| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.81144487 |
| The UCN homologues SCP and SRP bind specifically to the CRFR 2 receptor , whereas UCN binds to both CRFR 1 and CRFR 2 . 0.81144487^^^ |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Both urocortin ( UCN ) and corticotropin releasing hormone ( CRH ) are known to stimulate secretion of adrenocorticotropic hormone ( ACTH ) by corticotroph cells via type 1 corticotropin releasing hormone receptor ( CRHR 1 ) . ^^^ We extensively examined UCN effects on the anterior pituitary ( AP ) , particularly on proopiomelanocortin ( POMC ) mRNA and CRHR 1 mRNA as well as ACTH secretion in vivo . ^^^ Similarly , intravenous administration of UCN increased POMC mRNA and decreased CRHR 1 mRNA in the AP . ^^^ The more potent effects of UCN relative to CRH may be attributable to UCN ' s higher affinity for CRHR 1 . . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Urocortin ( Ucn ) is related to corticotropin releasing hormone ( CRH ) , and both are released in the brain under stress where they stimulate CRH 1 and 2 receptors ( CRHR ) . ^^^ |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| A recently cloned related peptide , Urocortin ( Ucn ) , appears to have similar affinity for the CRF 1 receptor , but higher affinity at the CRF 2 receptor . ^^^ |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| The structure activity relationship ( SAR ) between the recently identified neuropeptide urocortin ( Ucn ) and corticotropin releasing factor ( CRF ) receptor , type 1 ( CRFR 1 ) , has been investigated . ^^^ To this end , rat Ucn ( rUcn ) , ovine CRF ( oCRF ) and chimeric peptides of rUcn and oCRF were synthesized and tested for their binding affinity and potency to stimulate cAMP production in human embryonic kidney ( HEK ) 293 cells stably transfected with cDNA encoding rat CRFR 1 ( rCRFR 1 ) . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Unique sites of CRF R 2 expression were relatively unresponsive to CRF but were more so after icv administration of urocortin ( UCN ) , a new mammalian CRF related peptide . ^^^ Both CRF and UCN elicited activational responses in cell groups that are involved in central autonomic control but that express neither CRF R , including the central amygdaloid and paraventricular hypothalamic nuclei , and brainstem catecholaminergic cell groups . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| The actions of corticotropin releasing hormone ( Crh ) , a mediator of endocrine and behavioural responses to stress , and the related hormone urocortin ( Ucn ) are coordinated by two receptors , Crhr 1 ( encoded by Crhr ) and Crhr 2 . ^^^ We also demonstrate that Crhr 2 is essential for sustained feeding suppression ( hypophagia ) induced by Ucn . ^^^ Feeding is initially suppressed in Crhr 2 / mice following Ucn , but Crhr 2 / mice recover more rapidly and completely than do wild type mice . ^^^ In addition to central nervous system effects , we found that , in contrast to wild type mice , Crhr 2 / mice fail to show the enhanced cardiac performance or reduced blood pressure associated with systemic Ucn , suggesting that Crhr 2 mediates these peripheral haemodynamic effects . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Crh has a higher affinity for Crhr 1 than for Crhr 2 , and urocortin ( Ucn ) , a Crh related peptide , is thought to be the endogenous ligand for Crhr 2 because it binds with almost 40 fold higher affinity than does Crh . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| The anorectic effects of CRF and UCN were not blocked by the CRF 1 receptor antagonist antalarmin , suggesting that the peripheral effects of CRF and UCN on food intake are mediated primarily by the CRF 2 receptor . . ^^^ |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| The rank orders of mRNA abundance in each of the tissue types were as follows : for CRF , brain > > thymus=spleen=heart ; for UCN , heart > / =brain > thymus > spleen ; for CRFR 1 , brain > > thymus > spleen ( absent in heart ) ; for CRF R 2 , brain=heart > thymus > spleen ; and CRF BP was only detectable in the brain . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| CRFR 1 and CRFR 2 , the receptors for CRF and Ucn , are expressed in neurons associated with appetite control and metabolism , but their relative contributions in mediating CRF or Ucn induced hypophagia and weight loss are not known . ^^^ We used homozygous mice lacking CRFR 1 ( CRFR 1 / ) and wild type littermates to determine the role of CRFR 1 in mediating the changes in food intake and body weight following intracerebroventricular administration of Ucn . ^^^ A 7 day intracerebroventricular infusion of Ucn transiently suppressed ad libitum food intake equally in CRFR 1 / and wild type mice . ^^^ Body weight reduction during Ucn infusion paralleled food intake in wild type mice , but persisted throughout the infusion in CRFR 1 / mice . ^^^ By contrast , CRFR 1 / mice did not respond to Ucn 1 . 5 h after injection . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| The distinctive expression pattern of CRF R 2 mRNA identifies additional putative central sites of action for CRF and / or UCN . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Unlike Crhr 1 or Crhr 2 deficient mice , Ucn deficient mice exhibit normal anxiety like behavior as well as autonomic regulation in response to stress . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| UCN is able to bind to two types of G protein coupled receptors : CRF receptor type 1 ( CRFR 1 ) and CRF receptor type 2 ( CRFR 2 ) , whereas , two homologues of UCN , stresscopin ( SCP ) or also known as urocortin 3 ( UCNIII ) and stresscopin related peptide ( SRP ) , or urocortin 2 ( UCNII ) , bind exclusively and with high affinity to CRFR 2 , we hypothesised that they will exhibit more pronounced cardioprotective effects than UCN . