Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.52054009
A novel protein was identified , TbetaR 1 associated protein 1 ( TRAP 1 ) , that interacts in yeast specifically with mutationally activated TbetaR 1 , but not wild type TbetaR 1 , TbetaR 2 , or irrelevant proteins . 0.52054009^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
TbetaR I / BMPR IB , containing the extracellular domain of TGF beta type 1 receptor ( TbetaR 1 ) and the intracellular domain of bone morphogenetic protein type IB receptor ( BMPR IB ) , and TbetaR II / ActR IIB , containing the extracellular domain of TGF beta type 2 receptor ( TbetaR 2 ) and the intracellular domain of activin type IIB receptor ( ActR IIB ) . ^^^ In the presence of TGF beta 1 , TbetaR I / BMPR IB and TbetaR II / ActR IIB formed heteromeric complexes with wild type TbetaR 2 and TbetaR 1 , respectively , upon stable transfection in mink lung epithelial cell lines . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Here we show that Smad 2 and Smad 3 interacted with the kinase deficient TGF beta type 1 receptor ( TbetaR ) 1 after it was phosphorylated by TbetaR 2 kinase . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) signals through two transmembrane serine / threonine kinases , known as TbetaR 1 and TbetaR 2 . ^^^ Several lines of evidence suggest that TbetaR 2 acts as a primary receptor , binding TGF beta and phosphorylating TbetaR 1 whose kinase activity then propagates the signal to unknown substrates . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) signals via an oligomeric complex of two serine / threonine kinase receptors denoted TGF beta type 1 receptor ( TbetaR 1 ) and type 2 receptor ( TbetaR 2 ) . ^^^ We investigated the in vivo phosphorylation sites in TbetaR 1 and TbetaR 2 after complex formation . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In mammals , transforming growth factor beta ( TGF beta ) is found in 3 highly homologous isoforms that exert their effects via heteromeric complexes of type 1 and type 2 receptors ( TbetaR 1 and TbetaR 2 ) . ^^^ We have investigated the immunohistological localization of TGF beta 1 , TGF beta 2 , TbetaR 1 and TbetaR 2 in normal human skin , basal cell carcinoma ( BCC ) , Bowen ' s disease , seborrheic keratosis , eccrine poroma and eccrine spiradenoma using frozen tissue specimens . ^^^ The epidermal expression of TbetaR 1 and TbetaR 2 was very weak in the majority of normal skins . ^^^ In addition , TbetaR 1 and TbetaR 2 positive stromal cells were accumulated in the fibrotic stroma in some BCCs . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGFbeta ) signaling requires phosphorylation of the type 1 receptor TbetaR 1 by TbetaR 2 . ^^^ Although TGFbeta promotes the association of TbetaR 1 with TbetaR 2 , these receptor components have affinity for each other which can lead to their ligand independent activation . ^^^ FKBP 12 does not inhibit TbetaR 1 association with TbetaR 2 , but inhibits TbetaR 1 phosphorylation by TbetaR 2 . ^^^ By impeding the activation of TGFbeta receptor complexes formed in the absence of ligand , FKBP 12 may provide a safeguard against leaky signaling resulting from the innate tendency of TbetaR 1 and TbetaR 2 to interact with each other . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) signal transduction is mediated via specific cell surface signaling TGF beta receptors , most notably the type 1 ALK 5 ( TbetaR 1 [ ALK 5 ] ) and the type 2 ( TbetaR 2 ) . ^^^ We evaluated TbetaR 1 ( ALK 5 ) and TbetaR 2 expression in 41 human pancreatic cancer tissue samples and correlated these findings with clinical data of the patients . ^^^ Northern blot analysis indicated that , in comparison with the normal pancreas , pancreatic adenocarcinomas exhibited 8 . 0 fold and 4 . 5 fold increases ( P < 0 . 01 ) , respectively , in mRNA levels encoding TbetaR 1 ( ALK 5 ) and TbetaR 2 . ^^^ In situ hybridization showed that both TbetaR 1 ( ALK 5 ) and TbetaR 2 mRNA were highly expressed in the majority of pancreatic cancer cells . ^^^ Immunohistochemical analysis of TbetaR 1 ( ALK 5 ) and TbetaR 2 revealed positive immunostaining in 73 % and 56 % of the tumors , respectively . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
We compared endoglin distribution with that of TGF beta receptors type 1 ( TbetaR 1 ) , type 2 ( TbetaR 2 ) and betaglycan . ^^^ TbetaR 1 , TbetaR 2 and betaglycan were observed on most cell types and had an overall similar pattern of distribution . ^^^ TbetaR 1 , TbetaR 2 and betaglycan were mostly found on cardiac myocytes , but were detectable at low levels on endocardium . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Binding of 125I TGF beta 1 to serine / threonine kinase receptor type 2 ( TbetaR 2 ) and TbetaR 1 was not seen in the retinoblastoma cells . ^^^ TbetaR 2 mRNA was not expressed in these cells , but TbetaR 1 mRNA was detected . ^^^ Transcriptional activation of the TGF beta responsive genes was not seen by the transfection of either receptor cDNA alone but could be induced by transfection of both TbetaR 2 and TbetaR 1 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In this study , the role of TGF beta 1 type 1 ( TbetaR 1 ) and TGF beta type 2 ( TbetaR 2 ) receptors in TGF beta 1 regulated gene expression in lactotropes was determined using anterior pituitary cells known to be responsive to TGF beta 1 growth inhibition and using a transformed PR 1 cell line known to be nonresponsive to TGF beta 1 growth inhibition . ^^^ Affinity labeling of TGF beta binding proteins indicated that anterior pituitary cells contain several TGF beta binding protein complexes , including the 65 kDa size TbetaR 1 and 95 kDa size TbetaR 2 . ^^^ Immunocytochemistry identified TbetaR 1 and TbetaR 2 receptor proteins in lactotropes but detected primarily TbetaR 1 receptor protein in PR 1 cells . ^^^ RT PCR detection of TbetaR 1 and TbetaR 2 mRNA identified both receptor mRNA transcripts in anterior pituitary cells and in PR 1 cells but the levels of TbetaR 2 and TbetaR 1 mRNA transcripts in PR 1 cells was much lower than that in anterior pituitary cells . ^^^ Determination of the TGF beta 1 gene responses in PR 1 cells following TbetaR 1 and TbetaR 2 gene transfection indicated that PR 1 cells transactivate transcription of the TGF beta responsive p3TP Lux reporter in the absence of cotransfected TbetaR 2 receptor . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
