| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.84397606 |
| Finally , a direct interaction between PPARgamma and NRF 2 was confirmed by glutathione S transferase pull down assay . 0.84397606^^^ |
|
| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| Nuclear respiratory factor ( NRF ) 1 and peroxisome proliferator activated receptor gamma coactivator 1 ( PGC 1 ) , but not NRF 2 , were up regulated within 6 h after T 3 administration , suggesting NRF 1 and / or PGC 1 as key regulators for mediating the ' late ' expression pattern . . ^^^ |
|
| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| In conclusion , the PPARgamma RXR heterodimer promotes GSTA 2 induction by activating PPREM in the GSTA 2 gene , as well as inducing Nrf 2 and C / EBPbeta activation . . ^^^ |
|
| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| Hyperoxia induced upregulation of many well known / new antioxidant / defense genes ( e . g . , Txnrd 1 , Ex , Cp 2 ) and other novel genes ( e . g . , Pkc alpha , Tcf 3 , Ppar gamma ) was markedly greater in Nrf 2 ( + / + ) mice than in Nrf 2 ( / ) mice . ^^^ |
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| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| Among their substrates , GSTs conjugate the signaling molecules 15 deoxy delta ( 12 , 14 ) prostaglandin J 2 ( 15d PGJ 2 ) and 4 hydroxynonenal with glutathione , and consequently they antagonize expression of genes trans activated by the peroxisome proliferator activated receptor gamma ( PPARgamma ) and nuclear factor erythroid 2 p 45 related factor 2 ( Nrf 2 ) . ^^^ |
|
| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| In order to study mitochondrial biogenesis in cells with impaired mitochondrial activity , we used rho L 929 and rho ( 0 ) 143 B cells ( partially and totally depleted of mtDNA , respectively ) , that maintain and even up regulate mitochondrial population , to characterize the activity of major transcriptional regulators ( Sp 1 , YY 1 , MEF 2 , PPARgamma , NRF 1 , NRF 2 , CREB and PGC 1alpha ) known to control the expression of numerous nuclear genes encoding mitochondrial proteins . ^^^ |
|
| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| Hence , PI 3 kinase mediated Nrf 2 activation in combination with activating PPARgamma RXR and C / EBPbeta contributes to antioxidant phase 2 enzyme induction via coordinate gene transactivation . . ^^^ |
|
| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| Although some of the transcription factors seem to be valid targets ( NFkappaB , Nrf 2 or STAT 6 ) or tools ( PPARgamma , alpha and C / EBP alpha ) for new therapeutic approaches , since many transcription factors play a central role in tissue and organ homeostasis , a longterm general suppression or overexpression , would cause severe side effects in other organs . ^^^ Cell type specific application of decoy or antisense oligonucleotides for NFkappaB , Nrf 2 or STAT 6 , or specific agonists for PPARgamma and alpha may help to control the inflammatory response in lung epithelial cells and infiltrated immune cells , but additional , unwanted , effects on other resident cells of the lung can not be excluded and a beneficial effect over known anti asthma drugs has first to be proven . ^^^ |
|
| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16236 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
|