Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.57216374
This effect of TGF beta was reversible with a neutralizing antibody specific for the extracellular domain of TbetaR 2 . 0.57216374^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :1.1133204
To study the protein protein interactions between TGF beta and the ligand specific receptor subunit , the extracellular domain of the human TGF beta receptor type 2 ( T beta R 2 ) has been expressed as an intracellular protein in insect cells using the baculovirus expression system . 1.1133204^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.67428269
TGF beta binds first to a Type 2 ( TGFBR 2 ) , then a Type 1 receptor ( TGFBR 1 ) . 0.67428269^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
RA treatment of SMS KCNR cells results in a 40 fold increase in TGF beta 1 mRNA after 4 days of RA , a dose dependent increase in TGF beta 1 secretion , an increase in types 1 ( TBRI ) and 3 ( TBRIII ) TGF beta receptor proteins , and an increase in type 2 TGF beta receptor ( TBRII ) mRNA coincident with RA responsiveness of the cells . ^^^ However , in the RA resistant line SK N AS , TGF beta 1 is constitutively secreted at levels that are unchanged after RA treatment , and although TBRI and TBRIII mRNA is expressed in untreated SK N AS cells , levels of TBRI and TBRIII protein and TBRII mRNA decrease after RA treatment . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To understand the molecular mechanisms whereby normal human salivary gland cells become malignant and escape growth inhibitory control by transforming growth factor ( TGF ) betaI , we examined the effect of TGF betaI on the proliferation and expression of TGF beta receptors in cells and the expression of TGF beta type 2 receptor ( TbetaR 2 ) mRNA . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) signals via an oligomeric complex of two serine / threonine kinase receptors denoted TGF beta type 1 receptor ( TbetaR 1 ) and type 2 receptor ( TbetaR 2 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In mammals , transforming growth factor beta ( TGF beta ) is found in 3 highly homologous isoforms that exert their effects via heteromeric complexes of type 1 and type 2 receptors ( TbetaR 1 and TbetaR 2 ) . ^^^ We have investigated the immunohistological localization of TGF beta 1 , TGF beta 2 , TbetaR 1 and TbetaR 2 in normal human skin , basal cell carcinoma ( BCC ) , Bowen ' s disease , seborrheic keratosis , eccrine poroma and eccrine spiradenoma using frozen tissue specimens . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGFbeta ) signaling requires phosphorylation of the type 1 receptor TbetaR 1 by TbetaR 2 . ^^^ Although TGFbeta promotes the association of TbetaR 1 with TbetaR 2 , these receptor components have affinity for each other which can lead to their ligand independent activation . ^^^ By impeding the activation of TGFbeta receptor complexes formed in the absence of ligand , FKBP 12 may provide a safeguard against leaky signaling resulting from the innate tendency of TbetaR 1 and TbetaR 2 to interact with each other . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TbetaR I / BMPR IB , containing the extracellular domain of TGF beta type 1 receptor ( TbetaR 1 ) and the intracellular domain of bone morphogenetic protein type IB receptor ( BMPR IB ) , and TbetaR II / ActR IIB , containing the extracellular domain of TGF beta type 2 receptor ( TbetaR 2 ) and the intracellular domain of activin type IIB receptor ( ActR IIB ) . ^^^ In the presence of TGF beta 1 , TbetaR I / BMPR IB and TbetaR II / ActR IIB formed heteromeric complexes with wild type TbetaR 2 and TbetaR 1 , respectively , upon stable transfection in mink lung epithelial cell lines . ^^^ We show that TbetaR II / ActR IIB restored the responsiveness upon transfection in mutant cell lines lacking functional TbetaR 2 with respect to TGF beta mediated activation of a transcriptional signal , extracellular matrix formation , growth inhibition , and Smad phosphorylation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here we show that Smad 2 and Smad 3 interacted with the kinase deficient TGF beta type 1 receptor ( TbetaR ) 1 after it was phosphorylated by TbetaR 2 kinase . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) signal transduction is mediated via specific cell surface signaling TGF beta receptors , most notably the type 1 ALK 5 ( TbetaR 1 [ ALK 5 ] ) and the type 2 ( TbetaR 2 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) signals through two transmembrane serine / threonine kinases , known as TbetaR 1 and TbetaR 2 . ^^^ Several lines of evidence suggest that TbetaR 2 acts as a primary receptor , binding TGF beta and phosphorylating TbetaR 1 whose kinase activity then propagates the signal to unknown substrates . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
One of the possible mechanisms of escape from growth control by TGFbeta during gastric carcinogenesis could involve frameshift mutations of the TbetaR 2 gene caused by DNA replication errors . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGFbeta ) signal transduction is mediated by two receptor Ser / Thr kinases acting in series , type 2 TGFbeta receptor ( TbetaR 2 ) phosphorylating type 1 TGFbeta receptor ( TbetaR 1 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We compared endoglin distribution with that of TGF beta receptors type 1 ( TbetaR 1 ) , type 2 ( TbetaR 2 ) and betaglycan . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Binding of 125I TGF beta 1 to serine / threonine kinase receptor type 2 ( TbetaR 2 ) and TbetaR 1 was not seen in the retinoblastoma cells . ^^^ Transcriptional activation of the TGF beta responsive genes was not seen by the transfection of either receptor cDNA alone but could be induced by transfection of both TbetaR 2 and TbetaR 1 . ^^^ These data suggest that the defect in the TGF beta response is caused by the lack of TbetaR 2 in the retinoblastoma cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , the role of TGF beta 1 type 1 ( TbetaR 1 ) and TGF beta type 2 ( TbetaR 2 ) receptors in TGF beta 1 regulated gene expression in lactotropes was determined using anterior pituitary cells known to be responsive to TGF beta 1 growth inhibition and using a transformed PR 1 cell line known to be nonresponsive to TGF beta 1 growth inhibition . ^^^ Affinity labeling of TGF beta binding proteins indicated that anterior pituitary cells contain several TGF beta binding protein complexes , including the 65 kDa size TbetaR 1 and 95 kDa size TbetaR 2 . ^^^ Determination of the TGF beta 1 gene responses in PR 1 cells following TbetaR 1 and TbetaR 2 gene transfection indicated that PR 1 cells transactivate transcription of the TGF beta responsive p3TP Lux reporter in the absence of cotransfected TbetaR 2 receptor . ^^^ Furthermore , the TGF beta 1 gene transcription response is less dependent on TbetaR 2 receptor expression than is the TGF beta 1 growth inhibitory response . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In hepatocytes derived from resting livers , mRNAs for TGF beta type 2 receptor ( TbetaR 2 ) , insulin like growth factor II / mannose 6 phosphate receptor ( IGF II / M 6 PR ) , and TGF beta 1 increased with time in primary culture . ^^^ In hepatocytes from regenerating livers after a partial hepatectomy ( PH ) , an increase of TbetaR 1 , TbetaR 2 , TbetaR 3 , IGF II / M 6 PR , and TGF beta 1 mRNAs was found , compared with hepatocytes from resting livers . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
A short 19 amino acid sequence of fetuin shows a degree of homology to an 18 amino acid sequence of the TGF beta type 2 receptor ( TbetaR 2 ) and in vitro fetuin binds to members of the TGF beta family of cytokines . ^^^ Thus , fetuin ' s proposed role as an antagonist of TGF beta cytokines and mimic of TbetaR 2 is not consistent with the observed distribution of these two molecules in the developing neocortex of the foetal sheep . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
DNA from human atherosclerotic and restenotic lesions was used to test the hypothesis that microsatellite instability leads to specific loss of the Type 2 receptor for TGF beta 1 ( TbetaR 2 ) , causing acquired resistance to TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To mediate a signal both TGF beta receptors type 1 and type 2 ( TbetaR 1 and TbetaR 2 ) have to be expressed . ^^^ These findings show that most KS lesions have the ability to produce TGF beta and that KS cells maintain a high expression of TbetaR 2 in the absence of TbetaR 1 , which may allow KS to escape growth inhibitory effects of endocrine or paracrine TGF beta . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The pleiotropic responses to TGF beta are mediated via ligand induced heteromeric complex formation by type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) serine threonine kinase receptors . ^^^ Several studies have shown that TbetaR 2 acts as a primary receptor , binding TGF beta and phosphorylating TbetaR 1 , whose kinase activity then propagates the signals . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We show that CG neurons ( E 8 ) are immunoreactive ( ir ) for TGF beta 2 and beta 3 as well as the TGF beta receptor TbetaR 2 , but are not ir for TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Northern blot analysis was used to examine the expression of TGF beta 1 , beta 2 and beta 3 and their receptors , type 1 ( TbetaR 1 ) , type 2 ( TbetaR 2 ) and type 3 ( TbetaR 3 ) . ^^^ RESULTS : Northern blot analysis revealed enhanced expression ( P < 0 . 05 ) of TGF beta 1 ( twofold increase ) , TGF beta 2 ( threefold increase ) and TGF beta 3 ( 8 . 5 fold increase ) and of TbetaR 2 ( threefold increase ) mRNA in liver cirrhosis in comparison with normal controls . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To investigate the nature of ligand receptor interactions in vivo between TGF beta 3 and the type 2 TGF beta receptor ( TbetaR 2 ) , we compared the expression pattern of the receptor with TGF beta 3 . ^^^ To verify the possibility that TGF beta 3 and TbetaR 2 expression coincide , immunohistochemistry was used to localize them both in serial sections . ^^^ The distribution pattern of TGF beta 3 was also epithelium limited in the palate from E 13 to E 15 , and the spatial localization was correlated with the expression of TbetaR 2 . ^^^ Immunohistochemical localization of TbetaR 2 and TGF beta 3 in palatal shelves in organ culture had patterns that were consistent with the in vivo results . ^^^ These results suggest that TGF beta 3 exerts its developmental role through TbetaR 2 in an autocrine fashion . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Furthermore , Renca cells expressed TbetaR 1 mRNA , but did not express TbetaR 2 mRNA , suggesting that the absence of this receptor may be the cause of TGF beta insensitivity . ^^^ These observations demonstrated that Renca cells lack the functional TbetaR 2 and suggest that their aggressive growth pattern is due , at least in part , to their insensitivity to TGF beta . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To identify molecular mechanisms of TGF beta resistance , we have conducted a comprehensive structural analysis of the TGF beta receptor types 1 ( TbetaR 1 ) and 2 ( TbetaR 2 ) genes in primary human breast carcinomas and associated axillary lymph node metastases . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Using stably transfected RAW 264 . 7 cells with the kinase deleted dominant negative mutant of TbetaR 2 ( TbetaR IIM ) cDNA , we demonstrate that this protective effect by TGF beta 1 is completely abrogated . ^^^ Taken together , our data demonstrate for the first time that TGF beta 1 is an inhibitor of apoptosis in cultured macrophages and may serve as a cell survival factor via TbetaR 2 mediated signaling and downstream intracellular MAPK signaling pathway . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Northern blot analysis was used in normal liver and HCC to examine the expression of TGF beta 1 , beta 2 , beta 3 and their receptors : type 1 ALK 5 ( TbetaR 1 ALK 5 ) , type 2 ( TbetaR 2 ) , and type 3 ( TbetaR 3 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The type 2 receptors examined were TGF beta type 2 receptor ( TbetaR 2 ) , activin type 2 receptor ( ActR 2 ) , and BMP type 2 receptor ( BMPR 2 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : Cultured bovine articular chondrocytes were treated with 10 ( 5 ) m diacerein , 10 ng / ml IL 1beta or the combination diacerein+interleukin ( IL ) 1 , and the expression of both TGF beta isoforms 1 , 2 and 3 and that of their receptors TbetaR 1 and TbetaR 2 was determined by Northern blot and reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The expression and localization of TGF beta 1 , TGF beta 2 , TGF beta 3 , TbetaR IALK 5 , TbetaR 2 , and TbetaR 3 were studied by Northern blot analysis , in situ hybridization , and immunohistochemistry . ^^^ RESULTS : On Northern blot analysis , 94 % of the CD samples exhibited enhanced TGF beta 1 , TGF beta 3 , and TbetaR 2 mRNA expression compared with controls . ^^^ On in situ hybridization and immunohistochemical analysis , TGF beta 1 , TbetaR IALK 5 , and TbetaR 2 were seen to be colocalized in the lamina propria cells and in the lymphocytes closest to the luminal surface , but also in the remaining epithelial cells , and in fibroblasts of CD tissue samples . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Interestingly , TGF beta 1 differentially stimulated or inhibited the expression of TbetaR 1 and TbetaR 2 mRNA in the gliomas . ^^^ Affinity cross linking studies using 125I TGF beta 1 revealed that the gliomas expressed TGF beta type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) receptors , although binding to TbetaR 2 in U 343 MGa 31L and U 251 MG AgCl 1 was low to undetectable . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) signaling is mediated by a complex of type 1 ( TBRI ) and type 2 ( TBRII ) receptors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Immunoblotting analyses revealed an almost complete disappearance of immunoreactive TbetaR 2 and TbetaR 3 proteins after a 24 h preincubation with TGF beta 1 . ^^^ Using semi quantitative reverse transcription PCR , no effect of TGF beta 1 on the expression of TbetaR 2 mRNA was observed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here we report that antibodies raised against the extracellular domain of the chicken type 2 TGFbeta receptor ( TBRII ) preferentially identify endothelial cells in the chick . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In order to identify possible molecular mechanisms responsible for TGFbeta resistance , we screened the 7 exons of the type 2 ( TbetaR 2 ) TGFbeta receptor and the 9 exons of the type 1 ( TbetaR 1 ) TGFbeta receptor genes for mutations in 16 paraffin embedded primary invasive cervical carcinoma specimens . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta exerts its antiproliferative effect via the TGF beta type 2 receptor ( TbetaR 2 ) . ^^^ A decrease in TbetaR 2 expression is believed to be responsible , in part , for the resistance of squamous cell carcinoma ( SqCC ) to the anti proliferative effects of TGF beta . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta stimulated Man 6 P / IGF 2 receptor mediated uptake ( approximately 2 fold after 12 h treatment ) of exogenous beta glucuronidase in Mv1Lu cells and type 2 TGF beta receptor ( TbetaR 2 ) defective mutant cells ( DR 26 cells ) but not in type 1 TGF beta receptor ( TbetaR 1 ) defective mutant cells ( R 1B cells ) and human colorectal carcinoma cells ( RII 37 cells ) expressing TbetaR 1 and TbetaR 2 but lacking TbetaR 5 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In the present study , the authors analyzed the concomitant presence of TGF beta 1 and its signaling receptors TGF beta receptor 1 , subtype ALK 5 ( TbetaR 1 ( ALK 5 ) ) , and TGF beta receptor 2 ( TbetaR 2 ) as well as CTGF and collagen type 1 in the pancreatic tissue of patients undergoing surgery for chronic pancreatitis . ^^^ The expression of TGF beta 1 , TbetaR 1 ( ALK 5 ) , TbetaR 2 , CTGF , and collagen type 1 was studied by Northern blot analysis . ^^^ RESULTS : Northern blot analysis showed that CP tissue samples exhibited concomitant enhanced mRNA expression of TGF beta 1 ( 38 fold ) , TbetaR 2 ( 5 fold ) , CTGF ( 25 fold ) , and collagen type 1 ( 24 fold ) compared with normal controls . ^^^ By in situ hybridization , TGF beta 1 , TbetaR 1 ( ALK 5 ) , and TbetaR 2 mRNA were often seen to be colocalized , especially in the ductal cells and in metaplastic areas where atrophic acinar cells appeared to dedifferentiate into ductal structures . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
CONCLUSIONS : The membranous location of TbetaR 2 in VC exposes the receptor to the growth inhibitory control of TGF beta and may explain why VC tumors are less aggressive clinically . ^^^ The marked reduction of membranous TbetaR 2 and their predominant cytoplasmic location diminishes TGF beta growth inhibition and may contribute to the transformation of VC into the more aggressive SqCC . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To distinguish between these possibilities in humans , immunohistochemical studies were performed examining the coexpression of TGF beta isoforms and the TGF beta receptors ALK 5 and TbetaR 2 in aorta during the various stages of atherosclerotic lesion development . ^^^ METHODS AND RESULTS : The spatial relationships between TGF beta 1 , TGF beta 3 , ALK 5 , and TbetaR 2 expression were compared in aortic segments from 21 subjects . ^^^ Nonatherosclerotic intima contained predominantly TGF beta 1 , low concentrations of TbetaR 2 , and barely detectable amounts of ALK 5 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To test this hypothesis , we examined the steady state mRNA level of TGF beta 1 and the protein localization of TGF beta 1 and its type 2 receptor ( TbetaR 2 ) during experimental tooth movement . ^^^ After 3 d of tooth movement , intense immunostaining for TGF beta 1 and TbetaR 2 was observed in cuboidally shaped osteoblasts in the tension zone , and in bone resorbing osteoclasts in the compression zone . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To better understand the regulatory mechanism of follicular development , immunohistochemistry was used to study the expression of insulin like growth factor ( IGF ) type 1 receptor ( IGF IR ) and transforming growth factor beta ( TGFbeta ) type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) receptors in fresh and frozen ovarian tissues from 14 women . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Treatment of ovarian cancer HEY cells with 500 nM 5alpha dihydrotestosterone ( DHT ) , but not estradiol 17beta or progesterone , for 60 h down regulated the expression of mRNA for TGF beta receptors 1 and 2 ( TbetaR 1 and TbetaR 2 ) , betaglycan , and endoglin but had no effect on TGF beta 1 mRNA levels . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The blood vessel defects in ALK 1 deficient mice are reminiscent of mice lacking TGF beta 1 , TGF beta type 2 receptor ( TbetaR 2 ) , or endoglin , suggesting that ALK 1 may mediate TGF beta 1 signal in endothelial cells . ^^^ Consistent with this hypothesis , we demonstrate that ALK 1 in endothelial cells binds to TGF beta 1 and TbetaR 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta 1 in Aplysia : role in long term changes in the excitability of sensory neurons and distribution of TbetaR 2 like immunoreactivity . ^^^ In addition , 5 HT induced facilitation was blocked by application of a soluble fragment of the extracellular portion of the TGF beta 1 type 2 receptor ( TbetaR 2 ) , which presumably acted by scavenging an endogenous TGF beta 1 like molecule . ^^^ Because TbetaR 2 is essential for transmembrane signaling by TGF beta , we sought to determine whether Aplysia tissues contained TbetaR 2 and specifically , whether neurons expressed the receptor . ^^^ The expression and distribution of TbetaR 2 immunoreactive proteins in the central nervous system was examined by immunohistochemistry to elucidate sites that may be responsive to TGF beta 1 and thus may play a role in synaptic plasticity . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of TGF beta receptor 1 ( TbetaR 1 ) and receptor 2 ( TbetaR 2 ) , essential for effective signaling , was determined by Western analysis of CSOC cultures . ^^^ All cell cultures expressed TbetaR 1 and TbetaR 2 and exhibited TbetaR 1 phosphorylation following TGF beta 1 treatment . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Resistance to the growth inhibitory effects of transforming growth factor beta ( TGFbeta ) has been associated with decreased levels of the TGFbeta type 2 receptor ( TbetaR 2 ) and has been correlated with tumorigenicity . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We analyzed the mRNA expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , the TGF beta receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) , Smad 2 , Smad 3 , and Smad 4 . mRNA expression of IL 10 and CD 95 ( FAS / APO 1 ) were also studied . ^^^ TGF beta normally up regulates the TGF beta receptors , and TbetaR 1 and TbetaR 2 showed stronger expression in all gliomas when compared to normal tissues . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Histological and immunohistochemical studies using specific antibodies for TGF beta 1 , beta 2 , beta 3 , TbetaR 1 , and TbetaR 2 were performed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Microsatellite mutation of the polyadenine tract ( 10 adenine repeat ) within the TbetaR 2 [ transforming growth factor beta ( TGF beta ) receptor type 2 ] coding region have been found in a variety of human cancers , particularly in association with microsatellite instability ( MSI ) . ^^^ Subsequently , sensitivity to TGF beta induced growth inhibitory effects of control and TbetaR 2 transfected MDA MB 231 cells was compared . ^^^ The sensitivity of TbetaR 2 transfectants to exogenous as well as endogenous TGF beta 1 was increased distinctly compared with control transfectant . ^^^ These results suggest that heterozygous deletion of one adenine base within the polyadenine tract in MDA MB 231 cells might lead to reduced TbetaR 2 expression and sensitivity to TGF beta . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In the present study , we investigated the role of the three mammalian TGFbeta subtypes ( beta 1 , beta 2 , and beta 3 ) and their receptors ( type 3 ( TbetaR 3 ) , type 2 ( TbetaR 2 ) , and two types 1 ( TbetaR 1 ) , ALK 1 and ALK 5 ) in early rat lung organogenesis by using an embryonic rat lung explant culture . ^^^ Antisense inhibition of ALK 5 and TbetaR 2 showed a similar reduction in early lung branching as observed with antisense TGFbeta 2 . ^^^ This TGFbeta signaling in rat lung branching in vitro appears to be predominantly mediated via the TbetaR 1 ( ALK 5 ) / TbetaR 2 heteromeric complex . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Cryosections of these specimens were processed for immunohistochemical analysis for TGF beta 1 , TGF beta 2 , TGF beta 3 , TGF beta receptor type 1 ( TbetaR 1 ) , type 2 ( TbetaR 2 ) and type 3 ( TbetaR 3 ) , and were observed under light micros copy . ^^^ RESULTS : Lens epithelial cells ( LECs ) lining the inner surface of the anterior capsules exhibited immunoreactivity for TGF beta 2 and TbetaR 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The state of the basal lamina , and the expression of connexin 43 , alpha ( 2 ) integrin subunit and TGF beta receptor type 2 ( TbetaR 2 ) were chosen as parameters to judge the progress of luteinization . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The biological effects of TGF beta are mediated by type 1 ( TbetaR 1 ) and 2 ( TbetaR 2 ) receptors . ^^^ TbetaR 1 , TbetaR 2 , and TGF beta isoforms exhibit distinct but overlapping patterns of expression during lung development . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Alterations in transforming growth factor beta 1 ( TGF beta 1 ) and its type 2 receptor ( TbetaR 2 ) have been implicated in the pathogenesis of a variety of human cancers and animal tumor models . ^^^ We postulated that TGF beta 1 and TbetaR 2 alterations may also be involved in mouse colon tumorigenesis induced by the chemical carcinogen , azoxymethane ( AOM ) . ^^^ In the present study , normal colon tissues and AOM induced colon tumors from SWR / J mice were analyzed for mutational changes in the TbetaR 2 gene , and the expression and localization of TGF beta 1 and TbetaR 2 were examined by reverse transcription polymerase chain reaction ( RT PCR ) and immunohistochemisty . ^^^ However , TGF beta 1 and TbetaR 2 mRNA levels in tumor samples were increased 1 . 8 fold ( p < 0 . 01 ) and 1 . 3 fold ( p < 0 . 01 ) , respectively , when compared with control mouse colon tissue . ^^^ The results of immunohistochemical analysis of TGF beta 1 and TbetaR 2 were correlated with mRNA expression data . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Cellular responses to the transforming growth factor beta ( TGFbeta ) ligand , including inhibition of cell proliferation , are mediated by a heteromeric receptor complex composed of TGFbeta types 1 and 2 receptors ( TbetaR 1 and TbetaR 2 ) . ^^^ To gain a better understanding of TGFbeta signal transduction pathways in endometrial carcinogenesis , we have investigated the role of the TbetaR complex by evaluating the TbetaR 1 and TbetaR 2 genes for mutations throughout the entire coding region in human sporadic endometrial tumors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