To mediate a signal both TGF beta receptors type 1 and type 2 ( TbetaR 1 and TbetaR 2 ) have to be expressed . ^^^ TbetaR 2 was strongly expressed in 10 of 12 samples , but none of the investigated tumor samples stained for TbetaR 1 . ^^^ These findings show that most KS lesions have the ability to produce TGF beta and that KS cells maintain a high expression of TbetaR 2 in the absence of TbetaR 1 , which may allow KS to escape growth inhibitory effects of endocrine or paracrine TGF beta . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The pleiotropic responses to TGF beta are mediated via ligand induced heteromeric complex formation by type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) serine threonine kinase receptors . ^^^ Several studies have shown that TbetaR 2 acts as a primary receptor , binding TGF beta and phosphorylating TbetaR 1 , whose kinase activity then propagates the signals . ^^^ STRAP associates with both functional TbetaR 1 and TbetaR 2 in vivo . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Northern blot analysis was used to examine the expression of TGF beta 1 , beta 2 and beta 3 and their receptors , type 1 ( TbetaR 1 ) , type 2 ( TbetaR 2 ) and type 3 ( TbetaR 3 ) . ^^^ For TbetaR 1 and TbetaR 2 , the immunoreactivity was localized in hepatocytes and biliary cells in normal and cirrhotic liver tissues , with higher intensity for TbetaR 2 in the cirrhotic liver . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
They function by binding to two receptors , type 1 ( TbetaR 1 ) subtype ALK 5 and type 2 ( TbetaR 2 ) , which are concomitantly required for signal transduction . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
FKBP 12 binds to the GS region of the receptor , capping the TbetaR 2 phosphorylation sites and further stabilizing the inactive conformation of TbetaR 1 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
These results suggest that IGFBP 3 , 4 , and 5 are specific ligands for TbetaR 5 , which mediates the growth inhibitory response through a signaling pathway ( s ) distinct from that mediated by the TbetaR 1 and TbetaR 2 heterocomplex . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In hepatocytes from regenerating livers after a partial hepatectomy ( PH ) , an increase of TbetaR 1 , TbetaR 2 , TbetaR 3 , IGF II / M 6 PR , and TGF beta 1 mRNAs was found , compared with hepatocytes from resting livers . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Furthermore , Renca cells expressed TbetaR 1 mRNA , but did not express TbetaR 2 mRNA , suggesting that the absence of this receptor may be the cause of TGF beta insensitivity . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
To identify molecular mechanisms of TGF beta resistance , we have conducted a comprehensive structural analysis of the TGF beta receptor types 1 ( TbetaR 1 ) and 2 ( TbetaR 2 ) genes in primary human breast carcinomas and associated axillary lymph node metastases . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Interestingly , TGF beta 1 differentially stimulated or inhibited the expression of TbetaR 1 and TbetaR 2 mRNA in the gliomas . ^^^ Affinity cross linking studies using 125I TGF beta 1 revealed that the gliomas expressed TGF beta type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) receptors , although binding to TbetaR 2 in U 343 MGa 31L and U 251 MG AgCl 1 was low to undetectable . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Immunohistochemical analysis was performed to localize expression of TbetaR 1 and TbetaR 2 , whereas the presence of genetic alterations in TbetaR 1 was examined through Southern blot analysis . ^^^ Immunohistochemical staining demonstrated that TbetaR 1 and TbetaR 2 expression localized to tumor cells ; however , receptor staining in stromal tissue also was detected . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Northern blot analysis was used in normal liver and HCC to examine the expression of TGF beta 1 , beta 2 , beta 3 and their receptors : type 1 ALK 5 ( TbetaR 1 ALK 5 ) , type 2 ( TbetaR 2 ) , and type 3 ( TbetaR 3 ) . ^^^ For TbetaR 1 ALK 5 and TbetaR 2 , the immunostaining in both HCC and normal liver was mild to moderate , with a slightly higher intensity in the normal tissues . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
METHODS : Cultured bovine articular chondrocytes were treated with 10 ( 5 ) m diacerein , 10 ng / ml IL 1beta or the combination diacerein+interleukin ( IL ) 1 , and the expression of both TGF beta isoforms 1 , 2 and 3 and that of their receptors TbetaR 1 and TbetaR 2 was determined by Northern blot and reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
To distinguish between these possibilities in humans , immunohistochemical studies were performed examining the coexpression of TGF beta isoforms and the TGF beta receptors ALK 5 and TbetaR 2 in aorta during the various stages of atherosclerotic lesion development . ^^^ METHODS AND RESULTS : The spatial relationships between TGF beta 1 , TGF beta 3 , ALK 5 , and TbetaR 2 expression were compared in aortic segments from 21 subjects . ^^^ Nonatherosclerotic intima contained predominantly TGF beta 1 , low concentrations of TbetaR 2 , and barely detectable amounts of ALK 5 . ^^^ These lesions also contained high , colocalized concentrations of ALK 5 and TbetaR 2 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In order to identify possible molecular mechanisms responsible for TGFbeta resistance , we screened the 7 exons of the type 2 ( TbetaR 2 ) TGFbeta receptor and the 9 exons of the type 1 ( TbetaR 1 ) TGFbeta receptor genes for mutations in 16 paraffin embedded primary invasive cervical carcinoma specimens . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
TGF beta stimulated Man 6 P / IGF 2 receptor mediated uptake ( approximately 2 fold after 12 h treatment ) of exogenous beta glucuronidase in Mv1Lu cells and type 2 TGF beta receptor ( TbetaR 2 ) defective mutant cells ( DR 26 cells ) but not in type 1 TGF beta receptor ( TbetaR 1 ) defective mutant cells ( R 1B cells ) and human colorectal carcinoma cells ( RII 37 cells ) expressing TbetaR 1 and TbetaR 2 but lacking TbetaR 5 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Here we report the cloning of chicken Tbr 1 and of murine and chicken Tbr 2 ( orthologs of the Xenopus eomesodermin gene ) , the mapping of the murine Tbr 2 to chromosome 9 , and their pattern of expression during mouse and chick embryogenesis . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Transforming growth factor ( TGF ) beta , a potent growth inhibitor of proliferation in most cells , usually exerts its effects through an interaction with membrane receptors , type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) . ^^^ Among these patients , 18 ( 30 . 5 % ) had loss of TbetaR 1 expression , whereas 27 ( 44 . 0 % ) had loss of TbetaR 2 expression . ^^^ There was a correlation between the loss of expression of TbetaR 1 and TbetaR 2 and the tumor grade ( P = 0 . 