| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.52555247 |
| We show that PGC 1alpha directly interacts with TRAP / Mediator , through the PPARgamma interacting subunit TRAP 220 , and stimulates TRAP / Mediator dependent function on DNA templates . 0.52555247^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Identification of a specific molecular repressor of the peroxisome proliferator activated receptor gamma Coactivator 1 alpha ( PGC 1alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator activated receptor gamma coactivator 1 alpha . ^^^ In the course of searching for the mediator of CAR activation , we found that ligand independent activation of CAR was achieved in cooperation with the peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1 alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We discuss the regulation of nuclear respiratory factor 1 ( NRF 1 ) and peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1alpha ) by T 3 , suggesting NRF 1 and PGC 1alpha as attractive candidates for an intermediate factor of T 3 action in vivo . . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Regulation of peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1 alpha ) and mitochondrial function by MEF 2 and HDAC 5 . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1 alpha ) : transcriptional coactivator and metabolic regulator . ^^^ We have reviewed here the molecular mechanisms and biological programs controlled by the transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1 alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In the liver , activation of LXR led to the suppression of the gluconeogenic program including down regulation of peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1 ) , phosphoenolpyruvate carboxykinase ( PEPCK ) , and glucose 6 phosphatase expression . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Overexpression of STAT 3 in cultured hepatocytes inhibited gluconeogenic gene expression independently of peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1 alpha ) , an upstream regulator of gluconeogenic genes . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Coactivation of the human vitamin D receptor by the peroxisome proliferator activated receptor gamma coactivator 1 alpha . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 alpha promoter polymorphisms are associated with early onset type 2 diabetes mellitus in the Korean population . ^^^ AIMS / HYPOTHESIS : Peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1alpha ) is a transcriptional coactivator implicated in insulin release by beta cells and in insulin resistance . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Exercise increased ( P < . 05 ) transcription and / or mRNA content of the pyruvate dehydrogenase kinase 4 , uncoupling protein 3 , lipoprotein lipase , carnitine palmitoyltransferase 1 , hexokinase 2 , peroxisome proliferator activated receptor gamma coactivator 1 alpha , and peroxisome proliferator activated receptor alpha . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| This was associated with a three fold stimulation of the expression of genes encoding regulatory factors for mitochondrial biogenesis and oxidative metabolism ( peroxisome proliferator activated receptor gamma coactivator 1 alpha [ Ppargc1a , also known as Pgc1alpha ] and nuclear respiratory factor 1 [ Nrf 1 ] respectively ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| To further explore the antiobesity effect of freeze dried bitter melon ( BM ) juice , activities of mitochondrial lipid oxidative enzymes as well as the expression of uncoupling proteins and their transcription coactivator peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1alpha ) were determined in diet induced obese ( DIO ) rats . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We show here that the underlying sequence motifs are not conserved in the human gene and provide evidence for regulatory mechanisms involving the transcriptional cofactor peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We have previously identified a transcriptional co activator , peroxisome proliferator activated receptor gamma co activator 1 ( PGC 1 alpha ) , which is expressed in several tissues including brown fat and skeletal muscle , and that activates mitochondrial biogenesis and oxidative metabolism . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte nuclear factor 4 alpha mediates the stimulatory effect of peroxisome proliferator activated receptor gamma co activator 1 alpha ( PGC 1 alpha ) on glucose 6 phosphatase catalytic subunit gene transcription in H4IIE cells . ^^^ It has recently been shown that adenoviral mediated expression of peroxisome proliferator activated receptor gamma co activator 1 alpha ( PGC 1 alpha ) in hepatocytes stimulates glucose 6 phosphatase catalytic subunit ( G6Pase ) gene expression . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma ( PPAR gamma ) and PPAR gamma coactivator 1 alpha ( PGC 1 alpha ) activate mouse UCP 1 gene transcription . ^^^ Peroxisome proliferator activated receptor gamma ( PPAR gamma ) and PPAR gamma coactivator 1 alpha ( PGC 1 alpha ) activate mouse UCP 1 gene transcription . ^^^ We show here that human PGC 1 alpha induced the activation of the human UCP 1 promoter by PPAR gamma . ^^^ The PPAR gamma agonist rosiglitazone potentiated the effect of PGC 1 alpha on UCP 1 expression and fatty acid oxidation . ^^^ Hence , PGC 1 alpha is able to direct human WAT PPAR gamma toward a transcriptional program linked to energy dissipation . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The expression of the peroxisome proliferator activated receptor gamma co activator 1 alpha ( PGC 1 alpha ) gene was downregulated in CHF , as well as nuclear respiratory factor 2 and mitochondrial transcription factor A , which act downstream from PGC 1 alpha . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| PXR also interacted with peroxisome proliferator activated receptor gamma coactivator ( PGC 1 alpha ) , which interacted with HNF 4 alpha and induced CYP7A1 gene transcription . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| METHODS : mRNA expression levels for peroxisome proliferator activated receptor ( PPAR ) alpha , gamma and delta , PPARgamma co factor 1 alpha and beta ( PGC 1 alpha and beta ) , 9 cis retinoc acid activated receptor alpha , beta and gamma ( RXR alpha , beta , gamma ) , 5 ' AMP activated protein kinase ( AMPK ) alpha 1 and alpha 2 , adiponectin receptor 1 and 2 ( AR 1 and AR 2 ) were measured in heart tissue of neonatal 0 day , 7 day and 21 day old rats . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| A JNK specific inhibitor blocked the inhibitory effect of IL 1 beta on HNF 4 alpha expression and CYP7A1 reporter activity . c Jun inhibited HNF 4 alpha and PPARgamma coactivator 1 alpha ( PGC 1 alpha ) coactivation of CYP7A1 reporter activity , whereas a dominant negative c Jun did not . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Animal and human data indicate a role for the peroxisome proliferator activated receptor gamma coactivator 1alpha ( PPARGC1A ) gene product in the development of maximal oxygen uptake ( 5 ( O 2 max ) ) , a determinant of endurance capacity , diabetes , and early death . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| High levels of expression of PPARG and the gene encoding its interacting protein , PPARGC1A , in most EMCs suggest activation of lipid metabolism pathways in this tumour . