| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| We show that RB mediated S phase inhibition does not inhibit the chromatin binding function of MCM 2 or RPA , suggesting that RB does not regulate the prereplication complex or disrupt early initiation events . ^^^ |
|
| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| Alterations of chromosomes ( 3p , 5q , 9p ) , genes ( Rb , C myc , C mos , hTERT ) , proteins ( p 16 , p 53 , K ras , hnRNP A2 / B1 , MCM 2 , EGFR , erbB 2 , erbB 3 , erbB 4 ) and others can be found in lung cancer . ^^^ |
|
| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| Acute Rb excision from conditional knockout myotubes caused reexpression of E2F transcriptional activity , cyclin E and A kinase activities , PCNA , DNA ligase 1 , RPA , and MCM 2 , but did not induce DNA synthesis , showing that pRb is not indispensable to preserve the postmitotic state of these cells . ^^^ |
|
| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| Full length Rb and MCM 7 form protein complexes in vitro , and the amino termini of two Rb related proteins , p 107 and p 130 , also bind MCM 7 . ^^^ Protein complexes between Rb and MCM 7 were also detected in anti Rb immunoprecipitates prepared from human cells . ^^^ The amino termini of Rb and p 130 strongly inhibited DNA replication in an MCM 7 dependent fashion in a Xenopus in vitro DNA replication assay system . ^^^ |
|
| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| Although the cyclin D 1 dependent kinase did not phosphorylate MCM 7 , active cyclin D1 / CDK4 , but not cyclin E / CDK2 , did catalyze the dissociation of an RB . ^^^ |
|
| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| Inhibition of mitogen induced MCM 6 and MCM 7 expression by PD 98059 was reversed by ectopic overexpression of E2F , indicating that ERK / MAPK signaling is required for events that occur upstream of E2F release from phosphorylated Rb . ^^^ |
|
| Interacting proteins: P33993 and P06400 |
Pubmed |
SVM Score :0.0 |
| A fragment of the retinoblastoma protein , Rb ( 1 400 ) , was used to neutralize MCM 7 , and antibodies were used to neutralize Cdc 45 . ^^^ |
|