Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
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Interacting proteins: P35556 and P35555 Pubmed SVM Score :1.1657034
During gel filtration on Sephadex G 200 human cancerocerebral antigen ( CCA ) was eluted as two protein fractions with molecular mass of 135 , 000 and 270 . 000 daltons . 1.1657034^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The CCA process was modeled by writing mass balance equations . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The MFS is caused by mutations in FBN 1 , while CCA has been genetically linked to FBN 2 ( refs 2 , 5 , 6 ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Examination of specific risk factors for increases in CCA intima media thickness in the presence of plaque showed that , after adjustment for sex , both ultrasound measurements were independently related to age , body mass index , hypertension , and ever smoking ( versus never smoking ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
METHODS : Because no data are available concerning the ultrasonographic characteristics of large arteries in athletes with physiological increases in left ventricular mass , we measured the intima media thickness ( IMT ) of the common carotid artery ( CCA ) in 14 normotensive subjects ( group 1 , aged 22 + / 4 years ) , in 14 borderline hypertensives ( group 2 , aged 24 + / 6 years ) and in 14 Japanese wrestling players ( group 3 , aged 23 + / 4 years ) . ^^^ In athletes and hypertensives both the left ventricular mass index and the IMT of the CCA were significantly greater than they were in control subjects ( 80 + / 12 g / m2 and 0 . 45 + / 0 . 05 mm in group 1 ; 106 + / 15 g / m2 and 0 . 57 + / 0 . 08 mm in group 2 ; and 122 + / 17 g / m2 and 0 . 55 + / 0 . 05 mm in group 3 ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Compared with control subjects , ESRD patients had greater left ventricular diameter ( P < 0 . 01 ) , wall thicknesses and mass ( P < 0 . 001 ) , increased CCA diameter ( 6 . 25 + / 0 . 87 vs . 5 . 55 + / 0 . 65 mm ; P < 0 . 001 ) , larger CCA intima media thickness ( 777 + / 115 vs . 678 + / 105 microns ; P < 0 . 001 ) and intima media cross sectional area ( 17 . 5 + / 4 . 5 vs . 13 . 4 + / 3 . 3 mm 2 ; P < 0 . 001 ) . ^^^ The CCA diameter was correlated with the left ventricular diameter ( P < 0 . 01 ) , and a significant correlations existed between CCA wall thickness or CCA intima media cross sectional area and left ventricular wall thicknesses and / or left ventricular mass ( P < 0 . 01 ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Findings were correlated against risk factors for atherosclerosis , CCA intima media thickness ( IMT ) , and echocardiographically determined left ventricular ( LV ) mass . ^^^ As an independent variable , LV mass ( r = . 40 and r = . 37 , respectively ; P < . 00001 ) had a strong positive relation to inner and outer CCA diameters . ^^^ In a model that controlled for age , sex , and estimated LV mass , an increase of 1 mm in CCA IMT corresponded to a 1 . 9 mm increase in the outer diameter of the artery ( P < . 00001 ) but was not significantly related to the inner diameter ( slope = +0 . 07 mm ; P = . 26 ) . ^^^ CONCLUSIONS : Increase in the outer diameter of the CCA is associated with subject size , sex , age , echocardiographically estimated LV mass , and CCA IMT . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The present study investigated cure rates in a mixed Schistosoma haematobium / S . mansoni endemic area by applying the CAA and CCA assays on 97 serum and urine specimens from Dogon , Mali . 8 weeks after mass treatment with 40 mg / kg of praziquantel , the cure rate was 87 % according to 2 urine egg counts and 96 % as determined by a single stool egg count . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Compared with controls , ESRD patients had elevated plasma ET levels ( 1 . 6 + / 1 . 4 vs 4 . 6 + / 3 . 8 pg / ml ; P < 0 . 001 ) , increased LV mass ( P < 0 . 001 ) , increased CCA IMT ( P < 0 . 001 ) , a higher prevalence of atherosclerotic plaques ( P < 0 . 001 ) and increased CF PWV ( P < 0 . 01 ) . ^^^ After adjustment for age , blood pressure , haemoglobin levels , gender and body dimensions , plasma ET levels were significantly correlated to LV mass ( r = 0 . 46 ; P < 0 . 001 ) , CCA IMT and CCA intima media cross sectional area ( r = 0 . 41 ; P < 0 . 001 ) , and CF PWV ( P < 0 . 05 ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The relation of far wall common carotid artery intima media thickness ( IMT CCA ) measured by B mode ultrasound to smoking , body mass index ( BMI ) , blood pressure , lipids , and angiotensin converting enzyme ( ACE ) gene polymorphism was analyzed . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