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Using Chinese hamster ovary cells stably expressing CRFR 1 and CRFR2beta , we show that Ucn 1 , Ucn 2 and Ucn 3 activate ERK1 / 2 p 42 , 44 via CRFR2beta . ^^^ CRF and Ucn 1 but not Ucn 2 or Ucn 3 activates ERK1 / 2 p 42 , 44 in Chinese hamster ovary cells stably expressing CRFR 1 . ^^^ Raf 1 kinase , tyrosine kinases , and possibly intracellular Ca ( 2+ ) provide regulatory roles for Ucn 1 activation of ERK1 / 2 p 42 , 44 by CRFR 1 and CRFR2beta . ^^^ Studies of the regulation of ERK1 / 2 p 42 , 44 by Ucn 1 were extended to cell lines that endogenously express CRFR 1 ( AtT 20 and CATHa cells ) and CRFR 2 ( A7r5 and CATHa cells ) . ^^^ Use of the G ( 1 ) and G ( o ) protein inhibitor pertussis toxin showed that ERK1 / 2 p 42 , 44 activation by Ucn 1 via CRFR 1 and CRFR2beta are both G ( 1 ) and / or G ( o ) protein dependent . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| In the CeA , CRF ( r / h ) depressed excitatory glutamatergic transmission through a CRF 1 mediated postsynaptic action , whereas Ucn 1 facilitated synaptic responses through presynaptic and postsynaptic CRF 2 mediated mechanisms . ^^^ Conversely , in the LSMLN , CRF caused a CRF 1 mediated facilitation of glutamatergic transmission via postsynaptic mechanisms , whereas Ucn 1 depressed EPSCs by postsynaptic and presynaptic CRF 2 mediated actions . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| The present study tested the hypothesis that the anorexigenic mode of action of Ucn 2 differed from that of ovine CRF ( oCRF ) , a preferential CRF 1 receptor agonist . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| The early and later phases of Ucn 1 mediated feeding suppression may be CRF 1 and CRF 2 receptor mediated events , respectively . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Urocortin 1 binds with high affinity to CRF type 1 ( CRF 1 ) and type 2 ( CRF 2 ) receptors while Ucn 2 and Ucn 3 are selective CRF 2 ligands . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| The two main mammalian peptides of this family , CRH and urocortin ( UCN ) , signal through the same receptors , CRH R 1 and CRH R 2 . ^^^ Recent studies conducted on mice deficient in CRH , CRH R 1 , CRH R 2 and CRH R1 / CRH R 2 , as well as in two different UCN deficient mice , have added relevant information towards the understanding of the role of this peptide family in the CNS . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Endogenous agonists ( urocortin ( UCN ) 2 , UCN 3 ) and synthetic antagonists ( astressin 2 B , antisauvagine 30 ) are selective for CRF 2 over the CRF 1 receptor . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Corticotropin releasing factor ( CRF ) and urocortin ( Ucn 1 ) are endogenous members among a family of CRF related peptides that activate two different and synaptically localized G protein coupled receptors , CRF 1 and CRF 2 . ^^^ In brain slice recordings from the LSMLN of control ( saline treated ) rats , glutamatergic synaptic transmission was facilitated by activation of CRF 1 receptors with CRF but was depressed after activation of CRF 2 receptors with Ucn 1 . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Ucn 1 binds to both CRF type 1 ( CRF 1 ) and type 2 receptors ( CRF 2 ) , whereas Ucn 3 is a specific agonist for CRF 2 . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| In vivo studies suggest that corticotrophin releasing factor ( CRF ) and CRF like peptides , urocortin 1 ( UCN 1 ) and UCN 2 , inhibit gastric emptying and stimulate colonic motility through CRF 2 and CRF 1 receptors , respectively . ^^^ We evaluated expression and functions of CRF , UCN 1 , UCN 2 and CRF 1 and CRF 2 receptors in the rat gastric antrum . ^^^ Quantitative RT PCR demonstrated UCN 2 , CRF 1 and CRF 2 receptors expressions in both muscle layers and mucosa of the gastric antrum . ^^^ These results demonstrate ( 1 ) the presence of CRF , UCN and CRF 1 and CRF 2 receptors in the rat gastric antrum ; ( 2 ) that , in vitro , CRF like peptides inhibit phasic contractions of the antrum through CRF 2 receptor . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| CRH mRNA levels did not change during the luteal phase , whereas expression of UCN , UCN 2 , CRHR 1 , and CRHR 2 was maximal at early or mid luteal phase before declining ( P < 0 . 05 ) at the later stages . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Urocortin 1 ( UCN 1 ) , a peptide of the CRF family , binds both CRF 1 receptor and CRF 2 receptor with equal affinities . ^^^ Urocortin 3 ( UCN 3 ) , a highly selective ligand for CRF 2 receptor with little affinity for CRF 1 receptor , has been shown in rat pancreatic beta cells . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| The CRFR 1 antagonist antalarmin inhibited the [ ( 3 ) H ] DA release induced by electrical stimulation and enhanced by CRF and Ucn 1 . ^^^ These results suggest that CRF and Ucn 1 mediate DA release through the activation of CRFR 1 . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Here we show in the Sprague Dawley rat that direct in vivo application to the ventromedial hypothalamus ( VMH ) , a key glucose sensing region , of urocortin 1 ( UCN 1 ) , an endogenous CRFR 2 agonist , suppressed ( approximately 55 60 % ) , whereas CRF , a predominantly CRFR 1 agonist , amplified ( approximately 50 70 % ) CRR to hypoglycemia . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| Corticotropin releasing hormone ( CRH ) and urocortins ( Ucn ) bind with various affinities to two G protein coupled receptors , CRHR 1 and CRHR 2 , which are expressed in brain and in peripheral tissues , including immune cells . ^^^ |
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| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P55089 and P34998 |
Pubmed |
SVM Score :0.0 |
| NA |
|