However , TGF beta type 2 receptor ( TbetaR 2 ) is expressed by all palatal epithelial cells during palatal fusion ( Cui et al . , 1998 ) and therefore can not localize TGF beta 3 responsiveness . ^^^ The expression of TbetaR 3 was temporo spatially restricted to the MEE during palatal fusion , while the expression of TbetaR 1 was primarily localized in all palatal epithelia , consistent with the expression patterns of TbetaR 2 and TGF beta 3 ( Cui et al . , 1998 ) . ^^^ TbetaR 3 may modulate TGF beta 3 binding to TbetaR 2 in the MEE cells to locally enhance TGF beta 3 autocrine signaling through the TbetaR I / TbetaR 2 receptor complex , which contributes to MEE selective epithelial mesenchymal transformation . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Lesion cells in vitro also express 2 3 fold higher Egr 1 mRNA and protein levels but express much lower levels of the transforming growth factor beta ( TGF beta ) Type 2 receptor ( TbetaR 2 ) and are functionally resistant to the antiproliferative effects of TGF beta . ^^^ Egr 1 transfection reduces the levels of TbetaR 2 and confers resistance to the antiproliferative effect of TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We tested the effect of hypercholesterolemia , a well known risk factor for atherosclerosis , on liver type 2 TGF beta receptor ( TbetaR 2 ) expression in atherosclerosis susceptible C57BL / 6 mouse strain fed atherogenic diet . ^^^ The TbetaR 2 profile on HepG 2 resulted in a time dependent increased expression when the cells were incubated with soluble free cholesterol , associated with an increased TGF beta dependent biological activity as detected by luciferase assay of reporter gene . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Likewise , preventing TGF beta signaling by treatment with a TbetaR 2 fusion protein during the period of ontogenetic cell death in the ciliary ganglion rescued all neurons that normally die . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
This study assessed whether in vivo administration of a soluble TGF beta type 2 receptor ( TbetaR 2 ) protein ameliorates intestinal radiation injury ( radiation enteropathy ) . ^^^ Intestinal TGF beta 1 messenger RNA increased in TbetaR 2 : Fc treated mice , whereas TGF beta immunoreactivity decreased . ^^^ CONCLUSIONS : Long term modulation of TGF beta with a TbetaR 2 : Fc fusion protein is feasible and ameliorates radiation enteropathy . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To learn about the role of TGF beta in vivo , phenotypes of targeted mutations of molecules within the TGF beta signalling pathway , TGF beta 1 , beta 2 , beta 3 , TGF beta receptor ( TbetaR 2 ) and the signalling molecules SMAD 2 , SMAD 3 and SMAD 4 , are discussed in this review . ^^^ The TbetaR 2 null phenotype closely resembles that of TGF beta 1 ( / ) conceptuses , which die in utero by E10 . 5 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Twenty four weeks after AOM exposure , mutational analysis of TGF beta type 2 receptor ( TbetaR 2 ) from normal colons and from tumors showed no AOM induced alterations . ^^^ Concomitant repression of TbetaR 2 and overexpression of c myc may render epithelial cells insensitive to TGF beta mediated growth arrest , a possibility that also is suggested by this model . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In many cancers , expression of TGF beta type 2 receptor ( TbetaR 2 ) is markedly decreased . ^^^ In the present study , we show that the hepatocytes isolated from 15 day old , but not 9 month old , mice heterozygous for the deletion of the TbetaR 2 gene are slightly less sensitive to the growth inhibitory effect of TGF beta when compared with wild type littermates of same age . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
A decrease in the levels of expression of one such tumor suppressor gene , the TGFbeta type 2 receptor ( TbetaR 2 ) , has been associated with increased tumorigenicity in a number of human tumors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : Steady state mRNA levels of TGF beta receptor 1 and 2 ( TbetaR 1 and TbetaR 2 ) were analysed by northern blot . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Crystal structure of the human TbetaR 2 ectodomain TGF beta 3 complex . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Initiation of signaling requires binding of TGF beta 1 to TGF beta type 2 receptor ( TbetaR 2 ) , a constitutively active serine / threonine kinase , which subsequently transphosphorylates TGF beta type 1 receptor ( TbetaR 1 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
OBJECTIVE : To explore the relationships between Smad 4 , TGF beta 1 and TbetaR 2 in the TGF beta pathway and the possible mechanisms by which they effect pancreatic carcinoma . ^^^ METHODS : The expression of Smad 4 , TGF beta 1 and TbetaR 2 in paraffin embedded pancreatic carcinoma tissues was detected by using antibodies against Smad 4 , TGF beta 1 and TbetaR 2 with EnVision immunohistochemistry . ^^^ RESULTS : The positive rates of Smad 4 , TGF beta 1 and TbetaR 2 were 58 . 93 % ( 33 ) , 66 . 07 % ( 37 ) and 60 . 71 % ( 34 ) , respectively . ^^^ There was also a significant relationship between the expressions of TGF beta 1 and TbetaR 2 ( P < 0 . 05 ) . ^^^ CONCLUSIONS : The expression of Smad 4 in pancreatic carcinoma tissue is significantly decreased but the expression of TGF beta 1 and TbetaR 2 are increased . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Messenger ribonucleic acid ( mRNA ) expression of TGF beta 1 , CTGF , TGF beta receptor subtype 1 ALK 5 ( TbetaR IALK 5 ) , and TGF beta receptor type 2 ( TbetaR 2 ) was studied by Northern blot analysis in esophageal cancer and the normal esophagus . ^^^ Northern blot analysis revealed 3 fold and 4 fold increases ( p < 0 . 05 ) in TGF beta 1 and CTGF mRNA levels , respectively , in esophageal cancer in comparison with normal controls , whereas TbetaR 1 mRNA levels were significantly decreased and TbetaR 2 mRNA levels were unchanged in the cancer samples . ^^^ TGF beta 1 and CTGF immunoreactivity were increased , TbetaR 2 was unchanged , and TbetaR IALK 5 immunoreactivity was decreased . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
BACKGROUND : Transforming growth factor beta ( TGF beta ) initiates intracellular signalling by inducing the formation of a heteromeric complex between TGF beta type 1 ( TbetaR 1 ) and TGF beta type 2 serine / threonine kinase receptors ( TbetaR 2 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Because both TbetaR 1 and TbetaR 2 are required for signal transduction , the reduction of TbetaR 1 levels on the alveolar epithelium may alter the sensitivity of AECs to the antiproliferative effects of TGF beta 1 present in increased quantities following bleomycin injury . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The expression of transforming growth factor beta 1 ( TGF beta 1 ) and TGF beta receptor type 2 ( TbetaR 2 ) of the renal cortex were measured by reverse transcription polymerase chain reaction ( RT PCR ) analysis . ^^^ The relative contents of TGF beta 1 and TbetaR 2 mRNA expression in renal cortex of STZ induced diabetic rats were 0 . 185 + / 0 . 037 and 0 . 194 + / 0 . 054 , much higher than those in other groups . ^^^ CONCLUSION : The selective COX 2 inhibitor meloxicam significantly suppresses TGF beta 1 and TbetaR 2 genes expression , elevates the protein level of AT 1 receptor and attenuate the renal lesion caused by diabetes . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
By immunohistochemistry , sutures rescued from obliteration by Tgf beta 3 had the same Tgf beta receptor type 2 ( Tbetar 2 ) distribution as controls . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Boston minipigs , treated with tranilast or vehicle , were subjected to endoluminal stenting , and the expression of TGF beta 1 and TGF beta 3 , the expression of their signaling receptors ALK 5 and TbetaR 2 , leukocyte numbers around the stent struts , and neointima development were assessed over 28 days . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here we report the 1 . 1 A resolution crystal structure of human TGF beta type 2 receptor ectodomain ( TBRII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We investigated whether CsA up regulates the expression of TGF beta 1 and its receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) in cultured rat MCs , and whether this effect translates into enhanced matrix protein accumulation . ^^^ Time and concentration dependent expression of TGF beta 1 , TbetaR 1 and TbetaR 2 were measured at both the mRNA ( competitive reverse transcription PCR ) and protein level ( enzyme linked immunosorbent assay ( ELISA ) and western blotting ) . ^^^ RESULTS : Compared with untreated controls , CsA stimulated mRNA production of TGF beta 1 ( maximum at 72 h , 500 ng / ml CsA : 2 . 1+ / 0 . 5 fold , P < 0 . 001 ) and TbetaR 2 ( maximum at 72 h , 1000 ng / ml CsA : 2 . 4+ / 0 . 4 fold , P < 0 . 005 ) time and dose dependently . ^^^ Protein concentrations were analysed at 96 h : TGF beta 1 , 220+ / 32 vs 86+ / 24 pg / ml , P < 0 . 001 ( 500 ng / ml CsA vs control ) ; TbetaR 1 , 2 . 0+ / 0 . 5 fold , P < 0 . 005 ( 1000 ng / ml CsA vs control ) ; TbetaR 2 , 2 . 5+ / 0 . 7 fold , P < 0 . 05 ( 1000 ng / ml CsA vs control ) . ^^^ Co incubation with neutralizing anti TGF beta 1 antibodies reduced ( P < 0 . 05 ) CsA induced expression of TbetaR 1 ( 1 . 0+ / 0 . 1 fold ) , TbetaR 2 ( 1 . 3+ / 0 . 1 fold ) and PAI 1 ( 1 . 3 fold ) , but not FN production ( 1 . 6 fold ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In the present study , we demonstrate that after mechanical wounding , ASMCs had an increased expression of the signal transducing TGF beta receptors TbetaR 1 and TbetaR 2 as detected by flow cytometry and Western analysis . ^^^ Corticosteroids are standard therapy in asthma and the presence of dexamethasone decreased wound induced release of TGF beta 1 and the expression of collagen 1 , fibronectin , and TbetaR 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , the spatial and temporal expressions of the type 1 receptor ( TbetaR 1 ) , type 2 receptor ( TbetaR 2 ) and endogenous TGF beta 1 in periosteal explants cultured in vitro were examined using reverse transcription polymerase chain reaction ( RT PCR ) and immunohistochemistry . ^^^ The temporal changes in the expression of the TbetaR 1 and TbetaR 2 mRNAs correlated with that of TGF beta 1 . ^^^ Immunohistochemical studies demonstrated co localization of TbetaR 1 and TbetaR 2 simultaneously among the same cells expressing TGF beta 1 . ^^^ TGF beta 1 treatment increased the expression of TGF beta 1 , TbetaR 1 and TbetaR 2 in mesenchymal cells in the cambium layer at 7 days in culture . ^^^ Small round chondrocytes showed widely distributed immunoreactivity of TGF beta 1 , TbetaR 1 and TbetaR 2 in the 42 day explants treated with TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In some cancers , TGF beta resistance has been linked to TGF beta receptor 2 ( TbetaR 2 ) and Smad 4 mutations ; however , in ovarian cancer , the mechanism of resistance remains unclear . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We have recently shown that CsA up regulates the expression of TGF beta 1 and its receptors type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) in rat mesangial cells ( MCs ) . ^^^ Here , we assessed the effect of PGE 1 on CsA induced up regulation of TGF beta 1 , TbetaR 1 , TbetaR 2 and related matrix production in MCs . ^^^ Co incubation with PGE 1 reduced CsA induced up regulation of TGF beta 1 and TbetaR 2 at the mRNA and protein level . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study we analyze 105 paraformaldehyde fixed and paraffin embedded tumor samples from 12 patients with invasive squamous cell carcinoma of the larynx for the presence of gene mutations of the complete TGF beta receptor 2 ( TBR 2 ) gene . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Isoforms of transforming growth factor beta ( TGFbeta ) are 25 kDa homodimeric polypeptides that signal by binding and bringing together two related , functionally distinct cell surface receptors designated as TbetaR 1 and TbetaR 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Furthermore , the expression pattern of seven selected genes such as Delta 1 , CRADD , PRSC 1 , PAI 1 , Apo 1 / Fas , CTS B , and TbetaR 2 were confirmed in either cultured cortical neurons or astrocytes following TGF beta 1 treatment . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta isoforms and TGF beta receptor ( TbetaR 2 ) were localized immunocytochemically in sections of Cowper ' s glands . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Subsequently , it was demonstrated that differentiation of F 9 EC cells leads to increases in the transcription of the type 2 TGF beta receptor gene ( TbetaR 2 ) and leads to significant increases in the steady state levels of TbetaR 2 mRNA . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Our study indicates differences in the expression of TGF beta in a human model of keratinocytes of varying tumorigenicity , but presents no evidence for mutations in the functionally most important TGF beta receptor TBR 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
GM CSF also induced ASMC to increase the expression of transforming growth factor ( TGF ) beta receptors type 1 , 2 , and 3 ( TbetaR 1 , TbetaR 2 , TbetaR 3 ) , but had no detectable effect on the release of TGF beta 1 by the same ASMC . ^^^ The presence of GM CSF also induced the association of TGF beta 1 with TbetaR 3 , which enhances binding of TGF beta 1 to TbetaR 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We also observed subsequent loss of type 2 TGFbeta receptor ( TBR 2 ) expression in metastatic RCCs . ^^^ Restoring TBR 2 and TBR 3 expression in UMRC 3 cells attenuates cell proliferation , completely restores TGFbeta mediated transcriptional responses , and completely blocks anchorage independent growth : while restoration of TBR 2 partially restores TGFbeta mediated signaling . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta type 2 receptor ( TbetaR 2 ) expression in the liver after PH was assessed immunohistochemically . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
A number of these cell lines carry inactivating mutations of the TGF beta type 2 ( TbetaR 2 ) receptor , and fail to phosphorylate receptor associated Smads , Smad 2 and Smad 3 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
These elevated pR Smad levels could not be attributed to a decreased dephosphorylation rate nor to increased expression of TGF beta type 1 ( TbetaR 1 ) or type 2 ( TbetaR 2 ) receptors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta 1 receptor 1 ( TbetaR 1 ) and transforming growth factor beta 1 receptor 2 ( TbetaR 2 ) on HSCs , type 1 collagen expression in HSC Induced by TGF beta 1 were detected with western blot assay . ^^^ Transforming growth factor beta 1 receptor 1 ( TbetaR 1 ) and transforming growth factor beta 1 receptor 2 ( TbetaR 2 ) on HSCs , type 1 collagen expression in HSC Induced by TGF beta 1 were detected with western blot assay . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The murine renal cell carcinoma ( Renca ) cells are insensitive to TGF beta due to a lack of TGF beta type 2 receptor ( TbetaR 2 ) . ^^^ After 5 Aza treatment , these cells expressed TbetaR 2 at both mRNA and protein levels , which corresponded to the restoration of sensitivity to TGF beta by an increase in P Smad 2 . ^^^ Results of the present study indicated that , in Renca cells , the loss of sensitivity to TGF beta is likely due to a promoter hypermethylation in the TbetaR 2 gene . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , we explore the expression and distribution characteristics of three TGF beta isoforms and their receptors , TGF betaRI ( TBRI ) and TGF betaRII ( TBRII ) , in fetal and postnatal skins to understand the relevance of these five proteins to skin development and elucidate the mechanism ( s ) underlying the phenotypic transition from scarless to scar forming healing observed during fetal gestation . ^^^ Gene expression and positive immunohistochemical signals of TGF beta ( 1 ) , TGF beta ( 2 ) , TGF beta ( 3 ) , TBRI , and TBRII could all be detected in fetal and postnatal skins . ^^^ In early gestation , gene expression of TGF beta ( 1 ) , TBRI , and TBRII was weaker and protein contents were less compared with postnatal skins ( p < 0 . 05 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta type 2 receptor ( TbetaR 2 ) was constantly expressed on biliary epithelial cells irrespective of biliary lesions . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : The expression of E 7 , TGF beta 1 , TbetaR 2 and Smad 4 was detected by immunohistochemistry in paraffin embedded cervical samples , and by RT PCR and Western blotting in cervical cancer cell lines . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : We used a combination of in vitro binding assays and co immunoprecipitation ( IP ) experiments to investigate whether TAK 1 interacted with the type 1 ( ALK 1 or ALK 5 ) or type 2 ( TBRII ) TGFbeta receptors . ^^^ CONCLUSIONS : We describe a novel and specific interaction between TAK 1 and TBRII which , for the first time , directly links TAK 1 to the TGFbeta signalling cascade and potentially explains how TGFbeta signalling in cardiomyocytes mediates a hypertrophic response . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
IFN gamma and TNF alpha inhibit expression of TGF beta 1 , its receptors TBETAR 1 and TBETAR 2 in the corpus luteum of PMSG / hCG treated rhesus monkey . ^^^ Using in situ hybridization , immunohistochemistry and computer imaging analysis , we have investigated the expression of transforming growth factor beta 1 ( TGF beta 1 ) , its receptors , type 1 ( TbetaR 1 ) and type 2 ( TbetaR 2 ) as well as steroidogenic acute regulatory protein ( StAR ) in the corpus luteum ( CL ) of the rhesus monkey at various stages of CL development . ^^^ The expression of TGF beta 1 , TbetaR 1 and TbetaR 2 as well as StAR was detected in the CL in a time dependent manner , reaching the maximum levels on D 10 ( functional stage ) , and decreased on Day 18 ( regression stage ) . ^^^ Injection of interferon gamma ( IFN gamma ) or tumor necrosis factor alpha ( TNF alpha ) at the functional stage of CL development significantly decreased the expression of StAR , as well as TGF beta 1 , and its receptors TbetaR 1 and TbetaR 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
However , mutations in the TGF beta receptor 1 and receptor 2 ( TbetaR 1 and TbetaR 2 ) genes have only been reported in a minority of ovarian carcinomas , suggesting that alterations in TGF beta signaling components may play an important role in the loss of TGF beta responsiveness . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
This article focuses on recent findings that the type 5 TGF beta receptor ( TbetaR 5 ) , which co expresses with other TGF beta receptors ( TbetaR 1 , TbetaR 2 , and TbetaR 3 ) in all normal cell types studied , is involved in growth inhibition by IGFBP 3 and TGF beta and that TGF beta activity is regulated by two distinct endocytic pathways ( clathrin and caveolar / lipid raft mediated ) . ^^^ Recent studies revealed that TbetaR 5 , which is identical to LRP 1 , mediates IGF independent growth inhibition by IGFBP 3 and mediates TGF beta induced growth inhibition in concert with TbetaR 1 and TbetaR 2 . ^^^ Finally , the ratio of TGF beta binding to TbetaR 2 and TbetaR 1 is a signal controlling TGF beta partitioning between two distinct endocytosis pathways and resultant TGF beta responsiveness . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
