| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.81374845 |
| We find that Cripto interacts with the type 1 receptor ALK 4 via the conserved CFC motif in Cripto . 0.81374845^^^ |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.56849355 |
| Biochemical studies of the interactions of ALK 4 with the CFC domain of Cripto by fluorescence activated cell sorter analysis indicate that the CFC domain binds to ALK 4 independent of the EGF domain . 0.56849355^^^ |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| The Activin receptor ALK 4 is also able to mediate Nodal signaling but only in the presence of Cripto , with which it can also interact directly . ^^^ |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| Cripto has important roles during development and oncogenesis and binds nodal or related ligands and ALK 4 to facilitate assembly of type 1 and type 2 receptor signaling complexes . ^^^ Because Cripto mediates signaling via activin receptors and binds directly to ALK 4 , we tested whether transfection with Cripto would affect the ability of activin to signal and / or interact with its receptors . ^^^ If cotransfected with ActRII / IIB and ALK 4 , Cripto inhibited crosslinking of activin to ALK 4 and the association of ALK 4 with ActRII / IIB . ^^^ |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| During embryogenesis , Cripto complexes with Alk 4 via its unique cysteine rich CFC domain to facilitate signaling by the TGF beta ligand Nodal . ^^^ G3 . 5 , both disrupts Cripto Nodal signaling and reverses Cripto blockade of Activin B induced growth suppression by blocking Cripto ' s association with either Alk 4 or Activin B . ^^^ |
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| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that the Cripto FRL 1 Cryptic ( CFC ) domain in Cripto , which is essential for its binding to ALK 4 , is also important for its interaction with TMEFF 1 . ^^^ |
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| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| Moreover , the induction of Cripto activates the Smad 2 pathway , and overexpression of activated forms of type 1 receptor ActRIB compensates for the lack of Cripto signaling in promoting cardiomyogenesis . ^^^ |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| We report for the first time the chemical synthesis of refolded CFC domain of mouse Cripto ( mCFC ) and of two variants bearing mutations on residues W 107 and H 104 involved in Alk 4 binding . ^^^ |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| Cripto 1 activates nodal and ALK 4 dependent and independent signaling pathways in mammary epithelial Cells . ^^^ |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| A Nodal and ALK 4 independent signaling pathway activated by Cripto 1 through Glypican 1 and c Src . ^^^ Human Cripto 1 ( CR 1 ) is a member of the epidermal growth factor Cripto FRL 1 Cryptic family that has been shown to function as a coreceptor with the type 1 Activin serine threonine kinase receptor ALK 4 for the transforming growth factor beta related peptide Nodal . ^^^ |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13385 and P36896 |
Pubmed |
SVM Score :0.0 |
| NA |
|