| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.53943287 |
| We also show that Chl 12 interacts physically with Rfc 2 , Rfc 3 , Rfc 4 , and Rfc 5 and forms an RFC related complex which is distinct from the RFC and RAD 24 complexes . 0.53943287^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.5559195 |
| The sister chromatid cohesion factor Chl 12 shares amino acid sequence similarity with RFC 1 , the largest subunit of replication factor C ( RFC ) , and forms a clamp loader complex in association with the RFC small subunits RFCs 2 5 . 0.5559195^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| We discuss functional implications stemming from the proposed model of the RFC 1 PCNA interaction and compare putative clamp interacting regions in RFC 1 and its paralogs , Rad 17 and Ctf 18 . ^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| In Saccharomyces cerevisiae , this process involves an alternative replication factor C ( RFC ) complex that contains the four small RFC subunits as well as CTF 18 , CTF 8 , and DCC 1 . ^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| The Elg 1 protein shares sequence homology with the large subunit of the clamp loader replication factor C ( RFC ) and with the product of two additional genes involved in checkpoint functions and genome maintenance : RAD 24 and CTF 18 . ^^^ Elg1p forms a complex with the Rfc 2 5 subunits of RFC that is distinct from the previously described RFC like complexes containing Rad 24 and Ctf 18 . ^^^ Genetic data indicate that the Elg 1 , Ctf 18 , and Rad 24 RFC like complexes work in three separate pathways important for maintaining the integrity of the genome and for coping with various genomic stresses . . ^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| In budding yeast , the establishment of sister chromatid cohesion requires Ctf 8 , Dcc 1 , and Ctf 18 , a homologue of the p 140 subunit of the replication factor C ( RFC ) . ^^^ In this report we demonstrate that in 293T cells , Flag tagged Ctf 18 forms a seven subunit cohesion RFC complex comprised of Ctf 18 , Dcc 1 , Ctf 8 , RFCp 40 , RFCp 38 , RFCp 37 , and RFCp 36 ( Ctf 18 RFC ) . ^^^ We demonstrate that a stoichiometric heteroheptameric Ctf 18 RFC complex can be assembled by coexpressing the seven proteins in baculovirus infected insect cells . ^^^ Both the five and seven subunit Ctf 18 RFC complexes bind to single stranded and primed DNAs and possess weak ATPase activity that is stimulated by the addition of primed DNA and proliferating cell nuclear antigen ( PCNA ) . ^^^ Consistent with these observations , both Ctf 18 RFC complexes substituted for the replicative RFC in the PCNA dependent DNA polymerase delta catalyzed DNA replication reaction . ^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Elg 1 acts in concert with the alternative Rfc 1 like proteins Rad 24 and Ctf 18 to enable Rad 53 checkpoint kinase activation in response to replication stress . ^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| These RFC like complexes ( RLCs ) share four common subunits ( Rfc 2 5 ) and each carry a unique large subunit ( Rad 24 or Ctf 18 ) replacing the Rfc 1 subunit of the replication complex . ^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| This seven subunit Ctf 18 RFC complex consists of the four small subunits of RFC , together with Ctf 18 , Dcc 1 , and Ctf 8 . ^^^ Ctf 18 RFC was also a weak loader of PCNA onto naked template primer DNA . ^^^ However , when the single stranded DNA template was coated by the yeast single stranded DNA binding protein replication protein A ( RPA ) but not by a mutant form of RPA or a heterologous single stranded DNA binding protein , both binding of Ctf 18 RFC to substrate DNA and loading of PCNA were strongly inhibited , and unloading predominated . ^^^ The Dcc 1 and Ctf 8 subunits of Ctf 18 RFC , while required for establishing sister chromatid cohesion in vivo , did not function specifically in PCNA unloading in vitro , thereby separating the functionality of the Ctf 18 RFC complex into two distinct paths . . ^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| The Ctf 18 RFC like complex positions yeast telomeres but does not specify their replication time . ^^^ We report that Ctf 18 , Ctf 8 , and Dcc 1 , the subunits of a Replication Factor C ( RFC ) like complex , are essential for the perinuclear positioning of telomeres . ^^^ Our results suggest that the Ctf 18 RFC like complex modifies telomeric chromatin to make it competent for normal localization to the nuclear periphery . . ^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| These alternative clamp loaders contain the small Rfc 2 5 subunits of RFC , but replace the large Rfc 1 subunit by a pathway specific alternative large subunit , Rad 24 for the DNA damage checkpoint , Ctf 18 for the establishment of sister chromatid cohesion , and Elg 1 for a general function in chromosome stability . ^^^ |
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| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WVB6 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|