All primary antibodies ( polyclonal antibodies ) to TGF beta 1 , type 2 Transforming growth factor beta receptor ( TbetaR 2 ) , nuclear factor kappaB ( NF kappaB ) , CD 34 , smad 4 and smad 7 , secondary antibodies and immunohistochemical kit were purchased from Zhongshan Biotechnology Limited Company ( Beijing , China ) . ^^^ The expressions of TGF beta 1 , TbetaR 2 , NF kappaB , smad 4 and smad 7 proteins in 36 specimens of hepatocellular carcinoma ( HCC ) and its adjacent tissue were separately detected by immunohistochemistry to observe the relationship between TGF beta 1 and TbetaR 2 , between NF kappaB and TGF beta 1 , between smad 4 and smad 7 and between TGF beta 1 or TbetaR IIand microvessel density ( MVD ) . ^^^ CONCLUSION : The expressions of TGF beta 1 , TbetaR 2 , NF kappaB , smad 4 and smad 7 in HCC tissue , which are major up and down stream factors of TGF beta 1 smad signal transduction pathway , are abnormal . ^^^ The inhibitory action of TGF beta 1 is weakened in hepatic carcinoma cells because of abnormality of TGF beta 1 receptors ( such as TbetaR 2 ) and postreceptors ( such as smad 4 and smad 7 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here we demonstrate that TGF beta 1 induces transcriptional activation of plasminogen activator inhibitor 1 ( PAI 1 ) and growth inhibition more potently in CHO cell mutants deficient in heparan sulfate ( CHO 677 cells ) than in wild type CHO K 1 cells . 125I TGF beta 1 affinity labeling analysis of cell surface TGF beta receptors reveals that CHO K 1 and CHO 677 cells exhibit low ( < 1 ) and high ( > 1 ) ratios of 125I TGF beta 1 binding to TbetaR 2 and TbetaR 1 , respectively . ^^^ In Mv1Lu cells ( which , like CHO K 1 cells , exhibit nystatin inhibitable rapid degradation of receptor bound 125I TGF beta 1 ) , treatment with heparitinase or a heparan sulfate biosynthesis inhibitor results in a change from a low ( < 1 ) to a high ( > 1 ) ratio of 125I TGF beta 1 binding to TbetaR 2 and TbetaR 1 and enhanced TGF beta 1 induced transcriptional activation of PAI 1 . ^^^ Sucrose density gradient analysis indicates that a significant fraction of TbetaR 1 and TbetaR 2 is localized in caveolae / lipid raft fractions in CHO K 1 and Mv1Lu cells whereas the majority of the TGF beta receptors are localized in non lipid raft fractions in CHO 677 cells . ^^^ These results suggest that heparan sulfate negatively modulates TGF beta 1 responsiveness by decreasing the ratio of TGF beta 1 binding to TbetaR 2 and TbetaR 1 , facilitating caveolae / lipid raft mediated endocytosis and rapid degradation of TGF beta 1 , thus diminishing non lipid raft mediated endocytosis and signaling of TGF beta 1 in these epithelial cells . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Inhibition of the ERK , p 38 kinase or JNK signal transduction pathways blocked the transcriptional up regulation of TGF beta 2 , TbetaR 1 , and TbetaR 2 in KKs . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Using transient expression of TGF beta signalling components and a Smad 3 dependent reporter assay , we show that BICR 31 and H 314 had defects of Smad 4 , BICR 56 had abnormal TbetaR 2 and BICR 19 overexpressed Smad 7 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Reported here is the isolation of a subtype of the human TGF beta receptor type 2 from a cDNA library using a Saccharomyces cerevisiae mutant . ^^^ The cloned subtype of the TGF beta receptor type 2 has a 25 amino acid insertion relative to the reported receptor type 2 sequence . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Growth inhibition by transforming growth factor beta ( TGF beta ) type 1 is restored in TGF beta resistant hepatoma cells after expression of TGF beta receptor type 2 cDNA . ^^^ A mutant cell line was derived that was not inhibited in growth by TGF beta 1 at 5 ng / ml ( 200 pM ) and that lacked TGF beta receptor type 2 ( TGF beta RII ) gene . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In addition , accumulation of TGF beta receptor type 2 mRNA is approximately 5 fold lower in ras expressing cells compared to control cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Accompanying these effects of TGF beta 1 , a low but statistically significant level of TGF beta 1 specific binding and an increased protein level of TGF beta receptor type 2 were detected by a competitive binding assay and Western blot analysis respectively . ^^^ These results indicate that LNCaP cells can be induced by DHT to respond to TGF beta 1 and that DHT modulates the sensitivity to TGF beta 1 and the level of TGF beta receptor type 2 in these cells . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The aim of this study was to investigate , in hypothyroid rats , the mRNA expression of genes modulating these effects , focusing on c fos and c myc , hallmarks of hepatocyte ' priming ' , and on transforming growth factor beta 1 ( TGF beta 1 ) and its receptor , the transforming growth factor beta 1 receptor type 2 ( TbetaR 2 ) , negative regulators of liver growth . ^^^ In this study , we show for the first time that , in the basal liver state , hypothyroidism increased TGF beta 1 and TbetaR 2 mRNA levels by 45 % and 30 % , respectively , as compared with the euthyroid condition and , after PH , resulted in a approximately 12 h delay in the activation of c fos and c myc mRNA expression . ^^^ Moreover , the increase in TGF beta 1 mRNA levels , detected 24 48 h after PH in euthyroid rats , was delayed by 72 h in hypothyroid rats , occurring when a concomitant reduction in TbetaR 2 was measured . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
However , IL 2R , IL 6R , granulocyte macrophage colony stimulating factor receptor , TNFR type 2 , and TGF beta receptor type 2 showed no change in expression during the study period and were comparable to controls . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We report that TGF beta 1 protein selectively increased steady state levels of the mRNA for the serine / threonine kinase receptor 1 ( SKR 1 ) , a member of the TGF beta superfamily receptor genes in these cells , whereas TGF beta 1 had little effect on expression of the TGF beta receptor type 2 gene . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Ligand induced dimerization of the extracellular domain of the TGF beta receptor type 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
There was also a marked increase in GEC immunostaining for TGF beta receptor type 1 ( T beta IR ) and TGF beta receptor type 2 ( T beta IIR ) at all time points in PHN . mRNA levels for both receptors increased at day 5 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Immunocytochemistry and western blot analysis indicated that E 8 DRG neurons have the TGF beta receptor type 2 , and treatment of these cells with NGF induces expression of TGF beta 3 mRNA . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To localize the expression of TGF beta receptor type 2 , immunohistochemical studies were performed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Immunohistochemical demonstration of TGF beta receptor type 2 in human pituitary adenomas . ^^^ To investigate whether the signalling pathway of transforming growth factor beta ( TGF beta ) is active in human pituitary tumors , an antibody against TGF beta receptor type 2 ( TGF beta R 2 ) was prepared to demonstrate immunohistochemically TGF beta R 2 expression in 48 cases of human pituitary adenoma . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
This kinase is distinct from TGF beta receptor type 2 , as well as several cytoplasmic serine / threonine kinases of similar size , including protein kinase C , Raf , mitogen activated protein kinase kinase kinase , and ribosomal S 6 kinase . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The spatial and temporal patterns of expression of TGF beta 1 , TGF beta 2 , TGF beta receptor type 2 messenger RNAs ( mRNAs ) , and TGF beta 1 proteins in the different hepatic lesions suggests that TGF beta isoforms may play a role in the pathogenesis of quartz induced fibrosis , cirrhosis , liver cell adenoma , and carcinoma . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Scanning deletion analysis of the extracellular domain of the TGF beta receptor type 2 . ^^^ TGF beta receptor type 2 has a crucial role in the cell ' s responsiveness to TGF beta as it is mandatory for the TGF beta binding to the signaling complex ( receptor type 1 and type 2 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In a competitive enzyme linked immunosorbent assay , fetuin blocked binding of TGF beta 1 to the extracellular domain of TGF beta receptor type 2 ( TbetaRII ) , one of the primary TGF beta binding receptors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We show here that the multifunctional cytokine transforming growth factor beta ( TGF beta ) fails to maintain sensory neurons cultured from embryonic day ( E ) 8 chick dorsal root ganglia ( DRG ) , although DRG neurons are immunoreactive for the TGF beta receptor type 2 , which is essential for TGF beta signaling . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta receptor type 2 deficiency results in defects of yolk sac hematopoiesis and vasculogenesis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Microsatellite instability is an early genetic event in myelodysplastic syndrome but is infrequent and not associated with TGF beta receptor type 2 gene mutation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta 1 and TGF beta receptor type 2 detected immunohistochemically were increased in 4 HPR treated PC 3 cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
A frequent cause of TGF beta resistance is decreased expression or mutation of TGF beta receptor Type 2 ( TGFbetaRII ) protein . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
This factor signals through a heteromeric complex composed of type 1 ( TGF beta receptor type 1 ) and type 2 [ TGF beta receptor type 2 ( TbetaRII ) ] receptors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Moreover , diethylnitrosamine initiated tumors in the c myc / TGF beta 1 mice showed a high rate of malignant conversion associated with a reduced expression or lack of TGF beta receptor type 2 . ^^^ The results suggest that overexpression of TGF beta 1 may contribute to liver carcinogenesis and that loss of TGF beta receptor type 2 transduced inhibitory growth signals and up regulation of c myc are critical steps in liver tumor progression . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here , we characterize the correlative expression pattern of the interdependent high affinity receptor proteins for TGF beta 1 and TGF beta 3 , TGF beta receptor type 1 ( TGF betaRI ) and TGF beta receptor type 2 ( TGF betaRII ) , during hair follicle development and cycling in C57BL / 6 mice . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , cell type specificity of TGF beta 1 and TGF beta receptor Type 2 ( RcII ) protein expression was determined by immunocytochemistry in human normal prostate and compared to prostate carcinoma tissues . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Abnormalities in the expression of the deoxyribonucleic acid ( DNA ) , messenger ribonucleic acid ( mRNA ) , and proteins of transforming growth factor beta ( TGF beta ) receptor type 1 ( T beta R 1 ) and TGF beta receptor type 2 ( T beta R 2 ) were investigated in 33 human pituitary adenomas . mRNA was extracted from the tumor tissue , and complementary DNA was produced by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
An important role for DNA replication errors in colorectal tumorigenesis has been suggested by the finding of frequent alterations in the length of specific mononucleotide tracts within genes controlling cell growth , including TGF beta receptor type 2 ( ref . 6 ) , BAX ( ref . 7 ) and APC ( ref . 8 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta receptor type 1 ( TGF RI ) and TGF beta receptor type 2 ( TGF RII ) are part of the complex which mediates the response to TGF beta . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Previous studies suggest that estrogen receptor positive ( ER+ ) breast cancer cells acquire resistance to transforming growth factor beta ( TGF beta ) because of reduced expression levels of TGF beta receptor type 2 ( RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
MCF 7E cells contained approximately threefold higher levels of TGF beta receptor type 2 ( TbetaRII ) mRNA than MCF 7L , but their TbetaRI levels were similar . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
These include an increase in cell proliferation , and an alteration in apoptosis , which may be secondary to loss of function of p 53 and loss of growth inhibition by growth factor ( TGF ) beta , due to mutation of the TGF beta receptor type 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To examine the involvement of transforming growth factor beta ( TGF beta ) in the pathogenesis of prion diseases , immunohistochemical studies on both TGF beta isoforms ( beta 1 , beta 2 and beta 3 ) and TGF beta receptor type 2 ( TGF beta RII ) were performed on the cerebral neocortices of 20 cases with human prion diseases , three cases with Alzheimer ' s disease , and five control cases . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Analysis of transforming growth factor ( TGF ) alpha / epidermal growth factor receptor , hepatocyte growth Factor / c met , TGF beta receptor type 2 , and p 53 expression in human hepatocellular carcinomas . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Concomitant with this differentiation , expression of transforming growth factor beta 2 ( TGF beta 2 ) , TGF beta 3 , and TGF beta receptor type 2 ( TbetaRII ) is induced , while those of TGF beta 1 and TbetaRI remain essentially unchanged . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
This was followed by an increase of TGF beta 1 and TGF beta receptor type 2 ( but not of types 1 and 3 ) mRNAs . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In order to compare the frequency of damage to the transforming growth factor TGF beta receptor type 2 gene ( RII gene ) and microsatellite instability ( MIN ) in oncogenesis of sporadic and hereditary cancer of gastrointestinal tract ( GIT ) , 4 groups of carcinomas were analyzed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
This study reports the immunohistochemical localization of TGF beta receptor type 2 ( T beta R 2 ) and type 3 ( T beta R 3 ) in cells of the forming periodontal ligament ( PDL ) in rat first molar roots . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Suppression of transforming growth factor beta isoforms , TGF beta receptor type 2 , and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Focal preneoplastic lesions lacking expression of TGF beta receptor type 2 ( TbetaRII ) were detected in c myc / TGF alpha but not in c myc livers . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Our results indicate for the first time that TGF beta 1 is synthesized in the marmoset epididymis , possibly in a different subpopulation of epididymal cells than the TGF beta receptor type 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Staining for TGF beta 3 and TGF beta receptor type 2 was predominantly in the oocytes . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of mRNAs for TGF beta 1 , TGF beta 2 , TGF beta receptor type 2 , and connective tissue growth factor ( CTGF ) was significantly greater in anterior polar type than in nuclear type cataracts . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
ANG 2 stimulated protein expression of TGF beta receptor type 2 , but not that of type 1 , in MCT cells as detected by immunofluorescence and western blotting of cell lysates . ^^^ Furthermore , ANG 2 also increased steady state mRNA expression for TGF beta receptor type 2 . ^^^ Transient transfection studies using various length enhancer / promoter elements of the human TGF beta receptor type 2 linked to the CAT gene revealed that AP 1 sites are a necessary prerequisite for ANG 2 induced transcriptional activity . ^^^ Our results provide for the first time convincing evidence that ANG 2 upregulates TGF beta receptor type 2 expression on proximal tubular cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
While TGF beta receptor type 2 mRNA levels were unchanged during progression , mRNA levels for TGF beta receptor type 1 decreased dramatically as the cells became TGF beta resistant . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Several proteins , including transforming growth factor beta ( TGF beta ) receptor type 1 ( RI ) , TGF beta receptor type 2 ( RII ) , Smad 2 , Smad 3 , and Smad4 / DPC4 , have been identified in the transduction pathway of the tumor suppressor TGF beta . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Further , transfection of Sp 1 cDNA into untreated GEO control cells increased RI promoter activity and thus induced RI expression . 5 aza C mediated Sp 1 expression in Sp 1 deficient GEO colon and MCF 7 breast cancer cells also enhanced the activity of several other Sp 1 dependent promoters such as TGF beta receptor type 2 ( RII ) , Cyclin A and p21 / waf1 / cip1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
RESULTS : The expression of transforming growth factor beta 1 ( TGF beta 1 ) , TGF beta receptor type 2 , hepatocyte growth factor alpha ( HGF alpha ) , c met , p 53 , and N CAM was higher in the areas of MPNST than in the neurofibromatous areas in four , five , five , eight , five , and three of the eight cases , respectively . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Heterogeneous transforming growth factor ( TGF ) beta unresponsiveness and loss of TGF beta receptor type 2 expression caused by histone deacetylation in lung cancer cell lines . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of TGF beta receptor type 2 mRNA was lower in the pituitary gland of Tgfbr 2 ( + / ) mice than in wild type mice before estrogen treatment and was significantly reduced after treatment . ^^^ Both the TGF beta receptor type 2 gene and p 27 gene and their products are involved in estrogen induced tumorigenesis . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Importantly , the TGF beta receptor type 2 expression was strongly downregulated in most tumours , indicating that impairment of TGF beta 1 mediated growth inhibition plays a major role in accelerated neoplastic development . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We evaluated the correlation of arterial proliferation with plasma levels of TGF beta 1 and TGF beta receptor type 2 , respectively , in Otsuka Long Evans Tokushima Fatty ( OLETF ) rats , a new strain of spontaneous non insulin dependent diabetes mellitus ( NIDDM ) models . ^^^ Immunoreactive TGF beta receptor type 2 antigen was detected by immunohistochemistry on the thoracic artery . ^^^ Furthermore , TGF beta receptor type 2 was detected on aortic wall as strong signals in OLETF rats , but only weakly in LETO rats . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta upregulated not only the expression of endoglin , but also that of TGF beta itself , TGF beta receptor type 2 , collagen 1 , collagen 4 , and fibronectin . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Photocoagulation induced retinal gliosis is inhibited by systemically expressed soluble TGF beta receptor type 2 via adenovirus mediated gene transfer . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH 8 cells by soluble TGF beta receptor type 2 . ^^^ In this study , we established three transfectant clones with stable expression of soluble TGF beta receptor type 2 ( sTRII ) , namely KT 1 , KT 2 and KT 3 , and one with an empty vector used as control vector ( KV ) , and then investigated the effects of sTRII on the tumorigenicity of KDH 8 cells and immune responses in syngeneic Wistar King Aptekman / Hok ( WKAH ) rats . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Mitogenic capacity of the CM , with or without anti TGF beta 1 or anti TbetaRII ( TGF beta receptor type 2 ) antibodies , was also assessed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Moreover , significantly elevated TGF beta receptor type 2 protein level was noted when depth of myometrial invasion of endometrial carcinomas was considered ( P < 0 . 05 ; Mann Whitney U test ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The NTHi induced TGF beta receptor Type 2 phosphorylation occurred at as early as 5 min . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
RESULTS : In normal adult rat retinas , immunoreactivity and mRNA expression of TGF beta receptor type 1 ( TbetaRI ) and TGF beta receptor type 2 ( TbetaRII ) were found in the ganglion cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
However , unlike VACO 411 , MCF 7 lacks cell surface expression of TGF beta receptor type 2 , but does contain an intact postreceptor signaling pathway , as shown by regeneration of TGF beta sensitivity following wild type TGF beta receptor type 2 transfection . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The balloon catheter denudation model was performed on rat carotid artery , and groups of rats were treated with vehicle or a TGF beta inhibitor , a soluble TGF beta receptor type 2 ( TGF beta R : Fc ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We demonstrate that expression of dominant negative TGF beta receptor type 2 by retroviral transduction of DP 153 cells leads to complete loss of TGF beta 1 induced growth inhibition . ^^^ When transplanted s . c . in athymic mice , DP 153 cells expressing dominant negative TGF beta receptor type 2 form tumors as early as 4 weeks , in contrast to the vector control and parental cell line , which do not form tumors even 8 months after transplantation , supporting the observation that TGF beta functions as a tumor suppressor in these cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transgenic mice that express a dominant negative TGF beta receptor type 2 under a T cell specific promoter were generated . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Furthermore , adoptive transfer experiments demonstrated that CD4+CD25+ Treg cells could not control nave or activated islet reactive CD8+ T cells bearing a dominant negative TGF beta receptor type 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We show that TGF beta receptor Type 2 is predominantly present in the basolateral membrane of intestinal epithelial cells . ^^^ In conclusion , we show that : 1 ) TGF beta receptor Type 2 is predominantly located on basolateral membrane and receptor stimulation activates Smad pathway ; 2 ) TGF beta 1 down regulates IL 6 induced tyrosine phoshorylation of STAT 1 and STAT 3 and ICAM 1 expression ; and 3 ) Smad 2 is required for the down regulation of IL 6 signaling by TGF beta . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Antagonistic effects of TNF alpha on TGF beta signaling through down regulation of TGF beta receptor type 2 in human dermal fibroblasts . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta receptor type 2 antibody significantly reversed induction of VEGF secretion by TGF beta . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Localization of recognition site between transforming growth factor beta 1 ( TGF beta 1 ) and TGF beta receptor type 2 : possible implications in breast cancer . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Moreover , down regulating the TGF beta receptor type 2 by the siRNA technique or antagonizing the S1P ( 3 ) receptor subtype with suramin abrogates S1P stimulated Smad phosphorylation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Serum level of transforming growth factor beta 1 ( TGF beta 1 ) and the expression of TGF beta receptor type 2 in peripheral blood mononuclear cells in patients with autoimmune hepatitis . ^^^ BACKGROUND / AIMS : To evaluate the association of the immunosuppressive effects of transforming growth factor beta 1 ( TGF beta 1 ) with abnormalities in immune regulation in autoimmune hepatitis ( AIH ) , we investigated the serum level of TGF beta 1 and expression of TGF beta receptor type 2 ( TbetaRII ) in peripheral blood mononuclear cells ( PBMC ) in patients with AIH . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Using the T cell transfer model of colitis , we show here that CD 4 ( + ) CD45RB ( high ) T cells that express a dominant negative TGF beta receptor type 2 ( dnTbetaRII ) and therefore can not respond to TGF beta , escape control by T reg cells in vivo . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
On the cell surface , TGF beta binds to receptor complexes consisting of TGF beta receptor type 2 ( TbetaRII ) and activin like kinase receptor 5 ( Alk 5 ) , and the downstream signaling is transduced by Smad and MAPK proteins . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Aberrant expression and mutations of TGF beta receptor type 2 gene in endometrial cancer . ^^^ In the present study , we examined aberrant expression and mutation of the gene TGF beta receptor type 2 ( TbetaRII ) in endometrial cancers of endometrioid subtype . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The presence of MSI was investigated in 76 BCCs using mononucleotide microsatellite markers , BAT 25 , BAT 26 and TGF beta receptor type 2 ( TGF beta RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta signalling was clearly involved since TGF beta 1 and TGF beta receptor type 2 protein levels were decreased , while TGF beta ( 1 ) injections into wound margins fully re established wound closure . ^^^ TGF beta signalling was clearly involved since TGF beta 1 and TGF beta receptor type 2 protein levels were decreased , while TGF beta ( 1 ) injections into wound margins fully re established wound closure . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Most interestingly , an in vitro kinase assay showed that PP 1 strongly inhibited the TGF beta receptor type 1 , and to a lesser extent , the TGF beta receptor type 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Mediation by stabilization of TGF beta receptor type 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Using cells from both NOD and BDC2 . 5 mice that express a dominant negative TGF beta receptor type 2 ( TGF betaDNRII ) , we show that 2H6 T cells protected from disease by producing TGF beta and that the ability of the target diabetogenic T cells to respond to TGF beta was crucial . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
