukin 6 receptor is a hexameric complex consisting of two molecules each of interleukin 6 , interleukin 6 receptor , and gp 130 . ^^^ The high affinity human interleukin 6 ( IL 6 ) receptor complex consists of IL 6 and two membrane associated receptor components , the IL 6 receptor ( alpha subunit ) and the high affinity converter and signal transducing molecule , gp 130 ( beta subunit ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Activation of JAK 2 kinase mediated by the interleukin 6 signal transducer gp 130 . ^^^ The interleukin 6 receptor associated signal transducer , gp 130 , is shared by receptor complexes for leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and interleukin 11 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 , leukemia inhibitory factor , and oncostatin M exert a broad range of similar biological activities through association of their receptors with the signal transducing component gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Ciliary neurotropic factor , interleukin 11 , leukemia inhibitory factor , and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Oncostatin M , leukemia inhibitory factor , and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer , gp 130 . ^^^ We analyzed the stimulatory effect of oncostatin M ( OSM ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , IL 11 , and the inhibitory effect of anti IL 6 antibody ( Ab ) , anti IL 6 receptor monoclonal antibody ( mAb ) , and anti gp 130 mAb on the growth of human plasmacytoma cells freshly isolated from a patient with multiple myeloma . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Oncostatin M binds directly to gp 130 and behaves as interleukin 6 antagonist on a cell line expressing gp 130 but lacking functional oncostatin M receptors . ^^^ Oncostatin M ( OM ) and interleukin 6 ( IL 6 ) are functionally related cytokines , which trigger similar biological responses because they share gp 130 as a common signal transducing transmembrane receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , IL 11 , and ciliary neurotropic factor are a family of cytokines and neuronal differentiation factors which bind to composite plasma membrane receptors sharing the signal transducing subunit gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We have studied the expression and regulation of the interleukin 6 receptor ( gp 80 ) and its signal transducer gp 130 in primary human blood monocytes . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The biological functions of LIF are mediated through a receptor and a signal transducer , gp 130 , which is also used by factors like interleukin 6 ( IL 6 ) , cilliary neurotropic factor ( CNTF ) , and oncostatin M ( OSM ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Association of transcription factor APRF and protein kinase Jak 1 with the interleukin 6 signal transducer gp 130 . ^^^ Interleukin 6 ( IL 6 ) , leukemia inhibitory factor , oncostatin M , interleukin 11 , and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In the present study , we investigate the transcription of the alpha and beta subunits of granulocyte macrophage colony stimulating factor ( GM CSF ) receptor , the alpha and beta subunits of interleukin 3 ( IL 3 ) receptor , and the single subunit of interleukin 6 ( IL 6 ) receptor and its associated gp 130 transduction protein by PCR amplification of reverse transcribed cellular mRNA in 34 malignant cell lines derived from a variety of histological cell types . mRNA for only a single subunit polypeptide was found in a significant minority of cell lines ( 23 % ) , while in 20 % both the alpha and beta subunits of either the GM CSF receptor or the IL 3 receptor were detected among a number of different histological cell types . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Soluble forms of the interleukin 6 signal transducing receptor component gp 130 in human serum possessing a potential to inhibit signals through membrane anchored gp 130 . ^^^ The interleukin 6 ( IL 6 ) signal is transduced through membrane anchored gp 130 , which is associated with IL 6 receptor ( IL 6R ) in the presence of IL 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Differentiation induction in murine M 1 leukemia cells by interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) is postulated to occur via a common receptor chain , gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Of the four endogenous pyrogens described to date ( interleukin 1 , tumor necrosis factor , interferon , and interleukin 6 ) , CNTF , like interleukin 6 , utilizes the cell surface gp 130 signal transduction apparatus . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
One of these proteins is the interleukin 6 signal transducing molecule gp 130 , which is required for signal transduction by both CNTF and LIF . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The ciliary neurotrophic factor ( CNTF ) receptor complex is shown here to include the CNTF binding protein ( CNTFR alpha ) as well as the components of the leukemia inhibitory factor ( LIF ) receptor , LIFR beta ( the LIF binding protein ) and gp 130 [ the signal transducer of interleukin 6 ( IL 6 ) ] . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In addition we show that the soluble forms of the IL 6R and gp 130 released by transfected cells can form a ternary complex with interleukin 6 indicating that such complexes also may occur in vivo . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The biological functions of interleukin 6 ( IL 6 ) are mediated through a signal transducing component of the IL 6 receptor , gp 130 , which is associated with the ligand occupied IL 6 receptor ( IL 6R ) protein . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Definition of a composite binding site for gp 130 in human interleukin 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Targeted disruption of gp 130 , a common signal transducer for the interleukin 6 family of cytokines , leads to myocardial and hematological disorders . gp 130 is a ubiquitously expressed signal transducing receptor component shared by interleukin 6 , interleukin 11 , leukemia inhibitory factor , oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 signal transducer gp 130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti gp 130 monoclonal antibodies . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Therefore , in this study , we immunolocalized the cytokine , interleukin 6 ( IL 6 ) , its receptor and the signal transducer gp 130 in human endometrium throughout the menstrual cycle . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The functional receptor complexes assembled in response to interleukin 6 and 11 ( IL 6 and IL 11 ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and ciliary neurotrophic factor ( CNTF ) , all involve the signal transducer gp 130 : IL 6 and IL 11 induce homodimerization of gp 130 , while the rest heterodimerize gp 130 with other gp 130 related beta subunits . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The steady state mRNA levels of the interleukin 6 receptor ( IL 6R , gp 80 ) and its signal transducing molecule , gp 130 , were examined in the rat hepatoma cell line , H 35 , stimulated by cytokines IL 6 , IL 1 , oncostatin M ( OSM ) and / or Dexamethasone ( Dex ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
This is mediated by an increase in the production of interleukin 6 ( IL 6 ) , as well as an increase in the sensitivity of the osteoclastic precursors to the action of cytokines such as IL 6 , owing to an up regulation of the gp 130 signal transduction pathway . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Anti gp 130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor or oncostatin M . ^^^ Five cytokines activate the gp 130 IL 6 transducer : ciliary neurotrophic factor , interleukin 6 , interleukin 11 , leukemia inhibitory factor and oncostatin M . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The interleukin 6 ( IL 6 ) partial antagonist ( Q159E , T162P ) IL 6 interacts with the IL 6 receptor and gp 130 but fails to induce a stable hexameric receptor complex . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A di leucine motif and an upstream serine in the interleukin 6 ( IL 6 ) signal transducer gp 130 mediate ligand induced endocytosis and down regulation of the IL 6 receptor . ^^^ The interleukin 6 ( IL 6 ) receptor complex is composed of two different subunits , the IL 6 binding protein ( IL 6R , gp 80 ) and the signal transducing component gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Six different cytokines that share GP 130 as a receptor subunit , induce serum amyloid A and potentiate the induction of interleukin 6 and the activation of the hypothalamus pituitary adrenal axis by interleukin 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Soluble interleukin 6 receptor ( sIL 6R ) , a new prognostic factor in multiple myeloma . sIL 6R is a 55 kD soluble molecule mediating the interleukin 6 ( IL 6 ) signal through the IL 6 receptor associated transmembrane signal transducer , gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We used this model to investigate the role of two cytokines , interleukin 6 and interleukin 11 , which share the signal transducing subunit , gp 130 , of their respective receptors . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Here we show that stimulation of glycoprotein ( gp 130 ) by a combination of recombinant human soluble interleukin 6 receptor ( sIL 6R ) and IL 6 but not sIL 6R or IL 6 alone can support proliferation , differentiation , and terminal maturation of erythroid cells in the absence of EPO from purified human CD34+ cells in suspension culture containing stem cell factor ( SCF ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) triggers the formation of a high affinity receptor complex with the ligand binding subunit IL 6Ralpha and the signal transducing chain gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Differential activation of acute phase response factor / STAT3 and STAT 1 via the cytoplasmic domain of the interleukin 6 signal transducer gp 130 . 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Differential activation of acute phase response factor / Stat3 and Stat 1 via the cytoplasmic domain of the interleukin 6 signal transducer gp 130 . 2 . ^^^ Chem . 271 , 12991 12998 ) , we demonstrated that two tyrosine motifs within the cytoplasmic part of the interleukin 6 signal transducer gp 130 specifically mediate APRF activation while two others can recruit both APRF and Stat 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 family of cytokines induced activation of different functional sites expressed by gp 130 transducing protein . ^^^ Gp 130 transducing protein was shown to be involved in the formation of the high affinity receptors for interleukin 6 ( IL 6 ) , interleukin 11 ( IL 11 ) , leukemia inhibitory factor , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , and cardiotrophin 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
One typical example is a group of receptor systems for interleukin 6 ( IL 6 ) and related cytokines that share gp 130 as a signal transducer . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The high affinity interleukin 6 ( IL 6 ) signaling complex consists of IL 6 and two membrane associated receptor components : a low affinity but specific IL 6 receptor and the affinity converter / signal transducing protein gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Reconstitution experiments suggest that , although OB R mediates intracellular signals with a specificity similar to interleukin 6 type cytokine receptors , signaling appears to be independent of the gp 130 signal transducing component of the interleukin 6 type cytokine receptors . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Expression of interleukin 6 receptor ( IL 6R ) and gp 130 mRNA in PC 12 cells and sympathetic neurons : modulation by tumor necrosis factor alpha ( TNF alpha ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Moreover , other members of the CNTF cytokine family that use gp 130 and / or LIF receptor beta as their signal transducing receptors LIF , oncostatin M , interleukin 6 , and interleukin 11 had similar effects on increasing ChAT activity and reducing 5HT expression in RN46A cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
CNTF induced proliferation was completely inhibited by antibodies to gp 130 interleukin 6 ( IL 6 ) transducer , unlike antibodies to IL 6 or IL 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The high affinity receptor for interleukin 11 ( IL 11 ) is composed of two subunits , IL 11 receptor alpha chain ( IL 11R alpha ) and gp 130 , the common subunit of the interleukin 6 ( IL 6 ) , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , and oncostatin M receptors . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Using a chimeric receptor system in COS 7 cells , we studied the activation of STAT 5 through the interleukin 6 signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Analysis of interleukin 6 receptor and gp 130 expressions and proliferative capability of human CD34+ cells . ^^^ We recently demonstrated that stimulation of gp 130 by a combination of soluble interleukin 6 receptor ( sIL 6R ) and IL 6 but not IL 6 alone significantly stimulates the ex vivo expansion of primitive hematopoietic progenitors and the generation of erythroid cells from human CD34+ cells in the presence of stem cell factor ( SCF ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Identification of residues in the putative 5th helical region of human interleukin 6 , important for activation of the IL 6 signal transducer , gp 130 . ^^^ We have previously shown that L 58 in the putative 5th helical region of human interleukin 6 ( IL 6 ) is important for activation of the IL 6 signal transducer gp 130 [ de Hon et al . ( 1995 ) FEBS Lett . 369 , 187 191 ] . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The receptor for interleukin 6 ( IL 6 ) is characterized by a ligand binding glycoprotein 80 ( gp 80 ) transmembrane chain ( IL 6R ) which associates with a signal transducer gp 130 chain . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The interleukin 6 ( IL 6 ) family of cytokines activates signaling through the formation of either gp 130 homodimers , as for IL 6 , or gp 130 leukemia inhibitory factor receptor ( LIFR ) heterodimers as for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , oncostatinM , and cardiotrophin 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cardiotrophin 1 ( CT 1 ) is a member of the gp 130 family of cytokines that includes interleukin 6 , interleukin 11 , ciliary neurotrophic factor , leukemia inhibitory factor , and oncostatin M . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The complex of the soluble interleukin 6 receptor ( sIL 6R ) and IL 6 ( IL 6 ) is a potent agonist on cells expressing the signal transducing protein gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A complex of the soluble interleukin 6 receptor and interleukin 6 is internalized via the signal transducer gp 130 . ^^^ In human body fluids a soluble form of the interleukin 6 receptor ( sIL 6R ) has been found which together with interleukin 6 ( IL 6 ) acts agonistically on cells expressing the signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The structure of leptin receptor ( OB R ) is highly homologous to that of gp 130 , the common signal transducing receptor component for the interleukin 6 family of cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Vav is associated with signal transducing molecules gp 130 , Grb 2 and Erk 2 , and is tyrosine phosphorylated in response to interleukin 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Fusion constructs were created that are composed of the extracellular parts of the interleukin 5 receptor alpha and beta chains , respectively , and the transmembrane and intracellular parts of gp 130 , the signal transducing chain of the interleukin 6 receptor complex . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The structure of the receptor for this factor , OB R , is considerably similar to those of gp 130 , the common signal transducing receptor component for the interleukin 6 ( IL 6 ) family of cytokines , and leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Three cytokines , interleukin 6 ( IL 6 ) , leukaemia inhibitory factor ( LIF ) , and oncostatin M ( OSM ) , that bind to composite receptors including a common signal transducer gp 130 suppressed proliferation of a mouse B cell hybridoma cell line 2E3 O cultured in serum free medium , while they enhanced antibody production of the cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The signal transducer gp 130 is shared by interleukin 6 family of haematopoietic and neurotrophic cytokines . ^^^ Functional receptor complexes for the interleukin 6 family of cytokines share a membrane glycoprotein 130 ( gp 130 ) as a critical component for signal transduction . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Impairment of antigen specific antibody production in transgenic mice expressing a dominant negative form of gp 130 . gp 130 is a common signal transducing receptor component for the interleukin 6 family of cytokines functioning in , for example , immune , hematopoietic , and nervous systems . ^^^ Expression of this form of gp 130 in lymphocytes significantly suppressed interleukin 6 induced tyrosine phosphorylation of endogenous gp 130 and a downstream signaling molecule , signal transducer and activator of transcription 3 , indicating that this form has a dominant negative function . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Because the requirement for Jak 1 is very similar to that previously shown for interleukin 6 signaling , the data support the concept that the G CSF receptor and gp 130 are both structurally and functionally similar . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In HepG 2 hepatoma cells , however , these truncated Stat 3 forms transmit signals from the interleukin 6 signal transducer gp 130 equally well as does full length Stat 3 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin 6 signal transducer gp 130 . ^^^ The membrane bound gp 130 glycoprotein acts as an affinity converting and signal transducing receptor ( R ) for interleukin 6 and several other cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The stoichiometry of this solution complex was 1 : 1 : 1 , in contrast with that of the complex of interleukin 6 , the interleukin 6 specific low affinity receptor subunit and gp 130 , which is 2 : 2 : 2 . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Moreover , the expression of other markers on U 266 ( interleukin 6 receptor and gp 130 ) were not influenced by epsilon specific antisense oligonucleotides . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Gp 130 and the interleukin 6 family of cytokines . ^^^ Functional receptor complexes for this interleukin 6 family of cytokines share gp 130 as a component critical for signal transduction . ^^^ Unlike cytokines sharing common beta and common gamma chains that mainly function in hematopoietic and lymphoid cell systems , the interleukin 6 family of cytokines function extensively outside these systems as well , e . g . from the cardiovascular to the nervous system , owing to ubiquitously expressed gp 130 . ^^^ Stimulation of cells with the interleukin 6 family of cytokines triggers homo or hetero dimerization of gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The pleiotropic cytokine interleukin 6 ( IL 6 ) triggers the formation of a high affinity receptor complex constituted by the ligand binding subunit IL 6 receptor alpha ( IL 6R alpha ) and the signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Glycoprotein 130 ( gp 130 ) , a shared component of all the receptors for the interleukin 6 cytokine family , transduces cytokine signals in part by activating latent cytoplasmic signal transducers and activators of transcription ( STATs ) . ^^^ These results establish that the DNA fragment we have isolated contains the human gp 130 promoter and that interleukin 6 type cytokines may influence the activity of this promoter via activated STATs . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 mediates its pleiotropic effects by interacting with its membrane bound receptor ( gp 80 ) or the soluble counterpart gp 54 , resulting in activation of a complex that includes the transducer protein gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Oncostatin M ( OSM ) and leukemia inhibitory factor ( LIF ) are members of the interleukin 6 ( IL 6 ) subfamily of cytokines that use a common signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In the case of interleukin 6 ( IL 6 ) , the signal transducing complex is composed of the ligand IL 6 , the IL 6 receptor ( IL 6R , gp 80 , CD 126 ) , and at least two gp 130 ( CD 130 ) molecules . ^^^ Molecular modeling guided mutagenesis of the extracellular part of gp 130 leads to the identification of contact sites in the interleukin 6 ( IL 6 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
BACKGROUND : The pleiotropic cytokine interleukin 6 mediates its multiple effects at the cell level through a multimeric receptor consisting of a binding protein ( gp 80 ) and a signal transducer ( gp 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Regulation of the genes encoding interleukin 6 , its receptor , and gp 130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin 1beta . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The stimulation by Flk 2 ligand ( FL ) of blast colony formation by murine bone marrow cells was selectively potentiated by the addition of regulators sharing in common the gp 130 signaling receptor leukemia inhibitory factor ( LIF ) , oncostatin M , interleukin 11 , or interleukin 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Each of these cytokines induces the hetero oligomerization of LIF R with gp 130 , a signal transducing subunit shared with interleukin 6 and interleukin 11 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Inhibition of interleukin 6 induced human immunodeficiency virus type 1 expression by anti gp 130 monoclonal antibody . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) induces the expression of acute phase plasma protein genes in hepatic cells through the action of gp 130 , the signal transducing subunit of the IL 6 receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The identification of the pivotal role of Interleukin 6 ( IL 6 ) , the soluble IL 6 receptor ( sIL 6R ) , and how the ligand receptor complex interacts with the signal transducer gp 130 has provided new biological insights into plasma cell disorders . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The molecular conjugates were used to deliver antisense oligonucleotides complementary to the mRNA of the interleukin 6 signal transduction protein ( gp 130 ) to modulate the acute phase response of hepatoma ( HepG 2 ) cells in vitro . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Binding of interleukin 6 to its receptor ( IL 6R ) induces the association of the IL 6R alpha chain ( IL 6Ralpha ) with a 130 kDa transmembrane glycoprotein , gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
RNA levels of SA , Cytochrome P 450 4B1 , IL 6ST ( interleukin 6 signal transducer ) , OATP ( organic anion transporter ) , and a newly identified gene , MJAM , were up regulated by androgen , while 16 alpha hydroxylase was decreased . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Internalization of the interleukin 6 signal transducer gp 130 does not require activation of the Jak / STAT pathway . ^^^ We have analysed whether internalization of the interleukin 6 signal transducer gp 130 is dependent on the activation of receptor associated Jak kinases . ^^^ Furthermore an antagonistic antibody that inhibits the signalling of all interleukin 6 type cytokines via gp 130 was internalized as efficiently as an agonistic one that activates the Jak / STAT pathway . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Signals propagated via the gp 130 subunit of the interleukin 6 ( IL 6 ) type cytokine receptors mediate , among various cellular responses , proliferation of hematopoietic cells and induction of acute phase plasma protein ( APP ) genes in hepatic cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Serum levels of interleukin 6 ( IL 6 ) , oncostatin M , soluble IL 6 receptor , and soluble gp 130 in patients with systemic sclerosis . ^^^ OBJECTIVE : To determine whether serum interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , soluble IL 6 receptor ( sIL 6R ) , and soluble gp 130 ( sgp 130 ) levels in patients with systemic sclerosis ( SSc ) are elevated and whether they are correlated with the clinical or serological features of the disease . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cytokines of the interleukin 6 ( IL 6 ) subfamily are a group of factors produced by osteoblasts and acting through the same transducing element , membrane protein gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We examined the effects of a monoclonal antihuman gp 130 antibody ( GPX 7 ) , which is known to inhibit interleukin 6 ( IL 6 ) and leukemia inhibitory factor mediated responses in human cells on the bone metabolism in normal and ovariectomized ( OVX ) , 7 month old , Wistar rats for 8 weeks . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) on target cells binds to the specific IL 6 receptor ( IL 6R ) and subsequently induces homodimerization of the signal transducing protein gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A potent interleukin 6 ( IL 6 ) antagonist ( Sant 5 ) , which binds tightly to the IL 6alpha receptor but has impaired gp 130 heterodimerization , has been developed recently by site directed mutagenesis of human IL 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We quantitated interleukin 6 ( IL 6 ) , soluble IL 6 receptor ( sIL 6R ) and soluble form of the IL 6 signal transducing protein gp 130 ( sgp 130 ) in cerebrospinal fluid ( CSF ) of patients with Alzheimer ' s disease ( AD ) ( n = 17 ) and control subjects ( n = 18 ) using sensitive enzyme linked immunosorbent assays ( ELISA ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
T cells in vivo by interleukin 6 . gp 130 is a common signal transducing receptor component for the interleukin 6 ( IL 6 ) family of cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Activation of the signal transducer gp 130 by interleukin 11 and interleukin 6 is mediated by similar molecular interactions . ^^^ Interleukin 6 ( IL 6 ) and interleukin 11 ( IL 11 ) , in complex with their specific alpha receptors , homodimerize gp 130 and , as a consequence , activate the Janus kinase ( Jak ) / signal transducer and activator of transcription ( STAT ) signalling pathway in their target cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The gp 130 cytokines leukemia inhibitory factor and interleukin 6 are neuroactive cytokines associated with peripheral nerve injury . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) has been postulated as a possible mediator of bone loss after estrogen deficiency , and its signal is transduced via glycoprotein 130 ( gp 130 ) after binding IL 6 receptor ( IL 6R ) in the membrane of target cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A gp 130 interleukin 6 transducer dependent SCID model of human multiple myeloma . ^^^ The agonist anti gp 130 MoAbs neither bound to murine gp 130 nor activated murine cells and , as a consequence , did not induce interleukin 6 ( IL 6 ) related toxicities in mice . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
