| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :1.1227462 |
| CONCLUSIONS : 1 ) FRET based coactivator association is a novel approach for characterizing nuclear receptor agonists or antagonists ; individual ligands display potencies that are predictive of in vivo effects and distinct profiles of maximal activity that are suggestive of alternative receptor conformations . 2 ) PPARgamma interacts with both CBP and SRC 1 ; transcriptional activation and coactivator association are AF 2 dependent . 3 ) Nuclear receptor LBDs have distinct affinities for individual coactivators ; thus , PPARgamma has a greater apparent affinity for CBP than for SRC 1 , whereas ERalpha interacts preferentially with SRC 1 but very weakly with CBP . . 1.1227462^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.9841855 |
| Both PPARgamma and PPARdelta directly interacted with a nuclear receptor co activator ( CREB binding protein ) in an agonist dependent manner . 0.9841855^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.51177719 |
| CBP and p 300 are thought to be recruited to nuclear receptors through bridging factors that include SRC 1 , although CBP also interacts directly with PPARgamma through its amino terminus . 0.51177719^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.74052541 |
| FK 614 induced interaction of PPARgamma with nuclear receptor coactivator CBP but of lower magnitude than rosiglitazone and pioglitazone . 0.74052541^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The docking of PGC 1 to peroxisome proliferator activated receptor gamma ( PPARgamma ) stimulates an apparent conformational change in PGC 1 that permits binding of SRC 1 and CBP / p300 , resulting in a large increase in transcriptional activity . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Differential recruitment of the coactivator proteins CREB binding protein and steroid receptor coactivator 1 to peroxisome proliferator activated receptor gamma / 9 cis retinoic acid receptor heterodimers by ligands present in oxidized low density lipoprotein . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptors as targets for drug development : molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator activated receptor gamma , CREB binding protein , and adiponectin . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Using the yeast transactivator GAL 4 system , we showed that both AF 1 and AF 2 ( activation functions 1 and 2 ) of HNF 4 are inhibited by TNFalpha and that this inhibition was abolished by overexpression of different HNF 4 co activators , including PGC 1 ( peroxisome proliferator activated receptor gamma co activator 1 ) , CBP [ CREB ( cAMP response element binding protein ) binding protein ] and SRC 3 ( steroid receptor co activator 3 ) . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The antidiabetic agent thiazolidinedione stimulates the interaction between PPAR gamma and CBP . ^^^ Interestingly , T 174 induced the interaction between PPAR gamma and CBP ( cAMP response element binding protein ( CREB ) binding protein ) , a co factor of various transcription regulators . ^^^ These results suggest that CBP plays a role in the PPAR gamma mediated signaling pathway activated by TZD , including adipogenesis . . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| We show here that the interaction between p300 / CBP and PPARgamma is complex and involves multiple domains in each protein . p300 / CBP not only bind in a ligand dependent manner to the DEF region of PPARgamma but also bind directly in a ligand independent manner to a region in the AB domain localized between residue 31 to 99 . ^^^ In transfection experiments , p300 / CBP could thereby enhance the transcriptional activities of both the activating function ( AF ) 1 and AF 2 domains . p300 / CBP displays itself at least two docking sites for PPARgamma located in its N terminus ( between residues 1 and 113 for CBP ) and in the middle of the protein ( between residues 1099 and 1460 ) . . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| In addition , PPARalphatr interfered with transcriptional activity of other nuclear receptors such as PPARgamma , hepatic nuclear factor 4 , and glucocorticoid receptor alpha , which share CREB binding protein / p300 as a coactivator . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The differences between CDDO and rosiglitazone as either partial or full agonists , respectively , are seen in the weaker ability of CDDO to recruit the coactivator CREB binding protein , CBP , to PPARgamma . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The coactivators CBP and PPARgamma coactivator 1 ( PGC 1 ) , which is highly expressed in brown fat , also enhanced the PPARalpha dependent regulation of the ucp 1 gene . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Analysis of receptor binding to a multiplexed set of coactivator peptides shows PPARgamma LBD binds with high affinity to cAMP response element binding protein ( CBP ) peptides and to the related P 300 peptide while ERbeta LBD exibits little binding to these peptides . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| In contrast , PIMT functioned as a repressor of CBP / p300 mediated transactivation of PPARgamma . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptor coactivator PRIP ( peroxisome proliferator activated receptor ( PPAR gamma ) interacting protein ) and PRIP interacting protein with methyltransferase activity , designated PIMT , appear to serve as linkers between cAMP response element binding protein binding protein ( CBP ) / p300 anchored and PBP ( PPAR gamma binding protein ) anchored coactivator complexes involved in the transcriptional activity of nuclear receptors . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| It has been reported that the mitogen activated protein ( MAP ) kinase pathway inhibits PPAR gamma function through its phosphorylation , and co activator CREB binding protein ( CBP ) / p300 interacts with PPAR gamma and modulates its activity . ^^^ Since both the MAP kinase pathway and CBP have recently been reported to be atherogenic , we examined their effects on PPAR gamma mediated AT1R gene transcription suppression . ^^^ We observed that 1 ) PPAR gamma mediated AT1R gene transcription suppression was augmented by treatment with the MAP kinase kinase inhibitor PD 98059 , while treatment with the p 38 kinase inhibitor SB 203580 showed no effect ; 2 ) the PPAR gamma mediated AT1R mRNA decrease was also augmented by PD 98059 treatment ; 3 ) CBP overexpression partially , but significantly , abrogated PPAR gamma mediated AT1R gene transcription suppression ; and 4 ) the CBP effect was eliminated when the 58 / 34 GC box related element was disrupted . ^^^ It is therefore speculated that : 1 ) PPAR gamma phosphorylation by the MAP kinase pathway may attenuate PPAR gamma mediated AT1R gene transcription suppression through the inhibition of PPAR gamma activity ; and 2 ) CBP may enhance the activity of the remaining Sp 1 on the 58 / 34 GC box related element , resulting in a reduction in PPAR gamma mediated AT1R gene transcription suppression . ^^^ The MAP kinase pathway and CBP may thus antagonize against PPAR gamma in AT1R gene transcription , probably leading to the progression of atherosclerosis . . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| In this study , we exploited an efficient approach for the discovery of PPARgamma agonist and antagonist via a yeast two hybrid system based on the fact that PPARgamma interacts with the coactivator CBP ( CREP binding protein ) ligand dependently . ^^^ We employed the MEL 1 reporter gene instead of the traditionally used LacZ gene to evaluate the protein protein interactions by conducting a convenient alpha galactosidase assay in the yeast strain AH 109 with genes of PPARgamma LBD ( ligand binding domain ) and CBP N terminus introduced . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The amount of CBP ( CREB binding protein ) and SRC 1 ( steroid receptor coactivator 1 ) recruited by FK 614 was less than that induced by rosiglitazone and pioglitazone , but FK 614 caused similar PGC 1alpha ( PPARgamma coactivator 1alpha ) recruitment as these compounds . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Moreover , LPS administration also decreased the expression of the coactivators CREB binding protein ( CBP ) / p300 , steroid receptor coactivator ( SRC ) 1 , SRC 3 , TR associated protein ( TRAP ) 220 , and PPARgamma coactivator ( PGC ) 1 , all of which are required for the transcriptional activity of RXR PPAR and RXR TR . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The dual agonist induced high affinity interactions of PPARalpha and PPARgamma with the transcriptional coactivator CBP in vitro . ^^^ |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
|