| Interacting proteins: Q13772 and P37231 |
Pubmed |
SVM Score :0.0 |
| Identification of ARA 70 as a ligand enhanced coactivator for the peroxisome proliferator activated receptor gamma . ^^^ In an effort to understand transcriptional regulation by the peroxisome proliferator activated receptor gamma ( PPARgamma ) , we have investigated its potential interaction with coregulators and have identified ARA 70 as a ligand enhanced coactivator . ^^^ Here we show that ARA 70 and PPARgamma specifically interact by coimmunoprecipitation and in a mammalian two hybrid assay . ^^^ PPARgamma and ARA 70 interact in the absence of the PPARgamma ligand 15 deoxy Delta 12 , 14 prostaglandin J 2 , although the addition of exogenous ligand enhances this interaction . ^^^ Similarly , in transient transfection of DU 145 cells , cotransfection of PPARgamma and ARA 70 induces transcription from reporter constructs driven by either three copies of an isolated PPAR response element or the natural promoter of the adipocyte fatty acid binding protein 2 in the absence of exogenous 15 deoxy Delta 12 , 14 prostaglandin J 2 . ^^^ |
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| Interacting proteins: Q13772 and P37231 |
Pubmed |
SVM Score :0.0 |
| We identified ARA 70 , a coactivator of the androgen receptor and PPARgamma , as a ligand enhanced coactivator of PPARalpha in the prostate cancer cell line DU 145 . ^^^ However , in the adrenal cell line Y 1 , ARA 70 behaved as a repressor of PPARalpha while still able to coactivate PPARgamma . . ^^^ |
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| Interacting proteins: Q13772 and P37231 |
Pubmed |
SVM Score :0.0 |
| However , it does not promote AR activity via the classic LXXLL motif located at amino acids 92 96 , although this classic LXXLL motif is important for ARA 70 to interact with other receptors , such as PPARgamma . ^^^ |
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| Interacting proteins: Q13772 and P37231 |
Pubmed |
SVM Score :0.0 |
| In fact , the ELE 1 RET ( PTC 3 ) fusion protein contains the ELE 1 nuclear receptor co activator domain and it appears to physically associate with and inhibit wild type PPARgamma in some papillary carcinomas . ^^^ |
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