| We have discovered that the large subunit , p 140 , of replication factor C ( RFC ) can function as a regulator of RelA . ^^^ We find that RFC ( p 140 ) interacts with RelA both in vitro and in vivo and stimulates RelA transactivation . ^^^ In contrast , coexpression of fragments of RFC ( p 140 ) that mediate the interaction with RelA results in transcriptional inhibition . ^^^ Dominant negative fragments of RFC ( p 140 ) also cooperate with overexpressed RelA to induce cell death . ^^^ |