| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.85550105 |
| We have purified a previously unknown glycoprotein ( designated gp 340 ) from human bronchioalveolar lung washings from a patient with alveolar proteinosis . gp 340 was identified by its calcium dependent binding to lung surfactant protein D ( SP D ) and by its molecular mass of 340 kDa in the reduced state on SDS polyacrylamide gel electrophoresis ( PAGE ) . gp 340 was purified from the 10 , 000 10 g pellet of the lavage fluid by ion exchange and gel permeation chromatography . 0.85550105^^^ |
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| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.59679251 |
| CRP ductin , the mouse homologue of gp 340 / deleted in malignant brain tumors 1 ( DMBT 1 ) , binds gram positive and gram negative bacteria and interacts with lung surfactant protein D . 0.59679251^^^ |
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| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.67205351 |
| A 340 kDa glycoprotein ( gp 340 ) has been shown to bind SP D in the presence of calcium but does so independently of carbohydrate recognition . 0.67205351^^^ |
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| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.54089927 |
| Gp 340 binds to SP D ( surfactant protein D ) , and we previously showed that lung gp 340 has co operative interactions with SP D in viral neutralization and aggregation assays . 0.54089927^^^ |
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| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.0 |
| Analysis of the distribution of gp 340 , together with the TFFs and SP D in normal lung and gastric mucosa , supported further our in vitro data . ^^^ |
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| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.0 |
| We now show that lung and salivary gp 340 inhibit the hemagglutination activity and infectivity of IAV and agglutinate the virions through a mechanism distinct from that of SP D . ^^^ Gp 340 inhibits IAV strains that are resistant to SP D . ^^^ Hence , gp 340 contributes to defense against IAV and may be particularly relevant to defense against SP D resistant viral strains . . ^^^ |
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| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.0 |
| The surfactant collectins , surfactant proteins A and D ( SP A and D ) , and scavenger receptor rich glycoprotein 340 ( gp 340 ) inhibit influenza A virus ( IAV ) in the following order of potency : SP D > gp 340 > SP A . ^^^ In this study , SP D , SP A , and gp 340 showed cooperative antiviral interactions . ^^^ The mechanism of binding between gp 340 and SP D was further characterized using monoclonal antibodies . ^^^ Although gp 340 can bind to SP D at a site distinct from the mannan binding site , binding of gp 340 to SP D did not contribute to cooperative antiviral interactions . ^^^ |
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| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.0 |
| Finally , several other innate immune proteins that bind to SP D and / or IAV ( i . e . , SP A , lung glycoprotein 340 or mucin ) significantly reduce the ability of SP D to promote neutrophil oxidant response . ^^^ |
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| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.0 |
| Human salivary agglutinin binds to lung surfactant protein D and is identical with scavenger receptor protein gp 340 . ^^^ The mass spectrum revealed 11 peaks with an identical mass as a computer simulated trypsin digest of gp 340 . gp 340 is a 340 kDa glycoprotein isolated from bronchoalveolar lavage fluid that binds specifically to lung surfactant protein D . ^^^ |
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| Interacting proteins: P35247 and Q9UGM3 |
Pubmed |
SVM Score :0.0 |
| In purifying SP A from proteinosis lavage , we isolated a protein that copurifies with SP A and SP D and that was later found by protein sequencing to be gp 340 . ^^^ |
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