| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| ActRIIB , and then partners with a type 1 receptor , either activin receptor like kinase 4 ( ALK 4 or ActRIB ) or ALK 5 ( TbetaRI ) , to induce phosphorylation of Smad2 / Smad3 and activate a TGF beta like signaling pathway . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Activins exert their effects by inducing heteromeric complexes of either of two different type 1 receptors , ActR 1 or ActR IB , and either of two type 2 receptors , ActR 2 or ActR IIB . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Using the ActR IB and ActR IIB receptor isoforms , we have investigated the mechanism of activin receptor activation . ^^^ Activin binds directly to ActR IIB , and this complex associates with ActR IB , which does not bind ligand on its own . ^^^ In the resulting complex , ActR IB becomes hyperphosphorylated , and this requires the kinase activity of ActR IIB . ^^^ Furthermore , the signalling activity of this mutant construct is undisturbed by overexpression of a dominant negative kinase defective ActR IIB construct , indicating that ActR IB ( T206D ) can signal independently of ActR IIB . ^^^ The evidence suggests that ActR IIB acts as a primary activin receptor and ActR IB acts as a downstream transducer of activin signals . . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Moreover , ActR IIB 2 is synergistic with ActR IA and ActR IB , demonstrating that ActR IIB 2 can interact with the zebrafish ligand . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| The effect of activin is most likely mediated through specific receptors as mRNAs encoding several forms of activin receptors , namely ActR 1 , ActR IB , ActR 2 and ActR IIB are found in the preovulatory follicles as well as in cultured granulosa luteal cells . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Primers specific for two type 1 and two type 2 activin receptors ( ActR 1 , ActR IB , ActR 2 , and ActR IIB ) were used in polymerase chain reaction ( PCR ) to amplify cDNAs prepared from granulosa luteal cells , placental tissues and isolated trophoblast cells . ^^^ PCR products with the expected sizes for ActR 1 , ActR IB , ActR 2 , and ActR IIB mRNAs were detected in freshly dissociated and 5 day cultured granulosa luteal cells ; and in trophoblast cells from both first trimester and term placentas . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Messenger RNAs for activin beta ( A ) subunit , activin binding protein ( follistatin ) , and various activin receptors , including ActR IA , ActR IB , ActR IIA , and ActR IIB , were detected in JEG 3 cells by reverse transcription polymerase chain reaction . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| The presence of inhibin subunits ( alpha , betaA and betaB ) , activin binding protein follistatin and activin receptors ( ActR 1 , ActR IB , ActR 2 and ActR IIB ) mRNA transcripts in bovine oocytes and preimplantation embryos was examined by reverse transcription polymerase chain reaction . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Actr Ib , Actr 2 and Actr IIb , Alk 1 , and Smad proteins ( Smads 1 5 and Smad 8 ) in the septal region of the basal forebrain during mouse development . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning has yielded genes encoding two type 2 receptors ( ActRII and ActRIIB ) and at least two type 1 receptors ( ALK 2 and ALK 4 ) . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Analysis in native tissues from 12 normal thyroids , 16 goiters , and 5 Graves thyroids demonstrated mRNA expression of the activin subunit betaA , TGFbeta receptor type 1 and 2 , activin receptors type 1 receptors alk 2 and alk 4 , and activin type 2 receptors actRII and actRIIb . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Expression of dominant negative mutants of various receptors indicated that ALK 4 , and either ActRIIA or ActRIIB , function as type 1 and type 2 receptors for Nodal , respectively . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , activin had no effect on follistatin mRNA levels , despite the fact that FS / D1h cells express ActRII , ActRIIB , and ALK 4 ( ActRIB ) . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Activins , like other members of the transforming growth factor beta ( TGF beta ) superfamily , initiate signaling by assembling a complex of two types of transmembrane serine / threonine receptor kinases classified as type 2 ( ActRII or ActRIIB ) and type 1 ( ALK 4 ) . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Previous studies have demonstrated that primary ovine pituitary cells express different activin receptor subtypes : activin receptor like ( ALK ) 2 , ALK 4 , activin type 2 receptor A ( ActRIIA ) , ActRIIB and Smad proteins in vitro . ^^^ Using Northern blots , we have shown that the levels of ALK 2 , ALK 4 and ActRIIB mRNA were significantly higher before the preovulatory surge and during the secondary surge of FSH as compared with both during the preovulatory surge and the luteal phase , whereas the level of the ActRIIA mRNA was similar throughout the oestrous cycle . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Our data showed that Alk 4 , ActRIIA , ActRIIB , and Smads 2 , 3 , and 4 , are expressed in fetal thymus ( E 14 > E 15 > E 16 ) and in thymocytes from adult mice ( mostly in the double negative [ DN ] subpopulation ) . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| A heterozygous mutation in Alk 5 , but not in Alk 4 or Alk 7 , potentiated Gdf 11 ( / ) like phenotypes in vertebral , kidney and palate development in an Acvr2b ( / ) background , indicating a genetic interaction between the two receptor genes . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| In addition , both ACTR1B and ACTRIIB were detectable and down regulated by exogenous activin , although not to the degree observed for ACTRIIA and betaA . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Furthermore , actRI , actRII and actRIIb were expressed in all cell lines and actRIb mRNA was evident in ASPC 1 , CAPAN 1 , COLO 357 and PANC 1 cells . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| In addition , mRNAs for all four activin receptor subtypes ( ActRIA , ActRIB , ActRIIA , and ActRIIB ) were easily detectable in both oocytes and granulosa cells and appeared to be differentially expressed in oocytes during nuclear maturation . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Activin receptor types IA ( ActRIA ) , IB ( ActRIB ) , IIA ( ActRIIA ) and IIB ( ActRIIB ) mRNAs were generally expressed in prostate epithelial cells , with significantly lower levels of ActRIB mRNA in prostate tumour material when compared to non malignant tissue ( P < 0 . 05 ; Mann Whitney U test ) . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| The mRNAs of four activin receptors ( ActRI , ActRIB , ActRII , and ActRIIB ) were also detected in the peritoneal macrophages , and the mRNA levels , except for ActRIB , were decreased during the LPS treatment . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| RT PCR revealed that cultured chondrocytes expressed mRNAs of inhibin / activin betaA and four activin receptors ( two type 1 ( ActRI and ActRIB ) and two type 2 ( ActRII and ActRIIB ) ) . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Activin / BMP receptors ( ActRIA , ActRIB , ActRIIA , and ActRIIB ) , beta glycan , and Smad 1 8 mRNAs were expressed by the ovary . ^^^ The emergence of antral follicles ( postnatal d 12 ) saw ActRIA , ActRIIB , and Smad 2 mRNA expression return to d 4 levels , whereas ActRIB , ActRIIA , and Smads 1 , 4 , 5 , and 7 remained at lower levels . beta glycan mRNA levels increased 2 fold between d 8 and 12 , suggesting expression by the developing theca . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| Complementary DNA samples produced by reverse transcription were used in the real time PCR to quantify the expression of inhibin alpha subunit , inhibin / activin beta ( A ) , beta ( B ) , beta ( C ) subunits , follistatin , ACTRIA , ACTRIB , ACTRIIA , ACTRIIB , beta glycan and GAPDH genes . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| The expression of the activin receptors ( ActRIIA , ActRIIB and ActRIB ) , the inhibin co receptor ( betaglycan ) , and ligand subunit ( alpha , beta A and beta B ) , mRNA was measured by semi quantitative RT PCR in these tissues . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| The results showed that the entire activin signaling system is expressed by the full grown immature zebrafish oocytes ( approximately 0 . 65 mm in diameter ) , including ALK 4 like ( ActRIB ) , ALK 2 like ( ActRIA ) , ActRIIA , ActRIIB , Smad 2 , Smad 3 , Smad 4 , and Smad 7 , therefore supporting our hypothesis that the oocytes are one of the direct targets of activin actions in the zebrafish ovary . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| The inhibin betaA and betaB subunit proteins , in addition to the activin type 1 ( ActRIB ) and activin type 2 receptor ( ActRIIB ) , are produced in primordial and primary follicle granulosa cells . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| All villous samples expressed inhibin alpha , inhibin / activin betaA , betaB , betaC , follistatin , activin receptors ( ACTRIA , ACTRIB , ACTRIIA , ACTRIIB ) and beta glycan genes . ^^^ |
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| Interacting proteins: P36896 and Q13705 |
Pubmed |
SVM Score :0.0 |
| For SNU 16 , changes in ActRIA , ActRIB , ActRIIA , ActRIIB , Smad 2 , Smad 4 , Smad 7 , and p 21 ( CIP1 / WAF1 ) mRNAs were detected with RT PCR after the cells were cultured with activin A for 24 , 48 and 72 h . ^^^ |
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