| Interacting proteins: P35346 and Q9HD26 |
Pubmed |
SVM Score :0.0 |
| PIST is Golgi associated and retains SSTR 5 in the Golgi apparatus when coexpressed with the receptor ; PDZK 1 on the other hand associates with the SSTR 5 at the plasma membrane . ^^^ Endogenous SSTR 5 in the neuroendocrine AtT 20 tumor cell line is colocalized with PIST in the Golgi apparatus . ^^^ |
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| Interacting proteins: P35346 and Q9HD26 |
Pubmed |
SVM Score :0.0 |
| The multi domain protein PIST ( protein interacting specifically with Tc 10 ) interacts with the SSTR 5 ( somatostatin receptor 5 ) and is responsible for its intracellular localization . ^^^ Here , we show that PIST is expressed in pancreatic beta cells and interacts with SSTR 5 in these cells . ^^^ After stimulation with SST , SSTR 5 undergoes internalization together with PIST . ^^^ These data suggest that PIST plays an important role in insulin secretion by regulating SSTR 5 availability at the plasma membrane . . ^^^ |
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