041 and P = 0 . 026 , respectively ) . ^^^ In addition , both pathological and lymph node status also were associated with the loss of TbetaR 1 and TbetaR 2 expression ( P = 0 . 025 and P = 0 . 004 , respectively ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Expression of TGF beta receptor 1 ( TbetaR 1 ) and receptor 2 ( TbetaR 2 ) , essential for effective signaling , was determined by Western analysis of CSOC cultures . ^^^ All cell cultures expressed TbetaR 1 and TbetaR 2 and exhibited TbetaR 1 phosphorylation following TGF beta 1 treatment . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In the present study , the authors analyzed the concomitant presence of TGF beta 1 and its signaling receptors TGF beta receptor 1 , subtype ALK 5 ( TbetaR 1 ( ALK 5 ) ) , and TGF beta receptor 2 ( TbetaR 2 ) as well as CTGF and collagen type 1 in the pancreatic tissue of patients undergoing surgery for chronic pancreatitis . ^^^ The expression of TGF beta 1 , TbetaR 1 ( ALK 5 ) , TbetaR 2 , CTGF , and collagen type 1 was studied by Northern blot analysis . ^^^ By in situ hybridization , TGF beta 1 , TbetaR 1 ( ALK 5 ) , and TbetaR 2 mRNA were often seen to be colocalized , especially in the ductal cells and in metaplastic areas where atrophic acinar cells appeared to dedifferentiate into ductal structures . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
We have identified and characterized a new member of the mammalian brain specific T box gene family , Tbr 2 , which is closely related to mouse Tbr 1 , and to the Xenopus earliest mesodermal gene , Eomesodermin . ^^^ As Tbr 1 , Tbr 2 is predominantly expressed in some regions of the developing brain , but in a strikingly complementary manner . ^^^ On embryonic day 14 . 5 ( E14 . 5 ) , Tbr 2 mRNA expression was observed in the mesencephalon and rhombencephalon in contrast to Tbr 1 which was expressed mostly in the telencephalon . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
TbetaR 2 expression was compared with expression of the type 1 receptor ( TbetaR 1 ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In the present study , we investigated the role of the three mammalian TGFbeta subtypes ( beta 1 , beta 2 , and beta 3 ) and their receptors ( type 3 ( TbetaR 3 ) , type 2 ( TbetaR 2 ) , and two types 1 ( TbetaR 1 ) , ALK 1 and ALK 5 ) in early rat lung organogenesis by using an embryonic rat lung explant culture . ^^^ Antisense inhibition of ALK 5 and TbetaR 2 showed a similar reduction in early lung branching as observed with antisense TGFbeta 2 . ^^^ This TGFbeta signaling in rat lung branching in vitro appears to be predominantly mediated via the TbetaR 1 ( ALK 5 ) / TbetaR 2 heteromeric complex . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Cryosections of these specimens were processed for immunohistochemical analysis for TGF beta 1 , TGF beta 2 , TGF beta 3 , TGF beta receptor type 1 ( TbetaR 1 ) , type 2 ( TbetaR 2 ) and type 3 ( TbetaR 3 ) , and were observed under light micros copy . ^^^ Post surgical LECs expressed TbetaR 1 and TbetaR 2 , and had also TbetaR 3 in seven of the nine specimens examined . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The biological effects of TGF beta are mediated by type 1 ( TbetaR 1 ) and 2 ( TbetaR 2 ) receptors . ^^^ These studies demonstrate a differential regulation and localization of TbetaR 1 that is different from that of TbetaR 2 during lung development . ^^^ TbetaR 1 , TbetaR 2 , and TGF beta isoforms exhibit distinct but overlapping patterns of expression during lung development . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
To better understand the regulatory mechanism of follicular development , immunohistochemistry was used to study the expression of insulin like growth factor ( IGF ) type 1 receptor ( IGF IR ) and transforming growth factor beta ( TGFbeta ) type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) receptors in fresh and frozen ovarian tissues from 14 women . ^^^ Unlike TbetaR 1 , TbetaR 2 was expressed only in the oocytes of primordial and primary follicles , and with weak staining intensity in thecal cells . ^^^ There was no difference in staining patterns for IGF IR , TbetaR 1 and TbetaR 2 between fresh and frozen ovarian tissues , indicating that cryopreservation might not significantly alter the immunoreactivities of these receptors in frozen ovarian tissue . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Treatment of ovarian cancer HEY cells with 500 nM 5alpha dihydrotestosterone ( DHT ) , but not estradiol 17beta or progesterone , for 60 h down regulated the expression of mRNA for TGF beta receptors 1 and 2 ( TbetaR 1 and TbetaR 2 ) , betaglycan , and endoglin but had no effect on TGF beta 1 mRNA levels . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
We analyzed the mRNA expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , the TGF beta receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) , Smad 2 , Smad 3 , and Smad 4 . mRNA expression of IL 10 and CD 95 ( FAS / APO 1 ) were also studied . ^^^ TGF beta normally up regulates the TGF beta receptors , and TbetaR 1 and TbetaR 2 showed stronger expression in all gliomas when compared to normal tissues . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Histological and immunohistochemical studies using specific antibodies for TGF beta 1 , beta 2 , beta 3 , TbetaR 1 , and TbetaR 2 were performed . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
METHODS : Steady state mRNA levels of TGF beta receptor 1 and 2 ( TbetaR 1 and TbetaR 2 ) were analysed by northern blot . ^^^ RESULTS : Steady state mRNA levels of TbetaR 1 and TbetaR 2 were induced in response to PDGF isoforms . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Messenger ribonucleic acid ( mRNA ) expression of TGF beta 1 , CTGF , TGF beta receptor subtype 1 ALK 5 ( TbetaR IALK 5 ) , and TGF beta receptor type 2 ( TbetaR 2 ) was studied by Northern blot analysis in esophageal cancer and the normal esophagus . ^^^ Northern blot analysis revealed 3 fold and 4 fold increases ( p < 0 . 05 ) in TGF beta 1 and CTGF mRNA levels , respectively , in esophageal cancer in comparison with normal controls , whereas TbetaR 1 mRNA levels were significantly decreased and TbetaR 2 mRNA levels were unchanged in the cancer samples . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Cellular responses to the transforming growth factor beta ( TGFbeta ) ligand , including inhibition of cell proliferation , are mediated by a heteromeric receptor complex composed of TGFbeta types 1 and 2 receptors ( TbetaR 1 and TbetaR 2 ) . ^^^ To gain a better understanding of TGFbeta signal transduction pathways in endometrial carcinogenesis , we have investigated the role of the TbetaR complex by evaluating the TbetaR 1 and TbetaR 2 genes for mutations throughout the entire coding region in human sporadic endometrial tumors . ^^^ Using reverse transcription PCR , `` Cold ' ' single strand conformation polymorphism analysis , and direct DNA sequencing , it was found that 1 of 39 ( 2 . 6 % ) and 7 of 42 samples ( 17 % ) contained code altering changes in the kinase domain of TbetaR 1 and TbetaR 2 , respectively . ^^^ These results suggest that alteration in TbetaR 2 , but not TbetaR 1 , has an important role in the development of endometrial carcinoma . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The expression of TbetaR 3 was temporo spatially restricted to the MEE during palatal fusion , while the expression of TbetaR 1 was primarily localized in all palatal epithelia , consistent with the expression patterns of TbetaR 2 and TGF beta 3 ( Cui et al . , 1998 ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Genomic organization , sequence and chromosomal localization of the mouse Tbr 2 gene and a comparative study with Tbr 1 . ^^^ We have also shown that the expression patterns of Tbr 2 and the closely related Tbr 1 appear to be reciprocal in the developing brain ; Tbr 2 is expressed in mesencephalon and rhombencephalon , but expression of Tbr 1 is restricted to telencephalon . ^^^ We also analyzed the 3 . 9kb sequence of the 5 ' promoter region flanking the Tbr 2 gene and the corresponding region of the Tbr 1 gene . ^^^ The sites for Brn 2 and Tst 1 were found in the promoter of Tbr 2 but not Tbr 1 . ^^^ On the contrary , there were eight HNF 3beta binding sites in the Tbr 1 gene promoter but only three in the Tbr 2 promoter . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Initiation of signaling requires binding of TGF beta 1 to TGF beta type 2 receptor ( TbetaR 2 ) , a constitutively active serine / threonine kinase , which subsequently transphosphorylates TGF beta type 1 receptor ( TbetaR 1 ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
BACKGROUND : Transforming growth factor beta ( TGF beta ) initiates intracellular signalling by inducing the formation of a heteromeric complex between TGF beta type 1 ( TbetaR 1 ) and TGF beta type 2 serine / threonine kinase receptors ( TbetaR 2 ) . ^^^ After the activation of TbetaR 1 kinase by TbetaR 2 kinase , specific receptor regulated Smads ( R Smads ) are phosphorylated by TbetaR 1 kinase . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
For TGF beta mediated signal transduction to occur , the expression of both TCF beta receptor types 1 ( TbetaR 1 ) and 2 ( TbetaR 2 ) must be present . ^^^ Using immunohistochemistry and in situ hybridization , 4 and 7 days after bleomycin administration the expression of TbetaR 1 on AECs was reduced whereas that of TbetaR 2 was unaltered . ^^^ In contrast , TbetaR 1 and TbetaR 2 were observed on interstitial fibroblasts at all time intervals after bleomycin administration . ^^^ Because both TbetaR 1 and TbetaR 2 are required for signal transduction , the reduction of TbetaR 1 levels on the alveolar epithelium may alter the sensitivity of AECs to the antiproliferative effects of TGF beta 1 present in increased quantities following bleomycin injury . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In this study , the spatial and temporal expressions of the type 1 receptor ( TbetaR 1 ) , type 2 receptor ( TbetaR 2 ) and endogenous TGF beta 1 in periosteal explants cultured in vitro were examined using reverse transcription polymerase chain reaction ( RT PCR ) and immunohistochemistry . ^^^ The temporal changes in the expression of the TbetaR 1 and TbetaR 2 mRNAs correlated with that of TGF beta 1 . ^^^ Immunohistochemical studies demonstrated co localization of TbetaR 1 and TbetaR 2 simultaneously among the same cells expressing TGF beta 1 . ^^^ TGF beta 1 treatment increased the expression of TGF beta 1 , TbetaR 1 and TbetaR 2 in mesenchymal cells in the cambium layer at 7 days in culture . ^^^ Small round chondrocytes showed widely distributed immunoreactivity of TGF beta 1 , TbetaR 1 and TbetaR 2 in the 42 day explants treated with TGF beta 1 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The gene and protein expression of TGFbeta 1 , 2 , 3 and their receptors , TbetaR 1 and TbetaR 2 , were analyzed by RT PCR and immunohistochemistry , respectively . ^^^ The mRNA and protein expression for TbetaR 1 and TbetaR 2 in 22 and 27 months rat prostate tissue recombinants were significantly lower than 4 , 12 , and 17 month tissue recombinants . ^^^ However , the action of TGFbetas may be through TbetaR 1 and TbetaR 2 independent pathways since these receptors were lacking or low in older rat prostate tissue recombinants . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Boston minipigs , treated with tranilast or vehicle , were subjected to endoluminal stenting , and the expression of TGF beta 1 and TGF beta 3 , the expression of their signaling receptors ALK 5 and TbetaR 2 , leukocyte numbers around the stent struts , and neointima development were assessed over 28 days . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In the present study , we demonstrate that after mechanical wounding , ASMCs had an increased expression of the signal transducing TGF beta receptors TbetaR 1 and TbetaR 2 as detected by flow cytometry and Western analysis . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
While most cells were positive for TBR 1 , only part of the cells contained TBR 2 and 3 , however , without obvious differences between the three cell lines . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
GM CSF also induced ASMC to increase the expression of transforming growth factor ( TGF ) beta receptors type 1 , 2 , and 3 ( TbetaR 1 , TbetaR 2 , TbetaR 3 ) , but had no detectable effect on the release of TGF beta 1 by the same ASMC . ^^^ Dexamethasone decreased GM CSF induced TbetaR 1 , TbetaR 2 , TbetaR 3 , pSmad 2 , CTGF , collagen 1 , and fibronectin . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
RESULTS : A loss of expression of TbetaR 1 and TbetaR 2 was identified in 29 patients ( 46 . 7 % ) and 31 patients ( 50 . 0 % ) , respectively . ^^^ Although the loss of TbetaR 1 was not associated with clinical stage , the loss of TbetaR 2 was associated with clinical stage ( P < 0 . 01 ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