PARP regulates TGF beta receptor type 2 expression in estrogen receptor positive breast cancer cell lines . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We demonstrate in this study that a mouse transgenic for directed expression of a dominant negative form of TGF beta receptor type 2 ( dnTGFbetaRII ) , under the direction of the CD 4 promoter , mimics several key phenotypic features of human PBC , including spontaneous production of AMAs directed to the same mitochondrial autoantigens , namely PDC E 2 , BCOADC E 2 , and OGDC E 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression cloning of the TGF beta type 2 receptor , a functional transmembrane serine / threonine kinase . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The amino acid sequence analysis of the peptide fragments produced by cyanogen bromide cleavage of the purified TGF beta type 5 receptor revealed that a peptide , namely CNBr 19 , contained an amino acid sequence which shows homology to the putative ATP binding site of the receptors for activin , the Caenorhabditis elegans daf 1 gene product , and TGF beta type 2 receptor ( Lin , H . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression cloning of the TGF beta type 2 receptor , a functional transmembrane serine / threonine kinase . ^^^ A cDNA encoding the TGF beta type 2 receptor protein has been isolated by an expression cloning strategy . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To determine the relation between the mutation of the TGF beta type 2 receptor gene and genomic instability in the tumorigenesis of hereditary nonpolyposis colorectal cancer ( HNPCC ) , we screened genomic DNA of 38 tumors from 25 HNPCC patients , 15 colorectal cancers from familial adenomatous polyposis patients , and 8 sporadic endometrial cancers , in two areas containing a ( A ) 10 repeat or a ( GT ) 3 repeat of the gene . ^^^ These data suggest that the TGF beta type 2 receptor gene is a major target of genomic instability in HNPCC tumorigenesis . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The TGF beta type 2 receptor ( RII ) was found to be mutated within a polyadenine tract in 100 of 111 ( 90 % ) colorectal cancers with microsatellite instability . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta 1 binds with high affinity ( KD = 25 50 pM ) directly to the TGF beta type 2 receptor serine threonine kinase ( T beta RII ) in the absence of expression of the TGF beta type 1 or 3 receptors ( T beta RI and T beta RIII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In situ analysis of transforming growth factor beta s ( TGF beta 1 , TGF beta 2 , TGF beta 3 ) , and TGF beta type 2 receptor expression in malignant melanoma . ^^^ We have analysed , by in situ hybridization , mRNA expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , and of TGF beta type 2 receptor in benign melanocytic naevi , primary melanomas , and in skin metastases of malignant melanomas . ^^^ In primary melanomas TGF beta type 2 receptor mRNA signals were much more heterogeneously distributed when compared to benign melanocytic naevi , suggesting variable degrees of TGF beta resistance among melanoma cells within individual lesions . ^^^ However , melanoma progression appeared not to be correlated with a complete loss of TGF beta type 2 receptor gene expression , since all skin metastases revealed clearly detectable although heterogeneous levels of TGF beta type 2 receptor mRNA expression . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To measure active TGF beta alone , we have developed a second ELISA using the extracellular domain of the TGF beta type 2 receptor as the capture reagent which detects active TGF beta in serum and plasma samples in the range 20 pmol / l to 4000 pmol / l . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Escape from negative growth regulation by transforming growth factor beta ( TGF beta ) as a result of the loss of TGF beta type 2 receptor ( RII ) expression has been found to be associated with the replication error ( RER ) colorectal cancer genotype , which is characteristic of hereditary nonpolyposis colorectal cancers . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The expression of the TGF beta type 2 receptor mRNA did not change after the addition of PMA or TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The TGF beta type 2 receptor ( T beta R 2 ) is a transmembrane serine / threonine kinase that , upon ligand binding , recruits and phosphorylates a second transmembrane kinase , T beta R 1 , as a requirement for signal transduction . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Repeated pulses of 200 pM of TGF beta did not significantly induce sustained procollagen alpha 1 ( 1 ) mRNA synthesis in normal fibroblasts , and this treatment did not significantly alter the characteristics of normal fibroblasts in a collagen gel . mRNA for both collagen and TGF beta type 2 receptor was induced by TGF beta in both SSc and control cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In situ hybridization and immunohistochemistry of the expression of the TGF beta type 2 receptor confirmed the data obtained by RT PCR . ^^^ In the embryo proper , TGF beta type 2 receptor expression was detected only later in differentiating tissues and developing organs , but not in the brain and neural tube . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
CONCLUSIONS : This decrease in TGF beta type 2 receptor expression may account for the reduction in the sensitivity of hepatocytes to TGF beta after PH . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , 23 midgut carcinoids and 7 endocrine pancreatic tumors were examined for the presence of TGF beta with affinity purified polyclonal antibodies raised against synthetic peptides coding for a specific region of latency associated peptide sequences of TGF beta 1 , beta 2 , beta 3 , a rabbit anti serum against TGF beta binding protein ( LTBP ) and a rabbit polyclonal antibody against TGF beta type 2 receptor ( TGF beta RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here we characterized the properties of the soluble extracellular domain of the human TGF beta type 2 receptor synthesized in COS 7 cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We explored the possibility of inhibiting TGF beta mediated events in glomerular capillary endothelial cells using a TGF beta type 2 receptor ( T beta R 2 ) transdominant negative mutant . ^^^ A mutant TGF beta type 2 receptor ( T beta R IIM ) , lacking the cytoplasmic serine / threonine kinase domain , was produced by polymerase chain reaction using rat T beta R 2 cDNA as template . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Cloning of an isoform of mouse TGF beta type 2 receptor gene . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In situ hybridization and immunohistochemical observations using TGF beta isoform specific [ 35S ] 40 mer oligonucleotide probes and polyclonal antibodies indicate that all the tubal cell types express TGF beta isoforms and TGF beta type 2 receptor mRNA and protein . ^^^ In the epithelial lining , both ciliated and nonciliated cells in the ampullary and isthmus regions appeared to express mRNA and protein for TGF beta s and TGF beta type 2 receptor at a similar level . ^^^ However , the intensity of immunoreactive TGF beta type 2 receptor in these cells did not vary during the cycle as much as that seen with TGF beta s . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The clones which express increased amounts of cyclin D 1 exhibited a decrease in the amount of TGF beta type 2 receptor , indicating a plausible mechanism for their diminished response to TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , we evaluated two GCTs for the presence of transforming growth factor beta 1 ( TGF beta 1 ) and TGF beta type 2 receptor gene transcripts and attempted to establish a possible role for TGF beta 1 in the interaction between tumor cells and osteoclast like cells . ^^^ By using in situ hybridization and Northern blot analysis , we have demonstrated that TGF beta 1 mRNA transcript is consistently detected in both tumor mononuclear cells and osteoclast like cells , whereas TGF beta type 2 receptor gene transcript is only present in osteoclast like cells . ^^^ Moreover , TGF beta type 2 receptor mRNA has been demonstrated in the normal rat osteoclasts and may be involved in the chemotactic action of TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Except for an enhanced muscular transforming growth factor beta 1 ( TGF beta 1 ) and TGF beta type 2 receptor expression , changes in expression patterns of growth factors or receptors were confined to the urothelium . ^^^ In addition , TGF beta type 2 receptor protein expression was similarly enhanced in the same urothelial cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Modulation of responses to TGF beta by 1 , 25 dihydroxyvitamin D 3 in MG 63 osteoblastic cells : possible involvement of regulation of TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of TGF beta s and TGF beta type 2 receptor mRNAs in mouse folliculogenesis : stored maternal TGF beta 2 message in oocytes . ^^^ The present in situ hybridisation study describes expression of TGF beta 1 , TGF beta 2 , TGF beta 3 , and TGF beta type 2 receptor mRNA during follicular development , and the temporal pattern and abundance of TGF beta 2 transcripts in early pre implantation embryos . ^^^ TGF beta 1 hybridisation signals were most prominent in the outer granulosa cell layers of the post antral follicles and in the corpus luteum , whereas strong expression of TGF beta type 2 receptor mRNA was confined to thecal cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
As shown by Northern analysis , diminished TGF beta receptor binding in hypoxia was accompanied by up to a 10 fold decrease in mRNA levels of TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We have found several genetic changes in the TGF beta type 2 receptor gene in human gastric cancer cell lines resistant to the growth inhibitory effect of TGF beta . ^^^ Some of the gastric cancer cells resistant to the growth inhibitory effect of TGF beta express either truncated or no detectable TGF beta type 2 receptor mRNAs , whereas the one that retains responsiveness to the growth inhibitory effect of TGF beta expresses a full size type 2 receptor mRNA . ^^^ Immunoprecipitation followed by Western blot analysis showed parallel changes in TGF beta type 2 receptor expression . ^^^ Our results suggest that one of the possible mechanisms of escape from autocrine or paracrine growth control by TGF beta during carcinogenesis could involve genetic changes in the TGF beta type 2 receptor gene itself or altered expression of its mRNA . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The receptor transiently expressed on COS cells bound TGF beta 1 not by itself but only when TGF beta type 2 receptor was coexpressed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Human uterine tissue throughout the menstrual cycle expresses transforming growth factor beta 1 ( TGF beta 1 ) , TGF beta 2 , TGF beta 3 , and TGF beta type 2 receptor messenger ribonucleic acid and protein and contains [ 125I ] TGF beta 1 binding sites . ^^^ The use of isoform specific transforming growth factor beta ( TGF beta ) primers , 35S labeled 40 mer oligonucleotide probes and polyclonal antibodies , reverse transcription polymerase chain reaction , in situ hybridization , and immunohistochemical observations has revealed that human uterine tissue at various reproductive stages expresses TGF beta s and TGF beta type 2 receptor messenger RNAs ( mRNAs ) and proteins . ^^^ The reverse transcription polymerase chain reaction revealed the predicted 443 , 310 , 524 , and 431 basepair fragments for TGF beta 1 , TGF beta 2 , TGF beta 3 , and TGF beta type 2 receptor , respectively , in both endometrial and myometrial tissues , which were further verified by restriction enzyme analysis . ^^^ The pattern and cellular distribution of TGF beta type 2 receptor protein were similar to those seen with TGF beta isoforms in both endometrial and myometrial tissues . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of transforming growth factor beta ( TGF beta ) isoforms and TGF beta type 2 receptor messenger ribonucleic acid and protein , and the effect of TGF beta s on endometrial stromal cell growth and protein degradation in vitro . ^^^ Reverse transcription polymerase chain reaction analysis of total RNA and immunocytochemical observations revealed that human endometrial glandular epithelial and stromal cells in primary culture express messenger RNAs and proteins for transforming growth factor beta 1 ( TGF beta 1 ) , TGF beta 2 , and TGF beta 3 as well as TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Using this method we demonstrated a difference in size of the TGF beta type 2 receptor between freshly isolated and cultured chondrocytes . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The rat TGF beta type 2 receptor comprises 567 amino acid residues with a cysteine rich extracellular domain , a single transmembrane domain and an intracellular protein kinase domain with predicted serine / threonine specificity . ^^^ RNA blot hybridization and reverse transcription polymerase chain reaction ( RT PCR ) analyses showed that rat TGF beta type 2 receptor is widely distributed in various tissues and is expressed abundantly in the ovary and lung . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The TGF beta type 2 receptor was recently cloned and shown to have a serine / threonine ( S / T ) kinase domain in the cytoplasmic part ; together with the type 1 receptor , it is thought to be most important for signal transduction . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We examined the expressions of latent TGF beta 1 , beta 2 , and beta 3 , the latent TGF beta 1 binding protein ( LTBP ) as well as TGF beta type 2 receptor ( TGF beta RII ) in the synovial biopsy tissues of 21 patients with RA by immunohistochemistry . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In order to assess the biological activities of exogenously added TGF beta 1 , RNA encoding the TGF beta type 2 receptor was introduced into Xenopus embryos . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Despite the presence of a normal TGF beta type 2 receptor gene , the mRNA transcript of the gene was undetectable by the extremely sensitive Intron differential RNA / PCR method . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Cloning of a TGF beta type 1 receptor that forms a heteromeric complex with the TGF beta type 2 receptor . ^^^ Immunoprecipitation of the cross linked complexes by antibodies against the cloned receptor revealed the 70 kd complex as well as a 94 kd TGF beta type 2 receptor complex . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The rat TGF beta type 2 receptor ( TGF beta RII ) homolog was cloned by screening a rat kidney cDNA library with a human TGF beta RII cDNA probe , and sequenced . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta s and TGF beta type 2 receptor in human epidermis : differential expression in acute and chronic skin wounds . ^^^ In humans , TGF beta 3 is constitutively expressed in the epidermis of intact skin and in that of acute and chronic wounds a pattern of expression closely mirrored by the TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We demonstrate that primary cultured human thymic epithelial cells ( TEC ) express TGF beta 1 , TGF beta 2 and TGF beta 3 , as well as TGF beta type 1 receptor ( T beta RI ) ( ALK 5 ) and TGF beta type 2 receptor ( T beta RII ) transcripts . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Recent studies have revealed that upon TGF beta binding several serine and threonine residues in the GS domain of TGF beta type 1 receptor ( T beta R 1 ) are phosphorylated by TGF beta type 2 receptor ( T beta R 2 ) and that the phosphorylation of GS domain is essential for TGF beta signaling . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta 1 and TGF beta 2 mRNAs were expressed at higher levels in QTT T1C cells than in FRLE and TR T1C cells , and there was an increase in TGF beta type 2 receptor ( TGR betaR ) mRNA expression in QTT T1C and RT T1C cells compared to FRLE cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Furthermore , the release is dependent on the kinase activity of the TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
A reduction in the autophosphorylation the TGF beta type 2 receptor protein , a constitutively active serine / threonine kinase , however , was detected in psoriatic DMEC . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Whereas expression of TGF beta 1 , TGF beta 2 , and TGF beta type 2 receptor was suppressed by glucocorticoids in normal and wounded skin , expression of TGF beta 3 and TGF beta receptor type 1 mRNA was stimulated . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In the signal transduction of transforming growth factor beta ( TGF beta ) , the TGF beta type 2 receptor ( betaR 2 ) binds TGF beta , presents the ligand to type 1 receptor , and forms a heterodimeric receptor complex that functions as an active signaling receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , we utilized a set of antibodies selective for the extracellular and intracellular domains of the TGF beta type 2 receptor as probes to investigate the intrinsic kinase activity of this receptor and its physical association in multimeric complexes with type 1 and type 3 receptors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The amount of TGF beta type 2 receptor on the surface of HBx gene transfected cells was about half of that on the parent or pRc / CMV transfected cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The TGF beta type 2 receptor , Tgfbr 2 , maps to distal mouse chromosome 9 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The pathway of TGF beta 1 suppression is independent of the p 53 and Rb genes , but requires an intact TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In situ analysis of transforming growth factors beta ( TGF beta 1 , TGF beta 2 , TGF beta 3 ) and TGF beta type 2 receptor expression in basal cell carcinomas . ^^^ In the present study , we have analysed and compared , by in situ hybridization , mRNA expression of transforming growth factors beta ( TGF beta 1 , TGF beta 2 , TGF beta 3 ) and TGF beta type 2 receptor ( T beta R 2 ) , and , by immunohistochemistry , the distribution of TGF beta 3 protein in normal human skin and in basal cell carcinoma ( BCC ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The promoter structure of TGF beta type 2 receptor revealed by `` oligo capping ' ' method and deletion analysis . ^^^ The promoter of TGF beta type 2 receptor lacks TATA box or CAAT box . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Furthermore , competition based quantitative reverse transcription PCR using synthetic internal standards revealed that leiomyomata express a significantly higher number ( copies per cell ) of TGF beta type 2 receptor mRNA , followed by TGF beta 1 , TGF beta type 1 receptor , TGF beta 2 , and TGF beta 3 ( P < 0 . 05 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
VES treated MDA MB 435 cells exhibited enhanced binding of radiolabeled TGF beta 1 , and Western immunoblotting analyses showed that VES treatment enhanced TGF beta type 2 receptor protein expression . ^^^ Although the mRNA transcript for the 5 . 5 kb TGF beta type 2 receptor was upregulated after four hours of treatment with VES , this treatment did not modify the 6 . 5 kb TGF beta type 1 or the 6 . 5 kb TGF beta type 2 receptor mRNAs . ^^^ Results demonstrate that biologically active TGF beta 1 , beta 2 , beta 3 and levels of TGF beta type 2 receptor expressed by human breast cancer cells are enhanced by VES treatment . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Thus , E2F 4 may be a clue of the target gene of defective repair genes in CRC with genetic instability in addition to the TGF beta type 2 receptor gene . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To determine the relation between the mutation of the TGF beta type 2 receptor gene and genomic instability in the tumorigenesis of HNPCC , we screened genomic DNA of tumors from HNPCC patients . ^^^ These data suggest that the TGF beta type 2 receptor gene is a major target of genomic instability in HNPCC tumorigenesis . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In addition , the recent topics of frequent association of TGF beta type 2 receptor gene insertion / deletion mutation and replication error positive colorectal cancers are also discussed . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) isoforms have differential binding affinities for the TGF beta type 2 receptor ( TbetaRII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We utilized immunoperturbation and antisense oligodeoxynucleotide inhibitory strategies to abrogate TGF beta type 2 receptor function in embryonic mouse lungs undergoing branching morphogenesis in serumless explant culture . ^^^ Antisera directed against a TGF beta type 2 receptor N terminal peptide that perturbs TGF beta ligand receptor binding increased branching by 70 % . ^^^ Similarly , antisense TGF beta type 2 receptor oligodeoxynucleotides ( 40 microM ) resulted in a 58 % increase in branching , compared to scrambled and mismatched sequence controls , while TGF beta , type 2 receptor mRNA and its protein expression levels were suppressed by 95 and 84 % , respectively . ^^^ Addition of exogenous TGF beta 1 did not overcome the stimulatory effects either of TGF beta type 2 receptor immunoperturbation or of antisense oligodeoxynucleotide treatment on lung branching morphogenesis . ^^^ Using in situ hybridization and immunohistochemistry , both TGF beta type 2 receptor mRNA and protein were localized to the epithelium lining the developing airways , and to the surrounding mesenchyme , indicating that TGF beta type 2 receptor is an important regulator of epithelial mesenchymal interaction . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Our data showed that the expression of TGF beta 1 is not altered in patients CD34+ cells ; in contrast , the expression of TGF beta type 2 receptor is significantly decreased in such cells , as compared with CD34+ cells from healthy subjects . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Mechanism of E1A induced transforming growth factor beta ( TGF beta ) resistance in mouse keratinocytes involves repression of TGF beta type 2 receptor transcription . ^^^ We demonstrate that development of resistance occurs simultaneously with decreased expression of TGF beta type 2 receptor ( TGF beta RII ) mRNA and protein . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Chem . 272 , 1110 1116 ) . p 36 is a WD 40 repeat protein , which is 46 % identical to the p 39 subunit of yeast eIF 3 and is identical to TRIP 1 , a phosphorylation substrate of the TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study we have investigated the expression of the precursor forms of TGF beta 1 , TGF beta 2 , TGF beta 3 , as well as TGF beta type 1 receptor ( TGF betaRI ) and TGF beta type 2 receptor ( TGF betaRII ) in the synovial tissue of arthritic rats during the course of the disease . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Interference of the TGF beta signaling pathway by transient transfection of MDA MB 435 cells with antisense oligomers to TGF beta type 2 receptor ( TGF beta R 2 ) blocked VES induced apoptosis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Cultured aortic smooth muscle cells of diabetic rats expressed TGF beta type 2 receptor about 8 . 7 times that of controls at the protein level and 5 . 7 times at the mRNA level , whereas the expression of the type 1 receptor did not differ between the two types of smooth muscle cells . ^^^ Furthermore , protein expression of fibronectin , and mRNA and protein of TGF beta type 2 receptor were increased in the diabetic aorta compared with the control aorta in vivo , implying the importance of the TGF beta fibronectin pathway for the unique biology of smooth muscle cells in the diabetic artery . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of TGF beta type 2 receptor mRNA in the CNS . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
