| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| The blood vessel defects in ALK 1 deficient mice are reminiscent of mice lacking TGF beta 1 , TGF beta type 2 receptor ( TbetaR 2 ) , or endoglin , suggesting that ALK 1 may mediate TGF beta 1 signal in endothelial cells . ^^^ Consistent with this hypothesis , we demonstrate that ALK 1 in endothelial cells binds to TGF beta 1 and TbetaR 2 . ^^^ |
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| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated the role of the three mammalian TGFbeta subtypes ( beta 1 , beta 2 , and beta 3 ) and their receptors ( type 3 ( TbetaR 3 ) , type 2 ( TbetaR 2 ) , and two types 1 ( TbetaR 1 ) , ALK 1 and ALK 5 ) in early rat lung organogenesis by using an embryonic rat lung explant culture . ^^^ |
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| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| We therefore studied the expression of UPA , UPAR , IGF2R , ALK 5 ( TGFBR 1 ) , TGFBR 2 , TGFBR 3 , ENG , ALK 1 , TGFB 1 , TGFB 2 , and TGFB 3 in a series of 14 pancreatic carcinoma cell lines . ^^^ |
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| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| Recently , a model has been proposed in which TGF beta by binding to the TGF beta type 2 receptor can activate two distinct type 1 receptors in endothelial cells ( ECs ) , i . e . , the EC restricted ALK 1 and the broadly expressed ALK 5 , which have opposite effects on ECs behavior . ^^^ |
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| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| METHODS : We used a combination of in vitro binding assays and co immunoprecipitation ( IP ) experiments to investigate whether TAK 1 interacted with the type 1 ( ALK 1 or ALK 5 ) or type 2 ( TBRII ) TGFbeta receptors . ^^^ |
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| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| Through binding to the TGF beta type 2 receptor , TGF beta can activate two distinct type 1 receptors ( ALK 1 and ALK 5 ) in endothelial cells , each one leading to opposite effects on endothelial cell proliferation and migration . ^^^ |
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| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| Targeted deletions of Tgfb 1 and other components of this signaling pathway , such as Acvrl 1 , Tgfbr 1 and Tgfbr 2 , result in abnormal vascular development especially of the yolk sac , leading to embryonic lethality . ^^^ |
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| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37023 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|