| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| HsMcm 10 also interacted with Orc 2 , Mcm 2 and Mcm 6 proteins in the yeast two hybrid system . ^^^ |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| The ectopic genomic replication of E2f2 mutant follicle cells can be suppressed by reducing the Orc 2 , Orc 5 , or Mcm 2 gene dose by half , indicating that small changes in pre RC gene expression can affect DNA synthesis in these cells . ^^^ |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| In particular CDC 6 was found to bind strongly to ORC 1 and ORC 2 , and to MCM 7 proteins . ^^^ |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| Moreover , Mcm 10 interacts with key members of the prereplication complex : Mcm 2 , Dup ( Cdt 1 ) , and Orc 2 . ^^^ Furthermore , depletion of Mcm 10 , Cdc 45 , Mcm 2 , Mcm 5 , and Orc 2 , respectively , results in aberrant chromosome condensation . ^^^ |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| Here , we sought to identify factors that associate with TR by using a TR DNA column and found that poly ( ADP ribose ) polymerase 1 ( PARP 1 ) and known replication factors , including ORC 2 , CDC 6 , and Mcm 7 , bound to TR . ^^^ |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| This mutant is unable to maintain interactions with either Mcm 2 or Orc 2 at the semipermissive temperature of 30 degrees C , while the interaction with Rad 53 is preserved . ^^^ |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| The expression of tCdc 6 perturbs the loading of Mcm 2 but not Orc 2 onto chromatin and activates ataxia telangiectasia mutated ( ATM ) and ATM and Rad 3 related ( ATR ) kinase activities with kinetics similar to that of the phosphorylation of Chk1 / 2 . ^^^ |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| The binding of the prereplication complex proteins Orc 1 , Orc 2 , Mcm 3 , Mcm 7 , and Cdc 6 and the novel DNA unwinding element ( DUE ) binding protein DUE B to the endogenous human c myc replicator was studied by chromatin immunoprecipitation . ^^^ In G ( 1 ) arrested HeLa cells , Mcm 3 , Mcm 7 , and DUE B were prominent near the DUE , while Orc 1 and Orc 2 were least abundant near the DUE and more abundant at flanking sites . ^^^ Similarly , the signals from Orc 1 , Mcm 3 , and Mcm 7 were at background levels in cells arrested in M phase , whereas Orc 2 retained the distribution seen in G ( 1 ) phase cells . ^^^ |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13416 and P33993 |
Pubmed |
SVM Score :0.0 |
| NA |
|