| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.97241927 |
| TRAP 220 has been reported to show ligand enhanced interaction with peroxisome proliferator activated receptor gamma ( 2 ) ( PPAR gamma ( 2 ) ) , a nuclear receptor essential for adipogenesis . 0.97241927^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.54772327 |
| TRAP 220 also interacts with other nuclear receptors [ vitamin D receptor , retinoic acid receptor alpha , retinoid 10 receptor alpha , peroxisome proliferation activated receptor ( PPAR ) alpha , PPARgamma and , to a lesser extent , estrogen receptor ] in a ligand dependent manner , whereas TRAP 100 shows only marginal interactions with estrogen receptor , retinoid 10 receptor alpha , PPARalpha , and PPARgamma . 0.54772327^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :1.0419777 |
| Here we report that PPARgamma and RXR selectively interacted with DRIP 205 and p 160 proteins in a ligand dependent manner . 1.0419777^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.73166942 |
| FK 614 behaves as a partial agonist in inducing the interaction of PPARgamma with both transcriptional coactivators , cAMP response element binding protein binding protein and steroid receptor coactivator 1 , but as a full agonist with both PPAR binding protein and PPAR interacting protein , which are required for PPARgamma mediated adipogenesis . 0.73166942^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| We previously isolated and identified peroxisome proliferator activated receptor ( PPAR ) binding Protein ( PBP ) as a coactivator for PPARgamma . ^^^ Transient transfection assays using fibroblasts isolated from PBP mutant embryos revealed a decreased capacity for ligand dependent transcriptional activation of PPARgamma as compared with fibroblasts derived form the wild type embryos . ^^^ These observations suggest that there is no functional redundancy between PBP and other coactivators such as steroid receptor coactivator 1 and that PBP plays a critical role in the signaling of PPARgamma and other nuclear receptors . . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activator receptor ( PPAR ) binding protein ( PBP ) is an important coactivator for PPARgamma and other nuclear receptors . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| PIMT enhanced PBP mediated transcriptional activity of the PPARgamma , as it did for PRIP , indicating synergism between PIMT and PBP . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor ( PPAR ) binding protein ( PBP ) is an important coactivator for PPARgamma and other transcription factors . ^^^ Binding of PBP to PPARgamma 1 or retinoid 10 receptor for 9 cis retinoic acid ( RXR ) is independent of their phosphorylation states , implying no changes in protein protein interaction after modification by phosphorylation . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| These defects include the failure of labyrinthine development , the dilation of maternal blood sinuses , the massive erythrophagocytosis by trophoblasts , the alteration of trophoblast populations , and the lower proliferation of myocardium , which are similar to those encountered in mice lacking PPARgamma or the PPARgamma binding protein ( PBP , TRAP 220 , or DRIP 205 ) . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptor coactivator PRIP ( peroxisome proliferator activated receptor ( PPAR gamma ) interacting protein ) and PRIP interacting protein with methyltransferase activity , designated PIMT , appear to serve as linkers between cAMP response element binding protein binding protein ( CBP ) / p300 anchored and PBP ( PPAR gamma binding protein ) anchored coactivator complexes involved in the transcriptional activity of nuclear receptors . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| Differential expression of the peroxisome proliferator activated receptor gamma ( PPARgamma ) and its coactivators steroid receptor coactivator 1 and PPAR binding protein PBP in the brown fat , urinary bladder , colon , and breast of the mouse . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| We now report the isolation of a cDNA encoding a 165 kDa PPARgamma binding protein , designated PBP which also serves as a coactivator . ^^^ Deletion of the last 12 amino acids from the carboxyl terminus of PPARgamma results in the abolition of interaction between PBP and PPARgamma . ^^^ PBP modestly increased the transcriptional activity of PPARgamma , and a truncated form of PBP ( amino acids 487 735 ) acted as a dominant negative repressor , suggesting that PBP is a genuine coactivator for PPAR . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| We show that PGC 1alpha directly interacts with TRAP / Mediator , through the PPARgamma interacting subunit TRAP 220 , and stimulates TRAP / Mediator dependent function on DNA templates . ^^^ These functions are mediated by largely independent PPARgamma , p 300 , and TRAP 220 interaction domains in PGC 1alpha , whereas p 300 and TRAP 220 show ligand dependent interactions with a common region of PPARgamma . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptor coactivator PRIP ( peroxisome proliferators activated receptor ( PPARgamma ) interacting protein ) appears to serve as a linker between cAMP response element binding protein binding protein ( CBP / p300 ) anchored and PBP ( PPARgamma binding protein ) anchored coactivator complexes involved in the transcriptional activity of nuclear receptors . ^^^ Both PRIP and PBP were initially identified as PPARgamma coactivators , suggesting a role for these molecules in PPARgamma induced adipogenesis . ^^^ PBP / mouse embryonic fibroblasts fail to exhibit PPARgamma stimulated adipogenesis indicating that PBP is a downstream regulator of PPARgamma mediated adipogenesis . ^^^ These data indicate that PRIP , like PBP , is a downstream regulator of PPARgamma mediated adipogenesis and that both these coactivators are required for the successful completion of adipogenic program . . ^^^ |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q15648 |
Pubmed |
SVM Score :0.0 |
| NA |
|