| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| In situ analysis of transforming growth factors beta ( TGF beta 1 , TGF beta 2 , TGF beta 3 ) and TGF beta type 2 receptor expression in basal cell carcinomas . ^^^ In the present study , we have analysed and compared , by in situ hybridization , mRNA expression of transforming growth factors beta ( TGF beta 1 , TGF beta 2 , TGF beta 3 ) and TGF beta type 2 receptor ( T beta R 2 ) , and , by immunohistochemistry , the distribution of TGF beta 3 protein in normal human skin and in basal cell carcinoma ( BCC ) . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Furthermore , competition based quantitative reverse transcription PCR using synthetic internal standards revealed that leiomyomata express a significantly higher number ( copies per cell ) of TGF beta type 2 receptor mRNA , followed by TGF beta 1 , TGF beta type 1 receptor , TGF beta 2 , and TGF beta 3 ( P < 0 . 05 ) . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| In situ analysis of transforming growth factor beta s ( TGF beta 1 , TGF beta 2 , TGF beta 3 ) , and TGF beta type 2 receptor expression in malignant melanoma . ^^^ We have analysed , by in situ hybridization , mRNA expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , and of TGF beta type 2 receptor in benign melanocytic naevi , primary melanomas , and in skin metastases of malignant melanomas . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| The present in situ hybridisation study describes expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , and TGF beta type 2 receptor mRNA during follicular development , and the temporal pattern and abundance of TGF beta 2 transcripts in early pre implantation embryos . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Human uterine tissue throughout the menstrual cycle expresses transforming growth factor beta 1 ( TGF beta 1 ) , TGF beta 2 , TGF beta 3 , and TGF beta type 2 receptor messenger ribonucleic acid and protein and contains [ 125I ] TGF beta 1 binding sites . ^^^ The reverse transcription polymerase chain reaction revealed the predicted 443 , 310 , 524 , and 431 basepair fragments for TGF beta 1 , TGF beta 2 , TGF beta 3 , and TGF beta type 2 receptor , respectively , in both endometrial and myometrial tissues , which were further verified by restriction enzyme analysis . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction analysis of total RNA and immunocytochemical observations revealed that human endometrial glandular epithelial and stromal cells in primary culture express messenger RNAs and proteins for transforming growth factor beta 1 ( TGF beta 1 ) , TGF beta 2 , and TGF beta 3 as well as TGF beta type 2 receptor . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| In humans , TGF beta 3 is constitutively expressed in the epidermis of intact skin and in that of acute and chronic wounds a pattern of expression closely mirrored by the TGF beta type 2 receptor . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that primary cultured human thymic epithelial cells ( TEC ) express TGF beta 1 , TGF beta 2 and TGF beta 3 , as well as TGF beta type 1 receptor ( T beta RI ) ( ALK 5 ) and TGF beta type 2 receptor ( T beta RII ) transcripts . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Whereas expression of TGF beta 1 , TGF beta 2 , and TGF beta type 2 receptor was suppressed by glucocorticoids in normal and wounded skin , expression of TGF beta 3 and TGF beta receptor type 1 mRNA was stimulated . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| The expression and localization of TGF beta 1 , TGF beta 2 , TGF beta 3 , TbetaR IALK 5 , TbetaR 2 , and TbetaR 3 were studied by Northern blot analysis , in situ hybridization , and immunohistochemistry . ^^^ RESULTS : On Northern blot analysis , 94 % of the CD samples exhibited enhanced TGF beta 1 , TGF beta 3 , and TbetaR 2 mRNA expression compared with controls . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemistry and western blot analysis indicated that E 8 DRG neurons have the TGF beta receptor type 2 , and treatment of these cells with NGF induces expression of TGF beta 3 mRNA . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| In this assay , the apparent dissociation constant of the TGF beta type 2 receptor ectodomain for TGF beta 3 was approximately 150 nM ( this value is approximately 1000 fold higher than that of the cell membrane receptor complex of living cells ) . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| In this study we have investigated the expression of the precursor forms of TGF beta 1 , TGF beta 2 , TGF beta 3 , as well as TGF beta type 1 receptor ( TGF betaRI ) and TGF beta type 2 receptor ( TGF betaRII ) in the synovial tissue of arthritic rats during the course of the disease . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Here , we characterize the correlative expression pattern of the interdependent high affinity receptor proteins for TGF beta 1 and TGF beta 3 , TGF beta receptor type 1 ( TGF betaRI ) and TGF beta receptor type 2 ( TGF betaRII ) , during hair follicle development and cycling in C57BL / 6 mice . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Corresponding increases in the levels of proliferating cell nuclear antigen ( PCNA ) and intracellular TGF beta 3 expression and a downregulation of the TGF beta type 2 receptor expression were also observed in the granulation tissue of the ulcer margins . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| To investigate the nature of ligand receptor interactions in vivo between TGF beta 3 and the type 2 TGF beta receptor ( TbetaR 2 ) , we compared the expression pattern of the receptor with TGF beta 3 . ^^^ To verify the possibility that TGF beta 3 and TbetaR 2 expression coincide , immunohistochemistry was used to localize them both in serial sections . ^^^ The distribution pattern of TGF beta 3 was also epithelium limited in the palate from E 13 to E 15 , and the spatial localization was correlated with the expression of TbetaR 2 . ^^^ Immunohistochemical localization of TbetaR 2 and TGF beta 3 in palatal shelves in organ culture had patterns that were consistent with the in vivo results . ^^^ These results suggest that TGF beta 3 exerts its developmental role through TbetaR 2 in an autocrine fashion . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Concomitant with this differentiation , expression of transforming growth factor beta 2 ( TGF beta 2 ) , TGF beta 3 , and TGF beta receptor type 2 ( TbetaRII ) is induced , while those of TGF beta 1 and TbetaRI remain essentially unchanged . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Northern blot analysis revealed enhanced expression ( P < 0 . 05 ) of TGF beta 1 ( twofold increase ) , TGF beta 2 ( threefold increase ) and TGF beta 3 ( 8 . 5 fold increase ) and of TbetaR 2 ( threefold increase ) mRNA in liver cirrhosis in comparison with normal controls . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : The spatial relationships between TGF beta 1 , TGF beta 3 , ALK 5 , and TbetaR 2 expression were compared in aortic segments from 21 subjects . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Staining for TGF beta 3 and TGF beta receptor type 2 was predominantly in the oocytes . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Messenger RNA ( mRNA ) was isolated from the nucleus pulposus using oligo ( dT ) 25 superparamagnetic beads and probing with gene specific primers in RT PCR . mRNA coding for TGF alpha ( 3 / 10 ) , EGF ( 0 / 10 ) , TGF beta 1 ( 0 / 10 ) and TGF beta 3 ( 2 / 10 ) or the EGF receptor ( EGF R ; 0 / 10 ) and TGF beta type 2 receptor ( 0 / 10 ) was found only occasionally . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Cryosections of these specimens were processed for immunohistochemical analysis for TGF beta 1 , TGF beta 2 , TGF beta 3 , TGF beta receptor type 1 ( TbetaR 1 ) , type 2 ( TbetaR 2 ) and type 3 ( TbetaR 3 ) , and were observed under light micros copy . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| We analyzed the mRNA expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , the TGF beta receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) , Smad 2 , Smad 3 , and Smad 4 . mRNA expression of IL 10 and CD 95 ( FAS / APO 1 ) were also studied . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| However , TGF beta type 2 receptor ( TbetaR 2 ) is expressed by all palatal epithelial cells during palatal fusion ( Cui et al . , 1998 ) and therefore can not localize TGF beta 3 responsiveness . ^^^ The expression of TbetaR 3 was temporo spatially restricted to the MEE during palatal fusion , while the expression of TbetaR 1 was primarily localized in all palatal epithelia , consistent with the expression patterns of TbetaR 2 and TGF beta 3 ( Cui et al . , 1998 ) . ^^^ TbetaR 3 may modulate TGF beta 3 binding to TbetaR 2 in the MEE cells to locally enhance TGF beta 3 autocrine signaling through the TbetaR I / TbetaR 2 receptor complex , which contributes to MEE selective epithelial mesenchymal transformation . . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Crystal structure of the human TbetaR 2 ectodomain TGF beta 3 complex . ^^^ Here , we present the 2 . 15 A crystal structure of the extracellular ligand binding domain of the human TGF beta type 2 receptor ( ecTbetaR 2 ) in complex with human TGF beta 3 . ecTbetaR 2 interacts with homodimeric TGF beta 3 by binding identical finger segments at opposite ends of the growth factor . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| By immunohistochemistry , sutures rescued from obliteration by Tgf beta 3 had the same Tgf beta receptor type 2 ( Tbetar 2 ) distribution as controls . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| Boston minipigs , treated with tranilast or vehicle , were subjected to endoluminal stenting , and the expression of TGF beta 1 and TGF beta 3 , the expression of their signaling receptors ALK 5 and TbetaR 2 , leukocyte numbers around the stent struts , and neointima development were assessed over 28 days . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : To evaluate this hypothesis , we tested the effects of a soluble TGF beta type 2 receptor ( sTGF beta R ) that specifically inhibits TGF beta 1 and TGF beta 3 in three different murine MM tumor models , AB 12 and AC 29 ( which produce large amounts of TGF beta ) and AB 1 ( which does not produce TGF beta ) . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| As transforming growth factor beta 3 ( TGF beta 3 ) is an essential growth factor for chondrogenesis of embryonic mesenchymal cells both in in vivo and in vitro conditions , we thereby explored the effects of atRA on TGF beta 3 signaling pathway . atRA led to an increase in mRNA expression of TGF beta 3 and an instantaneous decrease in TGF beta type 2 receptor ( TbetaRII ) as determined by real time RT PCR . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| We show here that transforming growth factor betas are synthesized , stored and released by the neuroendocrine chromaffin cells , which also express the transforming growth factor beta receptor type 2 . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| We therefore studied the expression of UPA , UPAR , IGF2R , ALK 5 ( TGFBR 1 ) , TGFBR 2 , TGFBR 3 , ENG , ALK 1 , TGFB 1 , TGFB 2 , and TGFB 3 in a series of 14 pancreatic carcinoma cell lines . ^^^ |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10600 and P37173 |
Pubmed |
SVM Score :0.0 |
| NA |
|