When COS 1 cells were transfected with type 2 receptor cDNAs , GDF 5 bound to Activin type 2 receptor ( ActR 2 ) and type IIB receptors as well as BMPR 2 but not to TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Recent studies have identified TGF beta type 2 receptor ( RII ) mutations in a subset of cancers , including colon cancer . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Changes in levels of mRNAs of transforming growth factor ( TGF ) beta 1 , beta 2 , beta 3 , TGF beta type 2 receptor and sulfated glycoprotein 2 during apoptosis of mouse uterine epithelium . ^^^ However , estrogen deprivation caused a gradual increase in the level of TGF beta type 2 receptor mRNA , and its level increased about six fold six days later . ^^^ Moreover , E 2 , P , and DHT markedly decreased the level of TGF beta type 2 receptor mRNA . ^^^ In situ hybridization demonstrated that mRNAs of TGF beta 1 , beta 2 , beta 3 and TGF beta type 2 receptor were localized to the epithelium . ^^^ Therefore , the present results suggest that increased sensitivity of uterine epithelial cells to TGF betas , as demonstrated by an increase in TGF beta type 2 receptor mRNA , is involved in the induction of apoptosis after estrogen deprivation , although signals produced by TGF betas do not appear sufficient to induce apoptosis . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHOD : To determine the roles of the transforming growth factor beta 1 ( TGF beta 1 ) , and TGF beta type 1 receptor ( T beta R 1 ) , and the TGF beta type 2 receptor ( T beta R 2 ) in the progression of a pulmonary adenocarcinoma , their respective expressions have been immunohistologically studied in specimens from 120 pulmonary adenocarcinoma patients . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Whereas all cell lines exhibited TGF beta type 2 receptor mRNA , type 1 receptor mRNA could be detected only in 3 cell lines . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We showed that restoration of TGF beta induced transcriptional responses by Smad 4 was inhibited by co transfection with a kinase dead TGF beta type 2 receptor and that constitutive activation was blocked with TGF beta neutralizing antibodies , confirming the essential role of Smad 4 in TGF beta signaling . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
None of these cell lines expressed more than one tenth the level of TGF beta type 2 receptor ( T beta R 2 ) gene mRNA produced by TGF beta sensitive normal epithelial cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The sequence of the fragment which correspond to the type 2 receptor showed partial homology with the promoter region of the human TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of a dominant negative mutant TGF beta type 2 receptor in transgenic mice reveals essential roles for TGF beta in regulation of growth and differentiation in the exocrine pancreas . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We examined TGF beta , TGF beta type 2 receptor ( TGF beta RII ) , and p 27 expression in normal pituitaries , pituitary adenomas , and carcinomas to analyze the possible roles of these proteins in pituitary tumorigenesis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The increased apoptosis was related to endogenous activation and was possibly mediated through increased expression of the TGF beta Type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Growth on control collagen inhibited TGF beta type 2 receptor binding in 10B cells , while this inhibition was reduced by AGE modification . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Northern blot analysis further detected TGF beta type 2 receptor ( T beta R 2 ) mRNA transcript in addition to the above identified receptors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We have shown that TGF beta induces p21waf1 expression in Panc 1 cells , whereas no induction of p21waf1 expression by TGF beta was detected in the other four cell lines lacking either DPC 4 expression or the TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Analyses of the APC and TGF beta type 2 receptor genes , and microsatellite instability in mucosal colorectal carcinomas . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta protects human hNT cells from degeneration induced by beta amyloid peptide : involvement of the TGF beta type 2 receptor . ^^^ Results of RT PCR , immunohistochemistry and analysis of receptor cross linking of [ 125I ] TGF beta 1 to the cell membrane , all showed that the TGF beta type 2 receptor is expressed by hNT cells , but not NT2 / D1 cells . ^^^ These results suggest that TGF beta can protect human , terminally differentiated , TGF beta type 2 receptor positive neurons from A beta P toxicity . ^^^ We propose that the increased expression of TGF beta in brains of patients with Alzheimer ' s disease may offer some degree of neuroprotection if neurons also express a functional TGF beta type 2 receptor . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of a truncated , kinase defective TGF beta type 2 receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of alpha smooth muscle actin , TGF beta 1 and TGF beta type 2 receptor during connective tissue contraction . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Corresponding increases in the levels of proliferating cell nuclear antigen ( PCNA ) and intracellular TGF beta 3 expression and a downregulation of the TGF beta type 2 receptor expression were also observed in the granulation tissue of the ulcer margins . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The role of bone derived TGF beta in the development and progression of bone metastasis was studied by transfecting MDA MB 231 cells with a cDNA encoding a TGF beta type 2 receptor lacking a cytoplasmic domain , which acts as a dominant negative to block the cellular response to TGF beta . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Previous work has shown that loss of functional TGF beta type 2 receptor ( RII ) due to a frameshift mutation in the 5 ' half of the RII gene leads to TGF beta resistance in a highly progressed , RER+ human colon carcinoma cell line designated HCT 116 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
JE cells expressed more TGF beta type 2 receptor specific mRNA than did OGE cells , but TGF beta 1 mRNA expression was similar in JE and OGE cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In the present study we have analyzed and compared , by immunohistochemistry and in situ hybridization , the expression pattern of the R4 / ALK5 transforming growth factor ( TGF ) beta type 1 receptor ( RI ) and the TGF beta type 2 receptor ( RII ) in normal human skin , in wounded skin at various stages during the transition of wound granulation tissue to scar , and in long persisting post burn hypertrophic scars . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To identify the target cells of transforming growth factor beta ( TGF beta ) in normal bone tissue , we examined TGF beta type 2 receptor expression using immunohistochemistry , reverse transcription polymerase chain reaction ( RT PCR ) , and in situ hybridization in young rat tibiae . ^^^ In the epiphyseal growth plate , the TGF beta type 2 receptor cDNA was detected by RT PCR and , alternatively , the TGF beta type 2 receptor protein and mRNA expression were observed in the chondrocytes in the lower part of the proliferative cell layer , and in maturative and hypertrophic cell layers by immunohistochemistry and in situ hybridization . ^^^ In the cortical bone area , immunoreactivity for the TGF beta type 2 receptor was detected in the fibroblastic cells near the osteoblasts on the endosteal surface of cortical bone . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Thus , inhibition of endogenous Smad 3 and Smad 2 gene expression resulted in stimulation of embryonic lung branching similar to that caused by inhibition of TGF beta type 2 receptor expression and signaling ( J . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To test this hypothesis , we measured mRNA encoding TGF beta 1 , the TGF beta Type 2 receptor and fibronectin , a key matrix component of the TGF beta 1 tissue response , after incubation of mesangial cells with glycated albumin . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta type 2 receptor in rat renal vascular development : localization to juxtaglomerular cells . ^^^ On gestational day 15 , TGF beta type 2 receptor immunoreactivity was restricted to perirenal stromal and vascular cells . ^^^ On gestational day 17 TGF beta type 2 receptor immunoreactive stromal cells were observed within the kidney , with the same distribution as stromal alpha smooth muscle actin and renin immunoreactive cells , and intense stromal TGF beta type 2 receptor immunoreactivity continued through postnatal day 5 . ^^^ As vascular development progressed , TGF beta type 2 receptor , alpha smooth muscle actin and renin immunoreactivity became progressively restricted to small renal arteries and arterioles . ^^^ Intense TGF beta type 2 receptor expression in renal stromal vascular smooth muscle cell precursors and developing blood vessels suggests a role for the TGF beta type 2 receptors in the formation of the renal vascular smooth muscle compartment . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The critical role of the TGF beta 1 and the TGF beta type 2 receptor in blood vessel formation in the yolk sac has been demonstrated by gene deletion experiments . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Epithelium specific adenoviral transfer of a dominant negative mutant TGF beta type 2 receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF AA . ^^^ A recombinant adenovirus was constructed , containing a mutated human TGF beta type 2 receptor with a truncated cytoplasmic kinase domain . ^^^ This resulted in over expression of exogenous truncated TGF beta type 2 receptor only in airway epithelium , not in mesenchyme , as assessed by mRNA level and protein localization . ^^^ Blockade of endogenous TGF beta receptor signaling in epithelial endoderm by the mutated dominant negative TGF beta type 2 receptor resulted in significant ( 65 % ) stimulation of epithelial branching morphogenesis , while exogenous TGF beta no longer downregulated epithelial PCNA immunoreactivity and surfactant protein C ( SP C ) expression . ^^^ We conclude that epithelium specific adenovirus mediated over expression of a dominant negative TGF beta type 2 receptor completely and specifically abolished the anti proliferative effects of both endogenous and exogenous TGF beta . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To evaluate the role of endogenous TGF betas in the growth and differentiation of the mammary gland in vivo , we have targeted expression of a truncated , kinase defective TGF beta type 2 receptor to mammary epithelial cells in transgenic mice using the mouse mammary tumor virus promoter / enhancer . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
These cells can also express TGF beta type 2 receptor and betaglycan . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We compared the expression of mRNA for alpha 1 ( 1 ) collagen , TGF beta , TGF beta type 1 receptor and TGF beta type 2 receptor in early and late passage fibroblasts by Northern blot hybridizations . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
SHR derived VSMC show the distinct expression and abnormal regulation by Ang 2 of TGF beta receptors when compared with cells from WKY rats , which express TGF beta type 2 receptor predominantly to induce PDGF A chain stimulation of VSMC growth . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In support of this hypothesis , we found that steady state levels of mRNA encoding the TGF beta type 2 receptor were significantly increased in renal cortex from db / db diabetic mice . ^^^ Additionally , the translated TGF beta type 2 receptor protein , assessed by immunoblot , also was increased in diabetic kidneys . ^^^ The findings are consistent with upregulation of TGF beta type 2 receptor activity as a consequence of hyperglycemia in the hyperinsulinemic db / db mouse and suggest that hyperinsulinemia inhibits TGF beta 1 production . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
CM also inhibited DNA synthesis in Mv1Lu wild type epithelial cells , but not DR 27 mutant epithelial cells which lack TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study we examined the possible correlations between radiobiological parameters and the expression of the TGF beta type 2 receptor ( TGF beta rII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Betaglycan was immunolocalized mainly to the epithelial cells in developing airways , a spatial distribution which overlaps with that of TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We investigated whether in vivo gene transfer of chimeric proteins , composed of the extracellular domain of TGF beta type 2 receptor fused with IgC Fc , suppresses experimental glomerulonephritis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Genetic alterations are frequent in APC but rare in the TGF beta type 2 receptor gene in cancer in adenomas of the colon . ^^^ We searched for alterations in the APC mutation cluster region , the whole coding regions of TGF beta type 2 receptor ( RII ) and beta catenin exon 3 in 16 cases of cancer in adenomas of the colon . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : The mRNA expression of TGF beta 1 , TGF beta type 1 receptor ( TGFbetaRI ) , TGF beta type 2 receptor ( TGFbetaRII ) and TGF beta type 3 receptor ( TGFbetaRIII ) in rat livers injured by CCl 4 administration was studied by Northern blotting . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Stretch induced collagen and total protein synthesis was further inhibited by either an anti TGF beta 1 neutralizing antibody or an adenovirus mediated transfer of a truncated TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
HNPCC associated with germline mutation in the TGF beta type 2 receptor gene . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Importantly , four of four clones that had been stably transfected with a dominant negative TGF beta type 2 receptor were unable to undergo this mesenchymal switch in vivo , despite the fact that all clones stably transfected with neomyocin resistance alone retained their spindle characteristics in vivo . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Furthermore , sTbetaR 1 is a functional protein capable of binding TGF beta 1 ligands in the presence of a TGF beta type 2 receptor on the cell surface , as determined by affinity cross linking with 125I labeled TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Fibronectin synthesis stimulated with 10 microg ml ( 1 ) of saponin was inhibited with 69 % by 5 microg ml ( 1 ) of an anti TGF beta 1 antibody . mRNA of TGF beta type 1 receptor increased 4 . 8 and 4 . 4 fold at fibroblasts treated with 1 and 10 microg ml ( 1 ) of saponin , respectively , and that of TGF beta type 2 receptor also increased 3 . 4 and 3 . 2 fold at fibroblasts treated with 1 and 10 microg ml ( 1 ) of saponin , respectively . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Furthermore , absence of frameshift mutations in the polypurine tracts present in the coding sequence of the TGF beta type 2 receptor ( TGF beta IIR ) and Bax implies that loss of function of BRCA 1 or BRCA 2 does not confer a mutator phenotype such as that found in tumours with microsatellite instability ( MSI ) . p21Waf1 was expressed in BRCA associated tumours regardless of p 53 status and , furthermore , some tumours expressing wild type p 53 did not express detectable p21Waf1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The transforming growth factor beta ( TGF beta ) receptor interacting protein TRIP 1 was originally identified as a WD 40 repeat containing protein that has the ability to associate with the TGF beta type 2 receptor and is phosphorylated by it ( 1 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Somatic alterations of the TGF beta type 2 receptor gene ( TGFBR 2 ) were identified in 4 of 97 ( 4 . 1 % ) pancreas cancers , including a homozygous deletion in a replication error negative cancer and three homozygous frameshift mutations of the poly ( A ) tract of the TGF beta type 2 receptor in replication error positive cancers . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Signal transduction by TGF beta 1 involves direct binding to the TGF beta Type 2 receptor and then the formation of a heterodimeric complex of TGF beta Type 1 and Type 2 receptor . ^^^ To explore the role of TGF beta 1 in thyroid carcinoma , we examined the expression of TGF beta 1 and TGF beta Type 2 receptor mRNA by northern blotting analysis in both 14 papillary thyroid carcinomas and surrounding normal thyroid tissues . ^^^ In contrast , the relative mRNA levels of TGF beta Type 2 receptor were reduced to 60 . 1+ / 18 . 3 % of those of normal thyroid tissues in 10 papillary thyroid carcinomas . ^^^ There were no clear relationships between the relative mRNA levels for TGF beta 1 and TGF beta Type 2 receptor and the histological characteristics of papillary thyroid carcinomas . ^^^ The relative mRNA levels for TGF beta 1 and TGF beta Type 2 receptor did not show significant differences in thyroid carcinomas with or without lymph node metastases . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
It binds TGF beta 1 and beta 3 by associating with the TGF beta type 2 receptor and interacts with activin A and BMP 7 via activin type 2 receptors , ActRII and ActRIIB , regardless of which type 1 receptor partner is coexpressed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Truncation of the TGF beta type 2 receptor gene results in insensitivity to TGF beta in human gastric cancer cells . ^^^ It has been reported that resistance to TGF beta correlates with inactivation of the TGF beta type 2 receptor ( RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of a dominant negative mutant ( TbetaRIIDeltacyt ) of the TGF beta type 2 receptor rendered the human breast cancer cell line MDA MB 231 unresponsive to TGF beta . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : We generated a chimeric cDNA , termed TGF beta RII / Fc , encoding an extracellular domain of the TGF beta type 2 receptor fused to the IgG Fc domain , and tested whether TGF beta RII / Fc could be a novel strategy for treating glomerular diseases . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
After E9 . 0 , the yolk sacs of the mutants contain red blood cells but lack a well organized vasculature , which is reminiscent of BMP 4 , TGF beta 1 and TGF beta type 2 receptor knockout mice . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transgenic mice that overexpress a dominant negative mutation of the TGF beta type 2 receptor ( DNIIR ) under the control of a metallothionein derived promoter ( MT DNIIR ) were used to determine the role of endogenous TGF betas in the developing mammary gland . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Taken together , these results show for the first time that TGF beta type 2 receptor expression can be controlled by alpha5beta1 ligation and integrin signal transduction . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The TGF beta type 2 receptor in chronic myeloid leukemia : analysis of microsatellite regions and gene expression . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
BACKGROUND : TGF beta type 2 receptor is considered as one of the tumor suppressor genes , and altered expression of TGF beta RII has been found in many kinds of cancers . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Indeed , 786 O cells were found to express no TGF beta type 2 receptor protein , thus allowing them to escape from the negative growth control of TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Albumin modified by Amadori glucose adducts induces coordinate increases in the expression of extracellular matrix proteins , transforming growth factor ( TGF ) beta 1 , and the TGF beta type 2 receptor in glomerular mesangial cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The phenotype found was very similar to that reported for transgenic mice expressing a dominant negative mutant TGF beta type 2 receptor ( TGFbetaRII mice ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We recently reported a germline mutation , i . e . , substitution of methionine for threonine at codon 315 in the kinase subdomain 4 , of the TGF beta type 2 receptor gene in a kindred of hereditary nonpolyposis colorectal cancer without microsatellite instability and found that the mutant receptor abolished the signal transduction for growth inhibition by TGF beta . ^^^ These data suggest that threonine 315 of the TGF beta type 2 receptor is dispensable for extracellular matrix protein production , but is essential for the growth inhibition by TGF beta , and that the lack of growth inhibition due to the mutant receptor is possibly mediated through its failure to upregulate p 15 ( INK4B ) . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We show here that the transforming growth factors beta 2 and beta 3 ( TGF beta ) and the TGF beta type 2 receptor are expressed in the embryonic rat raphe , when 5 HT neurons develop and differentiate . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Upon treatment of cell clones with TGF beta 1 , the NF kappaB activity in NS SV AC and HSGc , but not in cl 1 , which lacks the expression of TGF beta type 2 receptor , was suppressed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Gastric carcinomas with microsatellite instability : clinical features and mutations to the TGF beta type 2 receptor , IGFII receptor , and BAX genes . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The phylogenetic tree suggests that the sponge receptors sALK 1 sALK 3 , which are closely related to each other , are sponge homologs of vertebrate activin type 1 receptor ( ActR 1 ) . sALK 5 is likely to be a homolog of TGF beta type 2 receptor . sALK 4 and sALK 6 might be ancestral precursors of type 1 and type 2 receptors , respectively , and sALK 7 is possibly an ancestral precursor of both types . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We next investigated whether TGF beta type 2 receptor ( RII ) was involved in this regulation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Given that COX 2 is induced by transforming growth factor ( TGF ) beta and that TGF beta type 2 receptor ( RII ) mutations are found in HNPCCs , we determined the relationship between RII status and COX 2 expression . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here we tested the hypothesis that TGF beta type 2 receptor ( TGF beta IIR ) is a critical component in the TGF beta signaling pathway regulating tooth formation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Analysis of microsatellite instability , TGF beta type 2 receptor gene mutations and hMSH 2 and hMLH 1 allele losses in pancreaticobiliary maljunction associated biliary tract tumors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In particular , although at least five studies have concluded that active TGF beta is present in normal human plasma and serum , assays that use the extracellular domain of the TGF beta type 2 receptor as a capture agent have given contradictory results . ^^^ We show that there is an antagonist present in normal human serum which inhibits the binding of active TGF beta to the extracellular domain of the TGF beta type 2 receptor when it is coated on the well of an ELISA plate . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Repression of the gene encoding the TGF beta type 2 receptor is a major target of the EWS FLI 1 oncoprotein . ^^^ Because ETS transcription factors regulate expression of TGFBR 2 ( encoding the TGF beta type 2 receptor , TGF beta RII ; Refs 9 , 14 ) , a putative tumour suppressor gene , we hypothesized that TGFBR 2 may be a target of the EWS FLI 1 fusion protein . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Such an inhibition by exogenous TGF beta 1 was abolished by liposomal transfection of antisense oligodeoxynucleotide for the TGF beta type 2 receptor . ^^^ However , 10 microM antisense oligodeoxynucleotide for the TGF beta type 2 receptor seemed to attenuate the inhibition by TGF beta 1 . 1 10 10 ( 7 ) M AVP significantly increased inositol 1 , 4 , 5 trisphosphate ( IP 3 ) production by 1 . 8 fold , but this production was totally blunted by 1 ng / ml TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The antagonist consisted of a chimeric IgG containing the extracellular portion of the TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Co transfection into SW480 . 7 cells of Smad 4 together with a Ras phosphorylation resistant Smad 3 ( but not with wild type Smad 2 , Smad 3 , adenomatous polyposis coli ( APC ) , or TGF beta type 2 receptor ) restored the TGF beta antiproliferative response . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transfection of a dominant negative mutant of mouse TGF beta type 2 receptor to undifferentiated ATDC 5 cells completely inhibited cellular condensation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