AIMS AND METHODS : The aims of the present study were to examine : ( 1 ) immune inflammatory markers , i . e . serum interleukin 6 ( IL 6 ) , IL 8 , IL 6 receptor ( IL 6R ) , IL 1R antagonist ( IL 1RA ) , gp 130 , and prostaglandin E 2 ( PGE 2 ) production by mitogen stimulated whole blood and the availability of plasma tryptophan in patients with primary sleep disorders , major depression and healthy volunteers ; and ( 2 ) the relationships between the availability of tryptophan and indicators of the immune inflammatory response system . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Differential temporal expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha and gp 130 ) in injured peripheral nerves . ^^^ The mRNA expression of the neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptor components ( CNTFRalpha , LIFRbeta , IL 6Ralpha and gp 130 ) was examined in peripheral nerves after two different types of injury , crush and transection . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cardiotrophin 1 ( CT 1 ) , a cytokine with structural similarities to interleukin 6 , has been shown to signal through gp 130 dependent pathways . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The membrane proximal cytokine receptor domain of the human interleukin 6 receptor is sufficient for ligand binding but not for gp 130 association . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The immunoglobulin like module of gp 130 is required for signaling by interleukin 6 , but not by leukemia inhibitory factor . ^^^ The transmembrane protein gp 130 is a shared component of the receptor complexes for the interleukin 6 ( IL 6 ) type cytokines , which include IL 6 , leukemia inhibitory factor ( LIF ) and oncostatin M ( OSM ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) belongs to a family of cytokines using receptors sharing a common signal transducing chain , gp 130 and containing a specific ligand binding chain ( IL 6R alpha ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In addition , cytokines or their receptors not known to be expressed in RPE were included to widen our picture of cytokine gene expression in the eye : stem cell factor ( SCF ) , its receptor ( SCF R ) , low affinity nerve growth factor receptor p 75 ( p 75 ( NGF R ) , ciliary neutrothropic factor ( CNTF ) , and its receptor ( CNTF R ) , glycoprotein 130 interleukin 6 transducer ( gp 130 ( IL 6 SD ) , leukemia inhibitory factor ( LIF ) , and its receptor ( LIF R ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 , soluble interleukin 6 receptor ( agonist ) , soluble gp 130 and autoantibodies to IL 6 ( antagonist to IL 6 ) were measured , as well as C reactive protein as an indicator of disease activity . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Activation of the protein tyrosine phosphatase SHP 2 via the interleukin 6 signal transducing receptor protein gp 130 requires tyrosine kinase Jak 1 and limits acute phase protein expression . ^^^ Stimulation of the interleukin 6 ( IL 6 ) signalling pathway occurs via the IL 6 receptor glycoprotein 130 ( IL 6R gp 130 ) receptor complex and results in the regulation of acute phase protein genes in liver cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 and soluble interleukin 6 receptor : direct stimulation of gp 130 and hematopoiesis . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Characterization of soluble gp 130 released by melanoma cell lines : A polyvalent antagonist of cytokines from the interleukin 6 family . gp 130 acts as a common transducing signal chain for all receptors belonging to the interleukin ( IL ) 6 receptor family . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
SOCS 1 transcription is induced by cytokines , and the protein binds and inhibits Janus kinases and reduces cytokine stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 and the gp 130 component of the interleukin 6 receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Increased interleukin 6 levels , interleukin 6 receptor and gp 130 expression in peripheral lymphocytes of patients with inflammatory bowel disease . ^^^ Interleukin 6 binds to receptors on target cells ( such as hepatocytes and lymphocytes ) , consisting of an 80 kDa binding chain and gp 130 , a polypeptide responsible for signal transduction . ^^^ Our data show significantly elevated gene expression both of the 80 kDa interleukin 6 binding chain and gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The receptor gp 130 is utilized by cytokines including interleukin 6 , leukemia inhibitory factor , oncostatin M , cilary neurotrophic factor and cardiotrophin . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Constitutive internalization and association with adaptor protein 2 of the interleukin 6 signal transducer gp 130 . ^^^ The transmembrane protein gp 130 is the common signalling receptor subunit for the interleukin 6 ( IL 6 ) type cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Rat Chromosome 2 : assignment of the genes encoding cyclin B 1 , interleukin 6 signal transducer , and proprotein convertase 1 to the Mcs 1 containing region and identification of new microsatellite markers . ^^^ We report that the region ( 2q1 ) containing the mammary susceptibility cancer gene Mcs 1 also harbors the genes encoding cyclin B 1 , interleukin 6 signal transducer ( gp 130 ) , and proprotein convertase 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Oncostatin M ( OSM ) is a member of the interleukin 6 ( IL 6 ) family of cytokines that share the gp 130 receptor subunit . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Blocking signaling through the Gp 130 receptor chain by interleukin 6 and oncostatin M inhibits PC 3 cell growth and sensitizes the tumor cells to etoposide and cisplatin mediated cytotoxicity . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Blocking interleukin 6 activity with chimeric anti IL 6 monoclonal antibodies in multiple myeloma : effects on soluble IL 6 receptor and soluble gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 and the soluble IL 6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression : no alteration of soluble gp 130 . ^^^ We investigated whether cerebrospinal fluid ( CSF ) concentrations of interleukin 6 ( IL 6 ) , the soluble IL 6 receptor ( sIL 6R ) and the soluble form of the signal transducing and affinity converting receptor gp 130 ( sgp 130 ) are altered in geriatric patients with major depression ( MD ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Using immunohistochemistry , we also showed that Purkinje neurons express high levels of both the interleukin 6 receptor and its intracellular signaling subunit , gp 130 , indicating that interleukin 6 could act directly on Purkinje neurons to alter their physiological properties . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The high affinity interleukin 6 ( IL 6 ) receptor is a hexameric complex consisting of two molecules each of IL 6 , IL 6 receptor ( IL 6R ) , and the high affinity converter and signaling molecule , gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
They also had elevated ratios of TNFalpha / soluble TNF receptors and interleukin 6 / soluble gp 130 as well as enhanced interleukin 6 bioactivity in serum , suggesting inflammatory net effects . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Signal transduction in response to interleukin 6 ( IL 6 ) results from homodimerization of gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cell type specific responses to the leukemia inhibitory factor ( LIF ) / interleukin 6 cytokine family are mediated by dimerization of the LIF receptor alpha chain ( LIFRalpha ) with the signal transducer gp 130 or of two gp 130 molecules followed by activation of the JAK / STAT and Ras / mitogen activated protein kinase cascades . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We combined cerebrospinal fluid analyses of tau protein ( levels were significantly increased in AD patients [ p=0 . 0001 ] ) , a putative marker of neuronal degeneration , with components of the soluble interleukin 6 receptor complex ( sIL 6RC : IL 6 , soluble IL 6 receptor and soluble gp 130 ) , putative markers of neuroregulatory and inflammatory processes in the brain . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 receptor signaling . 1 . gp 80 and gp 130 receptor interaction in the absence of interleukin 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Leukemia inhibitory factor , Interleukin 6 , and other cytokines using the GP 130 transducing receptor : roles in inflammation and injury . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Both proteins share the same signalling pathways , which involve the interleukin 6 transducing receptor components leukaemia inhibitory factor receptor beta and gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
BACKGROUND : Oncostain M ( OM ) is a member of the interleukin 6 ( IL 6 ) cytokine family and all members utilize gp 130 as a common signal transducing receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Developmental requirement of gp 130 signaling in neuronal survival and astrocyte differentiation . gp 130 is a signal transducing receptor component used in common by the interleukin 6 ( IL 6 ) family of hematopoietic and neurotrophic cytokines , including IL 6 , IL 11 , leukemia inhibitory factor , ciliary neurotrophic factor , oncostatin M , and cardiotrophin 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The growth inhibition was postulated to result from a transcriptional downregulation of interleukin 6 receptor alpha ( IL 6Ralpha ) with IL 6Rbeta ( gp 130 ) unaffected . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Early hematopoietic cells express low levels of FLT 3 and c kit receptors , as well as the interleukin 6 ( IL 6 ) receptor signal transducing element , gp 130 , but do not express IL 6 receptor itself . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The N terminus of gp 130 is critical for the formation of the high affinity interleukin 6 receptor complex . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
