| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :1.1138926 |
| Peroxisome proliferator activated receptor gamma ( PPARgamma ) , a ligand activated transcription factor , forms a heterodimer with retinoid 10 receptor alpha ( RXRalpha ) , and its transcriptional activity is thought to be maximal in the presence of both PPARgamma and RXRalpha ligands . 1.1138926^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.51765989 |
| PPARgamma forms a heterodimer with the retinoid 10 receptor alpha ( RXRalpha ) and binds to a common consensus response element consisting of a direct repeat of two hexanucleotides spaced by one nucleotide ( DR 1 motif ) . 0.51765989^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.73646079 |
| Peroxisome prolixferator activated receptor gamma ( PPARgamma ) , a ligand activated transcription factor , forms a heterodimer with retinoid 10 receptor alpha ( RXRalpha ) , and its transcriptional activity is thought to be maximal in the presence of both PPARgamma and RXRalpha ligands . 0.73646079^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Transcription factor transcripts implicated in adipocyte differentiation ( peroxisome proliferator activated receptor gamma ( PPAR gamma ) , retinoid 10 receptor alpha ( RXR alpha ) , adipocyte determination and differentiation dependent factor 1 ( ADD 1 ) , and CCAAT / enhancer binding protein alpha ( C / EBP alpha ) ) and adipocyte characteristic protein transcripts ( lipoprotein lipase ( LPL ) and adipocyte fatty acid binding protein ( aP 2 ) ) were measured in pig tissues . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Human uterine leiomyomata express higher levels of peroxisome proliferator activated receptor gamma , retinoid 10 receptor alpha , and all trans retinoic acid than myometrium . ^^^ Compared with normal human myometrium , leiomyomata had 3 to 5 fold higher levels of peroxisome proliferator activated receptor gamma ( PPARgamma ) , retinoid 10 receptor alpha proteins , and all trans retinoic acid , but only during the follicular phase of the menstrual cycle . 9 cis Retinoic acid was undetectable in either leiomyomata or myometrium . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| In human coronary artery vascular smooth muscle ( hcaVSM ) cells , the mechanisms that mediate the antiproliferative effects of ligands for the peroxisome proliferator activated receptor gamma ( PPAR gamma ) and the retinoid 10 receptor alpha ( RXR alpha ) are unclear . ^^^ Ligands for the peroxisome proliferator activated receptor gamma and the retinoid 10 receptor alpha exert synergistic antiproliferative effects on human coronary artery smooth muscle cells . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Thus , our data demonstrate the feasibility of adipocyte selective temporally controlled gene engineering and reveal a central role of RXRalpha in adipogenesis , probably as a heterodimeric partner for peroxisome proliferator activated receptor gamma . . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Chemical sequencing and mass spectral analysis of tryptic peptides derived from the purified polypeptides identifies the ARF 6 complex as a heterodimer of the retinoid 10 receptor alpha ( RXR alpha ) and the murine peroxisome proliferator activated receptor gamma ( PPAR gamma ) . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The peroxisome proliferator activated receptor gamma ( PPAR gamma ) and the retinoid 10 receptor alpha ( RXR alpha ) form a heterodimeric complex that functions as a central regulator of adipocyte differentiation . ^^^ Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator activated receptor gamma and the retinoid 10 receptor . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor gamma ( PPARgamma ) heterodimerises with retinoid 10 receptor alpha ( RXRalpha ) and is thought to be a novel therapeutic target for human malignancies . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Among NRs , retinoid 10 receptor alpha ( RXRalpha ) peroxisome proliferator activated receptor gamma ( PPARgamma ) heterodimers can mediate adipocyte differentiation and obesity which has been demonstrated with in vitro cell culture systems and RXR and PPARgamma specific ligand studies . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| We investigated the changes in insulin resistance and adipose tissue expression of the adipokines resistin , adiponectin , and leptin and the transcription factors peroxisome proliferator activated receptor gamma ( PPAR gamma ) and retinoid 10 receptor alpha ( RXR alpha ) during 48 h of food deprivation . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Total RNA extracted from in vitro cultured cumulus granulosa cells was subjected to reverse transcription polymerase chain reaction ( RT PCR ) and mRNA expression for retinol binding protein ( RBP ) , retinoic acid receptor alpha ( RARalpha ) , retinoic acid receptor beta ( RARbeta ) , retinoic acid receptor gamma ( RARgamma ) , retinoid 10 receptor alpha ( RXRalpha ) , retinoid 10 receptor beta ( RXRbeta ) , retinaldehyde dehydrogenase 2 ( RALDH 2 ) , and peroxisome proliferator activated receptor gamma ( PPARgamma ) . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PIMT enhances the transcriptional activity of peroxisome proliferator activated receptor gamma and retinoid 10 receptor alpha , which is further stimulated by coexpression of PRIP , implying that PIMT is a component of nuclear receptor signal transduction apparatus acting through PRIP . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( PCR ) and whole mount in situ hybridization were utilized to investigate mRNA expression for RXR alpha , RXR beta , RXR gamma , alcohol dehydrogenase 1 ( ADH 1 ) , retinaldehyde dehydrogenase 2 ( RALDH 2 ) , peroxisome proliferator activated receptor gamma ( PPAR gamma ) , and glyceraldehyde 3 phosphate dehydrogenase . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| There were no differences in adipose tissue resistin , retinoid 10 receptor alpha , or peroxisome proliferator activated receptor gamma mRNA levels between Tg and Wt mice . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator activated receptor gamma coactivator 1 alpha . ^^^ In the course of searching for the mediator of CAR activation , we found that ligand independent activation of CAR was achieved in cooperation with the peroxisome proliferator activated receptor gamma coactivator 1 alpha ( PGC 1 alpha ) . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PCK 2 binds a peroxisome proliferator activated receptor gamma ( PPARgamma ) , retinoid 10 receptor alpha ( RXRalpha ) heterodimer . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Instead , NSAID inhibition of beta catenin requires the high level expression of peroxisome proliferator activated receptor gamma ( PPAR gamma ) and its co receptor retinoid 10 receptor alpha ( RXR alpha ) . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Coactivation of liver receptor homologue 1 by peroxisome proliferator activated receptor gamma coactivator 1alpha on aromatase promoter 2 and its inhibition by activated retinoid 10 receptor suggest a novel target for breast specific antiestrogen therapy . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| New data identify tributyltin chloride and triphenyltin chloride as nanomolar agonist ligands for retinoid 10 receptor ( RXR alpha , RXR beta , and RXR gamma ) and peroxisome proliferator activated receptor gamma , nuclear receptors that play pivotal roles in lipid homeostasis and adipogenesis . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| We further demonstrate that the adipocyte specific transcription factor PPAR gamma 2 , previously identified as a regulator of the adipocyte P 2 enhancer , binds in a heterodimeric complex with RXR alpha to the PEPCK 5 ' flanking region at two sites , termed PCK 1 ( bp 451 to 439 ) and PCK 2 ( bp 999 to 987 ) . ^^^ Forced expression of PPAR gamma 2 and RXR alpha activates the PEPCK enhancer in non adipose cells . ^^^ Mutation of the PPAR gamma 2 binding site ( PCK 2 ) abolishes both the activity of the enhancer in adipocytes and its ability to be activated by PPAR gamma 2 and RXR alpha . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Although forced expression of PPAR gamma and retinoid 10 receptor alpha activates the enhancer in HIB 1B preadipocytes , these receptors are not capable of activating the enhancer in NIH 3T3 fibroblasts . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| TCDD treatment decreased the mRNA levels of C / EBP alpha and PPAR gamma 2 but did not affect the mRNA levels of RXR alpha and RAR alpha . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PPARgamma and its heterodimerization partner , RXR alpha have been shown to be transcriptional activators of LPL in co transfection analysis . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The main results are as follows . ( 1 ) PPARgamma in combination with either RXRalpha or RXRgamma binds more strongly than PPARalpha or PPARbeta to all natural PPREs tested . ( 2 ) The binding of PPAR to strong elements is reinforced if the heterodimerization partner is RXRgamma . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| We report the isolation , by RT PCR , of partial cDNAs encoding the rat peroxisome proliferator activated receptor ( PPAR ) isoforms PPAR alpha , PPAR beta , and PPAR gamma and the rat retinoid 10 receptor ( RXR ) isoforms RXR alpha , RXR beta , and RXR gamma . ^^^ PPAR alpha , PPAR beta , RXR alpha , and RXR beta mRNAs are ubiquitously present in different brain regions during development , PPAR gamma mRNA is essentially undetectable , and RXR gamma mRNA is principally localised to cortex . ^^^ PPAR gamma mRNA is expressed at low levels in most cell types but is present at levels similar to those of PPAR alpha mRNA in adult astrocytes . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Ligand activation of the PPARgamma : RXRalpha heterodimer in myelomonocytic cell lines induces changes characteristic of monocytic differentiation and promotes uptake of oxLDL through transcriptional induction of the scavenger receptor CD 36 . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| TRAP 220 also interacts with other nuclear receptors [ vitamin D receptor , retinoic acid receptor alpha , retinoid 10 receptor alpha , peroxisome proliferation activated receptor ( PPAR ) alpha , PPARgamma and , to a lesser extent , estrogen receptor ] in a ligand dependent manner , whereas TRAP 100 shows only marginal interactions with estrogen receptor , retinoid 10 receptor alpha , PPARalpha , and PPARgamma . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The DNA binding activity of the PPARgamma / retinoid 10 receptor alpha ( RXRalpha ) to the ARE 7 element from the aP 2 gene was also reduced by approximately 50 % in response to GH . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the PPRE conferred the ability for luciferase expression to be up regulated by activators of both PPARgamma and retinoid 10 receptor alpha ( RXRalpha ) in a synergistic manner . ^^^ To correlate the expression of FATP to its physiological function , treatment of 3T3 L 1 adipocytes with PPARgamma and RXRalpha activators resulted in an increased uptake of oleate . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| A conserved DNA recognition element ( 171 to 149 bp ) within the promoter functions as a transcriptional enhancer when bound by the peroxisome proliferator activated receptor gamma 2 ( PPARgamma 2 ) / retinoid 10 receptor alpha ( RXRalpha ) heterodimer , but serves as a transcriptional silencer in the presence of unidentified double and single stranded DNA binding proteins . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Expression of retinoid receptors ( RARalpha and RXRalpha ) and PPARgamma was determined by western blot analysis . ^^^ The expression of PPARgamma and RXRalpha remained unchanged with the various treatments , whereas the expression of RARalpha was substantially reduced after treatment with the combination of retinoic acid and troglitazone . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PRIP acts as a strong coactivator for PPARgamma in the yeast and also potentiates the transcriptional activities of PPARgamma and RXRalpha in mammalian cells . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Asymmetry in the PPARgamma / RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors . ^^^ The nuclear receptor PPARgamma / RXRalpha heterodimer regulates glucose and lipid homeostasis and is the target for the antidiabetic drugs GI 262570 and the thiazolidinediones ( TZDs ) . ^^^ We report the crystal structures of the PPARgamma and RXRalpha LBDs complexed to the RXR ligand 9 cis retinoic acid ( 9cRA ) , the PPARgamma agonist rosiglitazone or GI 262570 , and coactivator peptides . ^^^ The PPARgamma / RXRalpha heterodimer is asymmetric , with each LBD deviated approximately 10 degrees from the C 2 symmetry , allowing the PPARgamma AF 2 helix to interact with helices 7 and 10 of RXRalpha . ^^^ The heterodimer interface is composed of conserved motifs in PPARgamma and RXRalpha that form a coiled coil along helix 10 with additional charge interactions from helices 7 and 9 . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Introduction of mutations in GLUT 2 PPRE resulted in loss of transactivational effects of the PPAR gamma / RXR alpha heterodimer . ^^^ Electrophoretic mobility shift assay using nuclear extracts of CV 1 cells , which were transfected with various combinations of PPARs or RXR alpha expression plasmids , revealed that heterodimers of PPAR gamma and RXR alpha preferentially bound to GLUT 2 PPRE . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Although , saquinavir , inhibited ligand binding to PPARgamma with an IC ( 50 ) of 12 . 7+ / 3 . 2 microM , none of the other PIs bound to the nuclear receptors RXRalpha or PPARgamma , ( IC ( 50 ) s > 20 microM ) , suggesting that inhibition of adipogenesis is not due to antagonism of ligand binding to RXRalpha or PPARgamma . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PPARgamma agonists ( troglitazone and 15 deoxy Delta ( 12 , 14 ) prostaglandin J 2 ) showed dose dependent inhibitory effects on the proliferation of the gastric cancer cells , and their effect was augmented by the simultaneous addition of 9 cis retinoic acid , a ligand of RXRalpha . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PPARgamma ( 1 / ) and RXRalpha ( 1 / ) mice both displayed a significantly enhanced susceptibility to 2 , 4 , 6 trinitrobenzene sulfonic acid ( TNBS ) induced colitis compared with their wild type littermates . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PPAR gamma / RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation . ^^^ Recent studies performed with null mice suggested a role of either RXR alpha or PPAR gamma in murine placental development . ^^^ We report here that both PPAR gamma and RXR alpha are strongly expressed in human villous cytotrophoblasts and syncytiotrophoblasts . ^^^ Therefore , in human placenta , PPAR gamma / RXR alpha heterodimers are functional units during cytotrophoblast differentiation into the syncytiotrophoblast in vitro . ^^^ Elements located in the regulatory region of the human CG beta gene ( beta 5 ) were found to bind RXR alpha and PPAR gamma from human cytotrophoblast nuclear extracts , suggesting that PPAR gamma / RXR alpha heterodimers directly regulate human CG beta transcription . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| This diet was offered to young rats for 8 and 28 days and the expression of nuclear receptors was determined at the end of each experimental time period ( 1 ) in the liver by assaying the binding properties of RAR and TR and by quantifying mRNA levels of RAR beta , TR alpha ( 1 ) beta ( 1 ) , RXR alpha , and PPAR alpha , and ( 2 ) in the white adipose tissue ( WAT ) by quantifying mRNA levels of RAR alpha , RXR alpha , TR alpha ( 1 ) beta ( 1 ) , and PPAR gamma ( 2 ) . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Retinoid 10 receptor alpha ( RXRalpha ) , a 9 cis retinoic acid stimulated ( 9 cis RA ) heterodimeric partner of PPARgamma , was also co expressed in all TCCa tissues and cell lines . ^^^ Retinoid 10 receptor alpha ( RXRalpha ) , a 9 cis retinoic acid stimulated ( 9 cis RA ) heterodimeric partner of PPARgamma , was also co expressed in all TCCa tissues and cell lines . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Regional differences in the response of human pre adipocytes to PPARgamma and RXRalpha agonists . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Interestingly , whereas the T 0070907 induced NCoR recruitment to PPARgamma / RXRalpha heterodimer can be almost completely reversed by the simultaneous treatment with RXRalpha agonist LGD 1069 , T 0070907 treatment has only modest effects on LGD 1069 induced coactivator recruitment to the PPARgamma / RXRalpha heterodimer . ^^^ T 0070907 is a novel tool for the study of PPARgamma / RXRalpha heterodimer function . . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PPARgamma / RXRalpha heterodimers control human trophoblast invasion . ^^^ The ligand dependent nuclear receptors PPARgamma and RXRalpha / beta were recently determined to be essential for murine placental development and trophoblast differentiation . ^^^ In the current study we examined the expression and role of the PPARgamma / RXRalpha heterodimers in human invasive trophoblasts . ^^^ We first report that in human first trimester placenta , PPARgamma and RXRalpha are highly expressed in cytotrophoblasts at the feto maternal interface , especially in the extravillous cytotrophoblasts involved in uterus invasion . ^^^ The coexpression of PPARgamma and RXRalpha genes in extravillous cytotrophoblast nuclei were then confirmed by immunocytochemistry , immunoblot , and real time quantitative PCR using cultured purified primary extravillous cytotrophoblasts . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Phytanic acid , a known retinoic 10 receptor ( RXRalpha ) and peroxisome proliferator activating receptor ( PPARalpha ) activator , also activated PPARdelta , and to a lesser degree PPARgamma , in a transactivation assay . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| This study determined the expression of genes coding for putative anticancer targets ( COX 2 , iNOS , MMP 7 , ODC , PKCbeta , PPARgamma , RXRalpha , RXRbeta , RXRgamma ) in FAP patients to provide one of the rationales for the design of chemotherapy and prevention strategies . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Western blotting showed that 15d PGJ 2 enhanced the levels of PPAR gamma , C / EBP alpha and RXR alpha proteins , while IL 11 and 9 cis RA decreased the level of PPAR gamma protein , but not C / EBP alpha protein and vitamin K 2 decreased the level of C / EBP alpha protein . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Atomic distances of M 807 ( H 8 ) to L 859 ( H 10 ) in corresponding residues of the distantly related ER alpha , RXR alpha , PPAR gamma and VDR LBD are highly conserved and almost invariant , suggesting that H8 / H10 interactions are critical for LBD stability in other members of the steroid / nuclear receptor superfamily . . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Retinoid 10 receptor alpha protein , which forms heterodimers with PPARgamma , was also detected in all the cells tested . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| However , EMSAs showed that PPARgamma and RXRalpha do not bind to promoter 2 of the CYP 19 gene , indicating that PPARgamma and RXR mediated inhibition of aromatase expression via promoter 2 occurs through an indirect mechanism of action . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Transient transfection assays using fibroblasts isolated from PRIP ( / ) embryos revealed a significant decrease in the capacity for ligand dependent transcriptional activation of retinoid 10 receptor alpha and to a lesser effect on PPAR gamma transcriptional activity . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Interestingly , coexpression of the obligate heterodimeric partner of PPARs , RXR alpha , resulted in an intranuclear redistribution of the GFP PPARm gamma isoform characterized by a reticulated pattern of the green fluorescent label for PPAR gamma within the nucleus , but not in nucleoli , and a heightened concentration of the fluorescent label surrounding nucleolar structures and at the nuclear membrane . ^^^ This localization pattern was not discernibly altered by PPAR gamma or RXR alpha specific ligands . ^^^ These results implicate RXR alpha in the nuclear reorganization of PPAR gamma and suggest that PPAR gamma colocalizes with RXR alpha at specific locations within the nucleus independent of added ligand . . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The rat ACBP gene is directly activated by PPARgamma / retinoid 10 receptor alpha ( RXRalpha ) and PPARalpha / RXRalpha , but not by PPARdelta / RXRalpha , through a PPAR response element in intron 1 , which is functionally conserved in the human ACBP gene . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PRMT 2 also binds to ERbeta , PR , TRbeta , RARalpha , PPARgamma , and RXRalpha in a ligand independent manner . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| A role for PPARgamma and its dimerization partner , retinoid 10 receptor ( RXR ) alpha , in death signaling was supported by 1 ) the expression of RXRalpha mRNA and cytosolic PPARgamma protein , 2 ) agonist induced binding of PPARgamma to a PPRE , and 3 ) synergistic increases in apoptosis following cotreatment with PPARgamma agonists and 9 cis retinoic acid , an RXRalpha agonist . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The role of PPAR gamma / RXR alpha heterodimers in the regulation of human trophoblast invasion . ^^^ We report here that PPAR gamma and RXR alpha are highly expressed in cultured primary extravillous cytotrophoblasts ( EVCT ) isolated from human first trimester placenta . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Furthermore , cotransfection experiments and pharmacological treatments in vitro , using the specific PPARgamma agonists LY 17883 and ciglitazone , demonstrate that the PPRE element confers peroxisome proliferator responsiveness via the PPARgamma and retinoid 10 receptor alpha heterodimer . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| We have next studied the role of PPARgamma / RXRalpha heterodimers in cell proliferation and invasion . ^^^ Our results show that PPARgamma and RXRalpha are co expressed by HIPEC 65 and that , as commonly observed , activation of PPARgamma / RXRalpha heterodimers with the specific PPARgamma agonist rosiglitazone induced lipid droplet accumulation as revealed by oil red O staining . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The DHA dependent induction of DR 1 Luc was reduced to basal levels upon RXRalpha antagonist treatment , with no effect on PPARgamma antagonist treatment . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of PPARgamma and RXRalpha were examined by RT PCR . ^^^ RESULTS : RT PCR showed that PPARgamma and RXRalpha mRNA were expressed in SW 1990 cell line . ^^^ Activation of RXRalpha has a synergic action with PPARgamma agonist on the growth inhibition of pancreatic carcinoma . . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| We pose that RXRalpha overexpression might represent an early protective effect in the process of laryngeal carcinogenesis that might be overwhelmed by an epigenetic disability in forming heterodimers with PPARgamma . . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| In spontaneous leiomyomata in women or leiomyomata induced in the guinea pig model , there is a likely synergism linking increased production of estradiol and all trans retinoic acid with up regulation of nuclear receptor PPARgamma and RXRalpha proteins to support tumor growth . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| To better understand their role , we studied the expression levels of all PPAR isoforms and transcriptional partners such as the retinoid 10 receptor alpha ( RXRalpha ) and PPARgamma coactivator 1 ( PGC 1 ) by means of real time PCR in 17 patients with colon cancer . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we demonstrated that 15d PGJ 2 enhanced the promoter activity of human TopoIIalpha promoter construct with a DR 1 like site by sevenfold when expressed with PPARgamma and RXRalpha . ^^^ The mutation of DR 1 like site decreased the promoter activity , although the direct binding between DR 1 like site and PPARgamma / RXRalpha heterodimer was not demonstrated . ^^^ CONCLUSIONS : We conclude that the induction of TopoIIalpha expression by PPARgamma ligands via DR 1 like site is an important mechanism for the enhancement of etoposide induced apoptosis and a DR 1 like site in TopoIIalpha promoter is involved in transcriptional regulation dependent on PPARgamma ligands and PPARgamma / RXRalpha heterodimer . . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The PPRE sequence specifically bound to the heterodimer of RXR alpha and PPAR alpha or PPAR gamma 2 , as assessed by electrophoretic gel mobility shift assays . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Co expression of PPARgamma and RXRalpha transactivated the INSIG 1 promoter in the presence of PPARgamma agonists . ^^^ We demonstrated with recombinant proteins that the PPARgamma / RXRalpha heterodimer binds directly to this PPAR response element . ^^^ In addition to regulation by PPARgamma / RXRalpha , we demonstrated that the INSIG 1 promoter is regulated by transcriptionally active SREBP . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| We also measured cytokeratin 7 transcripts , which are specifically expressed in the trophoblast , and transcripts corresponding to nuclear receptors PPARgamma and RXRalpha . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| We observed an increased mRNA expression level of the transcription factors peroxisomal proliferator activated receptor gamma ( PPAR gamma ) , retinoid 10 receptor alpha ( RXR alpha ) , and RA receptor alpha ( RAR alpha ) in 3T3 L 1 cells , whereas the mRNA level of these transcription factors was unchanged in human adipose tissue explants after incubation with RA . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Transactivation of PPREM by the PPARgamma RXR heterodimer was verified by the effective GSTA 2 induction in the cells treated with PGJ 2 + RA after transfecting them with the plasmids encoding PPARgamma 1 and RXRalpha . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| This study reports the modulating effects of n 6 , with or without vitamin A , on promotion of colon preneoplasic lesions induced by 1 , 2 dimethylhydrazine ( DMH ) and on the expression of nuclear receptors ( PPARgamma , RXRalpha , and RARbeta ) . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The transcriptional antagonism of the 3 ' n butyl analogue was demonstrated by its blockade of retinoic acid receptor ( RAR ) beta expression induced by the RXRalpha / peroxisome proliferator activated receptor ( PPAR ) gamma heterodimer complexed with an RXRalpha agonist plus the PPARgamma agonist ciglitazone and the inhibition of 9 cis RA induced coactivator SRC 1a recruitment to RXRalpha . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| It is a negative response element for PPARgamma , RXRalpha , COUP TFII , and several unidentified proteins in some cell types , and a positive element for COUP TFI and HNF 4 in other cells type . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate the impact of hyperlipidic diets on the expression of PPARg , RXRa and RARb mRNA in rat colon . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The ability of this region to confer enhanced activity in the adipocyte was mapped to a peroxisome proliferator response element ( PPRE ) like sequence that bound to peroxisome proliferator activated receptor gamma ( PPARgamma ) and its heterodimeric partner retinoid 10 receptor alpha ( RXRalpha ) in adipocyte nuclear extracts . ^^^ Mutation of the PPRE to prevent PPARgamma / RXRalpha binding resulted in a complete abrogation of the pMC 2 R ( 112 / +105 ) GL 3 reporter activity in day 3 differentiated 3T3 L 1 cells , demonstrating a key role played by this site in regulating MC 2 R expression in the murine adipocyte . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| In addition , ERBP also bound to PPARgamma , RXRalpha , and ERbeta . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PBAF , but not BAF , is able to potentiate transcriptional activation in vitro mediated by nuclear receptors , such as RXRalpha , VDR , and PPARgamma . ^^^ Here we show that the ablation of PBAF specific subunit BAF 180 in mouse embryos results in severe hypoplastic ventricle development and trophoblast placental defects , similar to those found in mice lacking RXRalpha and PPARgamma . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PPARalpha , PPARbeta , PPARgamma , RXRalpha , FABPpm , and FAT / CD36 isoforms exhibited ubiquitous expression in human GI tract , whereas RXRbeta was not detected . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| The troglitazone mediated suppressions of CYP3A5 and CYP3A7 were found to be independent of expression levels of nuclear transcriptional factors , PXR , RXRalpha and PPARgamma . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| In cultured myoblasts , we found that BTG 1 stimulates the transcriptional activity of nuclear receptors ( T 3 and all trans retinoic acid receptors but not RXRalpha and PPARgamma ) , c Jun and myogenic factors ( CMD 1 , Myf 5 , myogenin ) . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed that the protein level of RXR alpha , but not PPAR gamma , RXR beta , or PKC isoforms , was accumulated in the presence of proteasome inhibitors . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase reaction analysis of TNF alpha , PPAR gamma , RXR alpha , and beta actin mRNA was performed . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Cotreatment with a retinoid 10 receptor alpha ligand , 9 cis retinoic acid , decreased [ ( 3 ) H ] thymidine incorporation synergistically , thereby implicating activation of a PPARgamma retinoid 10 receptor alpha complex . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| We detected RNA expression of PPARalpha , PPARbeta , PPARgamma , retinoid 10 receptor alpha , liver 10 receptor alpha ( LXRalpha ) and pregnane 10 receptor but not FXR in freshly isolated and 7 day maintained sebaceous glands . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Both RXR alpha 2 and RXR alpha 3 showed a level of transcriptional activity and a dose response curve against the agonist LG 100268 similar to RXR alpha 1 in reporter assay for the RXR alpha homodimer or that for the heterodimer with PPAR gamma 2 . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Message levels of PPARgamma and retinoid 10 receptor alpha ( RXRalpha ) in the individual cell lines were quantitated by real time polymerase chain reaction ( RT PCR ) . ^^^ The ratio of PPARgamma to RXRalpha was predictive of how cells responded to co treatment of Ros and 9 cis retinoic acid , an RXRalpha agonist , in two out of three cell lines tested . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| As lethality of PPARgamma ( / ) and RXRalpha ( / ) mouse fetuses precluded the analysis of PPARgamma and RXRalpha functions in mature adipocytes , we generated RXRalpha ( ad / ) and PPARgamma ( ad / ) mice , in which RXRalpha and PPARgamma are selectively ablated in adult adipocytes , respectively . ^^^ However , mature adipocytes lacking either both RXRalpha and RXRgamma or PPARgamma die , and are replaced by newly formed adipocytes . ^^^ Thus , in adipocytes , RXRalpha is essential for lipogenesis , but RXRgamma can functionally replace RXRalpha for the adipocyte vital functions exerted by PPARgamma / RXR heterodimers . . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| All transformed cells expressed PPAR gamma and RXR alpha but TZDs did not change their expression . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| METHODS : Full length PPARgamma and retinoid 10 receptor alpha ( RXRalpha ) , biotinylated PPAR response element ( PPRE ) , [ 3H ] BRL 49653 and streptavidin coated FlashPlate or microbead were used to develop an HTS assay based on SPA technology . ^^^ RESULTS : ( 1 ) IC 50 values of positive control compounds ( BRL 49653 and troglitazone ) obtained from the ' ABCDE ' method and HA assay were comparable and consistent with those reported elsewhere ; ( 2 ) Approximately 178 compounds , showing more than 70 % competitive inhibition on BRL 49653 binding to PPARgamma , were identified initially by the ' ABCDE ' method ( microbead ) ; ( 3 ) Secondary screening using FlashPlate and cross reactivity studies with RARalpha , beta , gamma and RXRalpha , beta , gamma confirmed that 12 compounds possessed specific PPARgamma binding properties including 2 with IC 50 values less than 0 . 5 micromol / L and novel chemical structures . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| METHODS : mRNA expression levels for peroxisome proliferator activated receptor ( PPAR ) alpha , gamma and delta , PPARgamma co factor 1 alpha and beta ( PGC 1 alpha and beta ) , 9 cis retinoc acid activated receptor alpha , beta and gamma ( RXR alpha , beta , gamma ) , 5 ' AMP activated protein kinase ( AMPK ) alpha 1 and alpha 2 , adiponectin receptor 1 and 2 ( AR 1 and AR 2 ) were measured in heart tissue of neonatal 0 day , 7 day and 21 day old rats . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| We studied placental PPARdelta , PPARgamma , and retinoid 10 receptor alpha ( RXRalpha ) expression in healthy pregnancy and in preeclampsia ( PET ) and intrauterine growth restriction ( IUGR ) . ^^^ METHODS AND RESULTS : Using immunocytochemistry , PPARdelta , PPARgamma , and RXRalpha were localized to the cyto and syncytiotrophoblast and invading trophoblast columns in first and second trimester placentas . ^^^ Third trimester placentas from healthy pregnancy , and in PET and IUGR , demonstrated PPARdelta , PPARgamma , and RXRalpha staining within the syncytium , and localization within isolated cells in the stroma . ^^^ There were no consistent differences in PPARdelta , PPARgamma , or RXRalpha mRNA and protein expression among PET or IUGR placentas and controls . ^^^ We found no evidence that placental PPARdelta , PPARgamma , and RXRalpha expression is changed in PET or IUGR . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| In contrast , ectopic expression of PPARgamma / RXRalpha increases FA uptake and deposition as triacylglycerides . ^^^ Importantly , whereas expression of PPARgamma / RXRalpha attenuates GSIS , the expression of PPARalpha / RXRalpha potentiates GSIS in rat islets and INS 1E cells without affecting the mitochondrial membrane potential . ^^^ Peroxisome proliferator activated receptor alpha ( PPARalpha ) potentiates , whereas PPARgamma attenuates , glucose stimulated insulin secretion in pancreatic beta cells . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Overexpression of retinoid 10 receptor alpha ( RXRalpha ) partially restored not only the inhibition of transcriptional activation by PPARgamma but also T 3 induced hypertrophic differentiation . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| METHODS : We used the urothelium of anuric patients on long term hemodialysis , sampled at the time of renal transplantation , to investigate the expression of urothelial differentiation associated antigens , including uroplakins ( UPIa , UPIb , UPII , and UPIIIa ) , cytokeratin isotypes ( CK 7 , CK 8 , CK 13 , CK 14 , CK 17 , CK 18 , and CK 20 ) , nuclear hormone receptors [ peroxisome proliferators activated receptor gamma ( PPAR gamma ) and retinoid 10 receptor alpha ( RXR alpha ) ] , and a cell cycle marker ( Ki 67 ) . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Real time reverse transcription polymerase chain reaction and immunohistochemical analysis demonstrated markedly higher expression of Ppara , Pparg , and Rxra mRNA in labyrinth zone trophoblast as compared with basal zone near term . ^^^ These data suggest that PPARG : RXRA heterodimers play important roles in labyrinth zone growth late in pregnancy , possibly supporting vascular development . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptors mRNA levels of RARalpha , RARgamma , RXRalpha , PPARgamma were measured in the Swat by a real time semi quantitative RT PCR method . ^^^ The mRNA levels of PPARgamma and RXRalpha were significantly increased in the Caf+ group as compared to control group , with a significant positive correlation between these two parameters . ^^^ In conclusion , 8 week exposure to cafeteria diets with normal and higher levels of vitamin A led to an increase of adiposity in rats , associated , only in the group fed with the higher vitamin A level cafeteria diet , with an increase of PPARgamma and RXRalpha expressions in subcutaneous adipose tissue . . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| In transactivation assays in cultured HEK 293 cells , THC activated PPARgamma , transiently expressed in combination with retinoid 10 receptor alpha and a luciferase reporter gene , in a concentration dependent manner ( 100 nM 10 microM ) . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| KIAA 1769 encodes a 2080 amino acid protein ( molecular mass , 231 kDa ) that was recently identified to interact with PPARalpha and termed PPARalpha interacting cofactor 285 ( here referred to as PPARgamma DBD interacting protein 1 ( PDIP 1 ) alpha ) . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| PELP 1 could also function as a coactivator of the RXRalpha peroxisome proliferator activated receptor ( PPARgamma ) heterodimer as evident by the peroxisome proliferator activated receptor response element luciferase assay in response to both 9 cis RA and PPARgamma specific ligands . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of PPARgamma 1 and RXRalpha repressed pGL 3 323 transactivation with S6K1 inhibition , which was abrogated by CA S6K1 transfection . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Lutein interacted with fat in Expt . 1 and with EPA in Expt . 2 to affect mRNA levels of iNOS , PPARgamma , and RXRalpha in chicken macrophages and HD 11 cells , respectively ( P < 0 . 05 ) . ^^^ Increasing lutein with high fat ( 6 % ) or EPA ( 15 micromol / L EPA ) increased PPARgamma and RXRalpha mRNA levels . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| In this study , the activation of human , mouse , and rat PPARalpha , PPARbeta , PPARgamma , LXRbeta , and RXRalpha by PFOA ( including its linear and branched isomers ) and perfluorooctane sulfonate ( PFOS ) was investigated and compared to several structural classes of natural fatty acids and appropriate positive control ligands . ^^^ Due to its fatty acid structure , PFOA may activate other NRs , such as PPARbeta , PPARgamma , liver 10 receptor ( LXR ) , or retinoid 10 receptor ( RXR ) . ^^^ |
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| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| Results from a series of GST pulldown assays showed that these Gadd 45 family proteins interact with several nuclear hormone receptors including RXR alpha , RAR alpha , ER alpha , PPAR alpha , PPAR beta , and PPAR gamma 2 in vitro . ^^^ |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37231 and P19793 |
Pubmed |
SVM Score :0.0 |
| NA |
|