A fluorescent ligase based assay [ polymerase chain reaction / ligase detection reaction ( PCR / LDR ) ] correlated with results obtained using a radioactive assay to detect instability within the TGF beta Type 2 receptor gene . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta involvement in 4 HPR induced apoptosis , but not DNA synthesis arrest , in MDA MB 435 cells was demonstrated by 1 ) blockage of 4 HPR induced apoptosis by 66 75 % after treatment of cells with neutralizing antibodies to TGF beta s , 2 ) blockage of 4 HPR induced apoptosis by 64 67 % after transient transfection of cells with antisense oligomers to TGF beta 1 or TGF beta type 2 receptor , 3 ) blockage of 4 HPR induced apoptosis by approximately 50 % after inhibition of latent TGF beta activation , and 4 ) demonstration that human breast cancer cells ( T47D ) defective in TGF beta signaling were refractive to 4 HPR induced apoptosis . ^^^ TGF beta involvement in 4 HPR induced apoptosis , but not DNA synthesis arrest , in MDA MB 435 cells was demonstrated by 1 ) blockage of 4 HPR induced apoptosis by 66 75 % after treatment of cells with neutralizing antibodies to TGF beta s , 2 ) blockage of 4 HPR induced apoptosis by 64 67 % after transient transfection of cells with antisense oligomers to TGF beta 1 or TGF beta type 2 receptor , 3 ) blockage of 4 HPR induced apoptosis by approximately 50 % after inhibition of latent TGF beta activation , and 4 ) demonstration that human breast cancer cells ( T47D ) defective in TGF beta signaling were refractive to 4 HPR induced apoptosis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here , the authors examine the influence of TGF beta produced after an episode of cerebral ischemia by injecting a soluble TGF beta type 2 receptor fused with the Fc region of a human immunoglobulin ( TbetaRIIs Fc ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Messenger RNA ( mRNA ) was isolated from the nucleus pulposus using oligo ( dT ) 25 superparamagnetic beads and probing with gene specific primers in RT PCR . mRNA coding for TGF alpha ( 3 / 10 ) , EGF ( 0 / 10 ) , TGF beta 1 ( 0 / 10 ) and TGF beta 3 ( 2 / 10 ) or the EGF receptor ( EGF R ; 0 / 10 ) and TGF beta type 2 receptor ( 0 / 10 ) was found only occasionally . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The mutational status was compared for von Hippel Lindau ( VHL ) , p 53 , TGF beta type 2 receptor ( TGF betaRII ) , hMSH 2 , and hMLH 1 genes in the cell lines and their corresponding tumour tissues . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Over expression of ERT ( ESX / ESE 1 / ELF3 ) , an ets related transcription factor , induces endogenous TGF beta type 2 receptor expression and restores the TGF beta signaling pathway in Hs578t human breast cancer cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We constructed an adenovirus expressing an entire ectodomain of human TGF beta type 2 receptor fused to the Fc portion of human IgG ( AdTbeta ExR ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Bone biopsies were immuno histochemically stained for TGF beta 1 , IGF 1 , TGF beta type 2 receptor , IGF receptor , and proliferating cell nuclear antigen ( PCNA ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
HepG 2 and Hep3B cells do not express the TGF beta type 2 receptor while SK HEP 1 cells express 7x the level found in mink lung MvLu 1 cells . ^^^ KATO 3 cells are lacking in the TGF beta type 2 receptor while Hs 746T , RF 1 and RF 48 cells express 10x , 0 . 8x , and 1x the levels in mink lung MvLu 1 cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
HCT 116 cells lack TGF beta type 2 receptors , but stable transfection of TGF beta type 2 receptor cDNA did not alter the cellular response to mechanical deformation , as assessed by cell proliferation , morphology , or gene expression . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We review here a specific pathway of mutational inactivation of the TGF beta type 2 receptor resulting from microsatellite instability and demonstrate that , by contrast , the most common mechanism of loss of expression of the TGF beta type 2 receptor involves transcriptional repression . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Release from quiescence of primitive human hematopoietic stem / progenitor cells by blocking their cell surface TGF beta type 2 receptor in a short term in vitro assay . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Double visualization of TGF beta type 2 receptor ( TGFRII ) and TUNEL reactivity revealed colocalization of apoptotic nuclei and TGFRII in catagen follicles . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To determine the role of TGF beta in the initiation or progression of pancreatitis , TGF beta signaling was inactivated in mouse pancreata by overexpressing a dominant negative mutant form of TGF beta type 2 receptor in the pancreas , under control of the pS 2 mouse trefoil peptide promoter . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Detection of TGF beta type 2 receptor hot spot mutations : the BAT RII assay . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Stimulation of TGF beta type 2 receptor by high glucose in mouse mesangial cells and in diabetic kidney . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Resistance to TGF beta 1 correlates with a reduction of TGF beta type 2 receptor expression in Burkitt ' s lymphoma and Epstein Barr virus transformed B lymphoblastoid cell lines . ^^^ Lack of responsiveness to TGF beta 1 appears to correlate with a down regulation of TGF beta type 2 receptor expression . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Genetic analysis disclosed a nonsense mutation in the Mad homologue 2a domain of the Smad 4 gene in the SK ChA 1 cells and a heterozygous deletion in the TGF beta type 2 receptor gene in the KMBC cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
However , the addition of two different preparations of TSP 1 to recombinant small latent TGF beta 1 in the test tube resulted in only a very small increase in the proportion of the TGF beta 1 able to bind to the TGF beta type 2 receptor : from 0 . 1 % to a maximum of 0 . 4 % . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
BACKGROUND : TGF beta type 2 receptor ( TGF beta RII ) mutations associated with microsatellite instability ( MSI ) are characteristically frameshift mutations within a 10 bp poly A tract . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
No changes were found in TGF beta type 2 receptor or in bcl 10 ( L ) protein levels . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
First , a mutation analysis of the TGF beta type 2 receptor ( TGF beta RII ) was performed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We now show that FPPH is caused by mutations in BMPR 2 , encoding a TGF beta type 2 receptor ( BMPR 2 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Polyamine depletion by DFMO increased levels of the TGF beta type 1 receptor ( TGF betaRI ) mRNA and protein but had no effect on the TGF beta type 2 receptor expression . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To elucidate the role of transforming growth factor beta 1 ( TGF beta 1 ) and the TGF beta type 2 receptor ( TGF beta RII ) as tumor suppressor genes in lung carcinogenesis , we mated C57BL / 6 mice heterozygous ( HT ) for deletion of the TGF beta 1 gene with A / J mice to produce AJBL 6 TGF beta 1 HT progeny and their wild type ( WT ) littermates . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Blockade of TGF beta by in vivo gene transfer of a soluble TGF beta type 2 receptor in the muscle inhibits corneal opacification , edema and angiogenesis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Sequential resonance assignments of the extracellular ligand binding domain of the human TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Furthermore , treatment with TGF beta induced phosphorylation of Smad 2 in each of the SCCs with the exception of the two cell lines that carry inactivating mutations of the TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : TGF beta signalling was inactivated in mouse intestine by expressing a dominant negative mutant form of the TGF beta type 2 receptor under the control of the mouse intestinal trefoil peptide ( ITF ) / TFF3 promoter . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Reversion of transcriptional repression of Sp 1 by 5 aza 2 ' deoxycytidine restores TGF beta type 2 receptor expression in the pancreatic cancer cell line MIA PaCa 2 . ^^^ The pancreatic cancer cell line , MIA PaCa 2 is not responsive to transforming growth factor beta ( TGF beta ) because of a lack of expression of the TGF beta type 2 receptor ( RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Hepatocellular expression of a dominant negative mutant TGF beta type 2 receptor accelerates chemically induced hepatocarcinogenesis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
It has been previously demonstrated that a soluble TGF beta type 2 receptor could be used as a TGF beta antagonist . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Using an inducible system for the expression of a cytoplasmically truncated dominant negative TGF beta type 2 receptor , we blocked TGF beta mediated growth inhibition , transcriptional activation , and EMT progression . ^^^ Dominant negative TGF beta type 2 receptor expression inhibited TGF beta signaling to the SMAD and AKT pathways , but did not block TGF beta mediated p38MAPK activation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of transforming growth factor ( TGF ) beta 1 and TGF beta type 2 receptor in preneoplastic lesions during chemical hepatocarcinogenesis of rats . ^^^ Transforming growth factor ( TGF ) beta 1 is an important apoptotic growth inhibitor of hepatocyte proliferation , and the expression of TGF beta 1 , which regulates cell proliferation , is closely associated with the expression level of TGF beta type 2 receptor ( TGR 2 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Effects of anti TGF beta type 2 receptor antibody on experimental glomerulonephritis . ^^^ Interaction between transforming growth factor beta ( TGF beta ) and TGF beta type 2 receptor ( TGF betaIIR ) may play an important role in the ongoing fibrotic process . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Porcine coronary arteries were randomized to receive a recombinant adenovirus expressing a secreted form of TGF beta type 2 receptor ( Ad 5 RIIs ) , an adenovirus expressing beta galactosidase ( Ad 5 lacZ ) , or vehicle only by intramural injection at the site of PTCA . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We then analyzed TGF beta type 2 receptor ( T beta RII ) gene , immunoblots of Smad 4 , and restoration of the pathway by rescuing T beta R or Smad . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Conversely , in mesangial cells , leptin upregulates synthesis of the TGF beta type 2 receptor , but not TGF beta 1 , and stimulates glucose transport and type 1 collagen production through signal transduction pathways involving phosphatidylinositol 3 kinase . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , a dominant negatively acting mutant of TGF beta type 2 receptor ( TbetaRIIDN ) was transiently expressed in HSCs by using adenoviral vector mediated gene delivery , such that the effects of disrupting the autocrine TGF beta signaling in HSCs can be directly examined at a single cell level . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Labeling for the TGF beta type 2 receptor was seen in Mller cells , ganglion cells and the inner and outer plexiform layers in both normal and detached retinas . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Conditional inactivation of the TGF beta type 2 receptor using Cre : Lox . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Some cell lines have several distinguishing characteristics ; 1 ) two hepatocellular cell lines ( SNU 354 and 368 ) expressing the MDR 1 gene and hepatitis B virus , 2 ) Gastric carcinoma cell lines with mutations in TGF beta type 2 receptor gene , 3 ) uterine cervical carcinoma cell line ( SNU 1000 ) having intact episomal HPV 16 , and 4 ) ovarian carcinoma cell line ( SNU 251 ) have a nonsense mutation of codon 1815 in exon 23 of the BRCA 1 gene . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of a dominant negative TGF beta type 2 receptor in cells that over expressed endogenous TGF beta 1 resulted in enhanced cell growth in vitro and diminished the tumor suppressor effect of the ligand in vivo , indicating that the endogenous TGF beta 1 was acting in an autocrine capacity . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We performed Southern and Northern analysis of TGF beta type 1 and 2 receptors and examined poly adenine track mutation of the TGF beta type 2 receptor , but failed to find any genetic mutation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
CTLs were transduced with a retrovirus vector expressing the dominant negative TGF beta type 2 receptor HATGF betaRII Deltacyt . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : We generated transgenic mice , called pS 2 dnRII or ITF dnRII , of which the dominant negative mutant of the TGF beta type 2 receptor was expressed under the control of tissue specific promoters , the pS 2 promoter for stomach and ITF for intestine . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We now demonstrate that active TGF beta 1 in the PCT binds to intracellular TGF beta type 2 receptor ( TbetaRII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , we selected two peptides , IM 1 and IM 2 , that bind to the TGF beta type 2 receptor ( TGF beta RII ) using phage display . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Thus , we studied the effect of a soluble Fc : TGF beta type 2 receptor fusion protein ( Fc : TbetaRII ) on transgenic and transplantable models of breast cancer metastases . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Crystallization and preliminary crystallographic studies of human TGF beta type 2 receptor ligand binding domain . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We wanted to ask whether a lethal inflammatory phenotype would develop following transplantation of bone marrow deficient for the TGF beta type 2 receptor ( TbetaRII ) gene to normal recipient animals . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Decreased expression of TGF beta type 2 receptor in primary B cell lymphomas of the stomach . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We demonstrate that in vivo both mature and immature ORNs , and possibly a basal neuronal progenitor cell , express the TGF beta type 2 receptor ( TGF betaRII ) , suggesting that these cells are targets for TGF beta signaling . ^^^ Because TGF alpha overexpression has been reported to affect TGF beta signaling in other epithelia , we compared the expression of the TGF beta type 2 receptor ( TGF betaRII ) in T and NT mice . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : The authors performed intratracheal microinjections of a recombinant adenoviral vector encoding a dominant negative TGF beta type 2 receptor ( AdIIR DN ) in nitrofen exposed and control E 12 mouse lungs , which then were cultured for 4 days in serumless chemically defined media . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Unlike in other renal cell types , HG did not increase TGF beta 1 mRNA or protein in the podocyte , but HG did induce the expression of the ligand binding TGF beta type 2 receptor ( TbetaRII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
These genes were TGF beta type 1 receptor gene ( TGFBR 1 ) , TGF beta type 2 receptor gene ( TGFBR 2 ) , SMAD 2 gene ( SMAD 2 ) , SMAD 3 gene ( SMAD 3 ) , SMAD 4 gene ( SMAD 4 ) , and SMAD 7 gene ( SMAD 7 ) , all of which compose the TGF beta 1 signaling pathway . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The expression of TGF beta type 2 receptor protein was decreased in two of seven cell lines , and the expression of both Smad 2 and Smad 3 proteins was decreased in only one cell line . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Gene transfer of soluble TGF beta type 2 receptor inhibits experimental proliferative vitreoretinopathy . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Reconstitution of lethally irradiated adult mice with dominant negative TGF beta type 2 receptor transduced bone marrow leads to myeloid expansion and inflammatory disease . ^^^ Here we report the development of a murine model of TGF beta insensitivity limited to the hemopoietic tissue of adult wild type C57BL / 6 mice based on retroviral mediated gene transfer of a dominant negative TGF beta type 2 receptor targeting murine bone marrow . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In the present study , we performed an immunohistochemical examination of the expression of transforming growth factor beta ( TGF beta ) , TGF beta type 2 receptor ( TGF beta RII ) and a trefoil peptide , pS 2 , in the several types of gastric cancer . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Role of TGF beta 1 and TGF beta type 2 receptor in gastric cancer . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NCI H 23 , a human non small cell lung adenocarcinoma cell line which has a frameshift mutation in , and reduced expression of , the TGF beta type 2 receptor ( TGF beta RII ) , exhibits resistance to growth inhibition by TGF beta ( 1 ) in vitro . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Farnesyltransferase inhibitor ( L 744 , 832 ) restores TGF beta type 2 receptor expression and enhances radiation sensitivity in K ras mutant pancreatic cancer cell line MIA PaCa 2 . ^^^ Activated ras is known to dysregulate TGF beta signaling by altering the expression of TGF beta type 2 receptor ( RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Rap 1 reverses transcriptional repression of TGF beta type 2 receptor by a mechanism involving AP 1 in the human pancreatic cancer cell line , UK Pan 1 . ^^^ The human pancreatic ductal adenocarcinoma cell line , UK Pan 1 , which expresses DPC 4 , is not highly responsive to TGF beta due to transcriptional repression of TGF beta type 2 receptor ( RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
SF mRNA expression levels for TGF beta 1 , TGF beta type 2 receptor ( TGF beta RII ) , thrombospondin 1 , and latent TGF beta binding protein 1 ( LTBP 1 ) were measured by real time RT PCR . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
For example , in addition to mutations in TGF beta type 2 receptor ( TbetaRII ) that abrogate normal TGF beta function , its expression decreases during the transition from replication to extracellular matrix production , or in response to other growth regulators in bone . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transgenic mice of strain FVB / N were generated expressing a dominant negative TGF beta type 2 receptor in T cells under the control of the human CD 2 promoter / locus control region . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We report that transplantation of murine bone marrow ( BM ) expressing a dominant negative TGF beta type 2 receptor ( TbetaRIIDN ) leads to the generation of mature leukocytes capable of a potent antitumor response in vivo . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Catheter based adenovirus mediated local intravascular gene delivery of a soluble TGF beta type 2 receptor using an infiltrator in porcine coronary arteries : efficacy and complications . ^^^ Recombinant adenoviral vector expressing an ectodomain of the TGF beta type 2 receptor fused to the human immunoglobulin Fc portion ( AdTbeta ExR ) inhibits the action of TGF beta probably either by adsorbing TGF beta or by acting as a dominant negative receptor . ^^^ Local delivery of soluble TGF beta type 2 receptor in this way may provide an effective intravascular gene therapy to inhibit TGF beta signal pathway without any significant systemic side effect . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Chromatin immunoprecipitation revealed a direct interaction of EWS / Fli 1 with the promoter regions of the Id 2 , TGF beta type 2 receptor , cyclin D 1 , and c myc genes . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We demonstrate that impairment of TGF beta signaling in T cells of transgenic mice expressing a dominant negative TGF beta type 2 receptor leads to a decrease in airway reactivity in a non Ag dependent model . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Immunohistochemical analysis revealed that the expression of TGF beta 1 was markedly increased in DICC , especially of the schirrous type , compared to CCC , whereas the expression of the TGF beta type 2 receptor ( RII ) was significantly decreased in DICC compared to CCC . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