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Adipose tissue mRNA concentrations of facilitated glucose transporter , member 1 ( SLC2A1 , previously known as GLUT 1 ) , facilitated glucose transporter , member 4 ( SLC2A4 , previously known as GLUT 4 ) , peroxisome proliferator activated receptor gamma ( PPARG ) , peroxisome proliferator activated receptor gamma co activator 1alpha ( PPARGC1A ) , 11beta hydroxysteroid dehydrogenase 1 ( HSD11B1 ) , TNF , adiponectin ( ADIPOQ ) , IL 6 and the macrophage marker CD 68 were measured using real time PCR . ^^^ Insulin significantly increased expression of ' insulin sensitivity genes ' SLC2A4 , PPARG , PPARGC1A and ADIPOQ in the insulin sensitive group , while only expression of PPARG and PPARGC1A was increased in the insulin resistant group . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The mRNA gene expression of suppressor of cytokine signalling ( SOCS ) 3 , peroxisome proliferative activated receptor ( PPAR ) alpha / delta , PPAR gamma , coactivator 1 , alpha ( PPARGC1A ) , carnitine palmitoyltransferase 1B and solute carrier family 2 ( facilitated glucose transporter ) , member 4 ( formerly known as glucose transporter 4 / GLUT4 ) , was higher in adipose tissue , but lower in skeletal muscle of diabetic patients than in that of control subjects . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND AND PURPOSE : Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha , PPARGC1A ) integrates the transcriptional program of mitochondrial biogenesis . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| PPAR gamma coactivator 1 alpha rose 3 fold in the fat and 46 % in the liver of wild type mice but was unchanged in PPAR alpha ( / ) mice . ^^^ Thus , in PPAR alpha ( / ) mice , up regulation of carnitine palmitoyl transferase 1 mRNA in fat , down regulation of acetyl CoA carboxylase in liver , and up regulation of PPAR gamma coactivator 1 alpha mRNA in both tissues are abolished , as is the reduction in their triacylglycerol content . . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Although NRF 1 expression is decreased only in diabetic subjects , expression of both PPAR gamma coactivator 1 alpha and beta ( PGC 1 alpha / PPARGC1 and PGC 1 beta / PERC ) , coactivators of NRF 1 and PPAR gamma dependent transcription , is decreased in both diabetic subjects and family history positive nondiabetic subjects . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The transcriptional coactivator PPAR gamma coactivator 1 alpha ( PGC 1alpha ) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| PGC 1 greatly increases the transcriptional activity of PPARgamma and the thyroid hormone receptor on the uncoupling protein ( UCP 1 ) promoter . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In this work we studied the role of the beta ( 3 ) AR in regulating mRNA expression of genes involved in thermogenesis , i . e . , mitochondrial uncoupling proteins UCP 2 and UCP 3 , and peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) , in mouse skeletal muscle . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The docking of PGC 1 to peroxisome proliferator activated receptor gamma ( PPARgamma ) stimulates an apparent conformational change in PGC 1 that permits binding of SRC 1 and CBP / p300 , resulting in a large increase in transcriptional activity . ^^^ Here , it is shown that PPARgamma coactivator 1 ( PGC 1 ) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator 1 ( SRC 1 ) and CREB binding protein ( CBP ) / p300 . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Mouse peroxisome proliferator activated receptor gamma coactivator 1 ( Pgc 1 ) has been reported to enhance the expression of uncoupling protein 1 , a key mediator of thermogenesis in brown adipose tissue ( Puigserver et al . , 1998 , Cell 92 , 829 839 ) . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To determine human PPARgamma coactivator 1 ( PGC 1 ) amino acid sequence and to study PGC 1 mRNA tissue distribution . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In this study we sought to determine whether the recently identified PPAR gamma coactivator 1 ( PGC 1 ) is capable of coactivating PPARalpha in the transcriptional control of genes encoding FAO enzymes . ^^^ Glutathione S transferase `` pulldown ' ' studies revealed that in contrast to the previously reported ligand independent interaction with PPARgamma , PGC 1 binds PPARalpha in a ligand influenced manner . ^^^ These results identify PGC 1 as a coactivator of PPARalpha in the transcriptional control of mitochondrial FAO capacity , define separable PPARalpha interaction and transactivation domains within the PGC 1 molecule , and demonstrate that certain features of the PPARalpha PGC 1 interaction are distinct from that of PPARgamma PGC 1 . . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| A transcriptional coactivator of the peroxisome proliferator activated receptor gamma ( PPARgamma ) , PPARgamma coactivator 1 ( PGC 1 ) interacts in a constitutive manner with the hinge domain of PPARgamma and enhances its transcriptional activity . ^^^ However the mechanism by which PGC 1 interacts with ERalpha is different from that of PPARgamma . ^^^ It is concluded from these studies that PGC 1 is a bona fide ERalpha coactivator , which may serve as a convergence point between PPARgamma and ERalpha signaling . . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) , a cold inducible coactivator of nuclear receptors , stimulates mitochondrial biogenesis and respiration in muscle cells . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Recent studies have identified the transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) as a regulator of mitochondrial function in tissues specialized for thermogenesis , such as brown adipose . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) , a cold induced protein expressed in brown adipose tissue ( BAT ) , plays a role in adaptive thermogenesis by up regulating uncoupling proteins ( UCP ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Regulation of adipogenesis and energy balance by PPARgamma and PGC 1 . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Neither the rexinoids nor the thiazolidinedione had any effect on the level of mRNA encoding UCP 2 and the recently described PPARgamma coactivator 1 ( PGC 1 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| PGC 1 was originally identified as a transcriptional coactivator of the nuclear receptor PPARgamma . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Consistent with these observations , translation of the peroxisome proliferator activated receptor gamma co activator 1 ( PGC 1 ) , a transcriptional co activator implicated in mitochondrial biogenesis and adaptive thermogenesis , is increased in white adipose tissue of Eif4ebp1 / mice . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1beta ( PGC 1beta ) , a novel PGC 1 related transcription coactivator associated with host cell factor . ^^^ Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) plays a critical role in regulating multiple aspects of energy metabolism , including adaptive thermogenesis , mitochondrial biogenesis , and fatty acid beta oxidation . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We show here that many cytokines activate the transcriptional PPAR gamma coactivator 1 ( PGC 1 ) through phosphorylation by p 38 kinase , resulting in stabilization and activation of PGC 1 protein . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Although PGC 1 ( peroxisome proliferator activated receptor gamma coactivator 1 ) has been previously shown to enhance thyroid hormone receptor ( TR ) / retinoid 10 receptor mediated ucp 1 gene expression in a ligand induced manner in rat fibroblast cells , the precise mechanism of PGC 1 modulation of TR function has yet to be determined . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Nuclear respiratory factor ( NRF ) 1 and peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) , but not NRF 2 , were up regulated within 6 h after T 3 administration , suggesting NRF 1 and / or PGC 1 as key regulators for mediating the ' late ' expression pattern . . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) is a tissue specific coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for energy metabolism . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) mRNA level and mitochondrial transcription factor A ( mtTFA ) protein level peaked on day 10 concurrently with the state 3 rate of respiration . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| CaMK induced expression of peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) , a master regulator of mitochondrial biogenesis in vivo , and activated the PGC 1 gene promoter in cultured myocytes . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Mutation analysis of peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) and relationships of identified amino acid polymorphisms to Type 2 diabetes mellitus . ^^^ AIM / HYPOTHESIS : This study aimed to investigate if variability in the peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) gene is associated with Type 2 ( non insulin dependent ) diabetes mellitus . ^^^ Furthermore , a potential interaction between the Pro12Ala polymorphism of PPAR gamma 2 and the PGC 1 Gly482Ser variant on risk of Type 2 diabetes was investigated . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) mediates hepatic glucose production by controlling mRNA levels of glucose 6 phosphatase ( G 6 Pase ) , phosphoenolpyruvate carboxykinase ( PEPCK ) , and fructose 1 , 6 bisphosphatase ( FBPase ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| AIMS / HYPOTHESIS : Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) , a transcriptional coactivator of the nuclear receptor PPARgamma , plays a role in adaptive thermogenesis and insulin sensitivity . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We previously reported that the peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) mRNA in rat epitrochlearis muscle was increased after swimming exercise training . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the transcriptional peroxisome proliferator activated receptor gamma co activator 1 ( PGC 1 ) , which plays a key role in the sympathetic stimulated mitochondrial biogenesis of brown adipocytes , is expressed but not induced by NA in MSL cells , as it is in brown adipocytes . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We show that the peroxisome proliferator activated receptor gamma ( PPARgamma ) ( NR1C3 ) coactivator 1 ( PGC 1 ) requires both the intact AF 2 domain of PPARgamma and the LXXLL domain of PGC 1 for ligand dependent and ligand independent interaction and coactivation . ^^^ Although the AF 2 domain of PPARgamma is absolutely required for PGC 1 mediated coactivation , this coactivator displayed a unique lack of requirement for the charge clamp of the ligand binding domain of the receptor that is thought to be essential for LXXLL motif recognition . ^^^ Thus , the unique structural features of the PGC 1 LXXLL motif appear to mediate an atypical mode of interaction with PPARgamma . ^^^ Unexpectedly , we discovered that various ligands display variability in terms of their requirement for the charge clamp of PPARgamma for coactivation by PGC 1 . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma ( PPAR gamma ) co activator 1 ( PGC 1 ) regulates glucose metabolism and energy expenditure and , thus , potentially insulin sensitivity . ^^^ Peroxisome proliferator activated receptor gamma ( PPAR gamma ) co activator 1 ( PGC 1 ) regulates glucose metabolism and energy expenditure and , thus , potentially insulin sensitivity . ^^^ We examined the expression of PGC 1 , PPAR gamma , insulin receptor substrate 1 ( IRS 1 ) , glucose transporter isoform 4 ( GLUT 4 ) , and mitochondrial uncoupling protein 1 ( UCP 1 ) in adipose tissue and skeletal muscle from non obese , non diabetic insulin resistant , and insulin sensitive individuals . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) plays a major role in mediating hepatic gluconeogenesis in response to starvation , during which PGC 1 is induced by the cyclic AMP response element binding protein . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) is a transcriptional coactivator of peroxisome proliferator activated receptor gamma and alpha , which play important roles in adipogenesis and lipid metabolism . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma co activator 1 ( PGC 1 ) is a transcriptional co activator that affects gene expression of key lipid metabolizing enzymes such as carnitine palmitoyl transferase 1 ( mCPTI ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Regulation of hepatic fasting response by PPARgamma coactivator 1alpha ( PGC 1 ) : requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Among the upstream signals for UCP 1 regulation , expression levels of the beta 3 adrenergic receptor ( beta ( 3 ) AR ) and PPAR gamma coactivator 1 ( PGC 1 ) were significantly decreased in the OLETF rats and increased by DHEA administration . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Characterization of the human , mouse and rat PGC 1 beta ( peroxisome proliferator activated receptor gamma co activator 1 beta ) gene in vitro and in vivo . ^^^ Human PGC 1 beta 1a and 2a isoforms localized to the cell nucleus and , specifically , the isoform PGC 1 beta 1a co activated peroxisome proliferator activated receptor gamma , alpha and the thyroid hormone receptor beta 1 . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Expression of peroxisome proliferator activated receptor gamma ( PPARgamma ) and the PPARgamma co activator , PGC 1 , in human breast cancer correlates with clinical outcomes . ^^^ Our study examined the transcript levels of peroxisome proliferator activated receptor gamma ( PPARgamma ) and its co activator ( PGC 1 ) in a cohort of patients with breast cancer . ^^^ Although the levels of PPARgamma and PGC 1 did not correlate with nodal involvement and grade , significantly lower levels of PPARgamma were seen in TNM 3 and TNM 4 tumors and from patients with local recurrence and those who died of breast cancer . ^^^ We conclude that there is aberrant expression of PPARgamma and its co activator , PGC 1 , in human breast cancer and low levels of these molecules in cancer tissues are associated with poor clinical outcomes . . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The mRNA concentration of PPAR gamma co activator 1 ( PGC 1 ) , which regulates mitochondrial biogenesis , was lower in the lipodystrophic than the non lipodystrophic group . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In search for an intermediate factor of T 3 action , we examined whether various rather ubiquitous transcription factors , peroxisome proliferator activated receptors ( PPARs ) and coactivators of the PPARgamma coactivator 1 family ( PGC 1 ) are regulated by T 3 . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Here we show that PPARgamma coactivator 1 ( PGC 1 ) beta functions as ERRL 1 ( for ERR ligand 1 ) , which can bind and activate orphan ERRs ( estrogen receptor related receptors ) in vitro . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The transcript levels of PPARgamma Coactivator 1 ( PGC 1 ) showed a significant reduction . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The FOXC 2 expression correlated with that of Notch and Wnt signaling genes , as well as of the genes studied participating in brown adipogenesis , including MASK , MAP3K5 , PPARgamma , pRb , RXRgamma , and PGC 1 . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The effects of hibernation on the expression of Akt ( protein kinase B ) , the peroxisome proliferator activated receptor gamma isoform ( PPARgamma ) , and the PPARgamma coactivator PGC 1 were assessed in seven tissues of the little brown bat , Myotis lucifugus . ^^^ Differential expression of Akt , PPARgamma , and PGC 1 during hibernation in bats . ^^^ PPARgamma and PGC 1 levels showed parallel changes in all organs . ^^^ Reduced Akt activity is consistent with a probable reduced insulin response during torpor that facilitates the mobilization of lipid reserves for fuel supply and is further supported by increased gene expression of enzymes and proteins involved in lipid catabolism under the stimulation of enhanced PPARgamma and PGC 1 levels . . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The coordinate induction of PGC 1 and repression of PPAR gamma by CREB during fasting provides a molecular rationale for the antagonism between insulin and counter regulatory hormones , and indicates a potential role for CREB antagonists as therapeutic agents in enhancing insulin sensitivity in the liver . . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptors ( PPARs ) and associated transcription factors in colon cancer : reduced expression of PPARgamma coactivator 1 ( PGC 1 ) . ^^^ To better understand their role , we studied the expression levels of all PPAR isoforms and transcriptional partners such as the retinoid 10 receptor alpha ( RXRalpha ) and PPARgamma coactivator 1 ( PGC 1 ) by means of real time PCR in 17 patients with colon cancer . ^^^ Taken together our data suggest that the transcriptional activity of PPARgamma may not only be decreased by mutation but also by downregulation of the coactivator PGC 1 of PPARgamma . . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| For example , up regulation of fatty acid binding proteins during hibernation facilitates the switch to a primary dependence on lipid fuels by nearly all organs and new studies have shown that up regulation is mediated by the PPARgamma transcription factor and its co activator , PGC 1 . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| At pathophysiological levels , Cdk 9 activity suppresses many genes for mitochondrial proteins including master regulators of mitochondrial function ( peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) , nuclear respiratory factor 1 ) . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The transcriptional response also included nuclear accumulation of peroxisome proliferator activated receptor gamma co activator 1 ( PGC 1 ) and mRNA expression for redox regulated nuclear respiratory factors ( NRF 1 and 2 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| IUGR rats are further characterized by postnatal alterations in hepatic PPAR gamma coactivator ( PGC 1 ) and carnitine palmitoyl transferase 1 ( CPTI ) expression , as well as overall hyperacetylation of histone H 3 . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| IL 6 mRNA tended to increase , while GLUT 4 , peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) and adiponectin gene expression were unchanged . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| A Gly482Ser polymorphism of the peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) gene is associated with type 2 diabetes in Caucasians . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Although the cause and effect relationship between FFAs and insulin resistance is complex , plasma FFA is negatively correlated with the expression of peroxisome proliferator activated receptor gamma cofactor 1 ( PGC 1 ) and nuclear encoded mitochondrial genes . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Many nuclear changes correlated with changes in peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) , suggesting a central role for PGC 1 in nuclear responses to mitochondrial dysfunction . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| After this , insulin stimulated glycogen synthesis was determined . mRNA levels of the glucose transporters GLUT 1 and GLUT 4 , the peroxisomal proliferator activator receptor gamma ( PPAR gamma ) co activator 1 ( PGC 1 ) and the myocyte specific enhancer factors ( MEF 2 ) , MEF2A , MEF2C and MEF2D were determined using real time PCR analysis after 8 days exposure to the various antidiabetic agents . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Hepatic nuclear factor 4 ( HNF 4 ) and chicken ovalbumin upstream transcription factor 2 participate in the transcriptional regulation of the PPARalpha gene , while peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) behaves as a PPAR coactivator . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| An acute bout of exercise is sufficient to induce the expression of a variety of metabolic genes , such as GLUT 4 , pyruvate dehydrogenase kinase 4 ( PDK 4 ) , uncoupling protein 3 ( UCP 3 ) , and peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) alpha and PGC1beta mRNA were decreased by 20 % , P < 0 . 01 , and 25 % , P < 0 . 01 , respectively . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| TH also putatively controls genes indirectly by modulating transcription and / or translation of other nuclear steroid receptors and coactivators , such as peroxisome proliferator activated receptor alpha ( PPARalpha ) and peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Atorvastatin prevents peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) downregulation in lipopolysaccharide stimulated H9c2 cells . ^^^ LPS stimulation of H9c2 cardiac cells also led to a 30 % reduction ( P < 0 . 05 ) in the mRNA levels of PPARgamma Coactivator 1 ( PGC 1 ) that was consistent with the reduction in the protein levels of this coactivator . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We hypothesized that flutamide mediates its beneficial effects via an estrogen dependent pathway through upregulation of peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Although Ser 482 Ser PGC 1alpha homozygotes had lower WHRs than other PGC 1alpha genotypes , they were more frequent in the hypertensive group than in the normotensive ( 44 . 4 vs 24 . 5 % , P < 0 . 03 ) , so the 482 Ser PGC 1 allele was in our population a risk factor for hypertension independently of WHR , homeostasis model assessment of insulin resistance , BMI and Pro 12 Ala PPARgamma variant ( odds ratio=4 . 0 , 95 % confidence interval 1 . 5 10 . 6 , P < 0 . 01 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We compared AMPK and ACC phosphorylation and the protein content of the upstream AMPK kinase LKB 1 and the AMPK regulated transcriptional coactivator PPARgamma coactivator 1 ( PGC 1 ) in gastrocnemius of sedentary obese Zucker rats and sedentary lean Zucker rats . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Increased FFA availability results in accumulation of intramyocellular fatty acyl CoA ( FA CoA ) inducing a series of alterations : ( 1 ) inhibition of insulin signaling , ( 2 ) reduction of insulin ( in ) dependent glucose transport / phosphorylation , ( 3 ) decreased insulin stimulated glycogen synthesis , ( 4 ) impaired insulin stimulated oxidative phosphorylation ( ATP synthesis ) , ( 5 ) accumulation of ectopic triglycerides ( IMCL ) , ( 6 ) reduced expression of peroxisome proliferator activated receptor gamma ( PPARgamma ) coactivator 1 ( PGC 1 ) and PGC 1 controlled genes involved in mitochondrial biogenesis and oxidative phosphorylation and possibly also ( 7 ) initiation of inflammatory processes by activation of PKC and nuclear factor kappaB and decreased expression of matrix metalloproteinases ( MMPs ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Previous studies yielded controversial results on the impact of peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1 ) gene variations on the development of type 2 diabetes mellitus . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In this introduction to this Review series , underlying mechanisms that enable nuclear receptors to positively and negatively regulate gene expression are presented as background to the focused reviews on estrogen receptors , PPARs , liver 10 receptors , and the PPARgamma coactivator 1 ( PGC 1 ) family of coactivators . . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Members of the PPARgamma coactivator 1 ( PGC 1 ) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the mutations do not compromise HNF 4alpha activity and are responsive to PPAR gamma coactivator 1 ( PGC 1 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Using the yeast transactivator GAL 4 system , we showed that both AF 1 and AF 2 ( activation functions 1 and 2 ) of HNF 4 are inhibited by TNFalpha and that this inhibition was abolished by overexpression of different HNF 4 co activators , including PGC 1 ( peroxisome proliferator activated receptor gamma co activator 1 ) , CBP [ CREB ( cAMP response element binding protein ) binding protein ] and SRC 3 ( steroid receptor co activator 3 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Here , we examined the effect of aging on the skeletal muscle expression of two isoforms of the transcriptional peroxisome proliferator activated receptor gamma ( PPARgamma ) coactivator 1 ( PGC 1 ) in an experimental murine model of accelerated aging , the senescence accelerated mouse ( SAM ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The transcriptional coactivator PPARgamma coactivator 1alpha ( PGC 1alpha ) has been characterized as a broad regulator of cellular energy metabolism . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In white adipose tissue , lack of TIF 2 decreases PPARgamma activity and reduces fat accumulation , whereas in brown adipose tissue it facilitates the interaction between SRC 1 and PGC 1alpha , which induces PGC 1alpha ' s thermogenic activity . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The transcriptional coactivator the peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) has been identified as an important mediator of mitochondrial biogenesis based on its ability to interact with transcription factors that activate nuclear genes encoding mitochondrial proteins . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Bioenergetic analysis of peroxisome proliferator activated receptor gamma coactivators 1alpha and 1beta ( PGC 1alpha and PGC 1beta ) in muscle cells . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Several major factors involved in this process have been identified , such as the calcium / calmodulin dependent protein kinase 4 ( CaMKIV ) , calcineurin A ( CnA ) , and the transcriptional component peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Recent studies indicate that an increased expression of the transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) by exercise may promote mitochondrial biogenesis and fatty acid oxidation . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) is a transcriptional coactivator that regulates multiple aspects of cellular energy metabolism , including mitochondrial biogenesis , hepatic gluconeogenesis , and beta oxidation of fatty acids . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Recent reports suggest that the peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) / mitochondrial transcription factor A ( Tfam ) pathway is involved in exercise induced mitochondrial biogenesis . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to elucidate the mechanisms underlying low intensity exercise induced peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) protein expression in rat skeletal muscles . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| While the transcriptional co activator PGC 1alpha ( peroxisome proliferator activated receptor gamma co activator 1 ) has emerged as a master controller of mitochondrial gene expression , it is important to consider other mechanisms by which coordinated changes in mitochondrial content could arise . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated recetor gamma ( PPARgamma ) and its coactivators , PGC 1alpha and SRC 1 , influence brown adipocyte metabolism and development . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) regulates triglyceride metabolism by activation of the nuclear receptor FXR . ^^^ Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) has been shown to regulate adaptive thermogenesis and glucose metabolism . ^^^ PGC 1alpha increases FXR activity through two pathways : ( 1 ) it increases FXR mRNA levels by coactivation of PPARgamma and HNF4alpha to enhance FXR gene transcription ; and ( 2 ) it interacts with the DNA binding domain of FXR to enhance the transcription of FXR target genes . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) was recently identified as a key regulator for these adaptive processes . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) participates in control of expression of genes involved in adaptive thermogenesis , muscle fiber type differentiation , and fuel homeostasis . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The developmental regulation of peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) gene expression was studied in mice and compared with that of marker genes of liver energy metabolism . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| PGC 1alpha [ PPARgamma ( peroxisome proliferator activated receptor gamma ) co activator 1alpha ] is known to control energy homoeostasis in adipose tissue , skeletal muscle and liver . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) has been shown to play an important role in energy metabolism by coordinating transcriptional programs involved in mitochondrial biogenesis , adaptive thermogenesis , gluconeogenesis , and fatty acid oxidation . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| RESULTS : CLA induced PPAR gamma and delta , transcriptionally modulated PPAR gamma and delta responsive gene clusters involved in lipid metabolism ( uncoupling protein [ UCP ] 1 , UCP 3 , PPAR gamma coactivator 1alpha [ PGC 1alpha ] , and CD 36 ) and epithelial cell maturation ( Gob 4 and Keratin 20 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The genes involved in this key energy metabolic pathway are transcriptionally regulated by members of the nuclear receptor superfamily , specifically the fatty acid activated peroxisome proliferator activated receptors ( PPARs ) and the nuclear receptor coactivator , PPARgamma coactivator 1alpha ( PGC 1alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Estrogen related receptors ( ERRs ) are orphan nuclear receptors activated by the transcriptional coactivator peroxisome proliferator activated receptor gamma ( PPARgamma ) coactivator 1alpha ( PGC 1alpha ) , a critical regulator of cellular energy metabolism . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| To test this , we performed a short term human endurance exercise study in which muscle biopsies were obtained from healthy untrained individuals ( n=14 ) before and in the hours after exercise to measure the expression of mRNA for previously reported exercise related genes ( e . g . , PPARgamma coactivator 1alpha ( PGC 1alpha ) , pyruvate dehydrogenase kinase 4 ( PDK 4 ) , MyoD , p 21 , ( heat shock protein 72 ( HSP 72 ) , lipoprotein lipase ( LPL ) , citrate synthase ( CS ) , and glucose transporter 4 ( GLUT 4 ) ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Moreover , peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1alpha ) and PGC 1 related estrogen receptor coactivator ( PERC ) robustly increase the transcriptional function of ERalpha in the presence of the ERRE . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Recent studies have reported reduced expression of PPARgamma coactivator 1alpha ( PGC 1alpha ) and PGC 1beta genes in skeletal muscle from type 2 diabetic patients , but it is not known whether this is an inherited or acquired defect . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Now genetic , functional genomic , and transgenic approaches have identified PPARgamma coactivators ( PGC 1alpha and PGC 1beta ) as key regulators of mitochondrial number and function . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Synergistic activation of piscine G6pc promoter was induced by cotransfection with expression plasmids for hepatocyte nuclear factor 4alpha ( HNF 4alpha ) and peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Common polymorphisms of the PPAR gamma 2 ( Pro12Ala ) and PGC 1alpha ( Gly482Ser ) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP NIDDM trial . ^^^ AIM / HYPOTHESIS : We investigated the effects of the common polymorphisms in the peroxisome proliferator activated receptor gamma 2 ( PPAR gamma 2 ; Pro12Ala ) and in PPAR gamma coactivator 1alpha ( PGC 1alpha ; Gly482Ser ) genes on the conversion from impaired glucose tolerance to type 2 diabetes in participants in the STOP NIDDM trial . ^^^ Acarbose prevented the development of diabetes independently of the genotype of the PPAR gamma 2 gene , but only the carriers of the 482Ser allele of the PGC 1alpha gene were responsive to acarbose treatment . ^^^ CONCLUSION / INTERPRETATION : We conclude that the Pro12Pro genotype of the PPAR gamma 2 gene and the 482Ser allele of the PGC 1alpha gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP NIDDM trial . . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Recent studies indicate that decreased expression of PPARgamma coactivator 1alpha ( PGC 1alpha ) , a `` master switch ' ' which induces mitochondrial biogenesis by supporting the transcriptional activity of the nuclear respiratory factors , may largely account for the diminished oxidative capacity of subjects prone to insulin resistance . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) , a transcriptional coactivator , plays a role in mitochondrial biogenesis , muscle fiber specialization , and adaptive thermogenesis . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| PPARgamma coactivator 1alpha ( PGC 1alpha ) , in cooperation with several transcription factors , has emerged as a key regulator of several aspects of mammalian energy metabolism including mitochondrial biogenesis , adaptive thermogenesis in brown adipose tissue , glucose uptake , fiber type switching in skeletal muscle , gluconeogenesis in liver and insulin secretion from pancreas . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Real time PCR analysis showed decreased transcript levels of mtDNA and nuclear encoded mitochondrial genes and of peroxisome proliferator activated receptor gamma co activator 1alpha ( PGC 1alpha ) , a key regulator of mitochondrial biogenesis . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Studies of the Gly482Ser polymorphism of the peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) gene in Danish subjects with the metabolic syndrome . ^^^ The peroxisome proliferator activated receptor gamma co activator 1alpha ( PGC 1alpha ) is a novel transcriptional co activator that holds an important role in lipid and glucose metabolism . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Here , we report identification of peroxisome proliferator activated receptor gamma co activator 1alpha ( PGC 1alpha ) as a coactivator for Sox 9 during chondrogenesis . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In mammals , one of the most characterized examples of regulation of metabolic pathways by transcriptional coactivators is peroxisome proliferator activated receptors gamma ( PPARgamma ) coactivator 1 alpha ( PGC 1alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| TZDs also induce PPARgamma Coactivator 1alpha ( PGC 1alpha ) , whose recruitment to the GyK gene is sufficient to release the corepressors . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The gene encoding the transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) was targeted in mice . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| This cold sensitive phenotype occurred , although UCP 1 and PGC 1alpha ( peroxisome proliferator activated receptor gamma co activator 1alpha ) gene expression was unaltered in brown fat of C / EBPbeta ( / ) mice . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma co activator 1alpha ( PGC 1alpha ) promotes mitochondrial biogenesis and slow fiber formation in skeletal muscle . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Cloning and expression of PPAR gamma and PGC 1alpha from the hibernating ground squirrel , Spermophilus tridecemlineatus . ^^^ Partial cDNA sequences for one of the PPAR proteins , PPARgamma and the PPARgamma co activator ( PGC 1alpha ) have been cloned from the hibernating ground squirrel , Spermophilus tridecemlineatus and show differential regulation during hibernation at the mRNA level using relative RT PCR and at the protein level via immunoblotting in brown adipose tissue ( BAT ) , heart , skeletal muscle and white adipose tissue ( WAT ) . ^^^ RT PCR revealed a near 2 fold up regulation of PPARgamma in BAT and to a lesser extent ( < 1 . 5 fold ) in heart and WAT , while PGC 1alpha displayed significantly higher levels of expression in skeletal muscle during hibernation ( 3 . 1 fold , p < 0 . 005 ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Recently , a correlation between ERRalpha expression and the induction of peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) in the liver of fasting animals and in cold stressed brown fat tissues and skeletal muscle was shown . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| To investigate whether variations in the peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) are associated with essential hypertension and type 2 diabetes in a Chinese population . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Furthermore , cells with overexpressed adiponectin were observed to differentiate into adipocytes more rapidly , and during adipogenesis , they exhibited more prolonged and robust gene expression for related transcriptional factors , CCAAT / enhancer binding protein alpha ( C / EBP2 ) , peroxisome proliferator activated receptor gamma ( PPARgamma ) , and adipocyte determination and differentiation factor 1 / sterol regulatory element binding protein 1c ( ADD1 / SREBP1c ) and earlier suppression of PPARgamma coactivator 1alpha ( PGC 1alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| AIM : The aim of the present investigation was to elucidate the effects of exercise intensity on exercise induced expression of peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) protein in rat skeletal muscle . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Peroxisome proliferator activated receptor gamma coactivator 1beta ( PGC 1beta ) is a recently identified homologue of the tissue specific coactivator PGC 1alpha , a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We postulated that a transcriptional coactivator , peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) , a major regulator of oxidative metabolism and mitochondrial biogenesis , could be involved in the transcriptional regulation of the mitochondrial antioxidant defense system in vascular endothelial cells . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Because both GABP and calcineurin mediated pathways are targeted by peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) , we examined whether this coactivator contributes to utrophin gene expression . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The effect of norepinephrine on PPARgamma gene expression , at least in vitro , is negative , PPARgamma ablated brown adipose tissue can express UCP 1 , and PGC 1alpha coactivates other transcription factors ( including PPARalpha ) ; thus , the significance of PPARgamma for the physiological control of UCP 1 gene expression is not settled . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) , a tissue specific and inducible transcriptional coactivator for several nuclear receptors , plays a key role in energy metabolism . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The peroxisome proliferator activated receptor gamma coactivator ( PGC 1alpha ) stimulates the expression of genes involved in hepatic gluconeogenesis and mitochondrial fatty acid oxidation . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) is a master coordinator of mitochondrial biogenesis . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| AIMS / HYPOTHESIS : The coactivator of nuclear receptors , peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) has been implicated in a series of events that contribute to the control of glucose metabolism . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Therefore , we investigated whether the APR affects the expression of medium chain acyl coenzyme A dehydrogenase ( MCAD ) , its regulator the estrogen related receptor alpha ( ERRalpha ) , and a key coactivator of ERRalpha , the peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) . mRNA levels of PGC 1alpha , ERRalpha , and MCAD are markedly reduced in the liver , heart , and kidney of mice during the lipopolysaccharide ( LPS ) induced APR . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We show that the rate limiting enzyme in hepatic heme biosynthesis , 5 aminolevulinate synthase ( ALAS 1 ) , is regulated by the peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| AIMS / HYPOTHESIS : The transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) enhances metabolically relevant pathways , such as gluconeogenesis , fatty acid oxidation , thermogenesis , oxidative phosphorylation and mitochondrial biogenesis . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The most upstream sites of regulation for Ucp 1 that differed between A / J and B 6 were the phosphorylation of p 38 mitogen activated protein kinase and CREB and then followed by downstream changes in levels of mRNA for PPARgamma , PPARalpha , PGC 1alpha , and type 2 deiodinase . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Here , we used variants of the extended half site sequence and selective DNA binding domain mutants of ERRalpha to investigate the effects of ERRE sequence specificity on ERRalpha DNA binding mode , transactivation and interaction with the coactivator protein peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In order to study mitochondrial biogenesis in cells with impaired mitochondrial activity , we used rho L 929 and rho ( 0 ) 143 B cells ( partially and totally depleted of mtDNA , respectively ) , that maintain and even up regulate mitochondrial population , to characterize the activity of major transcriptional regulators ( Sp 1 , YY 1 , MEF 2 , PPARgamma , NRF 1 , NRF 2 , CREB and PGC 1alpha ) known to control the expression of numerous nuclear genes encoding mitochondrial proteins . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma co activator 1alpha ( PGC 1alpha ) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians . ^^^ AIMS : The objective of the present investigation was to examine the relationship of three polymorphisms , Thr394Thr , Gly482Ser and +A2962G , of the peroxisome proliferator activated receptor gamma co activator 1 alpha ( PGC 1alpha ) gene with Type 2 diabetes in Asian Indians . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In LKB 1 deficient livers , TORC 2 , a transcriptional coactivator of CREB ( cAMP response element binding protein ) , was dephosphorylated and entered the nucleus , driving the expression of peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) , which in turn drives gluconeogenesis . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The amount of CBP ( CREB binding protein ) and SRC 1 ( steroid receptor coactivator 1 ) recruited by FK 614 was less than that induced by rosiglitazone and pioglitazone , but FK 614 caused similar PGC 1alpha ( PPARgamma coactivator 1alpha ) recruitment as these compounds . ^^^ |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that the coactivator peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) is a physiologically relevant modulator of LRH 1 , and that its transcriptional activity can be inhibited effectively using receptor interacting peptide antagonists that prevent PGC 1alpha recruitment . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Overexpression of constitutively active calcineurin increases expression of peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) and induction of genes involved in mitochondrial energy metabolism in muscle cells . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Exercise seems to improve insulin resistance through mitochondrial function by activating AMP activated protein kinase ( AMPK ) and PPARgamma coactivator 1alpha ( PGC 1alpha ) . . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Thiazolidinediones and rexinoids induce peroxisome proliferator activated receptor coactivator ( PGC ) 1alpha gene transcription : an autoregulatory loop controls PGC 1alpha expression in adipocytes via peroxisome proliferator activated receptor gamma coactivation . ^^^ Here we report that PGC 1alpha gene expression in brown and white adipocytes is a direct target of TZDs via PPARgamma activation . ^^^ This is due to the presence of a PPARgamma responsive element in the distal region of the PGC 1alpha gene promoter that binds PPARgamma / retinoid 10 receptor heterodimers . ^^^ Moreover , there is a positive autoregulatory loop of control of the PGC 1alpha gene through coactivation of PPARgamma responsiveness to TZDs by PGC 1alpha itself . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) is a transcriptional coactivator involved in several aspects of energy metabolism . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Here , we report that the human hepatic lipase gene ( LIPC ) promoter is regulated by hepatocyte nuclear factor 4alpha ( HNF4alpha ) , peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) , apolipoprotein A 1 regulatory protein 1 ( ARP 1 ) , and hepatocyte nuclear factor 1alpha ( HNF1alpha ) . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| METHODS : The interaction of a nuclear receptor , peroxisome proliferator activated receptor gamma ligand binding domain ( PPARgamma LBD ) , with a synthetic peptide derived from a nuclear receptor coactivator protein , PPARgamma coactivator 1 alpha ( PGC 1alpha ) , is the interacting system being studied . ^^^ RESULTS : As the immobilized binding site density of PGC 1alpha peptide on fluorescent microspheres is increased the measured apparent affinity for PPARgamma LBD is increased . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| There were no significant changes in the relative transcript levels of regulators of genes for fatty acid oxidizing enzymes : peroxisome proliferator activated receptor alpha ( PPARalpha ) , PPARbeta , or PPARgamma coactivator 1alpha ( PGC 1alpha ) . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| These studies find possible roles for histone deacetylase 5 ( HDAC 5 ) , adenosine monophosphate activated protein kinase ( AMPK ) , peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) and p 38 mitogen activated protein kinase ( MAPK ) in regulating MEF 2 through a series of complex interactions potentially involving MEF 2 repression , coactivation and phosphorylation . 4 . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Impaired coactivator activity of the Gly 482 variant of peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) on mitochondrial transcription factor A ( Tfam ) promoter . ^^^ Peroxisome proliferation activated receptor gamma ( PPAR gamma ) coactivator 1 alpha ( PGC 1alpha ) increases mitochondrial transcription factor A ( Tfam ) resulting in mitochondrial DNA content increase . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) deficient mice . ^^^ The peroxisome proliferator activated receptor gamma ( PPARgamma ) coactivator 1alpha ( PGC 1alpha ) is a highly inducible transcriptional coactivator implicated in the coordinate regulation of genes encoding enzymes involved in hepatic fatty acid oxidation , oxidative phosphorylation , and gluconeogenesis . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1alpha and 1beta ( PGC 1alpha and PGC 1beta ) were overexpressed by adenovirus mediated gene transfer in cultures of primary rat skeletal muscle cells derived from neonatal myoblasts . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| PGC 1alpha ( peroxisome proliferator activated receptor [ PPARgamma ] coactivator 1alpha ) activates PPARalpha and mitochondrial transcription factor A ( Tfam ) , which regulate proteins , fatty acid and ATP metabolism ( i . e . , FAT / CD36 , MCAD , and COX 1 ) . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The transcriptional coactivator peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) is a powerful regulator of mitochondrial biology and metabolism . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We show in primary hepatocytes that both mid and long chain fatty acids ( saturated or unsaturated ) could activate p 38 and increase levels of phosphoenolpyruvate carboxykinase ( PEPCK ) , glucose 6 phosphatase , and peroxisome proliferator activated receptor gamma coactivator alpha ( PGC 1alpha ) gene transcripts . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Resveratrol further increased the expression of PPARgamma coactivator PGC 1alpha ( P < 0 . 05 ) as well as SIRT 1 ( P < 0 . 01 ) in a dose dependent manner after 24 hours of incubation . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| We investigated if calorie restriction ( CR ) preserved skeletal muscle oxidative capacity with aging after accounting for life span extension by CR , and determined if mitochondrial content , mitochondrial DNA integrity , and peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC 1alpha ) were involved . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| PGC 1alpha ( peroxisome proliferator activated receptor gamma coactivator 1alpha ) is a master regulator of mitochondrial biogenesis and plays an important role in several other aspects of energy metabolism . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma coactivator 1 ( PPARGC 1 ) is a transcriptional coactivator that has been implicated in the regulation of genes involved in energy metabolism . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Two strong positional candidates , the human peroxisome proliferator activated receptor gamma coactivator 1 ( PPARGC 1 ) and cholecystokinin A receptor ( CCKAR ) with major roles in the development of obesity , are located in this region . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| AIMS / HYPOTHESIS : Peroxisome proliferator activated receptor gamma coactivator 1 ( PPARGC 1 ) acts as a cofactor for several nuclear hormone receptors in many tissues and organs implicated in blood pressure regulation . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| The PPARgamma gene and its coactivator , the peroxisome proliferator activated receptor gamma coactivator 1 ( PPARGC 1 ) gene , have been implicated to be involved in glucose uptake and altered lipid oxidation . ^^^ We therefore hypothesized that the Gly482Ser polymorphism of the PPARGC 1 gene and Pro12Ala polymorphism of the PPARgamma gene might confer susceptibility to diabetic retinopathy in type 2 diabetes . ^^^ The aim of this study was to investigate the association between the Pro12Ala polymorphism in the PPARgamma gene and Gly482Ser polymorphism in the PPARGC 1 gene and the development of diabetic retinopathy in the Slovene population ( Caucasians ) with type 2 diabetes . ^^^ RESULTS : A significantly higher frequency of the AA genotype of the Gly482Ser polymorphism of the PPARGC 1 gene was found in the patients with diabetic retinopathy compared to the patients without diabetic retinopathy ( 14 . 4 % vs 5 . 9 % ; p = 0 . 035 ) , whereas the Pro12Ala polymorphism of the PPARgamma gene failed to yield an association with diabetic retinopathy . ^^^ CONCLUSIONS : The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC 1 gene might be a risk factor for diabetic retinopathy in the Slovene population ( Caucasians ) with type 2 diabetes ( odds ratio 2 . 7 , 95 % confidence interval 1 . 0 6 . 8 ) , whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy . . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma co activator 1 ( PPARGC 1 ) is a transcriptional co activator of many nuclear receptors including PPAR gamma , involved in the regulation of fatty acid oxidation , skeletal muscle fiber type specificity , and gluconeogenesis . ^^^ Peroxisome proliferator activated receptor gamma co activator 1 ( PPARGC 1 ) is a transcriptional co activator of many nuclear receptors including PPAR gamma , involved in the regulation of fatty acid oxidation , skeletal muscle fiber type specificity , and gluconeogenesis . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Frequency distribution of a Cys430Ser polymorphism in peroxisome proliferator activated receptor gamma coactivator 1 ( PPARGC 1 ) gene sequence in Chinese and Western pig breeds . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| Regardless , few hepatic genes changed expression significantly in Irs 1 / or LKO mice , whereas hundreds of genes changed in LKO : : Irs 1 / mice including elevated levels of Pck 1 , G6pc , Ppargc 1 , Pparg , and Igfbp 1 . ^^^ |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBK2 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
|