| Interacting proteins: Q15466 and P37231 |
Pubmed |
SVM Score :0.90137313 |
| Immunoprecipitation and glutathione S transferase pull down assay showed that SHP directly bound to PPARgamma and competed with nuclear receptor corepressor for binding to PPARgamma . 0.90137313^^^ |
|
| Interacting proteins: Q15466 and P37231 |
Pubmed |
SVM Score :0.0 |
| The human Na+ taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator activated receptor gamma coactivator 1alpha , and suppressed by bile acids via a small heterodimer partner dependent mechanism . ^^^ |
|
| Interacting proteins: Q15466 and P37231 |
Pubmed |
SVM Score :0.0 |
| In this work , we found that SHP expression is abundant in murine macrophage cell line RAW 264 . 7 but was suppressed by oxidized low density lipoprotein ( oxLDL ) and its constituent 13 hydroxyoctadecadienoic acid , a ligand for peroxisome proliferator activated receptor gamma . ^^^ |
|
| Interacting proteins: Q15466 and P37231 |
Pubmed |
SVM Score :0.0 |
| A peroxisome proliferator activated receptor gamma ( PPARgamma ) antagonist , GW 9662 , did not block the SHP effect on GSIS . ^^^ These results suggest that SHP positively regulates GSIS in beta cells and restores glucose sensitivity in UCP 2 overexpressing beta cells by enhancing mitochondrial glucose metabolism , independent of PPARgamma activation . . ^^^ |
|
| Interacting proteins: Q15466 and P37231 |
Pubmed |
SVM Score :0.0 |
| The mechanism responsible for this phenotype includes SHP mediated direct repression of downstream target genes and the bile acid sensor FXRalpha , and an indirect activation of PPARgamma and SREBP 1c genes . ^^^ |
|
| Interacting proteins: Q15466 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15466 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15466 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15466 and P37231 |
Pubmed |
SVM Score :0.0 |
| NA |
|