In women the CCA diameter was correlated with a combined risk factor score ( P=0 . 010 ) , systolic blood pressure ( P=0 . 033 ) , body mass index ( P < 0 . 001 ) , cholesterol ( P=0 . 009 ) , triglycerides ( P=0 . 14 ) , apoB ( P=0 . 002 ) , and apoB / A1 ( P=0 . 003 ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
METHODS : Common carotid artery ( CCA ) intima media thickness ( IMT ) , CCA diameter , CCA distensibility , LV mass , and function were determined in 60 stable ESRD patients on hemodialysis and 34 age , sex , and blood pressure ( BP ) matched controls , and their relationships with endothelial alterations were estimated by forearm postischemic vasodilation [ flow debt repayment ( FDR ) ] measured by venous plethysmography . ^^^ RESULTS : ESRD patients had increased LV mass , CCA diameter and CCA IMT , and had decreased CCA distensibility ( P < 0 . 05 ) . ^^^ FDR and time to FDR were negatively correlated with CCA IMT and LV mass . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
A case report on 80 year patient ruptured aneurysm of the common carotid artery ( CCA ) , immediately below its branching which leading to pulsatile mass on the neck . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
RESULTS : The outer and inner CCA diameters for the high group were significantly ( P : < 0 . 05 ) enlarged in comparison with those for the moderate and normal groups in all age / sex groups of both sexes after adjustment for body mass index , pack years of smoking , alcohol consumption , and total serum cholesterol . ^^^ Multiple regression analysis showed that age , body mass index , SBP , pack years of smoking , alcohol consumption , and IMT were positively and significantly ( P : < 0 . 005 ) related to both outer and inner CCA diameters in both sexes except for between alcohol consumption and outer CCA diameter in women and showed that only serum total cholesterol level was negatively and significantly ( P : < 0 . 01 ) related to inner CCA diameter in both sexes . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
CCA is caused by mutations in FBN 2 , whereas MFS results from mutations in FBN 1 . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The finding of mutations in FBN 1 and FBN 2 in the autosomal dominant microfibrillopathies Marfan syndrome ( MFS ) and congenital contractural arachnodactyly ( CCA ) , respectively , has highlighted their essential role in the development and homeostasis of elastic fibres . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
To characterize the mammalian mt CCA adding enzymes , we have partially purified the enzyme from bovine liver mitochondria and determined cDNA sequences from human and mouse dbESTs by mass spectrometric analysis . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
We have assessed the functional correlates of common carotid artery ( CCA ) arterial geometry , derived by combining a measure of vascular mass ( VM ) with the wall to lumen ( W / L ) ratio in both untreated hypertensive ( HT ) and normotensive ( NT ; blood pressure < 140 / 90 mm Hg ) subjects of a broad age span ( 30 to 79 years ) of both genders . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
CCA and MFS result from mutations in highly similar genes , FBN 2 and FBN 1 , respectively . ^^^ All the identified CCA mutations in FBN 2 cluster in a limited region similar to where severe MFS mutations cluster in FBN 1 , specifically between exons 23 and 34 . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
A 60 year old woman presented with the complaint of right neck swelling and dysphagia that was considered to be the mass effect of a pseudoaneurysm caused by dissection of the right common carotid artery ( CCA ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Mechanical properties of a great elastic trunk , the common carotid artery ( CCA ) and endothelium function of the brachial artery were studied in 130 obese children ( age : 12 + / 3 years , body mass index ( BMI ) : 29 + / 5 . 5 kg / m2 , without hypertension ( 115 + / 19 / 58 + / 8 mmHg ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
A mass balance approach was used to compute the potential metal concentrations ( mg / kg ) that would result from CCA treated wood being present in wood mulch . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The clamp glucose disposal rate was an independent predictor of CCA IMT in multivariate models adjusting for blood pressure , smoking , serum cholesterol , and body mass index ( 1 % decrease in CCA IMT for a 1 unit increase in glucose disposal rate , P=0 . 009 ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
By using a multivariate model including age , office pulse pressure , left ventricular mass index , and CCA distensibility , it was revealed that only CCA distensibility was a significant determinant of CSStim responses index ( P < . 005 ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Increased body surface area ( BSA ) and body mass index ( BMI ) were associated with more CCA contact at head rotations of 45 degrees or 60 degrees . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
