| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| Here we show that Smad 2 and Smad 3 interacted with the kinase deficient TGF beta type 1 receptor ( TbetaR ) 1 after it was phosphorylated by TbetaR 2 kinase . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| We analyzed the mRNA expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , the TGF beta receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) , Smad 2 , Smad 3 , and Smad 4 . mRNA expression of IL 10 and CD 95 ( FAS / APO 1 ) were also studied . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| To learn about the role of TGF beta in vivo , phenotypes of targeted mutations of molecules within the TGF beta signalling pathway , TGF beta 1 , beta 2 , beta 3 , TGF beta receptor ( TbetaR 2 ) and the signalling molecules SMAD 2 , SMAD 3 and SMAD 4 , are discussed in this review . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| A number of these cell lines carry inactivating mutations of the TGF beta type 2 ( TbetaR 2 ) receptor , and fail to phosphorylate receptor associated Smads , Smad 2 and Smad 3 . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| Using transient expression of TGF beta signalling components and a Smad 3 dependent reporter assay , we show that BICR 31 and H 314 had defects of Smad 4 , BICR 56 had abnormal TbetaR 2 and BICR 19 overexpressed Smad 7 . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| Several proteins , including transforming growth factor beta ( TGF beta ) receptor type 1 ( RI ) , TGF beta receptor type 2 ( RII ) , Smad 2 , Smad 3 , and Smad4 / DPC4 , have been identified in the transduction pathway of the tumor suppressor TGF beta . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| Thus , inhibition of endogenous Smad 3 and Smad 2 gene expression resulted in stimulation of embryonic lung branching similar to that caused by inhibition of TGF beta type 2 receptor expression and signaling ( J . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| Co transfection into SW480 . 7 cells of Smad 4 together with a Ras phosphorylation resistant Smad 3 ( but not with wild type Smad 2 , Smad 3 , adenomatous polyposis coli ( APC ) , or TGF beta type 2 receptor ) restored the TGF beta antiproliferative response . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| These genes were TGF beta type 1 receptor gene ( TGFBR 1 ) , TGF beta type 2 receptor gene ( TGFBR 2 ) , SMAD 2 gene ( SMAD 2 ) , SMAD 3 gene ( SMAD 3 ) , SMAD 4 gene ( SMAD 4 ) , and SMAD 7 gene ( SMAD 7 ) , all of which compose the TGF beta 1 signaling pathway . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| The expression of TGF beta type 2 receptor protein was decreased in two of seven cell lines , and the expression of both Smad 2 and Smad 3 proteins was decreased in only one cell line . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of TGF beta type 2 receptor , Smad 2 , Smad 3 , Smad 4 , Smad 6 and Smad 7 genes in colorectal cancer . ^^^ Then , all coding regions of the TGF beta type 2 receptor ( TRII ) and the genes for Smad 2 , Smad 3 , Smad 4 , Smad 6 , and Smad 7 were analyzed by PCR SSCP and direct sequencing . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| Furthermore , co treatment of the cells with GnRH + TGF beta , or pretreatment with TGF beta type 2 receptor antisense to block TGF beta autocrine / paracrine action , in part inhibited TGF beta activated Smad 3 . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| Here we show that in isolated human NK cells , proinflammatory monokines antagonize antiinflammatory TGF beta signaling by downregulating the expression of the TGF beta type 2 receptor , and its signaling intermediates SMAD 2 and SMAD 3 . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated in T47D cells transfected to express the transforming growth factor beta receptor type 2 ( TGF betaRII ) that insulin like growth factor binding protein 3 ( IGFBP 3 ) could stimulate Smad 2 and Smad 3 phosphorylation , potentiate TGF beta 1 stimulated Smad phosphorylation , and cooperate with exogenous TGF beta 1 in cell growth inhibition ( Fanayan , S . , Firth , S . ^^^ |
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| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| We report results of an association study between BMD and nine candidate genes ( TGFB 1 , TGFBR 2 , SMAD 2 , SMAD 3 , SMAD 4 , IFNB 1 , IFNAR 1 , FOS and LRP 5 ) , as well as of a case control study of osteoporosis . ^^^ |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and P84022 |
Pubmed |
SVM Score :0.0 |
| NA |
|