| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Expression of three somatostatin receptor subtypes in pituitary adenomas : evidence for preferential SSTR 5 expression in the mammosomatotroph lineage . ^^^ The expression of three somatostatin receptor subtypes , SSTR 3 , SSTR 4 , and SSTR 5 , was evaluated in 33 pituitary tumor specimens . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| To determine the molecular mechanisms of action of somatostatin , we have investigated the interaction of the different cloned receptors with G proteins and cellular effector systems . sstr 2 , sstr 3 and sstr 5 associate with pertussis toxin sensitive G proteins and are able to mediate the inhibition of adenylyl cyclase activity by somatostatin . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Inhibition in vivo by somatostatin of insulin release , amylase release and binding to rat pancreatic acinar cells is highly correlated with sstr 5 receptor affinity . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The human somatostatin receptors vary in size from 364 ( sstr 5 ) to 418 ( sstr 3 ) amino acids with 46 61 % amino acid identity between receptors , and 105 amino acids are invariant . ^^^ Somatostatin analogues selective for sstr 2 , sstr 3 and sstr 5 have been identified which will facilitate in vivo studies of the functions of these somatostatin receptors . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Localization of human somatostatin receptor 5 gene ( SSTR 5 ) to chromosome band 16p13 . 3 by fluorescence in situ hybridization . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| In 1992 , a major breakthrough in our understanding of somatostatin functions was made with the cloning of five different receptor genes ( sstr 1 to sstr 5 ) which belong to the seven transmembrane domain receptor family . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| This effect of octreotide , which appears to be mediated by the SSTR 2 and SSTR 5 subtypes of somatostatin receptors , was paralleled by its ability to inhibit TPA stimulated GH 3 cell proliferation . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin ( SRIF ) binding was also adapted to the SPA format in a GH4C1 cell line transfected with the SRIF receptor subtype 2 ( SSTR 2 ) and in HEK 293 cells transfected with the SRIF receptor subtype 5 ( SSTR 5 ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The somatostatin receptor agonists included peptides with relative specificity for SSTR 1 5 ( somatostatin 14 ; 10 nmol . kg 1 . h 1 ) ; SSTR 2 , SSTR 3 , and SSTR 5 [ SMS ( 201 995 ) ; 10 nmol . kg 1 . h 1 ] ; SSTR 2 ( 1 1 , 000 nmol . kg 1 . h 1 ) ; SSTR 3 ( 10 1 , 000 nmol . kg 1 . h 1 ) ; and SSTR 5 ( 10 1 , 000 nmol . kg 1 . h 1 ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Inhibition of cell proliferation by the somatostatin analogue RC 160 is mediated by somatostatin receptor subtypes SSTR 2 and SSTR 5 through different mechanisms . ^^^ In addition , in SSTR 5 expressing cells , RC 160 inhibited CCK stimulated intracellular calcium mobilization at doses ( EC 50 , 0 . 35 nM ) similar to those necessary to inhibit somatostatin 14 binding ( IC 50 , 21 nM ) and CCK induced cell proliferation ( EC 50 , 1 . 1 nM ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning , functional characterization , and chromosomal localization of a human somatostatin receptor ( somatostatin receptor type 5 ) with preferential affinity for somatostatin 28 . ^^^ Using a combination of polymerase chain reaction and genomic library screening we have cloned a human gene for a subtype of the somatostatin ( SST ) receptor ( SSTR ) termed human SSTR 5 ( hSSTR 5 ) , which is located on chromosome 16 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Characterization of cloned human somatostatin receptor SSTR 5 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Characterization of cloned somatostatin receptors SSTR 4 and SSTR 5 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The tissue distribution of mRNA encoding five somatostatin receptor subtypes , SSTR 1 , SSTR 2 , SSTR 3 , SSTR 4 , and SSTR 5 , was determined in adult rat tissues by solution hybridization / nuclease protection analysis using sequence specific cRNA probes . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Human somatostatin receptor genes : localization of SSTR 5 to human chromosome 20p11 . 