| Interacting proteins: P36896 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36896 and O15105 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P36896 and O15105 |
Pubmed |
SVM Score :0.0 |
| Smad 7 blocked rFS ( rin 3 ) Luc activation by activin A or Alk 4 ( T > D ) . ^^^ |
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| Interacting proteins: P36896 and O15105 |
Pubmed |
SVM Score :0.0 |
| When coexpressed with type 1 activin receptor ActR 1 or ActR IB in concert with type 2 receptor ActR 2 , Smad 7 efficiently reduced an early transcriptional response mediated by ActR 1 but had only a minimal effect on the response mediated by ActR IB . ^^^ In the presence of Smad 7 , overexpression of an activated form of ActR IB , but not of an activated form of ActR 1 , induced F 5 5 cells to differentiate . ^^^ |
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| Interacting proteins: P36896 and O15105 |
Pubmed |
SVM Score :0.0 |
| The induction of mesoderm by TGF beta like signals is mediated by receptor ALK 4 and we show that Smad 7 blocks signaling of ALK 4 in a graded fashion : lower levels of Smad 7 block activation of dorsal mesoderm genes and higher levels block all mesoderm genes expression . ^^^ |
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| Interacting proteins: P36896 and O15105 |
Pubmed |
SVM Score :0.0 |
| When expressed in Chinese hamster ovary cells , Smad 7 inhibited the transcriptional response induced by either activin treatment or a constitutively active activin type 1 receptor ( ALK 4 ) . ^^^ In addition , Smad 7 also inhibited mouse FAST 2 mediated transactivation of the Xenopus Mix . 2 promoter stimulated by the constitutively active ALK 4 . ^^^ Smad 7 was able to directly associate with ALK 4 and this association was dependent on the phosphorylation of the type 1 receptor in its GS domain by activin type 2 receptors . ^^^ Expression of kinase defective activin type 2 receptors decreased the association of Smad 7 with ALK 4 . ^^^ Correspondingly , Smad 7 bound poorly to a mutant ALK 4 bearing serine to alanine substitutions in four putative phosphorylation sites in its GS domain . ^^^ |
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| Interacting proteins: P36896 and O15105 |
Pubmed |
SVM Score :0.0 |
| Because SMAD 7 functions by preventing access of SMAD 2 and SMAD 3 to ALK 4 , these data suggested that both activins and ALK 4 require SMAD 2 and / or SMAD 3 to affect FSHbeta transcription . ^^^ |
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| Interacting proteins: P36896 and O15105 |
Pubmed |
SVM Score :0.0 |
| The results showed that the entire activin signaling system is expressed by the full grown immature zebrafish oocytes ( approximately 0 . 65 mm in diameter ) , including ALK 4 like ( ActRIB ) , ALK 2 like ( ActRIA ) , ActRIIA , ActRIIB , Smad 2 , Smad 3 , Smad 4 , and Smad 7 , therefore supporting our hypothesis that the oocytes are one of the direct targets of activin actions in the zebrafish ovary . ^^^ |
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| Interacting proteins: P36896 and O15105 |
Pubmed |
SVM Score :0.0 |
| For SNU 16 , changes in ActRIA , ActRIB , ActRIIA , ActRIIB , Smad 2 , Smad 4 , Smad 7 , and p 21 ( CIP1 / WAF1 ) mRNAs were detected with RT PCR after the cells were cultured with activin A for 24 , 48 and 72 h . ^^^ |
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