These mutations are similar to those of the 10 bp polyadenine tract within the TGF beta type 2 receptor ( TGFBR 2 ) , a well characterized target of frameshift mutations in the same neoplasms . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Stable transfectants were generated of TK 173 cells expressing a dominant negative TGF beta type 2 receptor . ^^^ Importantly , fibroblasts expressing a dominant negative TGF beta type 2 receptor were defective in TGF beta 1 induced fibronectin production , whereas glucose induced fibronectin and collagen type 3 were unaffected . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Staining distribution and intensity for TGF beta , PDGF , VEGF , TGF beta type 2 receptor , a receptor for PDGF , and receptors for VEGF and bFGF were similar in patients and controls . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Fibroblasts from chronic wounds show altered TGF beta signaling and decreased TGF beta Type 2 receptor expression . ^^^ Using Northern analysis and affinity labeling , we show that venous ulcer fibroblasts have decreased TGF beta Type 2 receptor expression . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Finally , when antibody to TGF beta type 2 receptor was added before TGF beta 1 treatment of these fibroblasts , the expression of type 1 collagen and CTGF was significantly reduced . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We generated mice expressing an activated TGF beta type 1 receptor or dominant negative TGF beta type 2 receptor under control of the mouse mammary tumor virus promoter . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Mutational analysis of TGF beta type 2 receptor , Smad 2 , Smad 3 , Smad 4 , Smad 6 and Smad 7 genes in colorectal cancer . ^^^ Then , all coding regions of the TGF beta type 2 receptor ( TRII ) and the genes for Smad 2 , Smad 3 , Smad 4 , Smad 6 , and Smad 7 were analyzed by PCR SSCP and direct sequencing . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In prostate cancer , studies using human samples have correlated the loss of the TGF beta type 2 receptor ( T beta R 2 ) with higher tumor grade . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : We examined the expression patterns of TGF beta 1 , thrombospondin 1 ( TSP 1 ) , TGF beta type 2 receptor ( TGF beta IIR ) , phosphorylated Smad2 / Smad3 , and podocyte specific epitopes [ Wilms ' tumor protein 1 ( WT 1 ) and glomerular epithelial protein 1 ( GLEPP 1 ) ] in 15 renal biopsy specimens with idiopathic FSGS and six renal biopsies with no detectable abnormalities by means of immunohistochemistry . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The effect of TGF beta on pSmad 3 induction was , in part , abrogated by the pretreatment of HES and ESC with TGF beta type 2 receptor antisense oligonucleotides . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
It has previously been reported that the adenovirus mediated overexpression of a soluble receptor against the extracellular domain of the TGF beta type 2 receptor prevents hepatofibrogenesis in vivo , although its inhibitory role and mechanism in HSC activation remains to be elucidated . ^^^ METHODS : In this study , we report on an examination of the actual role of TGF beta inhibition on oxidative stress and the activation of cultured rat HSCs , using the adenovirus mediated soluble TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transcriptional repression of the TGF beta type 2 receptor ( RII ) is one of the mechanisms leading to TGF beta resistance . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of TGF beta type 2 receptor antisense RNA impairs TGF beta signaling in vitro and promotes mammary gland differentiation in vivo . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To define the role of transforming growth factor beta 1 ( TGF beta 1 ) in modulating pericyte contractile phenotype , we have ablated the TGF beta signaling pathway by infection with a retrovirus bearing a TGF beta type 2 receptor with a truncated C terminal intracellular kinase domain ( DNT beta RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
These were inhibited by the TGF beta inhibitor soluble TGF beta type 2 receptor ( TbetaRII : Fc ) , suggesting they were activated by autocrine TGF beta . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In experimental diabetes mellitus , several reports describe overexpression of TGF beta or TGF beta type 2 receptor in the glomerular and tubulointerstitial compartments . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of latency associated peptide TGF beta 1 , latent TGF beta binding protein 1 , TGF beta type 1 receptor , and TGF beta type 2 receptor was readily seen , but only very little TGF beta 1 was activated . ^^^ In erythematous oral lichen , basal and lower spinous epithelial layers showed staining for latency associated peptide TGF beta 1 , TGF beta type 1 receptor , and TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The TGF beta receptor signaling system is also triggered , as evidenced by upregulation of the TGF beta type 2 receptor and activation of the downstream Smad signaling pathway . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
When this element was used to express soluble TGF beta type 2 receptor ( sTbetaRII ) through the gene amplification system , the frequency of colonies expressing detectable amounts of sTbetaRII was much higher than that of the control vector . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The role of transforming growth factor beta ( TGF beta ) signaling in such epithelial mesenchymal interactions was determined by conditional inactivation of the TGF beta type 2 receptor gene in mouse fibroblasts ( Tgfbr2fspKO ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The gene transfer of soluble VEGF type 1 receptor ( Flt 1 ) attenuates peritoneal fibrosis formation in mice but not soluble TGF beta type 2 receptor gene transfer . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Inhibition of endogenous TGF beta with an adenovirus expressing a soluble truncated TGF beta type 2 receptor attenuated the increase in SMC selective gene expression in the ESC EBs , as did an antibody specific for TGF beta 1 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We report here that UV irradiation impairs TGF beta / Smad pathway in human skin by down regulation of TGF beta type 2 receptor ( TbetaRII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : To evaluate this hypothesis , we tested the effects of a soluble TGF beta type 2 receptor ( sTGF beta R ) that specifically inhibits TGF beta 1 and TGF beta 3 in three different murine MM tumor models , AB 12 and AC 29 ( which produce large amounts of TGF beta ) and AB 1 ( which does not produce TGF beta ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To directly address the role of TGF beta signaling in liver regeneration in vivo , the TGF beta type 2 receptor gene ( Tgfbr 2 ) was selectively deleted in hepatocytes by crossing `` floxed ' ' Tgfbr 2 conditional knockout mice with transgenic mice expressing Cre under control of the albumin promoter . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To block intrinsic TGF beta activity completely , we constructed an adenovirus vector expressing a truncated TGF beta type 2 receptor with a dominant negative effect ( AdexTbetaTR ) that blocks TGF beta signal transduction . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Furthermore , co treatment of the cells with GnRH + TGF beta , or pretreatment with TGF beta type 2 receptor antisense to block TGF beta autocrine / paracrine action , in part inhibited TGF beta activated Smad 3 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
This was paralleled by the downregulation of the levels of the EWS / FLI 1 proteins , regardless of their fusion type , and the concomitant restoration of the expression of the TGF beta type 2 receptor ( TGFbeta RII ) , which is known to be repressed by several EWS ETS fusion proteins . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : In the present study , we examined whether decreased expression of the TGF beta type 2 receptor ( TGF betaIIR ) in TGF betaIIR gene heterozygous ( TGF betaIIR+ / ) ( HT ) mice could inhibit the Smad signaling pathway and subsequent progression of renal lesions when streptozotocin ( STZ ) diabetes is induced . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Analysis of transcriptional activity showed that promoter segments containing activating protein ( AP 1 ) binding sites are necessary for albumin induced transcription of the TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Conditional deletion of the TGF beta type 2 receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones . ^^^ To address the question of the role of TGF beta signaling in skeletal development , we generated mice with a conditional deletion of the TGF beta type 2 receptor gene ( Tgfbr 2 ) specifically in Col2a expressing cells using the Cre / lox recombinase system . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
This effect was inhibited by neutralizing antibodies to either TGF beta or to the TGF beta type 2 receptor ( TbetaRII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To block TGF beta signaling during the early phase of MI , an extracellular domain of TGF beta type 2 receptor ( TbetaIIR ) plasmid was transfected into the limb skeletal muscles 7 days before ligation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Ectopic expression of a dominant negative mutant of the TGF beta type 2 receptor in PANC 1 cells abrogated TGF beta induced BGN up regulation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study we performed microarray analysis to characterize the gene expression profile of leiomyoma and matched myometrial smooth muscle cells ( LSMC and MSMC , respectively ) in response to the time dependent action of TGF beta and , after pretreatment with TGF beta type 2 receptor ( TGF beta RII ) antisense oligomer blocking / reducing TGF beta autocrine / paracrine actions . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Recently , a model has been proposed in which TGF beta by binding to the TGF beta type 2 receptor can activate two distinct type 1 receptors in endothelial cells ( ECs ) , i . e . , the EC restricted ALK 1 and the broadly expressed ALK 5 , which have opposite effects on ECs behavior . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The present study examined the influence of streptozotocin induced diabetes on the renal expression of bradykinin ( BK ) B 2 receptors ( B2KR ) , connective tissue growth factor ( CTGF ) , transforming growth factor beta ( TGF beta ) , and TGF beta type 2 receptor ( TGF betaRII ) and assessed the signaling mechanisms through which B2KR activation may promote glomerular injury . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In an attempt to understand the role TGF beta plays during normal mammary gland development , and ultimately cancer , we previously generated transgenic mice that express a dominant negative TGF beta type 2 receptor under control of the metallothionine promoter ( MT DNIIR ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Specificity analysis demonstrated that the peptide is phosphorylated by only TbetaRI and not TGF beta type 2 receptor kinase , indicating that the peptide is a physiologically relevant substrate suitable for kinetic analysis and screening of TbetaRI kinase inhibitors . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
CD8+ T cells were isolated from the spleen of primed animals , were expanded ex vivo , and were rendered TGF beta insensitive by infecting with a retrovirus containing dominant negative TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : TGF beta signaling was inactivated by overexpressing a dominant negative mutant form of TGF beta type 2 receptor ( pS 2 dnR 2 ) only in the pancreas under control of pS2 / TFF1 promoter . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta 1 and VEGF were assayed by enzyme linked immunosorbent assay ( ELISA ) ; alpha 3 ( 4 ) collagen , TGF beta type 2 receptor and phospho Smad 2 were assayed by immunoblotting . ^^^ The expression of alpha 3 ( 4 ) collagen was influenced by the TGF beta system , but AngII did not increase the podocyte ' s production of TGF beta 1 ligand ; rather , it increased the expression of the TGF beta type 2 receptor and activated the TGF beta signalling system through Smad 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Loss of TGF beta type 2 receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF alpha , MSP and HGF mediated signaling networks . ^^^ To clarify the role of TGF beta signaling in stromal fibroblasts during mammary development and tumorigenesis , we conditionally knocked out the TGF beta type 2 receptor gene in mouse mammary fibroblasts ( Tgfbr 2 ( fspKO ) ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
An adenovirus harboring soluble TGF beta type 2 receptor ( Ad . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Delivery of plasmid DNA expressing small interference RNA for TGF beta type 2 receptor by cationized gelatin to prevent interstitial renal fibrosis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In the present study , we demonstrated that human skin cancers frequently overexpress TGF beta 1 but exhibit decreased expression of the TGF beta type 2 receptor ( TGF ( beta ) RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The expressions of TGF beta 1 , TGF beta type 2 receptor , and Sma and Mad related ( Smad ) 3 were increased by topical 17 beta estradiol in aged human skin , and TGF beta 1 neutralizing antibody inhibited 17beta estradiol induced procollagen synthesis in cultured fibroblasts . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To determine the functional roles of the TGF beta mediated signaling and the STAT 1 pathway , cells were either stably transfected with a dominant negative TGF beta type 2 receptor ( MCC DNTbetaRII ) or treated with a STAT 1 morpholino antisense oligonucleotide . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGF beta receptor interacting protein ( TRIP 1 ) is a cytoplasmic substrate of the TGF beta type 2 receptor kinase and plays a role in TGF beta signaling . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
A plasmid DNA , pcDNA sTGFbetaR / huIg , encoding a fusion protein consisting of the extracellular domain of TGF beta type 2 receptor ( TGFbetaRII ) and the Fc portion of human IgG heavy chain , was injected through different routes into B 6 mice carrying established tumors of E . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We previously reported silencing of the TGF beta type 2 receptor gene ( TGFbetaRII ) , involving histone deacetylation , instead of DNA methylation ( DNA Me ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Dopamine , dopamine D 2 receptor short isoform , transforming growth factor ( TGF ) beta 1 , and TGF beta type 2 receptor interact to inhibit the growth of pituitary lactotropes . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We identified the cysteine protease inhibitor cystatin C ( CystC ) as a novel TGF beta type 2 receptor antagonist that inhibits TGF beta binding and signaling in normal and cancer cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
After ex vivo expansion , these tumor reactive CD8+ cells were rendered TGF beta insensitive by infection with a retroviral ( MSCV ) mediated dominant negative TGF beta type 2 receptor ( TbetaRIIDN ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Decreased expression of TGF beta type 2 receptor in bronchial glands of smokers with COPD . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The ETV 6 NTRK3 chimeric tyrosine kinase suppresses TGF beta signaling by inactivating the TGF beta type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
However , the level of TGF beta type 2 receptor phosphorylation was not elevated under the same conditions . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
As transforming growth factor beta 3 ( TGF beta 3 ) is an essential growth factor for chondrogenesis of embryonic mesenchymal cells both in in vivo and in vitro conditions , we thereby explored the effects of atRA on TGF beta 3 signaling pathway . atRA led to an increase in mRNA expression of TGF beta 3 and an instantaneous decrease in TGF beta type 2 receptor ( TbetaRII ) as determined by real time RT PCR . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Mutations of the TGF beta type 2 receptor BMPR 2 in pulmonary arterial hypertension . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To determine the role of transforming growth factor beta ( TGF beta ) signaling in mammary development and tumor formation , we previously generated transgenic mice that expressed a dominant negative form of the TGF beta type 2 receptor ( DNIIR ) under the control of DNA regulatory elements from the metallothionein promoter ( MT DNIIR 28 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Through binding to the TGF beta type 2 receptor , TGF beta can activate two distinct type 1 receptors ( ALK 1 and ALK 5 ) in endothelial cells , each one leading to opposite effects on endothelial cell proliferation and migration . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
IGF 1 effects were evaluated in the presence or absence of TGF beta signaling by conditionally inactivating the TGF beta type 2 receptor . ^^^ We conditionally inactivated the TGF beta type 2 receptor ( TbetaRII ) in MSCs using a cre lox system , generating TbetaRII knockout MSCs ( RIIKO MSCs ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , we examined TGF beta 1 , TGF beta type 1 receptor ( TbetaRI ) and TGF beta type 2 receptor ( TbetaRII ) expression in SW 13 adrenocortical carcinoma cells by Northern and Western blot analysis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Prevention of radiation induced pneumonitis by recombinant adenovirus mediated transferring of soluble TGF beta type 2 receptor gene . ^^^ We used an adenoviral vector expressing a soluble TGF beta type 2 receptor ( AdCMVsTbetaR ) , which can bind to TGF beta and then block the TGF beta receptor mediated signal transduction . ^^^ Our results demonstrated that TGF beta 1 plays an important role in radiation pneumonitis , thus suggesting that the adenovirus mediated overexpression in soluble TGF beta type 2 receptor gene therapy may be a potentially feasible and effective strategy for the prevention of radiation pneumonitis . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here we show that in isolated human NK cells , proinflammatory monokines antagonize antiinflammatory TGF beta signaling by downregulating the expression of the TGF beta type 2 receptor , and its signaling intermediates SMAD 2 and SMAD 3 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Moreover , the facial phenotypes of neural crest specific Alk 5 mutants included devastating facial cleft and appeared significantly more severe than the defects seen in corresponding mutants lacking the TGF beta type 2 receptor ( TGFbetaRII ) , a prototypical binding partner of ALK 5 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
CDDO Im induced the synthesis of mRNA for TGF beta 2 , BMP 6 , TGF beta type 2 receptor , and BMP type 2 receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Previously , we showed that deletion of the TGF beta type 2 receptor ( Tgfbr 2 ) in Type 2 Collagen ( Col2a ) expressing cells results in defects in the development of the axial skeleton . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Tumor reactive CD 8 ( + ) T cells from C57BL / 6 mice were isolated , expanded ex vivo , and rendered insensitive to TGF beta by introducing a dominant negative TGF beta type 2 receptor vector . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The transforming growth factor betas ( TGF betas ) comprise a family of pleiotropic members that signal through two types of serine / threonine kinase receptors , named TGFRI ( TGF beta type 1 receptor ) and TGFRII ( TGF beta type 2 receptor ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effect of substance P ( SP ) on gene expression of transforming growth factor beta 1 ( TGFbeta 1 ) , transforming growth factor receptor 1 ( TGFR 1 ) and transforming growth factor receptor 2 ( TGFR 2 ) in fibroblasts cultured in vitro from rat ' s granulation tissues . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The mRNA expressions of TGF beta 1 , TGF beta 2 and TGFRI were evidently increased with decreased mRNA expression of TGF beta 3 and TGFR 2 in the hypertrophic scar when compared with those in the normal skin . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Most colon cancers exhibiting microsatellite instability ( MI ) , a mutator phenotype of mismatch repair failure , are associated with mutations of the transforming growth factor beta receptor type 2 genes ( TGF beta RII ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Based on partial amino acid homology , new members , such as the invariant chain ( 2 ) , and the transforming growth factor beta receptor type 2 ( TGF beta receptor 2 ) may , in fact , represent members of an emerging family within the superfamily that may have used some common building blocks to form functionally diverse proteins . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Recently , the transforming growth factor beta receptor type 2 ( TGF beta RII ) and the insulin like growth factor 2 receptor ( IGF IIR ) genes were shown to have inactivating mutations within coding microsatellite sequences . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Frame shift mutations in a run of 10 adenines ( A 10 ) of the transforming growth factor beta receptor type 2 gene ( TGF beta RII ) are commonly seen in inherited and sporadic colonic cancers that exhibit microsatellite instability . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) type 1 and type 2 receptors form a ligand dependent heteromeric signalling complexes , in which transforming growth factor beta receptor type 2 ( TbetaRII ) trends to act as the primary receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The expression of transforming growth factor beta 1 ( TGF beta 1 ) , and transforming growth factor beta receptor type 2 ( T beta R 2 ) , were evaluated in periovulatory marmoset ovaries . ^^^ Possible involvement of transforming growth factor beta 1 and transforming growth factor beta receptor type 2 during luteinization in the marmoset ovary . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Somatic mutations in the transforming growth factor beta receptor type 2 ( TGF beta RII ) gene have been observed in various human cancers showing microsatellite instability . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Recent investigations revealed microsatellite instability in colon cancers are associated with mutations of the transforming growth factor beta receptor type 2 gene ( TGF beta RII ) that encodes a transmembrane protein containing an intracellular serine / threonine kinase domain . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To clarify how microsatellite instability ( MI ) is involved in carcinogenesis of sporadic endometrial carcinoma , we examined mutations of the transforming growth factor beta receptor type 2 ( TGF beta RII ) gene in 32 patients with MI positive sporadic endometrial carcinoma . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Mutations and expression of the transforming growth factor beta receptor type 2 ( TGF beta RII ) gene were investigated in lung adenocarcinomas induced by N nitrosobis ( 2 hydroxypropyl ) amine ( BHP ) in rats . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
