| KIAA 1769 encodes a 2080 amino acid protein ( molecular mass , 231 kDa ) that was recently identified to interact with PPARalpha and termed PPARalpha interacting cofactor 285 ( here referred to as PPARgamma DBD interacting protein 1 ( PDIP 1 ) alpha ) . ^^^ The C terminal region of PDIP 1 directly binds DBD of PPARgamma , and multiple LXXLL motifs in PDIP 1 were not required for the interaction . ^^^ PDIP1alpha and beta similarly enhanced PPARgamma mediated transactivation in transfection assays and short interfering RNA targeting PDIP 1 mRNA significantly reduced transactivation by PPARgamma . ^^^ No potent intrinsic activation domain was identified in either PDIP 1 isoforms in mammalian one hybrid assays , and mutation of all LXXLL motifs did not affect enhancement of PPARgamma mediated transactivation . ^^^ KIAA 1769 encodes a 2080 amino acid protein ( molecular mass , 231 kDa ) that was recently identified to interact with PPARalpha and termed PPARalpha interacting cofactor 285 ( here referred to as PPARgamma DBD interacting protein 1 ( PDIP 1 ) alpha ) . ^^^ |