| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| PIMT enhances the transcriptional activity of peroxisome proliferator activated receptor gamma and retinoid 10 receptor alpha , which is further stimulated by coexpression of PRIP , implying that PIMT is a component of nuclear receptor signal transduction apparatus acting through PRIP . ^^^ |
|
| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| The amplified in breast cancer 3 ( AIB 3 , ASC 2 , RAP 250 , PRIP , TRBP , NRC , or NcoA 6 ) gene is characterized as a cancer amplified transcriptional coactivator for nuclear receptors , which include the peroxisome proliferator activated receptor gamma ( PPARgamma ) . ^^^ |
|
| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| Transcriptional coactivator PRIP , the peroxisome proliferator activated receptor gamma ( PPARgamma ) interacting protein , is required for PPARgamma mediated adipogenesis . ^^^ |
|
| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| Importantly , the inhibitory effects of peroxisome proliferator activated receptor gamma ( PPARgamma ) and retinoid 10 receptor ( RXR ) ligands on AIB 3 ( + / ) / PyMT cell proliferation and the transcriptional function of PPARgamma in AIB 3 ( + / ) / PyMT cells were reduced . ^^^ |
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| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| The amino terminal LXXLL motif ( amino acid position 892 to 896 ) of PRIP was found to be necessary for nuclear receptor interaction , but the second LXXLL motif ( amino acid position 1496 to 1500 ) appeared unable to bind PPARgamma . ^^^ Deletion of the last 12 amino acids from the carboxyl terminus of PPARgamma resulted in the abolition of the interaction between PRIP and PPARgamma . ^^^ PRIP acts as a strong coactivator for PPARgamma in the yeast and also potentiates the transcriptional activities of PPARgamma and RXRalpha in mammalian cells . ^^^ |
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| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| PIMT enhanced PBP mediated transcriptional activity of the PPARgamma , as it did for PRIP , indicating synergism between PIMT and PBP . ^^^ |
|
| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptor coactivator PRIP ( peroxisome proliferator activated receptor ( PPAR gamma ) interacting protein ) and PRIP interacting protein with methyltransferase activity , designated PIMT , appear to serve as linkers between cAMP response element binding protein binding protein ( CBP ) / p300 anchored and PBP ( PPAR gamma binding protein ) anchored coactivator complexes involved in the transcriptional activity of nuclear receptors . ^^^ Transient transfection assays using fibroblasts isolated from PRIP ( / ) embryos revealed a significant decrease in the capacity for ligand dependent transcriptional activation of retinoid 10 receptor alpha and to a lesser effect on PPAR gamma transcriptional activity . ^^^ |
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| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| Both ERalpha and ERbeta exhibited strong preferences for coactivator peptides corresponding to steroid receptor coactivator 1 and PPARgamma coactivor 1 vs . peroxisome proliferator activated receptor interacting protein and cAMP response element binding protein binding protein . 17beta Estradiol acted as a nonselective agonist for ERalpha and ERbeta . ^^^ |
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| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| Moreover , the transcriptional activity of PPAR gamma is reduced in fibroblasts derived from Rap 250 ( / ) embryos , suggesting that RAP 250 is an essential coactivator for this nuclear receptor in the placenta . ^^^ |
|
| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| FK 614 behaves as a partial agonist in inducing the interaction of PPARgamma with both transcriptional coactivators , cAMP response element binding protein binding protein and steroid receptor coactivator 1 , but as a full agonist with both PPAR binding protein and PPAR interacting protein , which are required for PPARgamma mediated adipogenesis . ^^^ |
|
| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and Q14686 |
Pubmed |
SVM Score :0.0 |
| NA |
|