| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The protein moesin is a member of a gene family consisting of talin , ezrin , radixin , protein 4 . 1 . , and merlin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Moesin is a member of a recently discovered family of closely related proteins that includes ezrin , radixin , and merlin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Ezrin , radixin , moesin and merlin form a subfamily of conserved proteins in the band 4 . 1 superfamily . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The encoded protein , Merlin , is closely related to the Ezrin , Radixin , and Moesin family of membrane / cytoskeletal linker proteins . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Levels of ezrin and moesin , proteins related to the NF 2 gene product , merlin , were unchanged in schwannoma cells compared to NHSC . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Ezrin , radixin , moesin and merlin form a subfamily of conserved proteins in the band 4 . 1 superfamily . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The NF 2 encoded protein , merlin , belongs to the ERM ( ezrin , radixin , and moesin ) family of cytoskeleton : membrane linkers . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The ERM proteins ( ezrin , radixin , moesin ) together with merlin comprise a subgroup of the band 4 . 1 superfamily . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The Nf 2 encoded protein , merlin , is related to the ERM ( ezrin , radixin , and moesin ) family of membrane : cytoskeleton associated proteins . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The NF 2 tumor suppressor protein , merlin , is related to the ERM ( ezrin , radixin , and moesin ) family of membrane / F actin linkers . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| This assumption is based on the homology of the NF 2 protein to a group of band 4 . 1 related proteins , ezrin , radixin , and moesin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The recently isolated gene for neurofibromatosis type 2 ( NF 2 ) encodes a 595 amino acid protein , named merlin , which is related to the cytoskeleton associated proteins moesin , ezrin and radixin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Although the entire merlin ezrin radixin moesin ( MERM ) homology domain of merlin was found to be essential for binding to all five proteins , the MERM homology domains of ezrin and moesin did not bind to any of the five proteins . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Previously , we have cloned a candidate for the 595 amino acid neurofibromatosis type 2 tumor suppressor called NF 2 or Merlin , with striking sequence similarity in its N terminal half to an F actin binding protein family called TERM , which includes talin , ezrin , radixin , and moesin ( Trofatter , J . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The Merlin gene product belongs to a family of proteins which include moesin , ezrin and radixin , involved in linking the cytoskeleton to the cell membrane . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor , merlin . ^^^ Interest in members of the protein 4 . 1 super family , which includes the ezrin radixin moesin ( ERM ) group , has been stimulated recently by the discovery that the human neurofibromatosis 2 ( NF 2 ) tumor suppressor gene encodes an ERM like protein , merlin . ^^^ To investigate the cellular and developmental functions of these proteins , we have identified and characterized Drosophila homologues of moesin ( Dmoesin ) and of the NF 2 tumor suppressor merlin ( Dmerlin ) . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Merlin does not localize to the same structures as either ezrin or moesin in human meningioma cells , suggesting a function distinct from these ERMs . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Double immunofluorescence analyses of merlin and moesin revealed a colocalization in filopodia and ruffling membranes . ^^^ The localization of merlin in the actin rich cortical cytoskeleton corresponds to the ezrin radixin moesin family of proteins suggesting the NF 2 protein to contribute to the regulation of cell growth by interaction with cytoskeleton associated proteins . . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Merlin is structurally related to ezrin , radixin and moesin , which are also expressed in the CNS , as demonstrated by Western blotting . ^^^ The pattern of merlin expression , however , is distinct from that of ezrin , which has been previously described , and that of moesin , in which immunohistochemistry with an anti moesin antibody showed expression in endothelial cells , glia and neurons in a membranous or diffuse cytoplasmic pattern . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The NF 2 gene encodes a tumor suppressor protein , schwannomin ( or merlin ) , with sequence homology to erythrocyte band 4 . 1 , talin , ezrin , moesin and radixin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| In addition , the role of the merlin related ERM family members ( ezrin , radixin , and moesin ) remains unclear in these tumors . ^^^ We therefore studied expression of NF 2 encoded merlin as well as ezrin , radixin , and moesin in 22 vestibular and peripheral schwannomas that had been evaluated for NF 2 mutations and chromosome 22q loss . ^^^ These data indicate that the specific loss of merlin is universal to schwannomas and is not linked to loss of ezrin , radixin , or moesin expression . . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| We have localized human NHE RF to actin rich structures such as membrane ruffles , microvilli , and filopodia in HeLa and COS 7 cells , where it co localizes with merlin and moesin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The Neurofibromatosis 2 gene product , merlin , has striking similarity to ezrin , radixin , and moesin ( ERM ) , members of the protein 4 . 1 family which have been demonstrated to connect proteins in the plasma membrane to the cytoskeletal components . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The encoded protein , merlin , is closely related to ezrin , radixin , and moesin , which are members of the band 4 . 1 family of membrane / cytoskeletal linker proteins . ^^^ Thus , as has been described for the erzin , radixin , and moesin proteins , the activities of the carboxyl terminal domain of merlin may be suppressed by the amino terminal domain . . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Merlin , the product of the Neurofibromatosis type 2 ( NF 2 ) tumor suppressor gene , is a member of the protein 4 . 1 superfamily that is most closely related to ezrin , radixin , and moesin ( ERM ) . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Merlin differs from moesin in binding to F actin and in its intra and intermolecular interactions . ^^^ The neurofibromatosis type 2 ( NF 2 ) tumor suppressor gene encodes merlin , a protein with homology to the cell membrane / F actin linking proteins , moesin , ezrin and radixin . ^^^ As is true for ezrin , moesin and radixin , the N and C terminal domains of merlin type 1 bind to each other . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Merlin , which shares significant homology with the actin associated proteins ezrin , radixin and moesin ( ERM proteins ) , inhibits cell growth when overexpressed in cell lines . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Merlin , the neurofibromatosis 2 tumor suppressor protein , has two major isoforms with alternate C termini and is related to the ERM ( ezrin , radixin , moesin ) proteins . ^^^ Similarly , the N terminus of merlin can also associate with C terminus of moesin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The Neurofibromatosis 2 tumor suppressor gene encodes Merlin , a member of the Protein 4 . 1 superfamily most closely related to Ezrin , Radixin and Moesin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The NF 2 gene product , merlin ( or schwannomin ) , is a member of the protein 4 . 1 family of membrane associated proteins , which also includes ezrin , radixin and moesin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The product of the neurofibromatosis type 2 ( NF 2 ) tumor suppressor gene , merlin , is closely related to the ezrin radixin moesin ( ERM ) family , a group of proteins believed to link the cytoskeleton to the plasma membrane . ^^^ Merlin lacks an actin binding domain conserved among ezrin , radixin and moesin . ^^^ Because merlin , ezrin and moesin are co expressed in Schwann cells , and all homodimerize , we have examined whether merlin and ezrin dimerize with one another . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| NHE RF , a regulatory cofactor for NHE ( Na ( + ) H ( + ) exchanger ) type 3 , interacts with ion transporters and receptors through its PDZ domains and with the MERM proteins ( merlin , ezrin , radixin and moesin ) via its carboxyl terminus . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Homology analysis indicates that merlin is most closely related to members of the protein 4 . 1 superfamily especially ezrin , radixin and moesin , the ERM proteins . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The neurofibromatosis 2 ( NF 2 ) gene encodes merlin , an ezrin radixin moesin ( ERM ) related protein that functions as a tumor suppressor . ^^^ At low cell density , merlin is phosphorylated , growth permissive , and exists in a complex with ezrin , moesin , and CD 44 . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The neurofibromatosis 2 protein product merlin , named for its relatedness to the ezrin , radixin and moesin ( ERM ) family of proteins , is a tumour suppressor whose absence results in the occurrence of multiple tumours of the nervous system , particularly schwannomas and meningiomas . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The Nf 2 tumor suppressor gene product merlin is related to the membrane cytoskeleton linker proteins of the band 4 . 1 superfamily , including ezrin , radixin , and moesin ( ERMs ) . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The cause of the disease has been traced to mutations in the gene coding for a protein that is alternately called merlin or schwannomin and is a member of the ERM family ( ezrin , radixin and moesin ) . ^^^ The N terminal domain of merlin closely resembles those described for the corresponding domains in moesin and radixin and exhibits a cloverleaf architecture with three distinct subdomains . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Merlin , the neurofibromatosis 2 tumor suppressor protein , is related to the ERM ( ezrin , radixin , moesin ) proteins and , like its family members , is thought to play a role in plasma membrane cytoskeletal interactions . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Merlin and moesin were found to inhibit N WASP mediated actin assembly in vitro , a function that appears independent of their ability to bind actin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The DAL 1 / 41B gene ( differentially expressed in adenocarcinoma of the lung ) , located in the chromosome 18p11 . 3 region , belongs to the protein family 4 . 1 ( membrane associated proteins ) , which includes the product of the NF 2 gene ( merlin ) , and the proteins , ezrin , radixin , and moesin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The band 4 . 1 proteins are cytoskeletal proteins , harboring a conserved FERM domain highly homologous to the N terminal FERM domain of ezrin , radixin , moesin , and merlin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The sodium hydrogen exchanger regulatory factors ( NHERF 1 and NHERF 2 ) are a family of adaptor proteins characterized by the presence of two tandem PDZ protein interaction domains and a C terminal domain that binds the cytoskeleton proteins ezrin , radixin , moesin , and merlin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Merlin and Expanded are members of the FERM ( Four point one , Ezrin , Radixin , Moesin ) domain superfamily , which consists of membrane associated cytoplasmic proteins that interact with transmembrane proteins and may function as adapters that link to protein complexes and / or the cytoskeleton . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| Schwannomin itself lacks the actin binding sites found in ezrin , radixin and moesin , suggesting that signalling to the actin cytoskeleton occurs via actin binding sites on betaII spectrin . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| On the grounds of the homology to the ezrin , radixin , and moesin proteins and on the basis of its predicted secondary structure , the NF 2 protein is also thought to act as a cytoskeleton cell membrane linking protein . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The gene for NF 2 , a syndrome typically associated with vestibular schwannomas and meningiomas , is homologous with a family of genes whose members appear to play an important role in bridging the cell membrane with the intracellular cytoskeleton , including moesin , ezrin , radixin , and protein 4 . 1 . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The NF 2 gene is homologous to a family of genes whose products , including moesin , ezrin , radixin and protein 4 . 1 , appear to have an important role in bridging the cell membrane and the intracellular cytoskeletion . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The protein encoded by the NF 2 gene has striking similarities to ezrin , radixin and moesin ( ERM ) proteins which link membrane proteins to the cytoskeleton . ^^^ |
|
| Interacting proteins: P35240 and P26038 |
Pubmed |
SVM Score :0.0 |
| The protein encoded by the NF 2 gene has a similarity to ezrin , radixin and moesin ( ERM ) proteins that link membrane proteins to the cytoskeleton . ^^^ |
|