OBJECTIVES : To determine whether the spontaneous production of interleukin 6 ( IL 6 ) , oncostatin M ( OSM ) , soluble IL 6 receptor ( sIL 6R ) and soluble gp 130 ( sgp 130 ) from peripheral blood mononuclear cells ( PBMC ) is increased in patients with systemic sclerosis ( SSc ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Flow cytometric analysis revealed that most immature hematopoietic progenitors express gp 130 but not interleukin 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Human herpesvirus 8 interleukin 6 ( vIL 6 ) signals through gp 130 but has structural and receptor binding properties distinct from those of human IL 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The expression of interleukin 6 ( IL 6 ) , IL 6 receptor , and gp 130 kilodalton glycoprotein in the rat decidua and a decidual cell line : regulation by 17beta estradiol and prolactin . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Gp 130 is a receptor subunit shared by the interleukin 6 family of cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The receptor gp 130 is used by the interleukin 6 ( IL 6 ) type cytokines , which include IL 6 and leukaemia inhibitory factor ( LIF ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) , two cytokines sharing the common gp 130 receptor subunit and functioning through activation of the intracellular JAK / STAT pathway , induce POMC synthesis and ACTH release . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We have previously reported obtaining two monoclonal antibodies ( mAb ) against the human gp 130 interleukin 6 ( IL 6 ) transducer which made possible the dimerization of gp 130 and the activation of several IL 6 driven functions when used together . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Studies on the interleukin 6 type cytokine signal transducer gp 130 reveal a novel mechanism of receptor activation by monoclonal antibodies . ^^^ The individual antibodies inhibit activation of the signal transducer by interleukin 6 and interfere with binding of interleukin 6 to gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Serum concentrations of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , gp 130 ( the IL 6 signaling protein ) , IL 1R antagonist ( IL 1RA ) and leukemia inhibitory factor receptor ( LIFR ) were assayed in 22 nonpregnant women and in 91 pregnant women before delivery and 1 and 3 days after delivery . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Gp 130 cytokine receptor is involved in the formation of multimeric functional receptors for interleukin 6 ( IL 6 ) , IL 11 , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Different epitopes are required for gp 130 activation by interleukin 6 , oncostatin M and leukemia inhibitory factor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Endotoxin down regulates monocyte and granulocyte interleukin 6 receptors without influencing gp 130 expression in humans . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 11 ( IL 11 ) belongs to the interleukin 6 ( IL 6 ) type subfamily of long chain helical cytokines including IL 6 , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M , and cardiotrophin 1 , which all share the glycoprotein gp 130 as a signal transducing receptor component . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cardiotrophin 1 ( CT 1 ) , a novel cytokine that belongs to the interleukin 6 cytokine family , activates gp 130 dependent signaling pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Circulating concentrations of soluble interleukin 6 receptors gp 80 and gp 130 in chronic renal failure and effects of renal replacement therapy . ^^^ No data are available on the concentrations of the circulating interleukin 6 ( IL 6 ) receptors gp 80 and gp 130 during chronic renal insufficiency . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The interleukin 6 ( IL 6 ) receptor complex comprises the IL 6 receptor ( IL 6R , gp 80 ) and the signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The receptor for interleukin 6 ( IL 6 ) consists of two subunits : a ligand specific IL 6Ralpha and gp 130 that is responsible for signal transduction . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
SOCS 3 exerts its inhibitory function on interleukin 6 signal transduction through the SHP 2 recruitment site of gp 130 . ^^^ Furthermore , we show that tyrosine 759 in gp 130 is essential for both SHP 2 and SOCS 3 but not for SOCS 1 to exert their inhibitory activities on interleukin 6 signal transduction . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Regulation of CCAAT / Enhancer binding protein , interleukin 6 , interleukin 6 receptor , and gp 130 expression during myocardial ischemia / reperfusion . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor and interleukin 6 ( IL 6 ) , which belong to the cytokine receptor family using the common gp 130 signal transducer . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 exerts its activity via two receptor subunits , IL 6R and glycoprotein 130 ( gp 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Acute obstructive cholangiopathy in interleukin 6 deficient mice : compensation by leukemia inhibitory factor ( LIF ) suggests importance of gp 130 signaling in the ductular reaction . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Human herpes virus 8 interleukin 6 homologue triggers gp 130 on neuronal and hematopoietic cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) signals via the heterodimeric receptor complex comprising the LIF receptor alpha subunit ( LIFRalpha ) and the common signal transducing subunit for interleukin 6 cytokine receptors , gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cardiotrophin 1 ( CT 1 ) is a novel cytokine capable of inducing hypertrophy in cardiac myocytes and belongs to the interleukin 6 family that exert their biological effects through gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A single amino acid substitution ( Trp ( 666 ) > Ala ) in the interbox1 / 2 region of the interleukin 6 signal transducer gp 130 abrogates binding of JAK 1 , and dominantly impairs signal transduction . gp 130 is the common signal transducing receptor chain of interleukin ( IL ) 6 type cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
BACKGROUND : Interleukin 6 ( IL 6 ) exerts its actions through a cell surface receptor system that consists of two transmembrane subunits : the IL 6 binding glycoprotein gp 80 ( IL 6R ) and the signal transducing component ( gp 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cytokines of the interleukin 6 ( IL 6 ) family , which activates the signal transducer gp 130 , are major survival and growth factors for human multiple myeloma ( MM ) cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The biological actions of interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) are mediated via respective functional receptor complexes consisting of a common signal transducing component , gp 130 , and other specific receptor components , IL 6 receptor alpha ( IL 6R ) , LIF receptor beta ( LIFR ) , and CNTF receptor alpha ( CNTFR ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Serum levels of soluble interleukin 6 receptor and soluble gp 130 are elevated in patients with localized scleroderma . ^^^ OBJECTIVE : To investigate the clinical relevance of serum soluble interleukin 6 receptor ( sIL 6R ) and soluble gp 130 ( sgp 130 ) in localized scleroderma . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) type cytokines show functional redundancy in the immune , hematopoietic , and nervous system , which is believed to result from sharing of the signal transducing receptor gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) type cytokines stimulate osteoclast formation by activating the glycoprotein 130 ( gp 130 ) receptor subunit on stromal / osteoblastic cells , which in turn leads to signal transducer and activator of transcription 3 ( STAT 3 ) mediated expression of receptor activator of NF kappaB ligand ( RANKL ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cytokine inducible proteins named as suppressors of cytokine signaling ( SOCS ) are rapidly induced by interleukin 6 ( IL 6 ) and other members sharing the gp 130 receptor subunit after activation of the Janus kinases ( JAK ) and the signal transducers and activators of transcription ( STAT ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Although both cell lines express similar amounts of the interleukin 6 ( IL 6 ) signal transducer gp 130 , the DR transfected cells still show activation of STAT factors by IL 6 , whereas D 064 cells do not . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Levels of tumor necrosis factor alpha ( TNF alpha ) , its soluble receptors sTNF RI and sTNF RII , interleukin 6 ( IL 6 ) , IL 6 soluble receptor , soluble gp 130 , interleukin 2 soluble receptor , and soluble Fas were measured with enzyme linked immunosorbent assay kits . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
