| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| METHODS : Paraffin embedded tissue sections containing tumor and adjacent nonneoplastic parenchyma were analyzed by immunohistochemistry for the expression of TbetaR type 2 ( TbetaR 2 ) and Smad 2 , Smad 4 , Smad 6 , and Smad 7 . ^^^ |
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| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| All primary antibodies ( polyclonal antibodies ) to TGF beta 1 , type 2 Transforming growth factor beta receptor ( TbetaR 2 ) , nuclear factor kappaB ( NF kappaB ) , CD 34 , smad 4 and smad 7 , secondary antibodies and immunohistochemical kit were purchased from Zhongshan Biotechnology Limited Company ( Beijing , China ) . ^^^ The expressions of TGF beta 1 , TbetaR 2 , NF kappaB , smad 4 and smad 7 proteins in 36 specimens of hepatocellular carcinoma ( HCC ) and its adjacent tissue were separately detected by immunohistochemistry to observe the relationship between TGF beta 1 and TbetaR 2 , between NF kappaB and TGF beta 1 , between smad 4 and smad 7 and between TGF beta 1 or TbetaR IIand microvessel density ( MVD ) . ^^^ CONCLUSION : The expressions of TGF beta 1 , TbetaR 2 , NF kappaB , smad 4 and smad 7 in HCC tissue , which are major up and down stream factors of TGF beta 1 smad signal transduction pathway , are abnormal . ^^^ The inhibitory action of TGF beta 1 is weakened in hepatic carcinoma cells because of abnormality of TGF beta 1 receptors ( such as TbetaR 2 ) and postreceptors ( such as smad 4 and smad 7 ) . ^^^ |
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| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| Using transient expression of TGF beta signalling components and a Smad 3 dependent reporter assay , we show that BICR 31 and H 314 had defects of Smad 4 , BICR 56 had abnormal TbetaR 2 and BICR 19 overexpressed Smad 7 . ^^^ |
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| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| These genes were TGF beta type 1 receptor gene ( TGFBR 1 ) , TGF beta type 2 receptor gene ( TGFBR 2 ) , SMAD 2 gene ( SMAD 2 ) , SMAD 3 gene ( SMAD 3 ) , SMAD 4 gene ( SMAD 4 ) , and SMAD 7 gene ( SMAD 7 ) , all of which compose the TGF beta 1 signaling pathway . ^^^ |
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| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of TGF beta type 2 receptor , Smad 2 , Smad 3 , Smad 4 , Smad 6 and Smad 7 genes in colorectal cancer . ^^^ Then , all coding regions of the TGF beta type 2 receptor ( TRII ) and the genes for Smad 2 , Smad 3 , Smad 4 , Smad 6 , and Smad 7 were analyzed by PCR SSCP and direct sequencing . ^^^ |
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| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P37173 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
|