| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that in vitro , PPARgamma 1 is efficiently phosphorylated by JNK / SAPK ( c Jun N terminal kinase or stress activated protein kinase ) but only weakly phosphorylated by p 38 . ^^^ In transfected 293T cells , PPARgamma 1 is phosphorylated at Ser 82 in response to known JNK activators such as UV irradiation and anisomycin treatment . ^^^ Finally , in transient transfection reporter assays , activation of JNK by anisomycin or by overexpression of MKK 4 ( the upstream JNK kinase ) decreased ligand dependent PPARgamma 1 transcriptional activity . ^^^ These results suggest that the activation of the JNK / SAPK pathway by extracellular signals , perhaps by inflammatory cytokines such as tumor necrosis factor alpha , would result in a reduction of PPARgamma transcriptional activity and reduce the effects of PPARgamma ligands . . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| In contrast , both troglitazone ( at 10 microM ) and 15 deoxy Delta ( 12 , 14 ) prostaglandin J ( 2 ) ( 15d PGJ ( 2 ) , at 15 microM ) , a natural ligand for PPARgamma , induce c Jun phosphorylation by activation of c Jun N terminal kinase ( JNK ) through a posttranslational regulation of c Jun activity , therefore increasing AP 1 / DNA binding activity and transcriptional responses as results of increasing basal ICAM 1 gene expression . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These data suggest that 15d PGJ 2 inhibits IL 1beta induced COX 2 expression , independent of PPARgamma activation , by suppression of ERK and JNK pathways and AP 1 activation in mesangial cells . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| Using pharmaceutical inhibitors and dominant active MAP kinase kinases , we demonstrated that activation of the p 38 pathway , but not the ERK or JNK pathways , is necessary and sufficient to transactivate PPARgamma , a nuclear receptor that has recently been shown to play a pivotal role in oxLDL induced CD 36 expression . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| TNF alpha also stimulated JNK activity , which was not affected by PD 98059 or PPARgamma agonist treatment . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| Compared with adipogenesis , however , SP 600125 , a chemical JNK inhibitor hardly relieved TNF alpha effect on PPARgamma expression whereas S32A / S36A mutant of IkappaBalpha considerably recovered PPARgamma expression , indicating that two signal mediators exploit separable main routes to achieve reduced adipogenesis . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| TNF alpha increased activation of ERK1 / 2 and JNK , previously implicated in phosphorylation of Ser ( 82 ) of PPARgamma 1 and resultant negative regulation of PPARgamma transactivity . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| Inhibited JunD activity by PPARgamma is not due to reduced JunD expression or JNK activity or to a competition for p 300 . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| However , we could not detect PPARgamma phosphorylation by incubation with activated ERK 5 in vitro , in contrast to ERK1 / 2 and JNK , suggesting a role for ERK 5 as a scaffold . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| The decreased adiponectin mRNA levels by TNF alpha were partially recovered by treatment with a c Jun N terminal kinase ( JNK ) inhibitor or the PPAR gamma agonist rosiglitazone in 3T3 L 1 adipocytes . ^^^ The JNK inhibitor regulated the expression of adiponectin by the increase of PPAR gamma DNA binding activity and the recovery of its mRNA expression while rosiglitazone acted via a PPAR gamma independent pathway which remains to be elucidated . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we showed that 15d PGJ 2 transiently induces Cry 1 , Cry 2 , and Roralpha mRNA expressions and that 15d PGJ 2 induced entrainment signaling pathway is PPAR gamma and MAPKs ( ERK , JNK , p38MAPK ) independent . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| A JNK specific inhibitor blocked the inhibitory effect of IL 1 beta on HNF 4 alpha expression and CYP7A1 reporter activity . c Jun inhibited HNF 4 alpha and PPARgamma coactivator 1 alpha ( PGC 1 alpha ) coactivation of CYP7A1 reporter activity , whereas a dominant negative c Jun did not . ^^^ |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
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