| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| Mutations in the cell division cycle genes CDC 46 and CDC 47 were originally isolated as suppressors of mutations in two other cell division cycle genes ( CDC 45 and CDC 54 ) . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| CDC 45 genetically interacts with at least two members of the MCM ( minichromosome maintenance ) family of replication genes , CDC 46 and CDC 47 , which are proposed to perform a role in restricting initiation of DNA replication to once per cell cycle . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| Although CDC 45 genetically interacts with a group of MCM genes ( CDC 46 , CDC 47 , and CDC 54 ) , the predicted sequence of its protein product reveals no significant sequence similarity to any known Mcm family member . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| CDC 45 interacts genetically with CDC 46 and CDC 47 , both members of the MCM family of genes which have been implicated in the licensing of DNA replication . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| The temperature sensitive sld 3 mutation confers a defect in DNA replication at the restrictive temperature and reduces an interaction not only between Sld 3 and Cdc 45 , but also between Cdc 45 and Mcm 2 . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| Class 1 includes genes that encode components of the pre RC and pre IC and are represented by SLM 3 , 4 and 5 which are allelic to MCM 7 , MCM 2 and CDC 45 , respectively . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| Furthermore , depletion of Mcm 10 , Cdc 45 , Mcm 2 , Mcm 5 , and Orc 2 , respectively , results in aberrant chromosome condensation . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| Inactivation of Cdc 23 before replication initiation using tight degron mutations has no effect on Mcm 2 chromatin association , and thus pre replicative complex ( pre RC ) formation , although Cdc 45 chromatin binding is blocked . ^^^ These observations show that Cdc23 / Mcm10 function is conserved between fission yeast and Xenopus , where in vitro analysis has indicated a similar requirement for Cdc 45 binding , but apparently not compared with Saccharomyces cerevisiae , where Mcm 10 is needed for Mcm 2 chromatin binding . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| A requirement for MCM 7 and Cdc 45 in chromosome unwinding during eukaryotic DNA replication . ^^^ Here , we use Xenopus egg extracts to investigate the roles of MCM 7 and Cdc 45 in DNA replication . ^^^ A fragment of the retinoblastoma protein , Rb ( 1 400 ) , was used to neutralize MCM 7 , and antibodies were used to neutralize Cdc 45 . ^^^ When added immediately after origin unwinding , or after significant DNA synthesis , both inhibitors blocked further DNA replication , indicating that MCM 7 and Cdc 45 are required throughout replication elongation in vertebrates . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| Inhibition of uncoupling during elongation with inhibitors of MCM 7 or Cdc 45 , a putative helicase cofactor , results in abrogation of Chk 1 phosphorylation , indicating that uncoupling is necessary for activation of the checkpoint . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| Consistent with the DNA replication defects , chromatin immunoprecipitation experiments revealed significantly lower levels of the replication factors Mcm 4 , Mcm 7 , and Cdc 45 at replication origins in met 30 mutants than in wild type cells . ^^^ |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75419 and P33993 |
Pubmed |
SVM Score :0.0 |
| NA |
|