BACKGROUND : Cardiotrophin 1 ( CT 1 ) , a member of the interleukin 6 related cytokine family that act via the gp 130 signalling pathway , has been shown to stimulate the assembly of sarcomeric units in series in cardiomyocytes resulting in eccentric hypertrophy , ventricular dilatation and finally loss of function . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Soluble gp 130 is the natural inhibitor of soluble interleukin 6 receptor transsignaling responses . ^^^ Signal transduction in response to interleukin 6 ( IL 6 ) requires binding of the cytokine to its receptor ( IL 6R ) and subsequent homodimerization of the signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We generated several chimaeric proteins of gp 130 and the proteins tumour necrosis factor alpha ( TNF alpha ) , transforming growth factor alpha ( TGF alpha ) and interleukin 6 receptor ( IL 6R ) , which are known to be subject to shedding . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Signalling of interleukin 6 type cytokines via gp 130 , leukemia inhibitory factor ( LIF ) receptor and oncostatin M receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Signals of interleukin 6 ( IL 6 ) are transduced by binding of IL 6 to its cell surface receptor ( IL 6R ) and subsequent association of the resultant IL 6 / IL 6R complex with gp 130 , the signal transducing receptor component utilized in common by all the IL 6 family of cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A model of the Ig like domain showed that the binding site is very similar to the viral interleukin 6 binding site ( site 3 ) on the Ig like domain of gp 130 , a related receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Here we show that the in vitro translated N terminal domains of Jak 1 are sufficient for binding to a biotinylated peptide comprising the membrane proximal 73 amino acids of gp 130 , the signal transducing receptor chain of interleukin 6 type cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cross talk of the interferon alpha / beta signalling complex with gp 130 for effective interleukin 6 signalling . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The biosynthesis of interleukin 6 receptor ( IL 6R ) and gp 130 in vitro was blocked using specific antisense oligonucleotides ( ASO ) in HepG 2 liver cells and the efficacy of various ASOs was tested on the generation of IL 6 induced junB mRNA . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Expression of interleukin 6 , interleukin 6 receptor ( gp 80 ) , and the receptor ' s signal transducing subunit ( gp 130 ) in human normal pituitary glands and pituitary adenomas . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
To determine the role of this domain in governing recruitment of Jak 1 , but not Jak 3 , to the gp 130 subunit of the interleukin 6 family of cytokine receptors , the interaction of three Jak1 / Jak3 chimeras with gp 130 was investigated . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The cytokines that signal through the common receptor subunit gp 130 , including ciliary neurotrophic factor ( CNTF ) , interleukin 6 , leukemia inhibitory factor ( LIF ) and oncostatin M , have pleiotropic functions in CNS development . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A tripartite receptor comprising the external region of the erythropoietin ( Epo ) receptor , the transmembrane and JAK binding domains of the gp 130 subunit of the interleukin 6 ( IL 6 ) receptor , and a seven amino acid STAT 1 recruitment motif ( Y 440 ) from the interferon ( IFN ) gamma receptor , efficiently mediates an IFN gamma like response . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The pericryptal fibroblast cells expressed messenger RNA ( mRNA ) for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , LIF receptor alpha , and the common coreceptor glycoprotein 130 ( GP 130 ) , but not the IL 6 receptor alpha . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Various cell lines expressing receptor subunits to the different interleukin 6 class cytokines revealed that only LIFRalpha degradation is promoted by activated ERK and that degradation of gp 130 , OSMRbeta , and a fraction of LIFRalpha involves mechanisms that are separate from signal transduction . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Investigation of interleukin 6 ( IL 6 ) , soluble IL 6 receptor ( sIL 6R ) and soluble gp 130 ( sgp 130 ) in sera of cancer patients . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) induces the activation of the Src family kinase Hck , which is associated with the IL 6 receptor beta chain , gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
BACKGROUND : Cardiotrophin 1 is a newly identified member of the interleukin 6 ( IL 6 ) family of cytokines and one of the endogenous ligands for gp 130 signaling pathways in the heart , and it has potent hypertrophic and survival effects on cardiac myocytes . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The secondary structure of leptin has similarities to the long chain helical cytokines family , which includes interleukin 6 ( IL 6 ) , IL 11 , CNTF , and LIF , and the leptin receptor is homologous to the gp 130 signal transducing subunit of the IL 6 type cytokine receptors . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) induces B cell proliferation by binding to receptor complexes composed of a specific alpha receptor ( gp 80 ; CD 126 ) and the signal transducing receptor subunit gp 130 ( CD 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Structural requirements of the interleukin 6 signal transducer gp 130 for its interaction with Janus kinase 1 : the receptor is crucial for kinase activation . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Determination of serum soluble interleukin 6 receptor and soluble gp 130 levels in patient with pregnancy induced hypertension and its significance ] . ^^^ OBJECTIVE : To observe the changes of serum soluble interleukin 6 receptor ( sIL 6R ) and soluble gp 130 ( sgp 130 ) in patients with pregnancy induced hypertension . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Among the proinflammatory mediators , leukemia inhibitory factor ( LIF ) , which shares a receptor component ( gp 130 subunit ) with interleukin 6 ( IL 6 ) , has been identified as a mast cell growth enhancing factor produced by cells of the keratinocyte derived cell line ( KCMH 1 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Oncostatin M ( OSM ) , an interleukin 6 type cytokine , acts via the gp 130 signaling receptor to inhibit proliferation and induce differentiation of breast cancer cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The primary structure of leptin receptor belongs to the cytokine class 1 family , the single membrane spanning receptor , and is highly related to the gp 130 signal transducing component of the interleukin 6 ( IL 6 ) receptor , the granulocyte colony stimulating factor ( G CSF ) receptor , and the leukemia inhibitory factor ( LIF ) receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
IL6RIL6 stimulates the interleukin 6 family cytokine receptor gp 130 , leading to the rapid phosphorylation of Stat 3 on tyrosine 705 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The effects of interleukin 6 on key intermediates in early steps of the interleukin 6 signaling pathway , including janus kinase 1 , gp 130 , the interleukin 6 receptor , STAT 1 , and STAT 3 , were examined in both saline and endotoxin treated rats . ^^^ MEASUREMENTS AND MAIN RESULTS : In endotoxin treated rats , there was significant inhibition of interleukin 6 activation of janus kinase 1 , gp 130 , the interleukin 6 receptor , STAT 1 , and STAT 3 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Signaling domains derived from receptors for interleukin 6 ( gp 130 ) , hepatocyte growth factor ( c met ) , epithelial growth factor ( EGF R ) , and thrombopoietin ( mpl ) triggered monkey hepatocytes to enter the cell cycle . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The glycoprotein 130 ( gp 130 ) is the common signal transducing receptor chain of the interleukin 6 family of cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Exposure of these cells to other gp 130 receptor family cytokines , including leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and IL 11 , do not significantly affect DNA synthesis or induction of tPA / PAI 1 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The levels of gp 130 were significantly stimulated by the addition of interleukin 1 beta ( IL 1 beta ) or interleukin 6 ( IL 6 ) but not by the addition of follicle stimulating hormone ( FSH ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cytokines belonging to the so called interleukin 6 ( IL 6 ) or gp 130 cytokine family , notably IL 6 and IL 11 , are known as pro resorptive cytokines , in that they promote osteoclastogenesis . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Suppressor of cytokine signaling 3 ( SOCS 3 ) and the protein tyrosine phosphatase SHP 2 both regulate signaling by cytokines of the interleukin 6 family , and this is dependent upon recruitment to tyrosine 757 in the shared cytokine receptor subunit gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
These data indicate that interleukin 6 receptor expression is very low on hippocampal neurons and that gp 130 stimulation can be used to rescue hippocampal neurons from excitotoxicity . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We also confirmed the previously reported activities of HHV 8 encoded huIL 6 homologue ( viral interleukin 6 [ vIL 6 ] ) on human immunodeficiency virus ( HIV ) replication in U 1 cell line and huIL 6 production by MT 4 T cells , and utilizing monoclonal antibodies to the huIL 6 receptor components , we elucidated that gp 130 is the signaling molecule necessary for these vIL 6 activities . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A point mutation of Tyr 759 in interleukin 6 family cytokine receptor subunit gp 130 causes autoimmune arthritis . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Gp 130 activation by soluble interleukin 6 receptor / interleukin 6 enhances osteoblastic differentiation of human bone marrow derived mesenchymal stem cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Analysis of myeloma cell derived plasma membrane fractions shows that caveolin 1 is co localized with interleukin 6 receptor signal transducing chain gp 130 and with insulin like growth factor 1 receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