We have recently shown that CsA up regulates the expression of TGF beta 1 and its receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) in rat mesangial cells ( MCs ) . ^^^ Here , we assessed the effect of PGE 1 on CsA induced up regulation of TGF beta 1 , TbetaR 1 , TbetaR 2 and related matrix production in MCs . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Isoforms of transforming growth factor beta ( TGFbeta ) are 25 kDa homodimeric polypeptides that signal by binding and bringing together two related , functionally distinct cell surface receptors designated as TbetaR 1 and TbetaR 2 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The expression of Tbr 1 ( Neuron 15 ( 1995 ) 63 ) and Tbr 2 ( Mech Dev 84 ( 1999 ) 133 ) have virtually identical onset , at around E10 . 5 , and expression domains in the mouse telencephalon . ^^^ While Tbr 1 is expressed in postmitotic neurons , Tbr 2 ( which is also expressed during gastrulation is also expressed in neural progenitors . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
We investigated whether CsA up regulates the expression of TGF beta 1 and its receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) in cultured rat MCs , and whether this effect translates into enhanced matrix protein accumulation . ^^^ Time and concentration dependent expression of TGF beta 1 , TbetaR 1 and TbetaR 2 were measured at both the mRNA ( competitive reverse transcription PCR ) and protein level ( enzyme linked immunosorbent assay ( ELISA ) and western blotting ) . ^^^ Protein concentrations were analysed at 96 h : TGF beta 1 , 220+ / 32 vs 86+ / 24 pg / ml , P < 0 . 001 ( 500 ng / ml CsA vs control ) ; TbetaR 1 , 2 . 0+ / 0 . 5 fold , P < 0 . 005 ( 1000 ng / ml CsA vs control ) ; TbetaR 2 , 2 . 5+ / 0 . 7 fold , P < 0 . 05 ( 1000 ng / ml CsA vs control ) . ^^^ Co incubation with neutralizing anti TGF beta 1 antibodies reduced ( P < 0 . 05 ) CsA induced expression of TbetaR 1 ( 1 . 0+ / 0 . 1 fold ) , TbetaR 2 ( 1 . 3+ / 0 . 1 fold ) and PAI 1 ( 1 . 3 fold ) , but not FN production ( 1 . 6 fold ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Pax 6 , Tbr 2 , and Tbr 1 are expressed sequentially by radial glia , intermediate progenitor cells , and postmitotic neurons in developing neocortex . ^^^ The subsequent transition from intermediate progenitor cell to postmitotic neuron is marked by downregulation of Tbr 2 and upregulation of Tbr 1 , another T domain transcription factor . ^^^ These findings delineate the transcription factor sequence Pax 6 > Tbr 2 > Tbr 1 in the differentiation of radial glia > intermediate progenitor cell > postmitotic projection neuron . ^^^ This transcription factor sequence is modified in preplate neurons , in which Tbr 2 is transiently coexpressed with Tbr 1 , and in the direct differentiation pathway from radial glia > postmitotic projection neuron , in which Tbr 2 is expressed briefly or not at all . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Intraspecific alignment of partial O . nubilalis cadherin gene sequences identified variance within proposed Cry1A toxin binding region 2 ( TBR 2 ) , 1328IPLQTSILVVT [ I / V ] N 1340 , and flanking Cry1A toxin binding region 1 ( TBR 1 ) , 861DIEIEIIDTNN871 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Two amino acid Bt R ( 1 ) toxin binding regions of 70 residues , one comprised of residues 831 900 containing the ( 865 ) NITIHITDTNN ( 875 ) epitope ( TBR 1 ) and the other comprised of residues 1291 1360 ( TBR 2 ) were cloned by RT PCR and produced in Escherichia coli . ^^^ Western blots and competition ELISA analysis showed that the Cry1Ab loop 2 RR 368 9EE mutant did not show observable binding to TBR 1 but still bound the TBR 2 peptide . ^^^ Competition ELISA analysis of Cry1Ab binding to the two TBR peptides revealed that the toxin binds the TBR 1 region with 6 fold higher affinity than the TBR 2 region . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Expression of the genes Emx 1 , Tbr 1 , and Eomes ( Tbr 2 ) in the telencephalon of Xenopus laevis confirms the existence of a ventral pallial division in all tetrapods . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
These elevated pR Smad levels could not be attributed to a decreased dephosphorylation rate nor to increased expression of TGF beta type 1 ( TbetaR 1 ) or type 2 ( TbetaR 2 ) receptors . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 receptor 1 ( TbetaR 1 ) and transforming growth factor beta 1 receptor 2 ( TbetaR 2 ) on HSCs , type 1 collagen expression in HSC Induced by TGF beta 1 were detected with western blot assay . ^^^ The expression of TbetaR 1 and TbetaR 2 on HSCs can not be affected by SA B . ^^^ This inhibition has no association with the expression of TbetaR 1 and TbetaR 2 on HSCs . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
IFN gamma and TNF alpha inhibit expression of TGF beta 1 , its receptors TBETAR 1 and TBETAR 2 in the corpus luteum of PMSG / hCG treated rhesus monkey . ^^^ Using in situ hybridization , immunohistochemistry and computer imaging analysis , we have investigated the expression of transforming growth factor beta 1 ( TGF beta 1 ) , its receptors , type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) as well as steroidogenic acute regulatory protein ( StAR ) in the corpus luteum ( CL ) of the rhesus monkey at various stages of CL development . ^^^ The expression of TGF beta 1 , TbetaR 1 and TbetaR 2 as well as StAR was detected in the CL in a time dependent manner , reaching the maximum levels on D 10 ( functional stage ) , and decreased on Day 18 ( regression stage ) . ^^^ Injection of interferon gamma ( IFN gamma ) or tumor necrosis factor alpha ( TNF alpha ) at the functional stage of CL development significantly decreased the expression of StAR , as well as TGF beta 1 , and its receptors TbetaR 1 and TbetaR 2 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
However , mutations in the TGF beta receptor 1 and receptor 2 ( TbetaR 1 and TbetaR 2 ) genes have only been reported in a minority of ovarian carcinomas , suggesting that alterations in TGF beta signaling components may play an important role in the loss of TGF beta responsiveness . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
This article focuses on recent findings that the type 5 TGF beta receptor ( TbetaR 5 ) , which co expresses with other TGF beta receptors ( TbetaR 1 , TbetaR 2 , and TbetaR 3 ) in all normal cell types studied , is involved in growth inhibition by IGFBP 3 and TGF beta and that TGF beta activity is regulated by two distinct endocytic pathways ( clathrin and caveolar / lipid raft mediated ) . ^^^ Recent studies revealed that TbetaR 5 , which is identical to LRP 1 , mediates IGF independent growth inhibition by IGFBP 3 and mediates TGF beta induced growth inhibition in concert with TbetaR 1 and TbetaR 2 . ^^^ Finally , the ratio of TGF beta binding to TbetaR 2 and TbetaR 1 is a signal controlling TGF beta partitioning between two distinct endocytosis pathways and resultant TGF beta responsiveness . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
