| Interacting proteins: Q92887 and P35241 |
Pubmed |
SVM Score :0.68353683 |
| In vitro binding studies show that radixin associates directly with the carboxy terminal cytoplasmic domain of human MRP 2 . 0.68353683^^^ |
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| Interacting proteins: Q92887 and P35241 |
Pubmed |
SVM Score :0.0 |
| Radixin , the dominant ezrin radixin moesin protein in hepatocytes , has been reported to selectively tether multidrug resistance associated protein 2 to the apical canalicular membrane . ^^^ |
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| Interacting proteins: Q92887 and P35241 |
Pubmed |
SVM Score :0.0 |
| METHODS : We investigated the uptake transporters OATP 2 ( SLC21A6 ) , OATP 8 ( SLC21A8 ) , and NTCP ( SLC10A1 ) , the export pumps MRP 2 ( ABCC 2 ) , MRP 3 ( ABCC 3 ) , MRP 6 ( ABCC 6 ) , and P glycoproteins ( ABCB 1 , ABCB 4 , ABCB 11 ) , and radixin , in non icteric primary biliary cirrhosis ( PBC stages 1 3 ) and control human liver needle biopsies using immunofluorescence microscopy and semi quantitative RT PCR . ^^^ Areas of irregular MRP 2 immunostaining showed largely reduced radixin immunostaining , whereas normal hepatocytes had MRP 2 and radixin confined to the canalicular membrane . ^^^ Disrupted localization of radixin and MRP 2 supports the concept that radixin contributes to the canalicular localization of MRP 2 . ^^^ |
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| Interacting proteins: Q92887 and P35241 |
Pubmed |
SVM Score :0.0 |
| Specific knockdown of Mrp 2 ( approximately 50 % decrease in expression ) resulted in an approximately 45 % decrease in the biliary excretion index of carboxydichlorofluorescein ( CDF ) ( 9 . 3 % versus 16 . 5 % ) , but did not affect Mrp 3 or radixin expression . ^^^ |
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