| Interacting proteins: P36776 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP stimulated mechanism . ^^^ Here we report that Lon protease , an ATP stimulated mitochondrial matrix protein , selectively recognizes and degrades the oxidized , hydrophobic form of aconitase after mild oxidative modification , but that severe oxidation results in aconitase aggregation , which makes it a poor substrate for Lon . ^^^ Similarly , a morpholino oligodeoxynucleotide directed against the lon gene markedly decreases the amount of Lon protein , Lon activity and aconitase degradation in WI 38 VA 13 human lung fibroblasts and causes accumulation of oxidatively modified aconitase . ^^^ By recognizing minor oxidative changes to protein structure and rapidly degrading the mildly modified protein , Lon protease may prevent extensive oxidation , aggregation and accumulation of aconitase , which could otherwise compromise mitochondrial function and cellular viability . ^^^ Aconitase is probably only one of many mitochondrial matrix proteins that are preferentially degraded by Lon protease after oxidative modification . . ^^^ |
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| Interacting proteins: P36776 and Q99798 |
Pubmed |
SVM Score :0.0 |
| Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress . ^^^ These results imply that aging and oxidative stress down regulate Lon protease expression which , in turn , may be responsible for the accumulation of damaged proteins , such as aconitase , within mitochondria . . ^^^ |
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| Interacting proteins: P36776 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The Lon protease is believed to play an important role in the degradation of oxidized matrix proteins such as oxidized aconitase . ^^^ Altogether , these results indicate that matrix proteins , such as the critical enzymes aconitase and Lon protease , are inactivated with ageing and that the effects of ageing vary from one organ to another . . ^^^ |
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| Interacting proteins: P36776 and Q99798 |
Pubmed |
SVM Score :0.0 |
| The phosphinomethylmalate isomerase gene pmi , encoding an aconitase like enzyme , is involved in the synthesis of phosphinothricin tripeptide in Streptomyces viridochromogenes . ^^^ However , in addition to the TCA cycle aconitase gene , a gene encoding an aconitase like protein ( the phosphinomethylmalate isomerase gene , pmi ) was identified in the PTT biosynthetic gene cluster by Southern hybridization experiments , using oligonucleotides which were derived from conserved amino acid sequences of aconitases . ^^^ Pmi and the S . viridochromogenes TCA cycle aconitase , AcnA , have 52 % identity . ^^^ |
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