| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.61659081 |
| SSTR 5 formed heterodimers with SSTR 1 but not with SSTR 4 suggesting that heterodimerization is a specific process that is restricted to some but not all receptor subtype combinations . 0.61659081^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| All five tumors expressed SSTR 2 mRNA and SSTR 5 mRNA , and three expressed SSTR 1 mRNA . ^^^ We conclude that : 1 ) human pituitary adenomas and normal pituitary express multiple SSTR gene transcripts ; 2 ) SSTR 5 mRNA , which has not been reported in other human endocrine tumor types , is expressed in neoplastic and normal pituitary tissue ; and 3 ) SSTR 2 mRNA , SSTR 5 mRNA , and variable SSTR 1 mRNA are expressed in GH secreting tumors , which are responsive to SRIF in vitro . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Cell proliferation was induced in CHO cells by 10 % ( vol / vol ) fetal calf serum , 1 microM insulin , or 0 . 1 microM cholecystokinin ( CCK ) 8 ; RC 160 inhibited serum induced proliferation of CHO cells expressing SSTR 2 and SSTR 5 ( EC 50 , 53 and 150 pM , respectively ) but had no effect on growth of cells expressing SSTR 1 , 3 , or 4 . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Amongst the 5 SSTRs , mRNA for SSTR2A was the most frequently expressed ( 87 % of tumors ) followed by SSTR 1 ( 73 % ) , SSTR 3 ( 53 % ) , SSTR 5 ( 47 % ) , and SSTR 4 ( 40 % ) . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| In rats deprived of food , pituitary sstr 1 , 2 and 3 mRNAs were reduced by 80 % compared to fed controls ; sstr 4 and sstr 5 mRNAs were unchanged . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Evidence exists for the importance of sstr 5 receptors in insulin secretion and sstr 1 receptors in oncology . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| In 1992 , a major breakthrough in our understanding of somatostatin functions was made with the cloning of five different receptor genes ( sstr 1 to sstr 5 ) which belong to the seven transmembrane domain receptor family . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin alone , GMPPNP alone , or somatostatin plus GDP were ineffective under these conditions . sstr 1 and sstr 5 failed to increase PTPase activity although both receptors were expressed , as assessed by appearance of high affinity binding sites for [ 125I Tyr 11 ] somatostatin 14 . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Octreotide , SSTR 5 , show moderate affinity for SSTR 3 and fail to bind with high affinity to the other subtypes ( SSTR 1 and 4 ) . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| SSTR 1 , SSTR 2 , and SSTR 3 mRNA expression was reduced 80 % in the pituitary of FD rats vs . fed controls , whereas pituitary levels of SSTR 4 and SSTR 5 mRNA were unaffected . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| The tissue distribution of mRNA encoding five somatostatin receptor subtypes , SSTR 1 , SSTR 2 , SSTR 3 , SSTR 4 , and SSTR 5 , was determined in adult rat tissues by solution hybridization / nuclease protection analysis using sequence specific cRNA probes . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Crypt epithelium expressed messenger RNA for SSTR 1 and SSTR 2 and low levels of SSTR 5 . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| SRIF analogs that selectively bind to SSTR 2 and SSTR 5 were impotent in displacing des AA 1 , 5 [ 125ITyr2 , DTrp 8 , IAmp 9 ] SRIF from human SSTR 1 . des AA 1 , 5 [ 125ITyr2 , DTrp 8 , IAmp 9 ] SRIF binding to SSTR 1 expressed in COS 7 cells was reduced by GTPgS , and this effect was prevented by pertussis toxin treatment . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| The messenger RNA ( mRNA ) expression of somatostatin ( SRIF ) receptors SSTR 1 , SSTR 2 , SSTR 3 , SSTR 4 and SSTR 5 ( called sst 1 5 , now ) was studied in rat brain between embryonic day 17 ( E 17 ) and post natal day 5 ( P 5 ) by in situ hybridization histochemistry and compared to that of adult rats . sst 1 receptor mRNA expression was very low and restricted at E 17 , spread out at E 18 , to reach very high levels comparable to that of adult at P 5 ( e . g . in temia tecta , posteromedial cortical amygdaloid nucleus , subiculum ) . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Analysis of residual tumors from thyroid hormone treated mice showed the specific up regulation of SSTR 1 and SSTR 5 mRNA subtypes and the appearance of abundant , high affinity SSTR receptor binding sites within the tumor . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Expression of SSTR 5 was detected in approximately one third of tumour and normal tissue , but fewer than 13 % of all tissues expressed SSTR 1 , 3 and 4 . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction ( RT PCR ) analyses revealed that SSTR 4 and SSTR 2 are major subtypes expressed predominantly in the iris / ciliary body and retina , respectively , and that SSTR 1 , SSTR 3 and SSTR 5 are minor subtypes expressed preferentially in the posterior eye segments including the retina . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Normal thyroid also expressed SSTR 3 and SSTR 5 mRNAs , with only faint expression of SSTR 1 and SSTR 2 mRNAs ( in one of five and three of five samples , respectively ) . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| In cells cultured from the 10 mixed adenomas that secreted both GH and PRL , RT PCR analysis revealed a consistent coexpression of SSTR 5 , SSTR 2 , and SSTR 1 mRNA . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| The transcripts of five SRIH receptor subtypes ( SSTR 1 , SSTR 2 , SSTR 3 , SSTR 4 , and SSTR 5 ) were investigated by RT PCR in epithelial cells ( EC ) and stromal cells ( SC ) from primary cultures of five normal human prostates and six prostate cancers . ^^^ RT PCR was performed after deoxyribonuclease treatment , using SSTR 1 , SSTR 2 , SSTR 3 , SSTR 4 , and SSTR 5 specific primers and adding glyceraldehyde 3 phosphate dehydrogenase specific primers as internal control . ^^^ SSTR 1 , SSTR 2 , SSTR 3 , SSTR 4 , and SSTR 5 messenger RNAs were not expressed in SC from both normal and cancer prostates . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| SSTR 2 , SSTR 5 and SSTR 4 were detected in most cases of endocrine GEP tumours ( 92 % , 84 % , and 82 % respectively ) , but SSTR 1 and SSTR 3 were less frequently observed ( 66 % and 50 % respectively ) . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Analysis by reverse transcription and polymerase chain reaction ( RT PCR ) methodologies showed that S 49 cells express predominantly sstr2A and sstr2B mRNAs ; other subtypes were either not detected , in the case of sstr 1 , sstr 3 , sstr 4 , or variably detected , in the case of sstr 5 . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| While SSTR 1 mRNA is present at relatively high amounts throughout the gastrointestinal tract , the levels of SSTR 2 , 3 and 4 mRNAs vary in different regions and SSTR 5 mRNA has not been detected . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| The number of SSTR immunopositive cells showed a rank order of SSTR 1 > SSTR 5 > SSTR 2 > SSTR 3 > SSTR 4 . ^^^ SSTR 2 was strongly colocalized with glucagon in 89 % of alpha cells , whereas SSTR 5 and SSTR 1 colocalized with glucagon in 35 and 26 % of alpha cells , respectively . ^^^ SSTR 5 was preferentially expressed in 75 % of SST positive cells and was the principal delta cell SSTR subtype , whereas SSTR 1 3 were colocalized in only a few delta cells , and SSTR 4 was absent . ^^^ These studies reveal predominant expression of SSTR 1 , SSTR 2 , and SSTR 5 in human islets . ^^^ Beta cells , alpha cells , and delta cells each express multiple SSTR isoforms , beta cells being rich in SSTR 1 and SSTR 5 , alpha cells in SSTR 2 , and delta cells in SSTR 5 . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Selective nonpeptide agonists with nanomolar affinity have been developed for four of the subtypes ( SSTR 1 , 2 , 3 , and 4 ) and putative peptide antagonists for SSTR 2 and SSTR 5 have been identified . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| In conclusion , prolactinomas have a specific pattern of SSTR subtype mRNA expression ( SSTR 5 and SSTR 1 ) . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Five distinct membrane receptors ( SSTR 1 5 ) for SST are known , and at least two ( SSTR 2 and SSTR 5 ) have been proposed to regulate pancreatic endocrine function . ^^^ L 817 , 818 , an SSTR 5 selective analog , slightly reduced glucagon release in both animal groups , whereas SSTR 1 , 3 , and 4 selective analogs were inactive . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| All thyroid tumor types regularly expressed sstr 1 , sstr 3 , sstr 4 , and sstr 5 . sstr 2 was expressed in most MTC tumors but was not detected in FA or PC and was irregularly expressed in HCA and HCC . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| The expression of messenger ribonucleic acid ( mRNA ) for SST receptor subtype 1 ( SSTR 1 ) , subtype 2 ( SSTR 2 ) , and subtype 5 ( SSTR 5 ) was also investigated in 22 samples by RT PCR . ^^^ The mRNA for SSTR 1 was detected in 86 % of samples , whereas the incidences of mRNA for SSTR 2 and SSTR 5 were 14 % and 64 % , respectively . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have assessed the role of a series of SST analogs , three of which were selective for SSTR 1 , SSTR 2 or SSTR 5 , in these cellular events . ^^^ Selective stimulation of SSTR 1 or SSTR 2 but not of SSTR 5 inhibited platelet derived growth factor ( PDGF ) induced [ ( 3 ) H ] thymidine incorporation . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| By means of RT PCR , we identified the expression of SSTR 1 , SSTR 2 , SSTR 3 and SSTR 4 , but not SSTR 5 , subtypes . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The obtained antibody did not crossreact with SSTR 1 , SSTR 3 , SSTR 4 , SSTR 5 , hypothalamic hormones , pituitary hormones , neuropeptides or gut hormones . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin and its receptors ( SSTR 1 to SSTR 5 ) are expressed in normal human parafollicular C cells and medullary thyroid carcinoma ( MTC ) , but the role of SSTR subtypes in cell growth regulation is still not clear . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| A series of 23 melanomas from 17 patients who underwent resection of regional or distant metastases were evaluated for the presence of SSTRs by the reverse transcriptase polymerase chain reaction ( RT PCR ) using primers specific for SSTR 1 through SSTR 5 . ^^^ SSTR 1 was expressed in 96 % of tumors , SSTR 2 in 83 % , SSTR 3 in 61 % , SSTR 4 in 57 % , and SSTR 5 in 9 % . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Normal T cells expressed SSTR 1 and SSTR 5 while T leukaemia lines did not . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Non peptide agonists selective for SSTR 1 ( L 797 , 591 ) , SSTR 3 ( L 796 , 778 ) , SSTR 4 ( L 803 , 087 ) or SSTR 5 ( L 817 , 818 ) showed little or no anti secretory activity in this preparation . 4 . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Somatostatin ( SRIH ) analogs are commonly used to treat symptoms in medullary thyroid carcinoma ( MTC ) , that expresses SRIH receptors ( SSTR 1 to SSTR 5 ) , as does the human MTC cell line TT . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| We have characterized the SRIF receptor that mediates the increase in [ Ca ( 2+ ) ] ( 1 ) and insulin secretion in HIT T 15 cells ( Simian virus 40 transformed Syrian hamster islets ) using high affinity , subtype selective agonists for SSTR 1 ( L 797 , 591 ) , SSTR 2 ( L 779 , 976 ) , SSTR 3 ( L 796 , 778 ) , SSTR 4 ( L 803 , 087 ) , SSTR 5 ( L 817 , 818 ) and PRL 2903 , a specific SSTR 2 antagonist . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : Expression of SSTR 3 , SSTR 4 , and SSTR 5 in mouse proximal tubules complements the expression of SSTR 1 and SSTR 2 in collecting ducts as seen in other species . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| By RT PCR , four of five known subtypes of SSTRs ( SSTR 1 , SSTR2A / 2B , SSTR 3 , and SSTR 4 , but not SSTR 5 ) were detected in cholangiocytes in wild type mice . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| A new SSTR2+5 bispecific analog with high affinity and selectivity for both SSTR 2 and SSTR 5 , and a somatostatin analog with a unique broad receptor ( SSTR 1 , 2 , 3 , and 5 ) binding profile , are both able to inhibit in vitro GH release in GH cell adenomas partially sensitive to octreotide . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| By sensitive and specific RT PCR , the mRNAs for the five SRIF receptors ( SSTR 1 to SSTR 5 ) could be detected . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| The progress depends on the introduction of new SS analogs with high affinity for SS receptor subtypes other than SSTR 2 , because some tumors present the high expression of SSTR 1 ( e . g . prostatic cancers ) or SSTR 5 ( e . g . colonic cancers ) . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| SSTR 2 mRNA was identified in 77 % of the adenomas , SSTR 1 and SSTR 3 in 69 % and SSTR 5 in 60 % . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| By using dual fluorescent ligands simultaneously applied to live cells monotransfected with SSTR 5 ( R 5 ) or SSTR 1 ( R 1 ) , or cotransfected with R 5 and R 1 , we have analyzed the ligand receptor stoichiometry and aggregation states for the three receptor systems by fluorescence resonance energy transfer and fluorescence correlation spectroscopy . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| RESULTS : There were mRNA expression of SSTR 2 , SSTR 3 and SSTR 5 but not SSTR 1 and SSTR 4 in SD rat HSCs . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Double gene ablation of SSTR 1 and SSTR 5 results in hyperinsulinemia and improved glucose tolerance in mice . ^^^ The objective of this study was to determine the effect of double gene ablation of SSTR 1 and SSTR 5 on insulin secretion and glucose homeostasis in mice . ^^^ CONCLUSIONS : Double gene ablation of SSTR 1 and SSTR 5 in mice resulted in a distinct phenotype with islet cell hyperplasia , hyperinsulinemia , and improved glucose tolerance . ^^^ This form of diabetes differs from that seen in mice in which only the SSTR 1 or SSTR 5 gene was ablated . ^^^ These results demonstrate that SSTR 1 and SSTR 5 are important regulators of insulin secretion and glucose regulation , and suggest that SSTR 1 and SSTR 5 are coordinately regulated . . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| We investigated the in vitro effects of SRIF and SSTR selective agonists interacting with SSTR 1 ( BIM 23926 ) , SSTR 2 ( BIM 23120 ) , SSTR 5 ( BIM 23206 ) , or both SSTR 2 and SSTR 5 ( BIM 23244 ) on alpha subunit and chromogranin A secretion and on cell viability of 12 nonfunctioning pituitary adenomas ( NFA ) expressing SSTR 1 , SSTR 2 , and SSTR 5 , as assessed by RT PCR . ^^^ These results demonstrate that , in the selected NFA , the SSTR 1 selective agonist inhibits secretory activity and cell viability , the SSTR 2 selective agonist inhibits secretion but not cell viability , and the SSTR 5 selective agonist does not influence secretion but promotes cell viability . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Five different subtypes of such receptors are identified ( SSTR 1 to SSTR 5 ) , having various tissue expression . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Cultured tumor cells were treated with SRIH , lanreotide ( BIM 23014 ) , or SRIH analogs selective for SSTR 2 ( BIM 23120 ) , SSTR 5 ( BIM 23206 ) , or SSTR 1 ( BIM 23926 ) . ^^^ GHRH secretion was significantly reduced by SRIH ( 50 % ) , Lan ( 35 % ) , as well as by the SSTR 2 , SSTR 5 , and SSTR 1 selective agonists ( 55 , 75 , and 20 % , respectively ) , whereas cell viability was not affected . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Without TNF alpha treatment , HCAECs showed mRNA expression of SST , SSTR 1 , SSTR 2 , and SSTR 5 . ^^^ The mRNA of SSTR 2 was expressed at a higher level than that of SSTR 1 and SSTR 5 . ^^^ After treatment with TNF alpha , the mRNA levels of SST , SSTR 1 , SSTR 2 , and SSTR 5 were significantly reduced in a dose dependent fashion . ^^^ TNF alpha ( 1 ng / ml ) reduced SST , SSTR 1 , SSTR 2 , and SSTR 5 by 93 , 51 , 85 , and 99 % , respectively , compared to controls ( P < 0 . 001 , t test ) . ^^^ CONCLUSIONS : HCAECs express SST , SSTR 1 , SSTR 2 , and SSTR 5 , which are all decreased by TNF alpha treatment . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| SSTR 2 , SSTR 5 , and SSTR 1 are thought to play major roles in inhibiting pancreatic cancer growth both in vitro and in vivo . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| This action has been considered to be generally mediated via six different specific somatostatin receptors ( sstr ) , sstr 1 , sstr2A , sstr2B , sstr 3 , sstr 4 , and sstr 5 . ^^^ Among human tissues in which the presence of sstr has not been previously reported , the parotid gland demonstrated immunoreactivity for sstr2B and sstr 5 , bronchial gland for sstr 1 , 2B , 3 , 4 , 5 , parathyroid gland for sstr 1 , 3 , 4 , and duodenum for all subtypes immunoreactivity . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Immunochemical analysis showed that the pancreatic islets of SSTR 1 / mice had significantly decreased levels of somatostatin staining and a significant decrease of SSTR 5 expression . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Eleven ( 61 % ) of 18 hepatic metastases from small intestinal and pancreatic ECAs were positive for SSTR 1 , 15 ( 83 % ) for SSTR 2 , 13 ( 72 % ) for SSTR 3 , 10 ( 56 % ) for SSTR 4 , and 15 ( 83 % ) for SSTR 5 . ^^^ Among 11 hepatic ECA metastases from small intestinal ECAs ( carcinoids ) , 7 ( 63 % ) expressed SSTR 1 , 9 ( 81 % ) expressed SSTR 2 , 8 ( 72 % ) expressed SSTR 3 , 6 ( 54 % ) expressed SSTR 4 , and 10 ( 91 % ) expressed SSTR 5 . ^^^ Of 7 hepatic ECA metastases from pancreatic ECAs , 4 expressed SSTR 1 , 6 expressed SSTR 2 , and 5 expressed SSTR 3 and SSTR 5 each . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| In both cell lines , SSTR 4 and SSTR 1 were highly expressed , followed by SSTR 2 and SSTR 5 with SSTR 3 being the least expressed subtype , at the protein level . ^^^ Using indirect immunofluorescence , we found that , in MCF 7 cells , SSTR 5 was the most prominent subtype coexpressed with ErbBs followed by SSTR 3 , SSTR 4 , SSTR 1 and SSTR 2 , respectively . ^^^ In MDA MB 231 cells , SSTR 1 colocalized strongly with ErbBs followed by SSTR 5 , SSTR 4 , SSTR 3 and SSTR 2 . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| All five SSTR subtypes are variably expressed at the mRNA level in breast tumors with 91 % of samples showing SSTR 1 , 98 % SSTR 2 , 96 % SSTR 3 , 76 % SSTR 4 , and 54 % SSTR 5 . ^^^ Levels of SSTR mRNA , when corrected for beta actin levels , were highest for SSTR 3 followed by SSTR 1 , SSTR 2 , SSTR 5 , and SSTR 4 . ^^^ Furthermore , there was good correlation between mRNA and protein expression with 84 % for SSTR 1 , 79 % for SSTR 2 , 89 % for SSTR 3 , 68 % for SSTR 4 , 68 % for SSTR 5 , and 78 % for all five receptors . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| SSTR 1 expression was significantly increased in islets at 3 months of age , but was nearly absent in islets at 12 months of age , as was somatostatin staining in SSTR 5 / mice . ^^^ CONCLUSIONS : These results suggest that both SSTR 5 and SSTR 1 play a pivotal role in insulin secretion and glucose regulation in mice and that their regulatory effects are age related . . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| Activation of SSTR 1 and SSTR 5 by their respective agonists , L 797 , 591 or L 817 , 818 ( 10 nM ) , increased K+ current amplitude , but SRIF evoked a further increase . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| In binding experiments , SOM 230 has a higher affinity to SSTR 1 , SSTR 3 and SSTR 5 and a slightly lower affinity to SSTR 2 compared to octreotide . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| GH secreting pituitary adenomas preferentially express SSTR 2 and SSTR 5 , prolactinomas SSTR 1 and SSTR 5 , and corticotroph adenomas express SSTR 2 ( low number ) and predominantly SSTR5s . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| The development of specific somatostatin subtypes analogs , mainly for SSTR 5 , of a SSTR 2 SSTR5 bispecific compound , and of a `` universal ' ' analog with high affinity to SSTR 1 , 2 , 3 , and 5 showed preliminary , albeit promising results for the treatment of resistant somatotropic adenomas . . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To clarify the possible effects of SRIH analogs on hormone secretion and proliferation in MTC primary cultures , we evaluated SSTR expression and assessed the in vitro effects on calcitonin ( CT ) and chromogranin A secretion as well as cell viability of SRIH analogs interacting with SSTR 1 , SSTR 2 , and SSTR 5 . ^^^ Primary cultures were developed and tested with SRIH analogs interacting with SSTR 1 , SSTR 2 , and SSTR 5 . ^^^ RESULTS : We selected 18 MTC tumor samples , expressing SSTR 1 , SSTR 2 , and SSTR 5 . ^^^ In the responder group , CT secretion was reduced by compounds interacting with SSTR 1 , SSTR 2 , and SSTR 5 , whereas cell viability was not affected . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| SSTR 1 was the most predominant subtype in both colorectal cancer and normal colorectal mucosa , and the second was SSTR 5 or SSTR 2 . ^^^ In addition , in the ulcerative type of colorectal cancer , SSTR 2 expression was obviously decreased ( P < 0 . 05 ) ; the correlation did not reach a statistical significance between the five SSTR subtypes expression and Dukes ' stages ( P > 0 . 05 ) , but the frequency of SSTR 1 expression increased with Dukes ' stage , while SSTR 3 and SSTR 5 expression decreased with Dukes ' stage . ^^^ CONCLUSION : The most predominant SSTR subtype is SSTR 1 , and the second is SSTR 2 or SSTR 5 . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| When SSTRs pan inhibitors such as BIM 23A779 ( binding affinity for SSTR 1 , SSTR 2 , SSTR 3 , SSTR 5 , respectively : 2 . 5 , 0 . 3 , 0 . 6 , 0 . 6 nmol / l ) or SOM 230 were tested for their suppressive effects on GH secretion , they were less potent than the previous dopastatin hybrid molecule . ^^^ |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P30872 and P35346 |
Pubmed |
SVM Score :0.0 |
| NA |
|