| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| These include genes encoding the anti apoptosis factor SURVIVIN , positive cell cycle regulators ( CDC 2 , CYCLIN B 1 , CYCLIN B 2 , CYCLIN G 1 , CHK 1 , BUB 3 , STK 6 , SKB 1 , CSE 1 L ) and chromosome replication proteins ( MCM 2 , MCM 3 , FEN 1 , RRM 2 , TOP2A , RFC 1 ) . ^^^ |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| Analysis of their functions , along with previously prepared alanine scanning mutants , demonstrated that some loops interact with DNA polymerase delta ( pol delta ) and replication factor C ( RFC ) . ^^^ The p 21 binding sites of PCNA , mapped by affinity measurement of the mutant forms , found to be located within a distinct structure of the PCNA monomer , overlap with RFC and pol delta interaction sites . ^^^ Competition between p 21 and pol delta or RFC for binding to PCNA results in efficient inhibition of its stimulation of pol delta DNA synthesis and RFC ATPase but not of PCNA loading on DNA by RFC . ^^^ CONCLUSIONS : Semi saturated amounts of p 21 selectively block formation of the active pol delta complex but not the RFC PCNA complex at 3 ' ends of DNA primers . ^^^ |
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| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| Deletion of the rfc 2 + gene from the chromosome is lethal but does not result in the checkpoint dependent cell cycle arrest seen in cells deleted for the gene encoding PCNA or for those genes encoding subunits of either Pol delta or Pol straightepsilon . ^^^ |
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| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| The nucleotide substitution error rate for pol delta holoenzyme ( HE ) ( pol delta + PCNA + RFC ) was 4 . 6 10 10 ( 4 ) for T . ^^^ |
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| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| Moreover , human replication factor C ( RFC ) enhances the PfuPCNA dependent DNA synthesis activity of Pol delta , indicating that human RFC works as the clamp loader for PfuPCNA . ^^^ |
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| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| Recently , we have reconstituted the PCNA dependent AP site repair reaction with six purified human proteins : AP endonuclease , replication factor C ( RFC ) , PCNA , flap endonuclease 1 ( FEN 1 ) , DNA polymerase delta ( pol delta ) , and DNA ligase 1 . ^^^ PCNA can directly interact with RFC , pol delta , FEN 1 and DNA ligase 1 . ^^^ |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28340 and P35251 |
Pubmed |
SVM Score :0.0 |
| NA |
|