METHODS : We used a combination of in vitro binding assays and co immunoprecipitation ( IP ) experiments to investigate whether TAK 1 interacted with the type 1 ( ALK 1 or ALK 5 ) or type 2 ( TBRII ) TGFbeta receptors . ^^^ Precipitation of endogenous TAK 1 protein in rat cardiomyocytes shows that , in addition to a direct association with TBRII , it also interacts indirectly with ALK 5 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
There was also a marked increase in GEC immunostaining for TGF beta receptor type 1 ( T beta IR ) and TGF beta receptor type 2 ( T beta IIR ) at all time points in PHN . mRNA levels for both receptors increased at day 5 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
This factor signals through a heteromeric complex composed of type 1 ( TGF beta receptor type 1 ) and type 2 [ TGF beta receptor type 2 ( TbetaRII ) ] receptors . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Here , we characterize the correlative expression pattern of the interdependent high affinity receptor proteins for TGF beta 1 and TGF beta 3 , TGF beta receptor type 1 ( TGF betaRI ) and TGF beta receptor type 2 ( TGF betaRII ) , during hair follicle development and cycling in C57BL / 6 mice . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Abnormalities in the expression of the deoxyribonucleic acid ( DNA ) , messenger ribonucleic acid ( mRNA ) , and proteins of transforming growth factor beta ( TGF beta ) receptor type 1 ( T beta R 1 ) and TGF beta receptor type 2 ( T beta R 2 ) were investigated in 33 human pituitary adenomas . mRNA was extracted from the tumor tissue , and complementary DNA was produced by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Here we demonstrate that TGF beta 1 induces transcriptional activation of plasminogen activator inhibitor 1 ( PAI 1 ) and growth inhibition more potently in CHO cell mutants deficient in heparan sulfate ( CHO 677 cells ) than in wild type CHO K 1 cells . 125I TGF beta 1 affinity labeling analysis of cell surface TGF beta receptors reveals that CHO K 1 and CHO 677 cells exhibit low ( < 1 ) and high ( > 1 ) ratios of 125I TGF beta 1 binding to TbetaR 2 and TbetaR 1 , respectively . ^^^ In Mv1Lu cells ( which , like CHO K 1 cells , exhibit nystatin inhibitable rapid degradation of receptor bound 125I TGF beta 1 ) , treatment with heparitinase or a heparan sulfate biosynthesis inhibitor results in a change from a low ( < 1 ) to a high ( > 1 ) ratio of 125I TGF beta 1 binding to TbetaR 2 and TbetaR 1 and enhanced TGF beta 1 induced transcriptional activation of PAI 1 . ^^^ Sucrose density gradient analysis indicates that a significant fraction of TbetaR 1 and TbetaR 2 is localized in caveolae / lipid raft fractions in CHO K 1 and Mv1Lu cells whereas the majority of the TGF beta receptors are localized in non lipid raft fractions in CHO 677 cells . ^^^ These results suggest that heparan sulfate negatively modulates TGF beta 1 responsiveness by decreasing the ratio of TGF beta 1 binding to TbetaR 2 and TbetaR 1 , facilitating caveolae / lipid raft mediated endocytosis and rapid degradation of TGF beta 1 , thus diminishing non lipid raft mediated endocytosis and signaling of TGF beta 1 in these epithelial cells . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The rhombic lip derived cells express transcription factors Pax 6 , Tbr 2 , and Tbr 1 sequentially as they enter the NTZ . ^^^ In organotypic slice cultures , the rhombic lip was necessary and sufficient to produce cells that migrate in the subpial stream , enter the NTZ , and express Pax 6 , Tbr 2 , Tbr 1 , and reelin . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Inhibition of the ERK , p 38 kinase or JNK signal transduction pathways blocked the transcriptional up regulation of TGF beta 2 , TbetaR 1 , and TbetaR 2 in KKs . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
We demonstrate that primary cultured human thymic epithelial cells ( TEC ) express TGF beta 1 , TGF beta 2 and TGF beta 3 , as well as TGF beta type 1 receptor ( T beta RI ) ( ALK 5 ) and TGF beta type 2 receptor ( T beta RII ) transcripts . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Recent studies have revealed that upon TGF beta binding several serine and threonine residues in the GS domain of TGF beta type 1 receptor ( T beta R 1 ) are phosphorylated by TGF beta type 2 receptor ( T beta R 2 ) and that the phosphorylation of GS domain is essential for TGF beta signaling . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Whereas expression of TGF beta 1 , TGF beta 2 , and TGF beta type 2 receptor was suppressed by glucocorticoids in normal and wounded skin , expression of TGF beta 3 and TGF beta receptor type 1 mRNA was stimulated . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Furthermore , competition based quantitative reverse transcription PCR using synthetic internal standards revealed that leiomyomata express a significantly higher number ( copies per cell ) of TGF beta type 2 receptor mRNA , followed by TGF beta 1 , TGF beta type 1 receptor , TGF beta 2 , and TGF beta 3 ( P < 0 . 05 ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
TGF beta receptor type 1 ( TGF RI ) and TGF beta receptor type 2 ( TGF RII ) are part of the complex which mediates the response to TGF beta . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
While TGF beta receptor type 2 mRNA levels were unchanged during progression , mRNA levels for TGF beta receptor type 1 decreased dramatically as the cells became TGF beta resistant . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
RESULTS : In normal adult rat retinas , immunoreactivity and mRNA expression of TGF beta receptor type 1 ( TbetaRI ) and TGF beta receptor type 2 ( TbetaRII ) were found in the ganglion cells . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
On the cell surface , TGF beta binds to receptor complexes consisting of TGF beta receptor type 2 ( TbetaRII ) and activin like kinase receptor 5 ( Alk 5 ) , and the downstream signaling is transduced by Smad and MAPK proteins . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Most interestingly , an in vitro kinase assay showed that PP 1 strongly inhibited the TGF beta receptor type 1 , and to a lesser extent , the TGF beta receptor type 2 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Cloning of a TGF beta type 1 receptor that forms a heteromeric complex with the TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In this study we have investigated the expression of the precursor forms of TGF beta 1 , TGF beta 2 , TGF beta 3 , as well as TGF beta type 1 receptor ( TGF betaRI ) and TGF beta type 2 receptor ( TGF betaRII ) in the synovial tissue of arthritic rats during the course of the disease . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
