| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| However , the ability of the CD 44 receptor to bind immobilized hyaluronan was restricted to CD44H+ cell lines without NMYC amplification ( SH EP and ACN ) . ^^^ |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| We examined CD 44 expression in normal sciatic nerves , in schwannomas with confirmed NF 2 mutations , and in neurofibromas and malignant peripheral nerve sheath tumor tissue and cell lines from NF 1 patients . ^^^ These data indicate that altered CD 44 expression correlates strictly with mutations in the NF 2 but not NF 1 gene and suggest that CD44v6 might be a marker for the malignant transformation of Schwann cells . . ^^^ |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| NF 2 protein colocalized with CD 44 , which in transfected cells accumulated into restructured cell membrane protrusions . ^^^ The association of CD 44 and NF 2 protein was further suggested by binding of CD 44 from cellular lysates to recombinant NF 2 protein . ^^^ |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| Under specific conditions , binding of another ligand , the ECM component hyaluronate , leads to the activation and binding to the CD 44 cytoplasmic tail of the tumor suppressor protein merlin . ^^^ |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| The NF 2 tumor suppressor gene product , merlin , mediates contact inhibition of growth through interactions with CD 44 . ^^^ Merlin ' s growth inhibitory activity depends on specific interaction with the cytoplasmic tail of CD 44 , a transmembrane HA receptor . ^^^ At low cell density , merlin is phosphorylated , growth permissive , and exists in a complex with ezrin , moesin , and CD 44 . ^^^ These data indicate that merlin and CD 44 form a molecular switch that specifies cell growth arrest or proliferation . . ^^^ |
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| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| On the basis of insights derived from studying the NF 2 tumor suppressor , we propose a model for merlin growth regulation in which CD 44 links growth signals from plasma membrane to the nucleus by interacting with ERM proteins and merlin . . ^^^ |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| In vitro studies have identified molecules that interact with the product ( merlin or schwannomin ) , some of which ( e . g . , CD 44 and paxillin ) may play critical roles in merlin growth regulation . ^^^ |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| Lastly , we show that Protein 4 . 1R interacted with a subset of merlin / Protein 4 . 1B interactors including CD 44 and betaII spectrin . ^^^ |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| Lastly , we show that PAK 2 phosphorylation impairs the ability of merlin to bind to two interacting proteins , CD 44 and hepatocyte growth factor regulated tyrosine kinase substrate ( HRS ) , both critical for merlin growth suppression . ^^^ |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| Four minutes after thiopental administration ( 7 min after MTC ) , after a 1 min period of relatively stable arterial pressure and ICP , Sch 1 mg / kg was administered as a bolus . ^^^ In group 1 ( MTC pretreatment ) , ICP did not change significantly from the mean value observed before Sch , 14 mmHg + / 2 SE . ^^^ This study not only confirms previous work showing that Sch may induce marked ICP increases in lightly anesthetized patients with intracranial mass lesions , but also indicates that pretreatment with a `` defasciculating ' ' dose of MTC can prevent these potentially deleterious ICP increases in patients known to be at risk . . ^^^ |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P35240 |
Pubmed |
SVM Score :0.0 |
| NA |
|