| Moreover , nonmuscle myosin heavy chain 9 ( MyH 9 ) , an actin based motor protein , is identified as a nucleolin binding protein . ^^^ Subsequent studies reveal that MyH 9 serves as a physical linker between nucleolin and cytoskeleton , thus modulating the translocation of nucleolin . ^^^ Knocking down endogenous MyH 9 , specifically inhibiting myosin activity , or overexpressing functional deficient MyH 9 disrupts the organization of cell surface nucleolin and inhibits its angiogenic function . ^^^ These studies indicate that VEGF , extracellular matrix , and intracellular motor protein MyH 9 are all essential for the novel function of nucleolin in angiogenic . . ^^^ |