In simple binary logistic regression , atherosclerotic plaques were associated with age , IMT CCA , smoking , and the levels of sICAM 1 , sE selectin , interleukin 2 soluble receptor alpha ( IL 2sRalpha ) , plasminogen activator inhibitor 1 ( PAI 1 ) mass , cholesterol , LDL cholesterol , and the LDL / high density lipoprotein ( HDL ) ratio . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
RESULTS : In multivariate analyses adjusted for major known cardiovascular risk factors in addition to age , gender and height , fat free mass , fat mass ( FM ) , and WC were positively associated with CCA IMT and lumen diameter . ^^^ Associations of CCA IMT and PWV with WC were not significant anymore after further adjustment on body mass index ( BMI ) or FM . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The CCA IMT and plasma levels of ApN and sTM were measured in 52 hypothyroid patients and in age , sex and body mass index ( BMI ) matched normal control subjects . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
From these compounds , only the Arg peptide ( TQTRT ) was detected with sufficient intensity in the MALDI TOF mass spectrum under typical MALDI conditions ( CCA matrix ) . ^^^ The addition of K ( + ) as a cationizing agent to the CCA matrix resulted in MALDI TOF mass spectra with relative ion intensities very similar to those obtained by electrospray ionization . . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
There was a strong positive correlation between LV mass and CCA IMT ( r2=0 . 27 ; P < 0 . 0001 ) . ^^^ VSMC and neonatal cardiomyocyte proliferative response in vitro correlated with CCA IMT ( r2=0 . 39 ; P < 0 . 0004 ) and LV mass index ( r2=0 . 19 ; P=0 . 028 ) , respectively . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The arsenic mass from hand rinses for children who played at non CCA treated playgrounds was < 0 . 2 microg , while mean arsenic mass was 0 . 6 microg ( range < 0 . 2 1 . 9 ) at CCA treated playgrounds . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
METHODS : Using multivariate regression , the best predictors of sonographic diameters of CCA and ICA were determined based on age , height , weight , body mass index , body surface area , neck circumference , neck length , and blood pressure . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Data from the deck study were combined with annual CCA treated wood production statistics to develop a mass balance model to estimate the extent of arsenic leaching from in service CCA treated wood structures to Florida soils . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
METHODS : Thirty eight young patients ( mean age 25 . 8 + / 14 . 1 years ) with FH were evaluated for the following parameters : age , sex , body mass index , degree of dyslipidemia , presence of a plaque , intima media thickness ( IMT ) , elastic modulus ( Ep ) and internal diameter of the CCA via duplex scan , wall shear stress , maximal diameter of the bloodstream swirl ( Sm ) at bifurcation , maximal diameter of the CCA ( Cm ) at the level of the swirl ' s center , and diameter ratio ( Sm / Cm ) via B flow sonography . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
RESULTS : In multiple linear regression analyses , after controlling for traditional cardiovascular risk factors , a significant correlation was found between CCA diameters and age ( p=0 . 034 ) , body mass index ( BMI ) ( p < 0 . 001 ) , smoking status ( p=0 . 039 ) , alcohol consumption ( < 0 . 001 ) and uric acid ( UA ) ( p=0 . 021 ) in men , and between CCA diameters and age ( < 0 . 001 ) , BMI ( p < 0 . 001 ) , systolic blood pressure ( SBP ) ( p=0 . 013 ) and antihypertensive drug use ( p=0 . 005 ) in women . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Clinic brachial BP and 24 hour ambulatory BP , carotid BP , left ventricular mass index , CCA intima media thickness , lumen diameter , intima media area , and carotid blood flow were measured . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Of mice and Marfan : genetic linkage analyses of the fibrillin genes , Fbn 1 and Fbn 2 , in the mouse genome . ^^^ The fibrillin genes , FBN 1 and FBN 2 , encode large extracellular matrix glycoproteins involved in the structure and function of microfibrils . ^^^ Restriction fragment length polymorphisms ( RFLPs ) between the progenitors of an interspecific backcross involving AEJ / Gn and Mus spretus mice were used to establish the segregation patterns of the murine homologs , Fbn 1 and Fbn 2 , in the backcross progeny . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
