| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| Compared with awake measurements , the mean arterial pressure ( MAP ) decreased 19 + / 3 torr ( mean + / SE ) and heart rate ( HR ) increased 9 + / 3 bpm 1 minute after thiamylal SCh . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| We describe a high resolution radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 ( NF 2 ) gene . ^^^ Based on the RH map , the NF 2 region of chromosome 22 , defined by the flanking markers D22S1 and D22S28 , is estimated to span a physical distance of approximately 6 Mb and is the most likely location for 9 of the 18 markers studied : D22S33 , D22S41 , D22S42 , D22S46 , D22S56 , LIF , D22S37 , D22S44 , and D22S15 . . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| The present study investigated the effect of co administration of SCH 23390 ( a selective D 1 dopamine receptor antagonist ) or YM 09151 2 ( a selective D 2 dopamine receptor antagonist ) prior to each MAP injection for 14 days on dopamine efflux in the striatal perfusates using in vivo dialysis . ^^^ After 3 months drug abstinence , MAP challenge alone produced augmented stereotypy in the MAP group , but not in the control , the SCH 23390 + MAP or the YM 09151 2 + MAP group . ^^^ In parallel with this behavioral observation , the degree to which dopamine efflux increased following the MAP challenge was significantly greater in the MAP group than that in the control , SCH 23390 + MAP group and the YM 09151 2 + MAP groups . ^^^ While dopamine efflux after MAP challenge did not differ between the control and the YM 09151 2 + MAP group , it was greater in the SCH 23390 + MAP group than the control group . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| To examine the possible involvement of D 1 dopamine receptors in behavioral sensitization induced by subchronic methamphetamine ( MAP ) administration , regional D 1 receptors labeled with [ 3H ] SCH 23390 were examined using binding assay and quantitative autoradiography . ^^^ Autoradiography revealed a significant increase in specific [ 3H ] SCH 22390 binding in the lateral part of the substantia nigra pars reticulata ( SNr ) of MAP treated rats . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| Following the determination of the binding characteristics of [ 3H ] SCH 23390 using slide mounted tissue sections of molded minced forebrain , the effects of chronic methamphetamine ( MAP ) treatment ( at a dose of 4 mg / kg for 14 days ) on D 1 receptors in the rat brain were studied using quantitative receptor autoradiography . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| Each group received a daily injection of saline ( control group ) , 4 mg / kg MAP ( MAP group ) , 1 mg / kg YM 09151 2 plus 4 mg / kg MAP ( YM + MAP group ) or 0 . 5 mg / kg SCH 23390 plus 4 mg / kg MAP ( SCH + MAP group ) for 14 days . ^^^ During daily injection for 14 days , the MAP group exhibited a progressive augmentation in locomotor and stereotyped behavior , whereas the progression of such behaviors in the YM + MAP and SCH + MAP group was completely prevented . ^^^ However , neither the YM + MAP group nor the SCH + MAP group showed stereotypy . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| The sequential administration of atenolol ( 0 . 5 mg / kg i . v . ) administered at a dose selective for beta 1 adrenoceptors , propranolol ( 2 . 5 mg / kg i . v . ) and the DA 1 dopamine receptor antagonist , SCH 23390 ( 10 micrograms / kg i . v . ) blocked the DPX induced changes in HR , CCF , MAP and renal blood flow , respectively . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| The infusion rate of SCH administered intrarenally was sufficiently low to produce no measurable systemic effects including PRA , PAC , and MAP . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| MAP given to pentobarbital narcotized rats restored HACU activity to nonanesthetized levels , but this restorative effect of MAP was blocked by SCH 23390 or raclopride . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| The initiation of behavioral sensitization to MAP in rats requires stimulation of dopaminergic neurons , and can be blocked by SCH 23390 ( a dopamine D 1 receptor antagonist ) and BMY 14802 ( a sigma receptor antagonist ) . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| Neither saline nor SCh cause any significant change in cerebral perfusion pressure , MAP , 5 mca , EEG , or ICP . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| SCH 23390 ( SCH : 0 . 001 0 . 03 mg / kg SC ) and YM 09151 2 ( YM : 0 . 001 0 . 03 mg / kg SC ) , the selective dopamine D 1 and D 2 antagonists , respectively , reduced dose dependently the ambulation increasing effect of methamphetamine ( MAP : 2 mg / kg SC ) in mice . ^^^ The sensitization to MAP was inhibited when it was administered in combination with SCH ( 0 . 003 0 . 03 mg / kg ) or YM ( 0 . 003 0 . 03 mg / kg ) in the repeated administration regimen . ^^^ The inhibitory action of YM on the MAP sensitization was more prominent than that of SCH . ^^^ However , the repeated treatment with either SCH or YM could not ameliorate the established MAP sensitization . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE To define the DNA mutation causing neurofibromatosis 2 ( NF 2 ) , a severe genetic disorder involving the development of multiple nervous system tumors in adulthood , in a large , well studied NF 2 pedigree previously used to chromosomally map and to isolate the disease gene . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| The effects of 4 succinylcholine ( SCh ) on the electroencephalogram ( EEG ) , cerebral blood flow ( CBF ) , cerebral metabolic rate ( CMRO 2 ) , intracranial pressure ( ICP ) , central venous pressure ( CVP ) , and mean arterial pressure ( MAP ) were tested in halothane anesthetized dogs . ^^^ CVP , MAP , and CMRO 2 did not significantly change after 4 SCh . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| We have sought to determine whether SCH 51344 disrupts the signaling pathway that activates mitogen activated protein ( MAP ) kinase or extracellular signal regulated kinase ( ERK ) in normal and ras transformed fibroblast cells . ^^^ Our results indicate that SCH 51344 inhibits the ability of 5 abl , 5 mos , H ras , 5 raf , and mutant active MAP kinase kinase transformed NIH 3T3 cells to grow in soft agar . ^^^ SCH 51344 treatment had very little effect , if any , on the activation of MAP kinase kinase , MAP kinase , and p90RSK activity in response to growth factor stimulation . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| The ambulation increasing effects of MAP ( 1 mg / kg ) , CAF ( 10 mg / kg ) and combination of MAP with CAF were almost equivalently inhibited by SCH 23390 ( 0 . 01 and 0 . 1 mg / kg SC ) and YM 09151 2 ( 0 . 01 and 0 . 1 mg / kg SC ) . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| To generate a domestic horse genome map we integrated synteny information for markers screened on a somatic cell hybrid ( SCH ) panel with published information for markers physically assigned to chromosomes . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| In contrast , the binding of [ 11C ] SCH 23390 to dopamine D 1 receptors in the monkey striatum was not altered after the administration of MAP . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| MAP , a protein interacting with a tumor suppressor , merlin , through the run domain . ^^^ Characterization of the positive clones revealed a protein of 749 amino acids named merlin associated protein ( MAP ) , which showed wide tissue distribution in Northern blot analysis . ^^^ MAP and merlin were directly associated in vitro and in vivo , and colocalized in NIH3T3 cells . ^^^ The RUN domain of MAP and the C terminus of merlin appeared to be responsible for their interaction . ^^^ MAP decreased the AP 1 dependent promoter activity additively with merlin in NIH3T3 cells . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| The binding of [ 11C ] SCH 23390 to dopamine D 1 receptors in the striatum was also not altered after the administration of MAP . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| SCH 23390 [ 0 . 003 0 . 03 mg / kg , subcutaneously ( SC ) ] , a dopamine D 1 receptor antagonist , dose dependently inhibited the ambulation stimulant effect of methamphetamine ( MAP ) ( 2 mg / kg , SC ) in mice when two drugs were combined in repeated administrations at 3 to 4 day intervals , repeated five times . ^^^ SCH 23390 ( 0 . 03 mg / kg ) , which was sufficient to abolish the acute effect of MAP completely throughout the repeated administrations , significantly inhibited the induction of MAP sensitization . ^^^ Moreover , when the mice were posttreated with SCH 23390 ( 0 . 01 and 0 . 03 mg / kg ) 3 h after each MAP administration , at which the ambulation stimulant effect of MAP had almost disappeared , they showed a significant and dose dependent retardation of the induction of MAP sensitization . ^^^ The administration of SCH 23390 ( 0 . 003 0 . 03 mg / kg ) alone in either the activity cage or the home cage , or saline in the activity cage with 3 or 24 h posttreatment with SCH 23390 ( 0 . 01 or 0 . 03 mg / kg ) five times at 3 to 4 day intervals did not elicit any significant changes in MAP sensitivity . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : When Sch is not desirable , mivacurium 0 . 25 mg / kg given as a divided dose provides good to excellent intubation conditions 90 seconds after the initial dose without significant changes in MAP or HR . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| This report examines the effects of various dopamine ( DA ) receptor antagonists [ haloperidol ( HAL ) , sulpiride ( SUL ) , YM 09151 2 ( YM ) , and SCH 23390 ( SCH ) ] on MAP induced abnormal behaviors and the changes of CCK LI in the rat mPFC . ^^^ However , the reduction of CCK LI induced by MAP ( 20 40 % ) was abolished by the pretreatment with HAL ( 0 . 025 and 0 . 25 mg / kg ) , YM ( 0 . 01 and 0 . 1 mg / kg ) , or SCH ( 1 . 0 mg / kg ) , without being affected by SUL ( up to 250 mg / kg ) . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| In addition , merlin prevented the Raf 1 complex activation process , which resulted in the suppression of MAP kinase / ERK , extracellular signal regulated kinase ( ERKs ) , and Elk 1 phosphorylation , which are the downstream signals of Raf 1 . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| Erbin regulates mitogen activated protein ( MAP ) kinase activation and MAP kinase dependent interactions between Merlin and adherens junction protein complexes in Schwann cells . ^^^ Here , we find that a novel PDZ protein , called erbin , binds directly to the merlin binding partner , EBP 0 , and regulates adherens junction dissociation through a MAP kinase dependent mechanism . ^^^ Collectively , these data indicate that erbin regulates MAP kinase activation in Schwann cells and suggest that erbin links merlin to both adherens junction protein complexes and the MAP kinase signaling pathway . . ^^^ |
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| Interacting proteins: Q96HU1 and P35240 |
Pubmed |
SVM Score :0.0 |
| The identity of RabGAPLP to merlin associated protein ( MAP ) , one of the interacting partners of neurofibromatosis type 2 ( NF 2 ) tumor suppressor gene product ( merlin ) , implies cross talk of membrane traffic and cell adhesion . . ^^^ |
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