| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| In ATC , high MCM 5 and MCM 7 expression was paralleled by high levels of MCM 2 and MCM 6 . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| The human homologs of the MCM 2 ( BM 28 ) , Mis 5 , Cdc 21 , and CDC 47 proteins were tightly bound to a histone Sepharose column and purified to near homogeneity , whereas the P1 / MCM3 and CDC46 / MCM5 proteins passed through . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| This gene family includes Saccharomyces cerevisiae MCM 2 , MCM 3 , MCM5 / CDC46 and CDC 47 , S . pombe nda 1 , nda 4 , cdc 21 and mis 5 , and genes encoding human BM 28 , P1MCM3 and P1 . 1MCM3 and mouse P1MCM3 , most of which are considered to be required for the initiation of DNA replication . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The members of the MCM protein family , including MCM 2 , MCM 3 , Cdc 21 , CDC 46 , Mis 5 and CDC 47 , are considered to be involved in the control of a single round of DNA replication during S phase in eukaryotes . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| Our group purified MCM protein complexes consisting of MCM 2 , 4 ( Cdc 21 ) , 6 ( Mis 5 ) , and 7 ( CDC 47 ) proteins from HeLa cells by using histone Sepharose column chromatography ( Ishimi , Y . , Ichinose , S . , Omori , A . , Sato K . , and Kimura , H . ( 1996 ) J . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| The highest similarity was found with Mcm2p ( 42 % identity over the whole length and higher than 75 % over a conservative region of 215 amino acid residues ) , suggesting that BM 28 could represent the human homologue of the S . cerevisiae MCM 2 . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| Purified Hsk 1 phosphorylates the Cdc 19 ( Mcm 2 ) subunit of the six member minichromosome maintenance protein complex purified from fission yeast . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| We investigated the basis for this late S phase arrest by analyzing the effects of a temperature sensitive mutation in fission yeast cdc 19 ( + ) ( mcm 2 ( + ) ) . cdc 19 P1 cells show a dramatic loss of viability at the restrictive temperature , which is not typical of all S phase mutants . ^^^ We compared the effects of disruptions of cdc 19 ( + ) ( mcm 2 ( + ) ) , cdc 21 ( + ) ( mcm 4 ( + ) ) , nda 4 ( + ) ( mcm 5 ( + ) ) and mis 5 ( + ) ( mcm 6 ( + ) ) ; in all cases , the null mutants underwent delayed S phase but were unable to proceed through the cell cycle . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| We report that antibodies against MCM 2 ( BM 28 ) specifically inhibited transcription by RNA polymerase 2 ( Pol 2 ) in microinjected Xenopus oocytes . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| Analyses of a newly isolated temperature sensitive mutant , hsk 1 89 , reveal that Hsk 1 plays crucial roles in DNA replication checkpoint signaling and maintenance of proper chromatin structures during mitotic S phase through regulating the functions of Rad 3 ( ATM ) Cds 1 and Rad 21 ( cohesin ) , respectively , in addition to expected essential roles for initiation of mitotic DNA replication through phosphorylating Cdc 19 ( Mcm 2 ) . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| Purified baculovirus expressed HsCdc 7 HsDbf4 selectively phosphorylates the MCM 2 subunit of the minichromosome maintenance ( MCM ) protein complex isolated by immunoprecipitation with MCM 7 antibodies in vitro . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| Class 1 includes genes that encode components of the pre RC and pre IC and are represented by SLM 3 , 4 and 5 which are allelic to MCM 7 , MCM 2 and CDC 45 , respectively . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| Moreover , cDNA array analysis showed that PC SPES caused up regulation of p 21 ( WAF1 / CIP1 ) and decreased expression of cyclin B , Nedd 8 , cdc 2 , skp 1 , PCNA , MAD2L1 , cyclin H , CKS 2 , E2F , Rbx 1 , MCM 2 , MCM 5 , Mpp 2 , Cullin Cul4A , Cks1p9 and McM 7 , which are involved in cell cycle progression . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| Such cells show a specific defect in loading of initiator proteins Mcm 4 , Mcm 7 , and to a lesser degree , Mcm 2 onto chromatin during telophase and early G 1 when Mcm 2 7 are normally recruited to license origins of replication . ^^^ Because minichromosome maintenance complex proteins are thought to function as a heterohexamer , loading of Mcm 2 , Mcm 4 , and Mcm 7 depleted complexes is likely to underlie the S phase defects observed in cyclin E deregulated cells , consistent with a role for minichromosome maintenance complex proteins in initiation of replication and fork movement . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| We validated the differential expression of several genes ( e . g . , CENPF , MCM 2 , MCM 7 , RAMP , IRAK 1 , and PTTG 1 ) in PDAC by immunohistochemistry and reverse transcription polymerase chain reaction . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| In a search for proteins that interact with the PBD of Plk 1 , we identified two of the minichromosome maintenance ( MCM ) proteins , Mcm 2 and Mcm 7 . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| Here , we show that expression levels of at least three of the PfMCM subunits , the homologues of MCM 2 , MCM 6 and MCM 7 , change during the intraerythrocytic development cycle , peaking in schizont and decreasing in the ring and trophozoite stages . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| An emerging class of markers , the minichromosome maintenance protein family of DNA licensing factors ( MCM 2 , MCM 6 , MCM 7 ) , shows promise for the specific detection of high grade cervical disease using simple antibody based immunochemistry formats . ^^^ |
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| Interacting proteins: P33993 and P49736 |
Pubmed |
SVM Score :0.0 |
| Some of the down regulated genes are involved in : cytoskeleton and cell movement ( WASF 2 , LCP 1 , MSN , NIPSNAP 1 , KIF2C ) ; DNA replication and repair ( MCM 2 , MCM 3 , MCM 7 and XRCC 4 ) . ^^^ |
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