METHOD : To determine the roles of the transforming growth factor beta 1 ( TGF beta 1 ) , and TGF beta type 1 receptor ( T beta R 1 ) , and the TGF beta type 2 receptor ( T beta R 2 ) in the progression of a pulmonary adenocarcinoma , their respective expressions have been immunohistologically studied in specimens from 120 pulmonary adenocarcinoma patients . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
We compared the expression of mRNA for alpha 1 ( 1 ) collagen , TGF beta , TGF beta type 1 receptor and TGF beta type 2 receptor in early and late passage fibroblasts by Northern blot hybridizations . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
METHODS : The mRNA expression of TGF beta 1 , TGF beta type 1 receptor ( TGFbetaRI ) , TGF beta type 2 receptor ( TGFbetaRII ) and TGF beta type 3 receptor ( TGFbetaRIII ) in rat livers injured by CCl 4 administration was studied by Northern blotting . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Fibronectin synthesis stimulated with 10 microg ml ( 1 ) of saponin was inhibited with 69 % by 5 microg ml ( 1 ) of an anti TGF beta 1 antibody . mRNA of TGF beta type 1 receptor increased 4 . 8 and 4 . 4 fold at fibroblasts treated with 1 and 10 microg ml ( 1 ) of saponin , respectively , and that of TGF beta type 2 receptor also increased 3 . 4 and 3 . 2 fold at fibroblasts treated with 1 and 10 microg ml ( 1 ) of saponin , respectively . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Polyamine depletion by DFMO increased levels of the TGF beta type 1 receptor ( TGF betaRI ) mRNA and protein but had no effect on the TGF beta type 2 receptor expression . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
These genes were TGF beta type 1 receptor gene ( TGFBR 1 ) , TGF beta type 2 receptor gene ( TGFBR 2 ) , SMAD 2 gene ( SMAD 2 ) , SMAD 3 gene ( SMAD 3 ) , SMAD 4 gene ( SMAD 4 ) , and SMAD 7 gene ( SMAD 7 ) , all of which compose the TGF beta 1 signaling pathway . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
However , we observed a markedly low TGF beta type 1 receptor protein level ( P < 0 . 028 ; Mann Whitney U test ) , while the malignant endometrium showed a significantly higher TGF beta type 2 receptor protein level ( P < 0 . 007 ; Mann Whitney U test ) than the normal endometrium . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
We generated mice expressing an activated TGF beta type 1 receptor or dominant negative TGF beta type 2 receptor under control of the mouse mammary tumor virus promoter . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Expression of latency associated peptide TGF beta 1 , latent TGF beta binding protein 1 , TGF beta type 1 receptor , and TGF beta type 2 receptor was readily seen , but only very little TGF beta 1 was activated . ^^^ In erythematous oral lichen , basal and lower spinous epithelial layers showed staining for latency associated peptide TGF beta 1 , TGF beta type 1 receptor , and TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Recently , a model has been proposed in which TGF beta by binding to the TGF beta type 2 receptor can activate two distinct type 1 receptors in endothelial cells ( ECs ) , i . e . , the EC restricted ALK 1 and the broadly expressed ALK 5 , which have opposite effects on ECs behavior . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Through binding to the TGF beta type 2 receptor , TGF beta can activate two distinct type 1 receptors ( ALK 1 and ALK 5 ) in endothelial cells , each one leading to opposite effects on endothelial cell proliferation and migration . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In this study , we examined TGF beta 1 , TGF beta type 1 receptor ( TbetaRI ) and TGF beta type 2 receptor ( TbetaRII ) expression in SW 13 adrenocortical carcinoma cells by Northern and Western blot analysis . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Moreover , the facial phenotypes of neural crest specific Alk 5 mutants included devastating facial cleft and appeared significantly more severe than the defects seen in corresponding mutants lacking the TGF beta type 2 receptor ( TGFbetaRII ) , a prototypical binding partner of ALK 5 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The transforming growth factor betas ( TGF betas ) comprise a family of pleiotropic members that signal through two types of serine / threonine kinase receptors , named TGFRI ( TGF beta type 1 receptor ) and TGFRII ( TGF beta type 2 receptor ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effect of substance P ( SP ) on gene expression of transforming growth factor beta 1 ( TGFbeta 1 ) , transforming growth factor receptor 1 ( TGFR 1 ) and transforming growth factor receptor 2 ( TGFR 2 ) in fibroblasts cultured in vitro from rat ' s granulation tissues . ^^^ When different concentrations ( 10 ( 9 ) 10 ( 5 ) mol / L ) of SP were added into the culture medium , the changes of gene expression of TGFbeta 1 , TGFR 1 and TGFR 2 in the cultured fibroblasts were observed with reverse transcription polymerase chain reaction at different intervals ( 0 , 3 , 6 , 12 and 24 hours after incubation ) . ^^^ RESULTS : The gene expression of TGFbeta 1 , TGFR 1 and TGFR 2 in the fibroblasts cultured from rat ' s granulation tissues was up regulated by SP . ^^^ The peak levels of gene expression of TGFbeta 1 , TGFR 1 and TGFR 2 in the fibroblasts treated with SP were achieved at 6 and 12 hours , respectively . ^^^ CONCLUSIONS : SP has up regulation effect on the gene expression of TGFbeta 1 , TGFR 1 and TGFR 2 in fibroblasts from rat ' s granulation tissues in vitro , and the effect is related to different stimulating concentrations of SP . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
An increased transforming growth factor beta receptor type 1 : type 2 ratio contributes to elevated collagen protein synthesis that is resistant to inhibition via a kinase deficient transforming growth factor beta receptor type 2 in scleroderma . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Hydroxyproline ( Hyp ) contents in liver tissue of the rats in 3 groups were determined with HCl hydrolysis , and collagen type 1 , transforming growth factor beta 1 ( TGF beta 1 ) , transforming growth factor beta receptor type 1 ( TbetaRI ) and transforming growth factor beta receptor type 2 ( TbetaRII ) were detected by Western blotting . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Reexamination of patients with a TGFBR 1 or TGFBR 2 mutation revealed extensive clinical overlap between patients with MFS 1 , MFS 2 , and LDS . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Eighty two % of these pancreatic cancers had genetic inactivation of the DPC 4 , p 15 , ALK 5 , or TGFBR 2 genes . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