To determine whether the pathophysiological processes after transient forebrain ischemia are mediated via a signal pathway involving gp 130 ( a signal transducer for the interleukin 6 family ) , we analyzed changes in the expression of gp 130 and its downstream transcription factor , signal transducer and activator of transcription factor 3 ( STAT 3 ) , in the rat hippocampus of a four vessel occlusive ischemia model . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
LIF acts on responding cells by binding to a heterodimeric membrane receptor composed of a low affinity LIF specific receptor and the gp 130 receptor chain also used as the receptor for interleukin 6 , oncostatin M , cardiotrophin 1 , and ciliary neurotrophic factor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cytokines of the interleukin 6 family utilize the shared cytokine receptor gp 130 in the formation of active signalling complexes . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In addition to CNTF , the mRNAs of leukemia inhibitory factor , interleukin 6 , ciliary neurotrophic factor receptor component alpha and gp 130 were detected in the Schwann cells . . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The objective of our study was to mimic in a typical reductionist approach the molecular interactions observed at the interface between the gp 130 receptor and interleukin 6 during formation of their complex . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Previous studies with rat CNTF demonstrated that rat CNTF is unable to interact with the human interleukin 6 alpha receptor , whereas at high concentrations , it can directly induce a signaling heterodimer of human gp 130 and human LIFR in the absence of the CNTF receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Here we show that Cdk 9 interacts with gp 130 , the receptor of the Interleukin 6 ( IL 6 ) family of cytokines , which includes Leukemia Inhibitory Factor ( LIF ) , Oncostatin M ( OSM ) , Ciliary Neurotrophic Factor ( CNTF ) , Interleukin 11 ( IL 11 ) and Cardiotrophin ( CT 1 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
SHP 2 and SOCS 3 contribute to Tyr 759 dependent attenuation of interleukin 6 signaling through gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Recently , a crystal structure of a viral interleukin 6 ( vIL 6 ) , complexed with the D1D2D3 domains of the gp 130 extracellular domain , has resolved many of these questions , and reconciled much of the functional and mutagenesis data which have existed for a variety of gp 130 cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In liquid cultures , megakaryocytes from gp 130 ( delta ) / ( delta ) mice are smaller than those from wild type mice and do not increase in size upon stimulation with interleukin 6 or interleukin 11 . ^^^ Administration of either interleukin 6 or interleukin 11 to gp 130 ( delta ) / ( delta ) mice failed to increase platelet numbers , despite an increase in the production of megakaryocytes . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Previous studies showed that activation of the gp 130 receptor system , using as ligand interleukin 6 fused to its soluble receptor ( IL6RIL6 ) , causes induction of myelin genes such as myelin basic protein ( MBP ) and myelin protein zero ( Po ) in embryonic dorsal root ganglia Schwann cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A fusion protein of the gp 130 and interleukin 6Ralpha ligand binding domains acts as a potent interleukin 6 inhibitor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Genetic profiling of alpha 1 adrenergic receptor subtypes by oligonucleotide microarrays : coupling to interleukin 6 secretion but differences in STAT 3 phosphorylation and gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Using the recently engineered designer cytokine IC 7 , which induces an active heterodimer of the LIFR and gp 130 after binding to the IL 6R , and several receptor chimeras of the LIFR and the interleukin 6 receptor ( IL 6R ) carrying the CBM of the IL 6R in place of the COOH terminal LIFR CBM , we could assign individual receptor subdomains to individual binding sites of the ligand . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) is an immunoregulatory cytokine that activates a cell surface signaling assembly composed of IL 6 , the IL 6 alpha receptor ( IL 6Ralpha ) , and the shared signaling receptor gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
DESIGN AND METHODS : ELISA was used to determine the serum levels of soluble interleukin 2 receptors , interleukin 1 , interleukin 6 , and 2 soluble interleukin 6 receptors ( sIL 6R and soluble gp 130 ) in 18 patients with cluster headache ( 6 women and 12 men ) during the cluster period and in 17 healthy controls who were headache free ( 3 women and 14 men ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) is a gp 130 neuroregulatory cytokine belonging to the interleukin 6 type cytokine superfamily . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Interleukin 6 ( IL 6 ) contributes via its signal transducer gp 130 to the acute phase response ( APR ) in hepatocytes . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We previously demonstrated that interleukin 6 related cytokine , leukemia inhibitory factor ( LIF ) , induced cardiac hypertrophy through gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
To avoid the disease progression and the adverse events of high dose corticosteroids , it might be a reasonable treatment strategy to inhibit the formation of interleukin 6 / interleukin 6 receptor complex to block the binding to gp 130 receptor , a biologically active receptor for interleukin 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We describe a novel cytokine receptor named GP 130 Like receptor , or GPL , that displays similarities with the interleukin 6 and interleukin 12 family of signaling receptors . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
On target cells , interleukin 6 first binds to its specific receptor and subsequently to a homodimer of the signal transducer protein gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The targets / drugs that are being developed to inhibit bone resorption include the OPG / RANKL / RANK system , cathepsin K inhibitors , vitronectin receptor antagonists , estren , the interleukin 6 and gp 130 system , cytokines and growth factors . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
BACKGROUND : Experimental studies indicate that interleukin 6 ( IL 6 ) related cytokines , signaling via the shared receptor gp 130 , Janus kinases ( JAKs ) , and signal transducers and activators of transcription ( STATs ) , provide a critical cardiomyocyte survival pathway in vivo . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
OBJECTIVE : Interleukin 6 ( IL 6 ) , a member of the gp 130 cytokine family , is considered to be an important modulator of function and growth in endocrine anterior pituitary cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) induced cell signaling occurs following sequential binding to the LIF receptor alpha chain ( LIFR ) , then to the gp 130 co receptor used by all members of the interleukin 6 family of cytokines . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We previously observed that triggering of the gp 130 receptor system by the IL6RIL6 ligand , comprising interleukin 6 ( IL 6 ) fused to the soluble IL 6 receptor , induces myelin gene expression in rat embryonic dorsal root ganglia ( DRG ) cultures as well as in the murine melanoma cell line B16 / F10 . 9 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cytokines of the gp 130 family , particularly interleukin 6 ( IL 6 ) , play a central role in the growth and survival of malignant plasma cells . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
How does interleukin 6 affect the membrane expressions of interleukin 6 receptor and gp 130 and the proliferation of the human myeloma cell line OPM 2 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Molecular mechanisms for viral mimicry of a human cytokine : activation of gp 130 by HHV 8 interleukin 6 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