2 . ^^^ The gene encoding the somatostatin receptor subtype designated as SSTR 5 was mapped to human chromosome 20p11 . 2 by using fluorescence in situ hybridization to metaphase chromosomes . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin receptor subtypes SSTR 2 and SSTR 5 couple negatively to an L type Ca2+ current in the pituitary cell line AtT 20 . ^^^ The somatostatin receptor subtypes SSTR 2 and SSTR 5 mediate distinct endocrine and exocrine functions of somatostatin and may also be involved in mediating the neuromodulatory actions of somatostatin in the brain . ^^^ L 362 , 855 is also an antagonist / partial agonist at the cloned rat SSTR 5 expressed in CHO cells since it is able to block the inhibition of cAMP accumulation induced by somatostatin at concentrations below 100 nM but at higher concentrations can inhibit cAMP formation itself . ^^^ These studies reveal that two different somatostatin receptor subtypes , SSTR 2 and SSTR 5 , can mediate the inhibition of an L type Ca2+ channel in AtT 20 cells by somatostatin . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The somatostatin analogue , octreotide , binds with high affinity to the SSTR 2 and SSTR 5 subtype and with a low affinity to the SSTR 3 subtype . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The messenger RNA ( mRNA ) expression of somatostatin ( SRIF ) receptors SSTR 1 , SSTR 2 , SSTR 3 , SSTR 4 and SSTR 5 ( called sst 1 5 , now ) was studied in rat brain between embryonic day 17 ( E 17 ) and post natal day 5 ( P 5 ) by in situ hybridization histochemistry and compared to that of adult rats . sst 1 receptor mRNA expression was very low and restricted at E 17 , spread out at E 18 , to reach very high levels comparable to that of adult at P 5 ( e . g . in temia tecta , posteromedial cortical amygdaloid nucleus , subiculum ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The tuberin ( TSC 2 ) , autosomal dominant polycystic kidney disease ( PKD 1 ) , and somatostatin type 5 receptor ( SSTR 5 ) genes form a synteny group in the Fugu genome . ^^^ In addition sequences homologous to the somatostatin type 5 receptor ( SSTR 5 ) were identified 5 ' to PKD 1 , defining a larger syntenic region , as this gene has also been mapped to human chromosome 16p13 . 3 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Peptide agonists with relatively high specificity for SSTR 1 5 ( somatostatin 14 ) , SSTR 2 ( MK 678 ) , SSTR 3 ( L 362823 ) , and SSTR 5 ( L 362855 ) were infused i . v . after nutrient stimulated gastric acid secretion and gastrin release with intraduodenal perfusions of 8 % peptone and after secretagogue stimulated acid secretion with gastrin ( 75 pmol kg 1 h 1 ) or histamine ( 20 micrograms kg 1 h 1 ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin alone , GMPPNP alone , or somatostatin plus GDP were ineffective under these conditions . sstr 1 and sstr 5 failed to increase PTPase activity although both receptors were expressed , as assessed by appearance of high affinity binding sites for [ 125I Tyr 11 ] somatostatin 14 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The lanthionine octapeptide with C terminal Thr ol ( 1 ) showed similar high affinity for rat SSTR 5 compared to somatostatin [ 1 14 ] and sandostatin . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Previously , we have shown somatostatin receptor ( SSTR ) subtype specific regulation of growth hormone ( GH ) , thyroid stimulating hormone , and prolactin ( PRL ) secretion in human fetal pituitary cultures , where GH and thyroid stimulating hormone are mediated by both SSTR 2 and SSTR 5 , whereas SSTR 2 preferentially mediates PRL secretion . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The binding characteristics of PTR 3046 to the different somatostatin receptors , expressed in CHO cells , indicate high selectivity to the SSTR 5 receptor . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization . ^^^ We have investigated the role of the cytoplasmic tail ( C tail ) of the human somatostatin receptor type 5 ( hSSTR 5 ) in regulating receptor coupling to adenylyl cyclase ( AC ) and in mediating agonist dependent desensitization and internalization responses . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Among the three cases with a true positive study , SSTR 2 , the SSTR subtype that preferentially binds to the somatostatin analogue octreotide , was detected in two , SSTR 5 was demonstrated in the three , and SSTR 3 was detected in one . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Recently , it was demonstrated that somatostatin analogs preferential for the SSTR 5 subtype suppress PRL release from prolactinoma cell cultures by 30 40 % . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Recently , studies using somatostatin ( SRIF ) analogs preferential for either the SRIF receptor 2 ( SSTR 2 ) or the SSTR 5 subtype demonstrated a variable suppression of GH and PRL release from GH secreting human adenomas . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Here , we show that dopamine receptor D2R and somatostatin receptor SSTR 5 interact physically through hetero oligomerization to create a novel receptor with enhanced functional activity . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| SALPR shares the highest amount of amino acid similarity with the somatostatin ( 35 % with SSTR 5 ) and angiotensin receptors ( 31 % with AT 1 ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that pharmacological doses of thyroid hormone ( levothyroxine [ LT 4 ] ) inhibit growth of murine TtT 97 thyrotropic tumors in association with upregulation of somatostatin receptor type 5 ( sst 5 ) mRNA and somatostatin receptor binding . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin 14 ( S 14 ) and somatostatin 28 ( S 28 ) bind to five distinct membrane receptors ( SSTRs ) , but S 28 has higher affinity for SSTR 5 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| In vitro experiments demonstrated the role of the SSTR 2 in inhibition of glucagon release from mouse pancreatic alpha cells and the somatostatin subtype 5 receptor ( SSTR 5 ) as a mediator of insulin secretion from pancreatic beta cells . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The role of somatostatin receptor subtypes 2 and 5 ( SSTR 2 and SSTR 5 ) in determining the secretory and proliferative phenotype as well as the sensitivity to somatostatin analogue treatment is not clearly established . ^^^ PCR products of SSTR 2 and SSTR 5 DNA from tumours resistant to somatostatin analogues were directly sequenced . ^^^ No significant correlation between the levels of SSTR 2 and SSTR 5 expression and the in vivo responsiveness to somatostatin analogues was observed , although a tendency to a low SSTR 2 expression in resistant tumours was found . ^^^ No mutations in the coding or bordering regions of either SSTR 2 or SSTR 5 adenomatous DNA from patients totally or partially resistant to somatostatin analogues were found . ^^^ The study shows that the different expression of SSTR 2 and SSTR 5 in GH secreting adenomas is not significantly correlated with the secretory and proliferative phenotype , although the large , hypersecretory tumours and those with a poor sensitivity to somatostatin analogues seem to express low levels of SSTR 2 mRNA . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin and its receptors ( SSTR 1 to SSTR 5 ) are expressed in normal human parafollicular C cells and medullary thyroid carcinoma ( MTC ) , but the role of SSTR subtypes in cell growth regulation is still not clear . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the inhibitory effect of two new SRIH analogs with high selectivity for SSTR 2 ( NC 4 28B ) and SSTR 5 ( BIM 23268 ) and compared it to that of native somatostatin ( SRIH 14 ) on a large number of GH secreting adenomas obtained by transphenoidal neurosurgery . ^^^ We conclude that the availability of somatostatin analogs selective for SSTR 5 will enhance the treatment potency and spectrum in acromegaly . . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Real time polymerase chain reaction was performed to quantify the expression of SSTR mRNAs and functionality of the SSTRs was assessed in cell culture studies with various concentrations of native somatostatin ( SRIF 14 ) and of analogues preferential for SSTR 2 or SSTR 5 . ^^^ DISCUSSION : In this plurihormonal secreting adenoma , the high efficacy of somatostatin analogues to inhibit PRL , LH and alpha subunit secretion in vivo may be explained by the unusually high level of expression and by the functionality of both SSTR 2 and SSTR 5 receptor subtypes . . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Although both somatostatin receptor subtype 2 ( SSTR 2 ) and SSTR 5 messenger ribonucleic acid ( mRNA ) are consistently expressed in GH secreting adenomas , SSTR 2 has been believed to be the key modulator of somatostatin mediated inhibition of GH release . ^^^ The somatostatin agonists currently in clinical use , octreotide and lanreotide , are directed mainly to SSTR 2 ( IC ( 50 ) 12 to 18 fold higher than for SSTR 5 ) . ^^^ In the present study we quantified SSTR 2 and SSTR 5 mRNA expression and the GH suppressive effects of somatostatin 14 ; octreotide ; a SSTR 2 preferential compound , BIM 23197 ; a SSTR 5 preferential compound , BIM 23268 ; and a new SSTR 2 and SSTR 5 bispecific compound , BIM 23244 , in GH secreting tumors classified as either full responders to octreotide ( n = 5 ) or partially sensitive to octreotide ( n = 5 ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Five somatostatin receptors ( SSTRs ) bind somatostatin 14 ( S 14 ) and somatostatin 28 ( S 28 ) , but SSTR 5 has the highest affinity for S 28 . ^^^ To determine whether S 28 acting through SSTR 5 mediates inhibition of glucagon like peptide 1 ( GLP 1 ) , fetal rat intestinal cell cultures were treated with somatostatin analogs with relatively high specificity for SSTRs 2 5 . ^^^ The results indicate that somatostatin regulation of GLP 1 secretion occurs via S 28 through activation of SSTR 5 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Novel polymorphisms in the somatostatin receptor 5 ( SSTR 5 ) gene associated with bipolar affective disorder . ^^^ The somatostatin receptor 5 ( SSTR 5 ) gene is a candidate gene for bipolar affective disorder ( BPAD ) as well as for other neuropsychiatric disorders . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Pancreatic somatostatin inhibits insulin secretion via SSTR 5 in the isolated perfused mouse pancreas model . ^^^ Immunoneutralization of pancreatic somatostatin resulted in enhanced glucose stimulated insulin secretion in WT controls , but decreased levels of insulin secretion in SSTR 5 / mice . ^^^ CONCLUSION : These results suggest that , in the mouse , pancreatic somatostatin regulates insulin secretion through SSTR 5 , and that the effect is age specific . . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Human GH is regulated through ligand binding to both SSTR 2 and SSTR 5 , but octreotide and lanreotide , the two clinically available somatostatin analogs , bind to human SSTR 2 much better than to SSTR 5 . ^^^ A new SSTR2+5 bispecific analog with high affinity and selectivity for both SSTR 2 and SSTR 5 , and a somatostatin analog with a unique broad receptor ( SSTR 1 , 2 , 3 , and 5 ) binding profile , are both able to inhibit in vitro GH release in GH cell adenomas partially sensitive to octreotide . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Here we report that the binding of somatostatin to the somatostatin receptor type 5 ( SSTR 5 ) upregulates SAPK / JNK activity . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Tc 99m depreotide is a new radiolabeled somatostatin analogue that shows high affinity for SSTR 2 , SSTR 3 , and SSTR 5 subtypes . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of the mouse somatostatin receptor type 5 gene promoter . ^^^ We have previously characterized the structure of the murine somatostatin receptor type 5 gene ( sst 5 ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| SUMMARY BACKGROUND DATA : The sulfonylurea receptor ( Sur ) and somatostatin receptor type 5 ( SSTR 5 ) play an integral role in the regulatory pathways of the endocrine pancreas . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin ( SRIH ) analogs are commonly used to treat symptoms in medullary thyroid carcinoma ( MTC ) , that expresses SRIH receptors ( SSTR 1 to SSTR 5 ) , as does the human MTC cell line TT . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The aim of the study was to determine the inhibitory effects of somatostatin analogues with relative specificity to somatostatin receptor subtype 2 ( SSTR 2 ) ( BIM 23197 ) , subtype 5 ( SSTR 5 ) ( BIM 23268 ) , and their combination on GH and PRL secretion in acromegalic adenomas in vitro . ^^^ In conclusion the somatostatin analogue BIM 23268 had an additive effect on suppression of GH secretion in a subset of adenomas , where both SSTR 2 and SSTR 5 were involved . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Like octreotide long acting repeatable ( LAR ) , it has high binding affinity for the somatostatin receptor subtype SSTR 2 and less binding affinity for SSTR 5 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : The effect exerted by somatostatin and its analogues on HSCs may mainly depend on the expression of SSTR 2 , SSTR 3 and SSTR 5 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Deficiency of somatostatin ( SST ) receptor type 5 ( SSTR 5 ) is associated with sexually dimorphic changes in the expression of SST and SST receptors in brain and pancreas . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin ( SRIF ) analogs interacting with SRIF receptor subtype ( SSTR ) 2 and SSTR 5 are known to reduce secretion in GH secreting pituitary adenomas . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Analysis of transmission of novel polymorphisms in the somatostatin receptor 5 ( SSTR 5 ) gene in patients with autism . ^^^ The somatostatin receptor 5 ( SSTR 5 ) gene is located on chromosome 16p13 . 3 and is thus a positional candidate gene for autism . ^^^ SSTR 5 may also be a functional candidate gene for autism because somatostatin inhibits growth hormone secretion , and increased growth hormone response has been reported in some individuals with autism . ^^^ Moreover , the somatostatinergic system interacts with the dopaminergic system , which has been hypothesized to be involved in the etiology of autism ; in particular , somatostatin secretion is regulated by dopamine , and the dopamine D 2 receptor and the SSTR 5 receptor interact to form a receptor complex with enhanced functional activity . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| InIII DOTA NOC exhibited the following IC 50 values ( nM ) when studied in competition with [ 125I ] [ Leu 8 , d Trp 22 , Tyr 25 ] somatostatin 28 ( values for YIII DOTA NOC are shown in parentheses ) : sstr 2 , 2 . 9 + / 0 . 1 ( 3 . 3 + / 0 . 2 ) ; sstr 3 , 8 + / 2 ( 26 + / 1 . 9 ) ; sstr 5 , 11 . 2 + / 3 . 5 ( 10 . 4 + / 1 . 6 ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin ( SRIF ) analogs interacting with SRIF receptor ( SSTR ) subtypes SSTR 2 and SSTR 5 reduce hormone secretion of pituitary adenomas , but their antiproliferative effects are still controversial . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The multi ligand somatostatin analogue SOM 230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin receptor type 5 modulates somatostatin receptor type 2 regulation of adrenocorticotropin secretion . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The aim of the study was to investigate the possible correlation of single nucleotide polymorphisms in somatostatin receptor ( SSTR ) 2 and SSTR 5 genes with the responsiveness to somatostatin analogs in a cohort of acromegalic patients . ^^^ STUDY DESIGN : Three single nucleotide polymorphisms ( a 83 g , c 57 g , and t80c ) of SSTR 2 and three ( t 461c , c325t , and c1004t ) of SSTR 5 were analyzed in 66 acromegalic patients with different responsiveness to somatostatin analogs and 66 healthy controls . ^^^ No correlation between SSTR 2 and SSTR 5 genotypes , responsiveness to somatostatin therapy , and mRNA expression in the removed adenomas ( n = 10 ) was found . ^^^ CONCLUSIONS : These data suggest a role for SSTR 5 t 461c and c1004t alleles in influencing GH and IGF 1 levels in patients with acromegaly , whereas SSTR 2 and SSTR 5 variants seem to have a minor role in determining the responsiveness to somatostatin analogs . . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin ( SST ) peptide is a potent inhibitor of insulin secretion and its effect is mediated via somatostatin receptor 5 ( SSTR 5 ) in the endocrine pancreas . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : This study compared the potency of a somatostatin receptor ( sstr ) 2 sstr 5 analog , BIM 23244 , of an sstr 2 dopamine D 2 receptor ( sstr 2 DAD2 ) molecule , BIM 23A387 and of new somatostatin dopamine chimeric molecules with differing , enhanced affinities for sstr 2 , sstr 5 and DAD 2 , BIM 23A758 , BIM 23A760 and BIM 23A761 , to suppress GH and prolactin ( PRL ) from 18 human GH adenomas that are partially responsive to octreotide or lanreotide . ^^^ CONCLUSIONS : Novel dopamine somatostatin chimeric molecules with differing , enhanced activity at sstr 2 , sstr 5 and DAD 2 , consistently produced significatly greater suppression of GH and PRL than either octreotide or single receptor interacting ligands in tumors from patients classified as only partially responsive to octreotide therapy . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| By yeast two hybrid screening we have identified interaction partners for the intracellular C terminal tail of the human and rodent somatostatin receptor subtype 5 ( SSTR 5 ) . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| SSTR 1 expression was significantly increased in islets at 3 months of age , but was nearly absent in islets at 12 months of age , as was somatostatin staining in SSTR 5 / mice . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The multi domain protein PIST ( protein interacting specifically with Tc 10 ) interacts with the SSTR 5 ( somatostatin receptor 5 ) and is responsible for its intracellular localization . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| This action has been considered to be generally mediated via six different specific somatostatin receptors ( sstr ) , sstr 1 , sstr2A , sstr2B , sstr 3 , sstr 4 , and sstr 5 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Immunochemical analysis showed that the pancreatic islets of SSTR 1 / mice had significantly decreased levels of somatostatin staining and a significant decrease of SSTR 5 expression . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin receptor subtype 5 ( SSTR 5 ) mRNA expression is related to histopathological features of cell proliferation in insulinomas . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Tumors and metastases bearing the somatostatin receptor subtypes 2 ( SSTR 2 ) or SSTR 5 can be visualized in vivo after injection of radiolabeled octapeptide somatostatin analogs like 111In pentetreotide . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The development of specific somatostatin subtypes analogs , mainly for SSTR 5 , of a SSTR 2 SSTR5 bispecific compound , and of a `` universal ' ' analog with high affinity to SSTR 1 , 2 , 3 , and 5 showed preliminary , albeit promising results for the treatment of resistant somatotropic adenomas . . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| SST 14 ( 1 microgram ) , the SSTR 5 agonist , BIM 23052 , ( 0 . 5 1 microgram ) , SSTR 3 ( 0 . 5 micrograms ) and 2 ( 0 . 5 microgram ) or vehicle injected i . c . did not modify basal acid secretion . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Phenylarsine oxide sensitive internalization of SSTR 1 3 is dependent on SST 14 or SST 28 , whereas only the octacosapeptide triggers this reaction with SSTR 5 . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| Five distinct membrane receptors ( SSTR 1 5 ) for SST are known , and at least two ( SSTR 2 and SSTR 5 ) have been proposed to regulate pancreatic endocrine function . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The expression of messenger ribonucleic acid ( mRNA ) for SST receptor subtype 1 ( SSTR 1 ) , subtype 2 ( SSTR 2 ) , and subtype 5 ( SSTR 5 ) was also investigated in 22 samples by RT PCR . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have assessed the role of a series of SST analogs , three of which were selective for SSTR 1 , SSTR 2 or SSTR 5 , in these cellular events . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Without TNF alpha treatment , HCAECs showed mRNA expression of SST , SSTR 1 , SSTR 2 , and SSTR 5 . ^^^ After treatment with TNF alpha , the mRNA levels of SST , SSTR 1 , SSTR 2 , and SSTR 5 were significantly reduced in a dose dependent fashion . ^^^ TNF alpha ( 1 ng / ml ) reduced SST , SSTR 1 , SSTR 2 , and SSTR 5 by 93 , 51 , 85 , and 99 % , respectively , compared to controls ( P < 0 . 001 , t test ) . ^^^ CONCLUSIONS : HCAECs express SST , SSTR 1 , SSTR 2 , and SSTR 5 , which are all decreased by TNF alpha treatment . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| The present study was performed to test the hypothesis that SSTR 2 , but not SSTR 5 , mediates SST induced inhibition of insulin release in hamster beta cells . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| We report the comparative efficacy of a somatostatin receptor 1 and 5 subtypes ( SSTR 2 and SSTR 5 ) , and dopamine D 2 ( DAD 2 ) compound , BIM 23A760 , in suppressing GH secretion , in cell culture from human GH secreting tumors , from patients partially responsive to long term treatments with octreotide or lanreotide . ^^^ |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61278 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|