| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| Although not correlated to the cell adhesion phenotype , four missense mutations decreased the binding of merlin to the ERM interacting protein EBP 50 , implicating this interaction in merlin inhibition of cell growth . ^^^ |
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| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| ERM Merlin and EBP 50 protein families in plasma membrane organization and function . ^^^ We also discuss membrane proteins to which ERM and merlin bind , including those making an indirect linkage through the PDZ containing adaptor molecules EBP 50 and E3KARP . ^^^ |
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| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| Hierarchy of merlin and ezrin N and C terminal domain interactions in homo and heterotypic associations and their relationship to binding of scaffolding proteins EBP 50 and E3KARP . ^^^ Both the ezrin and merlin N ERMAD bind EBP 50 . ^^^ |
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| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| The sodium hydrogen exchanger regulatory factors ( NHERF 1 and NHERF 2 ) are a family of adaptor proteins characterized by the presence of two tandem PDZ protein interaction domains and a C terminal domain that binds the cytoskeleton proteins ezrin , radixin , moesin , and merlin . ^^^ |
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| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| Mutations occurred at the conserved PDZ domains at NHERF NH 2 terminus that bound to SYK , or at its COOH terminus motif that binds to MERLIN , the product of Neurofibromatosis 2 ( NF 2 ) tumor suppressor gene . ^^^ NHERF tumorigenic mutations decreased or abolished its interaction with SYK or MERLIN , suggesting a pathway link among these three molecules that may play a critical role in mammary neoplastic progression . ^^^ Taken together , the results indicated NHERF to be a candidate tumor suppressor gene in human breast carcinoma that may be interconnected to the SYK and MERLIN suppressors . . ^^^ |
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| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| NHE RF , a regulatory cofactor for Na ( + ) H+ exchange , is a common interactor for merlin and ERM ( MERM ) proteins . ^^^ We have identified the human homologue of a regulatory cofactor of Na ( + ) H+ exchanger ( NHE RF ) as a novel interactor for merlin , the neurofibromatosis 2 tumor suppressor protein . ^^^ The carboxyl terminal region of NHE RF , downstream of the PDZ domains , interacts with the amino terminal protein 4 . 1 domain containing segment of merlin in yeast two hybrid assays . ^^^ We have localized human NHE RF to actin rich structures such as membrane ruffles , microvilli , and filopodia in HeLa and COS 7 cells , where it co localizes with merlin and moesin . ^^^ |
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| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE RF . ^^^ We have also explored the effect of merlin self association on binding to the regulatory cofactor of Na ( + ) H ( + ) exchanger ( NHE RF ) , an interacting protein for merlin and the ERMs . ^^^ Merlin isoform 2 captures more NHE RF than merlin isoform 1 in affinity binding assays , suggesting that in full length merlin isoform 1 , the NHE RF binding site is masked because of the self interactions of merlin . ^^^ Treatment with a phospholipid known to decrease self association of ERMs enhances the binding of merlin isoform 1 to NHE RF . ^^^ |
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| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| NHE RF , a merlin interacting protein , is primarily expressed in luminal epithelia , proliferative endometrium , and estrogen receptor positive breast carcinomas . ^^^ NHE RF , a regulatory cofactor for NHE ( Na ( + ) H ( + ) exchanger ) type 3 , interacts with ion transporters and receptors through its PDZ domains and with the MERM proteins ( merlin , ezrin , radixin and moesin ) via its carboxyl terminus . ^^^ |
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| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| NHERF overexpression in human breast cancers and mutations in NHERF targets , such as CFTR and merlin , the product of Neurofibromatosis NF 2 tumor suppressor gene , that impair NHERF binding suggest that aberrant NHERF function contributes to human disease . . ^^^ |
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| Interacting proteins: O14745 and P35240 |
Pubmed |
SVM Score :0.0 |
| NHERF associates with merlin and the ezrin / radixin / moesin ( MERM ) family of membrane actin cytoskeletal linker proteins through its C terminus and is capable of interacting via its PDZ 1 domain to the betaPDGF receptor ( betaPDGFR ) . ^^^ |
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