High glucose enhances interleukin 6 induced vascular endothelial growth factor 165 expression via activation of gp 130 mediated p44 / 42 MAPK CCAAT / enhancer binding protein signaling in gingival fibroblasts . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The mechanisms by which interleukin 6 ( IL 6 ) family cytokines , which utilize the common receptor signaling subunit gp 130 , influence monocyte / macrophage development remain unclear . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Kaposi ' s sarcoma associated herpesvirus interleukin 6 ( vIL 6 ) is a structural and functional homologue of the human cytokine IL 6 ( hIL 6 ) . hIL 6 and vIL 6 exhibit similar biological functions and both act via the gp 130 receptor subunit to activate the Janus tyrosine kinase ( JAK ) 1 and signal transducer and activator of transcription ( STAT ) 1 / 3 pathway . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Viral interleukin 6 ( vIL 6 ) is a homolog of cellular IL 6 that is encoded by the Kaposi ' s sarcoma associated herpesvirus ( KSHV ) genome . vIL 6 binds to the IL 6 signal transducer gp 130 without the cooperation of the IL 6 high affinity receptor to induce STAT 3 DNA binding and cell proliferation . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The preservation of `` stemness ' ' in mouse embryonic stem ( mES ) cells is maintained through a signal transduction pathway that requires the gp 130 receptor , the interleukin 6 ( IL 6 ) family of cytokines , and the Janus Kinase signal transducer and activator ( JAK / STAT ) pathway . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The interleukin 6 ( IL 6 ) family of cytokines signals through the common receptor subunit gp 130 , and subsequently activates Stat 3 , MAPK , and PI3K . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Circulating interleukin 6 family cytokines and their receptors in patients with congestive heart failure . gp 130 is a common signal transducing receptor subunit for the interleukin ( IL ) 6 cytokine family . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The interleukin 6 cytokines , acting via gp 130 receptor pathways , play a pivotal role in the reduction of cardiac injury induced by mechanical stress or ischemia and in promoting subsequent adaptive remodeling of the heart . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The relationship between circulating C reactive protein concentrations and potential cytokine and receptor mediators ( interleukin 6 , leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , soluble IL 6 receptor , soluble gp 130 , soluble TNF receptor , interleukin 1 receptor antagonist and interleukin 8 ( IL 8 ) ) of this acute phase protein were examined in healthy subjects ( n=11 ) and patients with non small cell lung cancer ( n=50 ) . ^^^ C reactive protein , interleukin 6 , soluble gp 130 , soluble TNF receptor , interleukin 1 receptor antagonist and IL 8 concentrations were significantly elevated in cancer patients ( P < or =0 . 001 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 is a multifunctional cytokine that exerts its biological activity through binding to an 80 Kd specific receptor ( IL 6Ralpha ) and a 130 Kd signal transducing unit ( gp 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
OBJECTIVE : Interleukin 6 ( IL 6 ) and soluble IL 6 receptor ( sIL 6R ) activation of gp 130 represents an alternative pathway for osteoclast development in inflammatory conditions . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Cytokines of the interleukin 6 ( IL 6 ) type family all bind to the glycoprotein gp 130 on the cell surface and require interaction with two gp 130 or one gp 130 and another related signal transducing receptor subunit . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
OBJECTIVE : To observe the effect of Chinese herbs for supplementing Shen and strengthening bone ( HB ) on myelogenic osteoclasts formation , and gene expression of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) and gp 130 in bone marrow . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
IL 6 acts on target cells via the ligand binding protein interleukin 6 receptor ( IL 6R ) and the affinity converting and signal transducing glycoprotein 130 ( gp 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Elevated serum levels of interleukin 6 ( IL 6 ) , an inflammatory cytokine and a member of the glycoprotein 130 ( gp 130 ) ligand family , are found in obese patients and might indicate low grade systemic inflammation . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) is a pleiotropic cytokine , signaling intracellularly via its unique membrane bound receptor IL 6R and gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 signaling during ischemia and reperfusion was assessed at the protein expression level by means of Western measurements of interleukin 6 receptor , the signaling subunit of the interleukin 6 receptor complex ( gp 130 ) , and signal transducer of activated transcription 3 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Finally , results from in vitro and in vivo experiments suggest a role for NF kappaB in the regulation of prohypertrophic interleukin 6 receptor gp 130 on mRNA levels . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In addition also the other gp 130 ligands tested , cardiotrophin 1 ( CT 1 ) , interleukin 6 ( IL 6 ) and leukemia inhibitory factor ( LIF ) had no effect on the expression of TIMPs and MMPs studied . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A crystal structure of the ligand binding domains of gp 130 in complex with human interleukin 6 ( IL 6 ) and its a receptor ( IL 6Ralpha ) revealed a hexameric architecture in which the gp 130 membrane distal regions were approximately 100 A apart , in contrast to the close apposition seen between short cytokine receptor complexes . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) is a 4 helical protein that binds to a specific IL 6 receptor on target cells and to two molecules of the promiscuous signal transducing protein , glycoprotein 130 ( gp 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) is a four helical protein which , on target cells , binds to a specific IL 6 receptor and two molecules of the promiscuous signal transducing protein gp 130 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Conversely , interleukin 6 ( IL 6 ) a potent cytokine inhibits myeloma cell apoptosis by activating GP 130 through the IL 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
The cytokine interleukin 6 ( IL 6 ) exerts it actions via the IL 6 receptor ( IL 6R ) in conjunction with the ubiquitously expressed gp 130 receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) is a central regulator of inflammation ; its action is augmented by the soluble IL 6 receptor ( sIL 6R ) and inhibited by the soluble gp 130 ( sgp 130 ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) belongs to the interleukin 6 cytokine family , all members of which signal through the common gp 130 receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) signals through gp 130 homodimers whereas leukaemia inhibitory factor ( LIF ) exerts its action through a heterodimer of gp 130 and the LIF receptor ( LIFR ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Identification of a basolateral sorting signal within the cytoplasmic domain of the interleukin 6 signal transducer gp 130 . ^^^ For the interleukin 6 receptor gp 80 and its signal transducer gp 130 , a preferential basolateral localization was demonstrated in Madin Darby canine kidney ( MDCK ) cells and two basolateral sorting signals were identified within the cytoplasmic domain of gp 80 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Enzyme linked immunosorbent assays ( ELISA ) were used to determine the concentration of interferon gamma ( IFN gamma ) and interleukin 6 ( IL 6 ) in the culture medium of mitogen stimulated lymphocytes as well as the plasma concentrations of IL 6 , soluble IL 6 receptor , soluble gp 130 , and IFN gamma . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
We show that LANA directly associates with an interleukin 6 signal transducer , signal transducer and activator of transcription 3 ( STAT 3 ) and that LANA enhances the transcriptional activity of STAT 3 . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
A form of circulating interleukin 6 receptor component soluble gp 130 as a potential interleukin 6 inhibitor in inflammatory bowel disease . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Although higher in HD group , inflammatory indexes ( C reactive protein , interleukin 6 , IL 6 , soluble IL 6 and soluble gp 130 ) were not correlated to telomerase activity in PBMCs . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
OBJECTIVE : Soluble gp 130 is the naturally occurring antagonist of the interleukin 6 ( IL 6 ) / soluble IL 6 receptor ( sIL 6R ) complex and selectively inhibits IL 6 trans signaling . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
These abilities were inhibited to approximately 60 % by the addition of antibodies against interleukin 6 , or alpha chain ( gp 80 ) or beta chain ( gp 130 ) of IL 6 receptor . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
Structural requirements for gp 80 independence of human herpesvirus 8 interleukin 6 ( vIL 6 ) and evidence for gp 80 stabilization of gp 130 signaling complexes induced by vIL 6 . ^^^ Human herpesvirus 8 interleukin 6 ( vIL 6 ) displays 25 % amino acid identity with human IL 6 ( hIL 6 ) and shares an overall four helix bundle structure and gp 130 mediated STAT / mitogen activated protein kinase signaling with its cellular counterpart . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
In both the CCs and BECs , exogenous HGF or IL 6 induced phosphorylation of met or gp 130 , respectively , and a concentration dependent increase in DNA synthesis . ^^^ However , the CCs but not BECs , continued to grow in basal serum free medium ( SFM ) and spontaneously produced both IL 6 and HGF under these conditions , which resulted in auto phosphorylation of gp 130 and met , respectively ; and neutralizing anti HGF or anti IL 6 alone inhibited CC growth , indicative of autocrine growth control circuits . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
RESULTS : Proliferation by CFU GM and BFU E was enhanced synergistically when common beta chain receptor cytokines ( IL 3 or GM CSF ) were combined with G CSF or EPO , but not with gp 130 receptor cytokines ( LIF or IL 6 ) or tyrosine kinase receptor cytokines ( SCF , HGF , Flt 3 ligand , or PDGF ) . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
To confirm the reliability of the microarray results , keratin K 5 and desmocolin , and vimentin and gp 130 , which showed higher mRNA levels in HGE and HGF , respectively , were selected and their mRNA levels were further analyzed by RT PCR . ^^^
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA
Interacting proteins: P05231 and P40189	Pubmed	SVM Score :0.0
NA