| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| On the other hand , the other thiazolidinediones pioglitazone ( PIO ) and rosiglitazone ( ROSI ) had little effect on Ang 2 induced activation of ERK or AP 1 , suggesting the inhibitory effects of TRO on VSMC activation by Ang 2 be independent of the peroxisome proliferator activated receptor gamma ( PPARgamma ) for which thiazolidinediones are ligands . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| We have shown that the peroxisome proliferator activated receptor gamma ( PPAR gamma ) ligands troglitazone and rosiglitazone inhibit VSMC migration downstream of ERK MAPK . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| To investigate the role of ERK activation , co treatment of RA with PD 98059 , a specific inhibitor of the ERK signalling pathway , prevented both adipocyte formation and expression of the adipogenic markers , adipocyte lipid binding protein and peroxisome proliferator activated receptor gamma . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Superoxide anion dependent Raf / MEK / ERK activation by peroxisome proliferator activated receptor gamma agonists 15 deoxy delta ( 12 , 14 ) prostaglandin J ( 2 ) , ciglitazone , and GW 1929 . ^^^ In this study , we examined the signaling pathways for extracellular signal related protein kinase ( ERK ) activation by three structurally different peroxisome proliferator activated receptor gamma ( PPARgamma ) agonists . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Activation of peroxisome proliferator activated receptor gamma impedes Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis through phosphatidylinositol 3 kinase / erk pathway . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Impedance of Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis by peroxisome proliferator activated receptor gamma activation involves phosphatidylinositol 3 kinase / ERK pathway . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Elevated levels of KSR 1 expression , previously shown to enhance cell proliferation , promote high , sustained ERK activation that phosphorylates and inhibits peroxisome proliferator activated receptor gamma , inhibiting adipogenesis . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| AIM : To observe the effects of acid and bile acid exposure on cell proliferation and the expression of extracellular signal regulated protein kinase ( ERK ) and peroxisome proliferator activated receptor gamma ( PPARgamma ) in normal human esophageal epithelial cells in vitro . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| The transcriptional activity of PPARgamma is positively modulated by ligand binding and negatively regulated by phosphorylation mediated by the MEK / ERK signaling pathway . ^^^ The phosphorylation of mouse PPARgamma 1 at Ser 82 by ERK causes a decrease in both basal and ligand dependent transcriptional activity . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Despite the fact that 15d PGJ 2 is a peroxisome proliferator activated receptor ( PPAR ) ligand , and PPARgamma is shown to be expressed by mesangial cells , the thiazolidinedione PPARgamma agonist ciglitazone does not activate ERK . ^^^ Additionally , a synthetic PPARgamma antagonist does not attenuate the activation of ERK by 15d PGJ 2 . 15d PGJ 2 mediated ERK activation is however blocked by the MEK inhibitor PD 098059 , appears to require phosphatidylinositol 3 kinase , but is independent of protein kinase C activation . ^^^ These results demonstrate a novel effect of 15d PGJ 2 to induce ERK in human mesangial cells independently of PPARgamma . . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| PPAR gamma agonists 15 d PGJ 2 and thiazolidinediones such as pioglitazone and troglitazone elicited rapid activation of ERK within 15 min and induced c fos mRNA expression within 30 min , whereas the PPAR alpha agonist bezafibrate failed to activate ERK . 15 d PGJ 2 induced expression of c fos mRNA was blocked by PD 98059 or U 0126 , two ERK kinase inhibitors , suggesting that the MEK / ERK pathway mediates 15 d PGJ 2 induced c fos gene expression . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These data suggest that 15d PGJ 2 inhibits IL 1beta induced COX 2 expression , independent of PPARgamma activation , by suppression of ERK and JNK pathways and AP 1 activation in mesangial cells . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Using pharmaceutical inhibitors and dominant active MAP kinase kinases , we demonstrated that activation of the p 38 pathway , but not the ERK or JNK pathways , is necessary and sufficient to transactivate PPARgamma , a nuclear receptor that has recently been shown to play a pivotal role in oxLDL induced CD 36 expression . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Several modes of action might be relevant for the biological activity of VPA : ( 1 ) VPA increases the DNA binding of activating protein 1 ( AP 1 ) transcription factor , and the expression of genes regulated by the extracellular regulated kinase ( ERK ) AP 1 pathway ; ( 2 ) VPA downregulates protein kinase C ( PKC ) activity ; ( 3 ) VPA inhibits glycogen synthase kinase 3beta ( GSK 3beta ) , a negative regulator of the Wnt signaling pathway ; ( 4 ) VPA activates the peroxisome proliferator activated receptors PPARgamma and delta ; ( 5 ) VPA blocks HDAC ( histone deacetylase ) , causing hyperacetylation . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Both PPARgamma ligands inhibited leptin stimulated Akt and eNOS phosphorylation , but neither attenuated ERK 1 / 2 activation in response to leptin . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| In addition , TGZ induces ERK dependent phosphorylation of PPAR gamma , resulting in the down regulation of PPAR gamma activity . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| In addition , mitogen activated protein kinase kinase ( MEK ) 1 / 2 inhibitor PD 98059 ( 2 ' amino 3 ' methoxyflavone ) decreased 15 deoxy PGJ 2 induced ERK 2 activation , and expression of PPAR gamma , capase 3 , and cyclin B 1 . ^^^ We also found that PPAR gamma antagonist GW 9662 ( 2 chloro 5 nitro N phenylbenzamide ) reversed the 15 deoxy PGJ 2 induced cell growth inhibition , PPAR gamma expression , and activation of ERK 2 . ^^^ These results demonstrate that 15 deoxy PGJ 2 inhibits growth of human neuroblastoma cells via the induction of apoptosis in a PPAR gamma dependent manner through activation of ERK pathway and suggest that 15 deoxy PGJ 2 may have promising application as a therapeutic agent for neuroblastoma . . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| We previously reported that TGZ induces an early growth response transcription factor ( EGR 1 ) by the ERK phosphorylation pathway rather than by the PPARgamma pathway ( Baek , S . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| PPARgamma ligand treatment was associated with phosphorylation of extracellular regulated kinase ( Erk ) , and inhibition of EP 2 receptor expression by PPARgamma ligands was prevented by PD 98095 , an inhibitor of the MEK 1 / Erk pathway . ^^^ PPARgamma ligands inhibit human lung carcinoma cell growth by decreasing the expression of EP 2 receptors through Erk signaling and PPARgamma dependent and independent pathways . . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| The PPARgamma mediated effect on UP gene expression was maximal when there was concurrent inhibition of autocrine activated epidermal growth factor receptor ( EGFR ) signalling through either the phosphatidylinositol 3 kinase or extracellular signal regulated kinase ( ERK ) pathways . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| PPAR gamma activity is regulated by extracellular signal regulated protein kinase ( ERK ) , mitogen activated protein ( MAP ) kinase , and PPAR gamma ligands have varying effects on activity of ERK . ^^^ The role of ERK and phosphorylation in PPAR gamma activation were studied , as were the effects of PPAR agonists on ERK activation and cell proliferation . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| However , the precise mechanisms of PPARgamma activators induced activation of PI 3 K / ERK pathway have not been determined . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| PPARgamma ligands also reduced alpha 5 gene promoter activity , and this was blocked by Erk antisense oligonucleotides . ^^^ PPARgamma ligands GW 1929 and BRL 49653 inhibited AP 1 DNA binding , whereas 15d PGJ ( 2 ) inhibited Sp 1 DNA binding ; both effects were blocked by Erk antisense oligonucleotides . ^^^ These results suggest that PPARgamma ligands inhibit alpha 5 expression in NSCLC through Erk related signals . . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation of focal adhesion kinase ( FAK ) was decreased by treatment with PPARgamma antagonists , and resulted in decreases in phosphorylation of Erk and mitogen activated protein kinase . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| This time precedes most PPARgamma stimulation but follows the period of TCDD / ERK cooperation and periods of increased cell contraction and DNA synthesis . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| The effect of 15d PGJ 2 on KLF 4 expression seems not to involve its nuclear receptor PPARgamma , in that our data show that : 1 ) KLF 4 gene promoter does not contain putative PPRE sequence , 2 ) 15d PGJ 2 rapidly activates extracellular signal regulated kinase ( ERK ) and induces KLF 4 mRNA expression , 3 ) KLF 4 is induced by 15d PGJ 2 but not by rosiglitazone , a synthetic PPARgamma ligand , and 4 ) 15d PGJ 2 is unable to stimulate PPAR dependent promoter activity in the absence of cotransfected PPARgamma . ^^^ This induction is unlikely to be mediated through the PPARgamma receptor but may involve the mitogen activated protein kinase kinase / ERK pathway and is STAT 1 dependent . . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| PPAR gamma activation reduced ANG 2 induced growth associated with inhibition of ERK 1 / 2 , Akt , 4E BP 1 , and SHIP 2 . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Here , we show that PPARgamma mediates the proliferation and differentiation of murine NSCs via up regulation of the epidermal growth factor receptor and activation of the ERK pathway . ^^^ The stimulation of cell growth by PPARgamma was associated with a rapid activation of the ERK pathway by phosphorylation and up regulation of epidermal growth factor receptor and cyclin B protein levels . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Dominant negative MEK 1 , MEK 2 , and ERK 2 block PPARgamma induced EMT , whereas constitutively active MEK 1 and MEK 2 induce a mesenchymal phenotype similar to that evoked by PPARgamma . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with bisindolylmaleimide 1 or NAC blocked TPA induced phosphorylation of extracellular signal regulated kinase ( ERK ) , suggesting that ERK mediated signaling is also involved in the induction of PPARgamma . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we showed that 15d PGJ 2 transiently induces Cry 1 , Cry 2 , and Roralpha mRNA expressions and that 15d PGJ 2 induced entrainment signaling pathway is PPAR gamma and MAPKs ( ERK , JNK , p38MAPK ) independent . ^^^ |
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| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|