During the previous cloning of the fibrillin gene ( FBN 1 ) , we isolated a partial cDNA coding for a fibrillin like peptide and mapped the corresponding gene ( FBN 2 ) to human chromosome 5 . ( Lee , B . , M . ^^^ Accordingly , we propose to classify the FBN 1 and FBN 2 gene products as a new family of extracellular proteins and to name its members fibrillin 1 and fibrillin 2 , respectively . . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The DNA of all living family members was studied with markers recognizing polymorphic loci flanking the PKD 1 region ( 3 ' HVR and O90a ) , as well as markers from the loci of chromosomes 15 and 5 , associated with fibrillin genes FBN 1 and FBN 2 , respectively . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Previous studies have mapped the human genes for two fibrillins to chromosome bands 15q21 ( FBN 1 ) and 5q23 q 31 ( FBN 2 ) and have demonstrated that FBN 1 mutations are associated with Marfan syndrome , while FBN 2 is linked to the gene for congenital contractural arachnodactyly . ^^^ Here , we report the isolation of genomic clones of the corresponding mouse fibrillin genes ( Fbn 1 and Fbn 2 ) . ^^^ By analyzing a mapping panel of mouse 10 rodent somatic hybrid cell lines , we have assigned the Fbn 1 gene to mouse chromosome 2 and the Fbn 2 gene to mouse chromosome 18 . ^^^ We then sublocalized the fibrillin genes to bands 2F ( Fbn 1 ) and 18D E 1 ( Fbn 2 ) by fluorescence in situ hybridization . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Repeat polymorphisms in human fibrillin genes on chromosome 15 ( FBN 1 ) and chromosome 5 ( FBN 2 ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Fibrillin 1 is encoded by FBN 1 on human chromosome 15q21 and fibrillin 2 is encoded by FBN 2 on 5q23 . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
We also applied this mRNA quantitation method to determine the relative ratio between transcripts from the genes coding for two highly homologous microfibrillar components , FBN 1 and FBN 2 , in control fibroblast cultures as well as in fibroblasts from MFS patients . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The first of them ( FBN 1 ) codes for the main constitutive protein of the elastic tissue : fibrillin 1 , present mainly in structures which must resist load and stress ( aortic adventitia , the suspending ligament of the lens , skin ) ; the second ( FBN 2 ) codes for fibrillin 2 : responsible for the orientation of the elastin and mainly present in cartilage , the aortic media , the bronchi , and all tissues rich in elastin . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Using primers specific for FBN 1 and FBN 2 in RT PCR reactions we confirm the presence of fib 1 and fib 2 mRNA in early embryonic stages . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
We have found that relaxin specifically inhibits a microfibril component , fibrillin 2 ( FBN 2 ) , without affecting fibrillin 1 ( FBN 1 ) . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The human genome contains three fibrillins : FBN 1 and FBN 2 , both well characterized , and FBN 3 , reported only as a cDNA sequence . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
Fibrillin 1 ( FBN 1 ) and 2 ( FBN 2 ) are large , secreted glycoproteins known to be components of extracellular matrix microfibrils located in the vasculature , basement membrane , and various connective tissues and are often associated with a superstructure known as the elastic fiber . ^^^ Diabetics showed statistically significant higher levels of FBN anti FBN 2 CIC IgG ( 0 . 303+ / 0 . 076 vs . 0 . 252+ / 0 . 029 ; p=0 . 029 ) and IgM ( 0 . 415+ / 0 . 085 vs . 0 . 348+ / 0 . 069 ; p=0 . 018 ) compared to the control group . ^^^ FBN anti FBN 2 CIC IgG correlate with microalbuminuria ( r=0 . 65 , p=0 . 0046 ) and retinopathy ( r=0 . 61 , p=0 . 0001 ) . ^^^ This study suggests that there may be a relationship of levels of FBN anti FBN 2 CIC IgG with the development of diabetic microangiopathy . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
In contrast to Fbn 1 / mice , Fbn 2 null mice had a well developed and morphologically normal aortic wall . ^^^ However , virtually all Fbn 1 / ; Fbn 2 / embryos and about half of the Fbn1+ / ; Fbn 2 / embryos died in utero and displayed a significantly more severe vascular phenotype than Fbn 1 / mice . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
In order to evaluate the contribution of FBN 1 , FBN 2 , TGFBR 1 , and TGFBR 2 mutations to the Marfan syndrome ( MFS ) phenotype , the four genes were analyzed by direct sequencing in 49 patients with MFS or suspected MFS as a cohort study . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
The gene for fibrillin 2 ( FBN 2 ) is highly homologous to FBN 1 , and mutations in FBN 2 have been shown to cause a phenotypically related disorder termed congenital contractural arachnodactyly . ^^^
Interacting proteins: P35556 and P35555 Pubmed SVM Score :0.0
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