We therefore studied the expression of UPA , UPAR , IGF2R , ALK 5 ( TGFBR 1 ) , TGFBR 2 , TGFBR 3 , ENG , ALK 1 , TGFB 1 , TGFB 2 , and TGFB 3 in a series of 14 pancreatic carcinoma cell lines . ^^^ We also analysed ALK 5 and TGFBR 2 for mutations , cell surface localisation of TGFBR 2 and ENG , and TGFB 1 response . ^^^ No mutations of ALK 5 or TGFBR 2 were found . ^^^ ALK 5 expression was strongly reduced in 9 cases , whereas TGFBR 2 expression was increased in 12 of the cell lines . ^^^ These results suggest that the ALK 5 SMAD4 part of the TGFB signalling pathway is a major target for inactivation in pancreatic carcinomas , that the expression of TGFBR 2 , TGFBR 3 , and receptors involved in TGFB activation are maintained , and that alterations of components of the TGFB signalling pathway may be accompanied by a positive effect of TGFB on cell growth . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
TGF beta binds first to a Type 2 ( TGFBR 2 ) , then a Type 1 receptor ( TGFBR 1 ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
A syndrome of altered cardiovascular , craniofacial , neurocognitive and skeletal development caused by mutations in TGFBR 1 or TGFBR 2 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The transforming growth factor beta ( TGF beta ) signaling pathway , which is activated by the TGF beta receptor complex consisting of type 1 and type 2 TGF beta receptors ( TGFBR 1 and TGFBR 2 ) , regulates cell growth and death . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) transmits signals through a heterotetrameric cell surface complex of type 2 ( TGFBR 2 ) and type 1 ( activin receptor like kinase 5 , ALK 5 ; TGFBR 1 ) serine / threonine kinase receptors , as well as Smad2 / 3 . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
RT PCR analysis of LbetaT 2 cells and whole adult murine pituitaries indicated that both expressed Tgfbr 1 mRNA , but that Tgfbr 2 was not detected in LbetaT 2 cells . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Targeted deletions of Tgfb 1 and other components of this signaling pathway , such as Acvrl 1 , Tgfbr 1 and Tgfbr 2 , result in abnormal vascular development especially of the yolk sac , leading to embryonic lethality . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The recent identification of TGFBR 2 mutations in Marfan syndrome 2 ( MFSII ) [ Mizuguchi et al . ( 2004 ) ; Nat Genet 36 : 855 860 ] and of TGFBR 1 and TGFBR 2 mutations in Loeys Dietz aortic aneurysm syndrome ( LDS ) [ Loeys et al . ( 2005 ) ; Nat Genet 37 : 275 281 ] [ OMIM 609192 ] has provided direct evidence of abnormal signaling in transforming growth factors beta ( TGF beta ) in the pathogenesis of Marfan syndrome ( MFS ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In a first systematic attempt to associate sequence variations in the FBN 1 5 ' alternatively spliced exons with MFS , we investigated 41 individuals fulfilling the diagnostic criteria of Ghent nosology or with features of MFS including at least one major criterion or involvement of two organ systems but not fulfilling a strict interpretation of the Ghent nosology , and known to be negative for mutations in the FBN 1 exons 1 65 as well as the TGFBR 2 and TGFBR 1 coding regions . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
As a recent study shows that heterozygous mutations in TGFBR 1 or TGFBR 2 cause multiple human congenital malformations , including soft palate cleft , we propose that TGF beta mediated Irf 6 expression plays an important , cell autonomous role in regulating the fate of MEE cells during palatogenesis in both mice and humans . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
Identification and in silico analyses of novel TGFBR 1 and TGFBR 2 mutations in Marfan syndrome related disorders . ^^^ Very recently , heterozygous mutations in the genes encoding transforming growth factor beta receptors 1 ( TGFBR 1 ) and 2 ( TGFBR 2 ) have been reported in Loeys Dietz aortic aneurysm syndrome ( LDS ) . ^^^ Here , we report a total of nine novel and one known heterozygous sequence variants in the TGFBR 1 and TGFBR 2 genes in nine of 70 unrelated individuals with MFS like phenotypes who previously tested negative for mutations in the gene encoding the extracellular matrix protein fibrillin 1 ( FBN 1 ) . ^^^ Our results showed that in all but one of the patients the pathogenic effect of at least one sequence variant is highly probable ( c . 722C > T , c . 799A > C , and c . 1460G > A in TGFBR 1 and c . 773T > G , c . 1106G > T , c . 1159G > A , c . 1181G > A , and c . 1561T > C in TGFBR 2 ) . ^^^ In order to be able to find the mutation that is indeed responsible for a MFS related phenotype , we also propose that genetic testing for sequence alterations in TGFBR 1 and TGFBR 2 should be complemented by mutation screening of the FBN 1 gene . . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
In order to evaluate the contribution of FBN 1 , FBN 2 , TGFBR 1 , and TGFBR 2 mutations to the Marfan syndrome ( MFS ) phenotype , the four genes were analyzed by direct sequencing in 49 patients with MFS or suspected MFS as a cohort study . ^^^ A total of 27 FBN 1 mutations ( 22 novel ) in 27 patients ( 55 % , 27 / 49 ) , 1 novel TGFBR 1 mutation in 1 ( 2 % , 1 / 49 ) , and 2 recurrent TGFBR 2 mutations in 2 ( 4 % , 2 / 49 ) were identified . ^^^ Three patients with either TGFBR 1 or TGFBR 2 abnormality did not fulfill the Ghent criteria , but expressed some overlapping features of MFS and Loeys Dietz syndrome ( LDS ) . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
The disease is characterized by the triad of arterial tortuosity and aneurysms , hypertelorism , and bifid uvula or cleft palate and is caused by heterozygous mutations in the genes encoding transforming growth factor beta receptors 1 and 2 ( TGFBR 1 and TGFBR 2 , respectively ) . ^^^ RESULTS : We found a mutation in TGFBR 1 or TGFBR 2 in all probands with typical Loeys Dietz syndrome ( type 1 ) and in 12 probands presenting with vascular Ehlers Danlos syndrome ( Loeys Dietz syndrome type 2 ) . ^^^ CONCLUSIONS : Mutations in either TGFBR 1 or TGFBR 2 predispose patients to aggressive and widespread vascular disease . ^^^
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
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Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P36897	Pubmed	SVM Score :0.0
NA