All three TGFbeta isoforms and their receptor , transforming growth factor beta receptor type 2 ( TGFbetaRII ) , proteins were found to be detected in the OSE from normal bovine ovaries using immunohistochemistry . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We previously demonstrated in T47D cells transfected to express the transforming growth factor beta receptor type 2 ( TGF betaRII ) that insulin like growth factor binding protein 3 ( IGFBP 3 ) could stimulate Smad 2 and Smad 3 phosphorylation , potentiate TGF beta 1 stimulated Smad phosphorylation , and cooperate with exogenous TGF beta 1 in cell growth inhibition ( Fanayan , S . , Firth , S . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Here , we demonstrate that PKCbetaII represses transforming growth factor beta receptor type 2 ( TGFbetaRII ) expression and reduces sensitivity to TGF beta mediated growth inhibition in intestinal epithelial cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
PURPOSE : Reduced expression of the transforming growth factor beta receptor type 2 ( TGF beta RII ) , a key inhibitor of epithelial cell growth and tumor suppressor gene , was reported frequently in many types of tumors including non small cell lung cancer ( NSCLC ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Hydroxyproline ( Hyp ) contents in liver tissue of the rats in 3 groups were determined with HCl hydrolysis , and collagen type 1 , transforming growth factor beta 1 ( TGF beta 1 ) , transforming growth factor beta receptor type 1 ( TbetaRI ) and transforming growth factor beta receptor type 2 ( TbetaRII ) were detected by Western blotting . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Recently , mutations in the TGFBR 2 gene have been identified as the cause of disease linked to the TAAD 2 locus , supporting the hypothesis that dysregulation of TGFbeta signaling is a mechanism leading to aneurysms and dissections . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
In this study , we map the chromosomal position of the gene that encodes the type 2 receptor of TGF beta ( HGM symbol TGFBR 2 ) , a multifunctional regulator of cell proliferation and differentiation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Mutations in the transforming growth factor beta type 2 receptor ( TGFbeta RII ) gene have been detected in several human cancers exhibiting microsatellite instability . ^^^ To extend analyses of this gene , we previously investigated the exon intron organization of the TGFbeta RII gene and defined seven exons and flanking intron sequences . ^^^ In this study , we further determined the nucleotide sequences surrounding these seven exons and designed eight sets of intron based primers to examine the entire coding region of the TGFbeta RII gene . ^^^ Using these primers , we screened genomic DNA sequences from 30 sporadic colorectal cancers for mutations of the TGFbeta RII gene . ^^^ TGFbeta RII mutations were detected in two of 30 tumors and both displayed microsatellite instability . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
DNA replication errors ( RERs ) were present in 13 % of sporadic carcinomas and in the carcinoma and dysplasias of 1 patient with Crohn ' s disease ( 14 % ) , but mutations in the transforming growth factor beta type 2 receptor ( TGFbeta RII ) gene were absent . ^^^ The infrequent loss of the APC and DCC regions and the absence of TGFbeta RII gene mutation in RER positive neoplasms contrast with colorectal carcinogenesis . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We then compared colorectal cancers with ' mild ' RER ( n = 15 ) , and those with ' severe ' RER without ( n = 11 ) or with ( n = 22 ) detectable mutations in MSH 2 or MLH 1 to assess the involvement of mononucleotide repeats contained in the coding regions of MSH 3 , MSH 6 , BAX , and TGFbeta RII . ^^^ Furthermore , the individual genes showed specific patterns of involvement ; for example , among tumors with ' severe ' RER , TGFbeta RII displayed uniformly high mutation rates while MSH 3 , MSH 6 , and BAX were more frequently altered in tumors that also showed MSH 2 or MLH 1 mutations . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : Immunoreactivity for TGF beta 1 and its receptors type 1 and type 2 ( TGFbeta RI and TGFbeta RII ) , tumor vascular count , and cell proliferation were studied in 73 cases of prostate cancer , diagnosed between 1975 1983 and followed with surveillance . ^^^ Patients with loss of tumor TGFbeta RII expression in combination with TGF beta 1 overproduction showed particularly short survival ( 2 . 6 vs . 10 years , P = 0 . 0000 ) , when compared to patients with normal immunoreactivity . ^^^ CONCLUSIONS : Overproduction of TGF beta 1 and loss of TGFbeta RII expression are associated with poor clinical outcome in prostate cancer , and TGF beta 1 may promote tumor progression by stimulating angiogenesis and metastasis . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Mutations in the transforming growth factor beta type 2 receptor ( TGFbeta RII ) gene have been detected in several types of human cancers that represent the phenotype of genomic instability . ^^^ The TGFbeta RII gene has been mapped to chromosome 3p , on which loss of heterozygosity ( LOH ) was frequently detected in both small cell lung carcinoma ( SCLC ) and non small cell lung carcinoma ( NSCLC ) . ^^^ To investigate whether the TGFbeta RII gene on 3p22 is inactivated in lung cancers , we examined 35 sporadic lung cancers ( 15 SCLC and 20 NSCLC ) with LOH on 3p for mutations of the TGFbeta RII gene . ^^^ We previously produced eight intron based primer pairs for mutational analysis of the entire coding region of the TGFbeta RII gene . ^^^ Using these primers , we screened for mutations of the TGFbeta RII gene by polymerase chain reaction single strand conformational polymorphism ( PCR SSCP ) analysis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The clinicopathological features of gastric carcinomas with microsatellite instability may be mediated by mutations of different `` target genes ' ' : a study of the TGFbeta RII , IGFII R , and BAX genes . ^^^ The RER phenotype has been identified as microsatellite instability in noncoding regions , as well as in repeat sequences within exons of several `` target genes ' ' : TGFbeta RII , IGFII R , and BAX . ^^^ Mutations in TGFbeta RII occurred in 67 . 9 % of the RER+ tumors and were significantly associated with the glandular histotype . ^^^ We conclude that the RER status is a significant prognostic indicator in gastric carcinoma and that such prognostic influence may be mediated by mutations in TGFbeta RII , IGFII R , and BAX genes . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The aim of our study was to determine the presence of alterations in the main putative components of the TGF beta inhibitory signaling pathways ( p 15 , Smad 4 , Smad 2 , TGFbeta RII , CDC25A ) . ^^^ Paradoxically , TGFbeta RII overexpression and a decrease in CDC25A protein levels were found in all tumors and cell lines . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Utilizing the cytoplasmic tail of Transforming Growth Factor Receptor Type 2 ( TGFbeta RII ) as bait in a yeast two hybrid system , we have identified human cyclin B 2 as a direct physical partner of TGFbeta RII . ^^^ Analysis of deletion mutants of glutathione S transferase ( GST ) cyclin B 2 mapped its binding domain for TGFbeta RII to the C terminal and revealed a negative regulatory region immediately upstream of the cyclin box . ^^^ Using recombinant proteins , Cdc 2 was demonstrated to indirectly interact with TGFbeta RII via cyclin B 2 . ^^^ This interaction was reproduced in THP 1 monocytic cells , where TGFbeta treatment markedly enhanced the ability of cyclin B 2 and , correspondingly , Cdc 2 from TGFbeta treated THP 1 cells , to bind the GST TGFbeta RII fusion protein . ^^^ More importantly , TGFbeta RII co precipitated with cyclin B 2 in TGFbeta treated THP 1 cells . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We conclude that ( 1 ) type 2 TGF beta receptor activity can be bypassed and thus TGFBR 2 mutations in RER+ cancers may , at least sometimes , be just `` bystander ' ' events and ( 2 ) TGF beta can affect adhesion molecule expression so that TGFBR 2 mutation may give rise to a selective advantage through an effect other escape from growth inhibition . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Several genes ( TGFbeta RII , IGFIIR , MSH 3 , MSH 6 , BAX , MBD 4 ) with significance in tumorigenesis harbor repeats in their coding regions and are often somatically inactivated because of deletions causing frameshifts . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
RESULTS : The prognostic impact of the factors , in decreasing order , was tumour grade , proliferation , stage , vascular density , TGFbeta RI , metastasis , TGF beta 1 , and TGFbeta RII . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To evaluate the role of TGF beta 1 and TGFbeta receptor types 1 and 2 in normal prostate and high grade PIN development , expression pattern of TGF beta 1 and TGFbeta RI and TGFbeta RII were studied on prostate samples with PIN lesions . ^^^ Similar expression pattern of TGFbeta RII was also observed . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Record no . 38 : TGFBR 2 ( type 2 TGFbeta receptor ) ] . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We therefore studied the expression of UPA , UPAR , IGF2R , ALK 5 ( TGFBR 1 ) , TGFBR 2 , TGFBR 3 , ENG , ALK 1 , TGFB 1 , TGFB 2 , and TGFB 3 in a series of 14 pancreatic carcinoma cell lines . ^^^ We also analysed ALK 5 and TGFBR 2 for mutations , cell surface localisation of TGFBR 2 and ENG , and TGFB 1 response . ^^^ These results suggest that the ALK 5 SMAD4 part of the TGFB signalling pathway is a major target for inactivation in pancreatic carcinomas , that the expression of TGFBR 2 , TGFBR 3 , and receptors involved in TGFB activation are maintained , and that alterations of components of the TGFB signalling pathway may be accompanied by a positive effect of TGFB on cell growth . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Expression of TGF beta 1 and TGFbeta receptor type 1 and type 2 ( TGFbeta RI and TGFbeta RII ) in rat dorsolateral prostate ( DLP ) and Dunning tumour sublines ( PAP , AT 1 , AT 2 , AT 3 and MatLyLu ) was examined in vitro and in vivo , using competitive reverse transcription polymerase chain reaction ( RT PCR ) , Northern and Western blot , and immunohistochemistry . ^^^ All tumours except MatLyLu also expressed elevated levels of TGFbeta RII mRNA ( P < or = 0 . 05 ) . ^^^ Interestingly , TGFbeta RII protein levels were very low in the highly metastatic AT 3 and MatLyLu tumours in vivo , when compared with levels in the PAP , AT 1 , and AT 2 tumours . ^^^ Immunostaining of TGF beta 1 , TGFbeta RI , and TGFbeta RII was localised principally in normal and tumour epithelial cells , and occasionally in smooth muscle cells . ^^^ In conclusion , high expression of TGF beta 1 and TGFbeta RI and low expression of TGFbeta RII may contribute to tumour progression and metastasis in the Dunning prostatic adenocarcinoma model . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The TGFbeta RII gene has been found mutated at the germline level in a small number of HNPCC patients . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
A kinase deficient form of TGFbeta RII prevents both mLC 7 1 phosphorylation and interaction with the dynein intermediate chain ( DIC ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGFbeta RII mutations occur in many types of malignancy . ^^^ This study has analysed the methylation status of the promoter region of the TGFbeta RI gene using a methylation sensitive enzyme followed by polymerase chain reaction ( PCR ) , and TGFbeta RII mutations ( BAT RII and a GT ( 3 ) ) in order to determine the frequency of alteration of the TGFbeta receptors in a series of 40 sporadic gastric carcinomas ( SGCs ) , 25 of which showed microsatellite instability ( MSI ) and 15 of which were microsatellite stable ( MSS ) . ^^^ Methylation in the promoter region of the TGFbeta RI gene was detected in 20 of the 40 ( 50 % ) SGCs ( 64 % of the MSI cases and 26 . 7 % of the MSS ) ; 17 of the 40 ( 42 . 5 % ) cases had mutations in the BAT RII region of the TGFbeta RII gene ( 68 % in the MSI cases ; 0 % in the MSS ) . ^^^ In conclusion , alterations in the receptors of TGFbeta ( TGFbeta RI promoter hypermethylation and TGFbeta RII mutations ) are frequent events in MSI SGC and are associated with large size and high proliferative activity of the tumours , in keeping with loss of the growth inhibitory effects of TGFbeta in this setting . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
While many tumor cell lines no longer respond to the inhibitory effects of TGFB due to a reduction or absence of the type 2 receptor ( TGFBR 2 ) , the role of TGFBR 2 in tumors from patients with breast cancer is less clear . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Levels of TGF betaRI and TGFbeta RII stayed the same in all cases . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGFbeta 1 , 2 , and 3 ligand immunoreactivity is observed in both small and large follicles , whereas the TGFbeta type 2 receptor ( TGFbeta RII ) is detected in the oocyte and granulosa cells of antral follicles . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Levels of proliferating nuclear antigen ( PCNA ) , TGF beta receptor 2 ( TGFbeta RII ) , and fibronectin were assessed by Western blot analysis . ^^^ In these animals , there was no change in glomerular levels of TGF beta receptor 2 ( TGFbeta RII ) or fibronectin . and there was no reduction in urine protein excretion . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Finally , the expression of TGF betaRI was slightly increased in the presence of combined LPS and L NMMA or NAC whereas that of TGFbeta RII was reduced in the same conditions . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
We report results of an association study between BMD and nine candidate genes ( TGFB 1 , TGFBR 2 , SMAD 2 , SMAD 3 , SMAD 4 , IFNB 1 , IFNAR 1 , FOS and LRP 5 ) , as well as of a case control study of osteoporosis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Identification of a 3p24 . 1 chromosomal breakpoint disrupting the gene encoding TGF beta receptor 2 ( TGFBR 2 ) in a Japanese individual with Marfan syndrome led us to consider TGFBR 2 as the gene underlying association with Marfan syndrome at the MSF 2 locus . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The expression levels of the vitamin D receptor ( VDR ) , proliferating cell nuclear antigen , PTEN ( MMAC1 / TEP1 ) , c Myc , transforming growth factor ( TGF ) beta receptor type 2 ( TGFbeta RII ) , and Bcl 2 were quantified using immunohistochemistry in the patients ' prostate specimens post surgery . ^^^ Calcitriol treatment did not result in a statistically significant change in the fraction of cells expressing TGFbeta RII , PTEN , or proliferating cell nuclear antigen . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Pancreatic presence of fibroblast growth factor 2 ( FGF 2 ) , vascular endothelial growth factor ( VEGF ) , platelet derived growth factor A ( PDGF A ) and transforming growth factor beta type 2 receptor ( TGFbeta RII ) was detected by immunohistochemisty . ^^^ In pancreatic acinar cells , I / R caused an increase in TGFbeta RII presence between the 5 ( th ) and 24 ( th ) h , and between 7 ( th ) and 9 ( th ) day of reperfusion . ^^^ Between the 2 ( nd ) and 5 ( th ) day of reperfusion the acinar presence of TGFbeta RII was reduced . ^^^ In the pancreatic ducts , the presence of TGFbeta RII was increased after I / R from the 1 ( st ) h to 9 ( th ) day of observation . ^^^ CONCLUSIONS : The presence of FGF , VEGF , PDGF A and TGFbeta RII is modified in the course of I / R induced acute pancreatitis . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Polymerase chain reaction ( PCR ) was done to amplify microsatellite sequences at mononucleotide BAT 26 , BAT 40 , TGFbeta RII , IGFIIR , hMSH 3 , BAX and dinucleotide D2S123 , D9S283 , D9S1851 and D18S58 loci in blood ( control ) and tumor DNA . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The transforming growth factor beta ( TGF beta ) signaling pathway , which is activated by the TGF beta receptor complex consisting of type 1 and type 2 TGF beta receptors ( TGFBR 1 and TGFBR 2 ) , regulates cell growth and death . ^^^ TGF beta and components of its signaling pathway , particularly TGFBR 2 , have been implicated as tumor suppressor genes and important antimitogenic factors in the gastrointestinal tract and liver . ^^^ An in vivo approach to study these effects has been hindered by the embryonic lethality of Tgfbr 2 ( / ) mice and poor viability of the Tgfb 1 ( / ) mice . ^^^ Consequently , we have developed a hepatocyte specific Tgfbr 2 knockout mouse , the Alb cre Tgfbr 2 ( flx / flx ) mouse , to study the physiologically relevant effects of TGF beta signaling on epithelial cell proliferation in vivo . ^^^ Consistent with these results , in a hepatocyte cell line derived from the Tgfbr 2 ( flx / flx ) mice , we found that TGF beta increases the nuclear localization of E2F4 , and presumably the transcriptional repression of the p 130 : E2F4 complex . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
To elucidate the role of TGF beta signaling in mammary gland development , tumorigenesis , and metastasis , the gene encoding type 2 TGF beta receptor , Tgfbr 2 , was conditionally deleted in the mammary epithelium ( Tgfbr2MGKO ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
DNA from peripheral blood samples was genotyped for single nucleotide polymorphisms ( SNP ) in 12 genes : NF 2 , XRCC 1 , XRCC 3 , XRCC 5 , ERCC 2 , Ki ras , p 16 , cyclin D 1 , PTEN , E cadherin , TGFB 1 , and TGFBR 2 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Transforming growth factor beta ( TGF beta ) transmits signals through a heterotetrameric cell surface complex of type 2 ( TGFBR 2 ) and type 1 ( activin receptor like kinase 5 , ALK 5 ; TGFBR 1 ) serine / threonine kinase receptors , as well as Smad2 / 3 . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Our previous study has demonstrated that conditional inactivation of Tgfbr 2 in the neural crest results in severe defects in calvarial development , although the cellular and molecular mechanisms by which TGFbeta signaling regulates the fate of CNC cells during frontal bone development remain unknown . ^^^ FGF acts downstream of TGFbeta signaling in regulating CNC cell proliferation , and exogenous FGF 2 rescues the cell proliferation defect in the frontal primordium of Tgfbr 2 mutant . ^^^ However , this requirement is restricted to the developing calvarial aspect of the frontal bone , whereas the orbital aspect forms despite the ablation of Tgfbr 2 gene , implying a differential requirement for TGFbeta signaling during the development of various regions of the frontal bone . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
TGFBR 2 and ACVR 2 , encoding TGFbeta superfamily receptors , and the proapoptotic gene BAX are frequent targets for frameshift mutation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
When cells were transfected with a human TGFBR 2 expression construct , TGFB 1 acquired the ability to significantly stimulate 1990 / +1 mFshb luc activity . ^^^ CONCLUSION : These data indicate that TGFB 1 insensitivity in LbetaT 2 cells results from a deficiency in Tgfbr 2 expression . ^^^ In primary gonadotropes , however , expression of Tgfbr 2 does occur , and its presence permits TGFB 1 to inhibit Fshb transcription , whereas activin A stimulates it . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Further , the kinase activity of both TGFbeta receptors appears to play a role in the TGFbeta mediated phosphorylation of km 23 , although TGFbeta RII kinase activity is absolutely required for km 23 phosphorylation . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Approximately 15 % of human colon cancers have microsatellite instability ( MSI ) and carry frameshift mutations in a polyadenine tract ( BAT RII ) in the type 2 transforming growth factor beta ( TGF beta ) receptor ( TGFBR 2 ) , a required component of the TGF beta receptor . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : In an effort to understand the specific role of TGF beta signaling in bladder stroma a fibroblast specific conditional knockout mouse of the type 2 TGF beta receptor gene , Tgfbr 2 ( / spko ) , was generated using Cre lox methodology . ^^^ Immunohistochemistry for the phosphorylated form of Smad 2 indicated a general loss in TGF beta signaling in the lamina propria of bladders of male and female Tgfbr 2 ( / spko ) , mice , and yet pronounced alpha smooth muscle actin expression was noted in male Tgfbr 2 ( / spko ) , bladders , which is a marker for myofibroblasts . ^^^ CONCLUSIONS : A sex disparity was observed in the Tgfbr 2 ( / spko ) , mouse model lacking TGF beta signaling in fibroblasts . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Cardiovascular malformations with normal smooth muscle differentiation in neural crest specific type 2 TGFbeta receptor ( Tgfbr 2 ) mutant mice . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS AND RESULTS : ATAA samples taken during aortic replacement from age matched MFS ( n=9 ) and non MFS ( n=18 ) patients were assessed for representative subtypes of all MMP classes , all 4 known TIMPs , and type 2 TGF beta receptors ( TGFBR 2 ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
Targeted deletions of Tgfb 1 and other components of this signaling pathway , such as Acvrl 1 , Tgfbr 1 and Tgfbr 2 , result in abnormal vascular development especially of the yolk sac , leading to embryonic lethality . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
The recent identification of TGFBR 2 mutations in Marfan syndrome 2 ( MFSII ) [ Mizuguchi et al . ( 2004 ) ; Nat Genet 36 : 855 860 ] and of TGFBR 1 and TGFBR 2 mutations in Loeys Dietz aortic aneurysm syndrome ( LDS ) [ Loeys et al . ( 2005 ) ; Nat Genet 37 : 275 281 ] [ OMIM 609192 ] has provided direct evidence of abnormal signaling in transforming growth factors beta ( TGF beta ) in the pathogenesis of Marfan syndrome ( MFS ) . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
METHODS : We examined the expression levels of TGF beta type 1 and type 2 receptors ( TGFbeta RI and TGFbeta RII ) in DF and DFSP using in situ hybridization and immunohistochemical analysis . ^^^ RESULTS : We detected strong expression of TGFbeta RI and TGFbeta RII on epidermis and epidermal appendages , moderate expression in vascular endothelial cells , smooth muscle cells and neural tissues , and weak expression in fibroblasts in normal skin sections . ^^^ The expression levels of TGFbeta RI and TGFbeta RII were elevated in the tissue sections of DF in comparison with normal dermal sections using in situ hybridization and immunohistochemical staining . ^^^ Furthermore , the expression of TGFbeta RI and TGFbeta RII was strong in spindle shaped cells around DF . ^^^ The expression of TGFbeta RI and TGFbeta RII was decreased in DFSP in comparison with DF , and their expression was found to be homogeneous in each DFSP tumour cell . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
As a recent study shows that heterozygous mutations in TGFBR 1 or TGFBR 2 cause multiple human congenital malformations , including soft palate cleft , we propose that TGF beta mediated Irf 6 expression plays an important , cell autonomous role in regulating the fate of MEE cells during palatogenesis in both mice and humans . . ^^^
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA
Interacting proteins: P37173 and P01137	Pubmed	SVM Score :0.0
NA