Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.62401779
The structurally related T cell surface molecules CD 28 and CTLA 4 interact with cell surface ligands CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) on antigen presenting cells ( APC ) and modulate T cell antigen recognition . 0.62401779^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.63985254
Collectively , these results demonstrate the importance of costimulation for naive CD8+ T cell activation , suggest that CD 80 and CD 86 can mediate opposing effects , possibly due to differential interaction with CD 152 and CD 28 , and indicate differences in the sensitivity of immature vs mature CD8+ T cells to the induction of nonresponsiveness following costimulation deficient Ag presentation . . 0.63985254^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
At 24 hr postactivation , B cells express a CTLA 4 counterreceptor not recognized by anti B 7 or BB 1 monoclonal antibodies ( mAbs ) , which induces detectable IL 2 secretion and T cell proliferation . ^^^ At 48 and 72 hr postactivation , B cells express both B 7 and a third CTLA 4 counterreceptor identified by the anti BB 1 mAb . ^^^ We propose the following terminology for these CTLA 4 counterreceptors : ( 1 ) B 7 , B 7 1 ; ( 2 ) early CTLA 4 binding counterreceptor , B 7 2 ; and ( 3 ) BB 1 , B 7 3 . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The CTLA 4 Ig fusion protein inhibited the ability of microglia to present antigen in both antigen presentation assays to an even greater extent than did the anti BB 1 mAb . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Monoclonal antibody BB 1 was previously shown to recognize the CD 80 protein as well as a putative B7 . 3 molecule , both ligands of the important T cell receptors CD 28 and CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
To examine if the muscle fibers in patients with inflammatory myopathies have the potential to behave as antigen presenting cells ( APCs ) , we investigated the expression of costimulatory molecules BB 1 , B 7 1 ( CD 80 ) , and B 7 2 ( CD 86 ) , and their counterreceptors , CD 28 or CTLA 4 ( CD 152 ) , in the muscle biopsies of patients with polymyositis ( PM ) , PM associated with human immunodeficiency virus infection ( HIV PM ) , sporadic inclusion body myositis ( s IBM ) , dermatomyositis ( DM ) , and normal or disease controls . ^^^ Expression of the costimulatory molecule BB 1 , the ligands CTLA 4 and CD 28 , and their mRNA in inflammatory myopathies . ^^^ Several of the BB 1 positive fibers bound strongly in a cell to cell contact with their CD 28 or CTLA 4 ligands on the autoinvasive CD8+ T cells , as confirmed by confocal microscopy . ^^^ Because the BB 1 positive fibers expressed MHC class 1 antigen and bound to up regulated counterreceptors CD 28 and CTLA 4 on the autoinvasive CD8+ T cells only in PM , HIV PM , and s IBM , the BB 1 molecule in these diseases should have a functional role in antigen presentation and T cell differentiation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
To examine whether the Schwann cells in patients with autoimmune neuropathies have the potential to behave as professional antigen presenting cells , we investigated the expression of the co stimulatory molecules BB 1 , B 7 1 ( CD 80 ) B 7 2 ( CD 86 ) and their counter receptors CD 28 or CTLA 4 ( CD 152 ) at the protein and mRNA levels in sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy ( CIDP ) , CIDP associated with human immunodeficiency virus infection ( HIV CIDP ) , IgM paraproteinaemic neuropathy and normal or non immune axonal neuropathy . ^^^ Expression of the co stimulatory molecule BB 1 , the ligands CTLA 4 and CD 28 and their mRNAs in chronic inflammatory demyelinating polyneuropathy . ^^^ The endoneurial T cells in the proximity of BB 1 positive Schwann cells expressed the CD 28 or CTLA 4 counter receptors . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 28 and CTLA 4 are homologous T cell receptors of the immunoglobulin ( Ig ) superfamily , which bind B 7 molecules ( CD 80 and CD 86 ) on antigen presenting cells and transmit important costimulatory signals during T cell activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We investigated expression of costimulatory molecules BB 1 , B 7 1 ( CD 80 ) , B 7 2 ( CD 86 ) , and their counter receptors CD 28 and CTLA 4 ( CD 152 ) in muscle biopsy specimens of patients with scleroderma polymyositis overlap syndrome ( SSc PM ) , primary polymyositis ( PM ) , and other related diseases to examine whether the muscle fibers in patients with SSc PM behave as antigen presenting cells ( APCs ) . ^^^ The CD4+ T cells expressed the counter receptors CD 28 and CTLA 4 , and bound with the BB 1 positive muscle fibers in cell to cell contact . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Binding of the CTLA 4 Ig fusion protein was completely inhibited by a combination of monoclonal antibodies ( mAbs ) against CD 80 and B70 / B7 2 , indicating the absence of expression of a third ligand for CD28 / CTLA 4 . ^^^ It is interesting to note that mAbs against CD 86 completely prevented the binding of CTLA 4 Ig in the presence of mAbs against CD 80 and bound to a B70 / B7 2 transfected fibroblast cell line , demonstrating that the B70 / B7 2 antigen is identical to CD 86 . ^^^ The present results demonstrate that D Lc express , in addition to CD 80 , the other ligand for CTLA 4 , CD 86 ( B70 / B7 2 ) , which plays a primordial role during D Lc induced alloreaction . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The DC dependent infection was inhibitable by anti CD 80 and a soluble fusion protein of the CD 80 ligand , CTLA 4 ; soluble CTLA 4 immunoglobulin also blocked infection augmented by cross linking CD 40 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Human B 7 1 ( CD 80 ) and B 7 2 ( CD 86 ) bind with similar avidities but distinct kinetics to CD 28 and CTLA 4 receptors . ^^^ B 7 0 or B 7 2 ( CD 86 ) is a T cell costimulatory molecule that binds the same receptors ( CD 28 and CTLA 4 ) as B 7 1 ( CD 80 ) , but shares with it only approximately 25 % sequence identity and is expressed earlier during an immune response . ^^^ However , CD 80 and CD 86 did not bind equivalently to CTLA 4 : CD 80 bound Y100A , a form of CTLA4lg with a mutation in the CDR 3 like region , > 200 fold better than did CD 86 ; inhibition of CD 80 mediated cellular responses required approximately 100 fold lower CTLA4lg concentrations ; and CD 80 CTLA4lg complexes dissociated 5 to 8 fold more slowly , Thus , CD 80 and CD 86 utilize different binding determinants and have different kinetics of binding to CD 28 and CTLA 4 . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD28 / CTLA 4 ligands : the gene encoding CD 86 ( B70 / B7 . 2 ) maps to the same region as CD 80 ( B7 / B7 . 1 ) gene in human chromosome 3q13 q 23 . ^^^ The CD 86 gene is , therefore , located in the proximity of the CD 80 ( B7 / B7 . 1 ) gene , the first identified ligand for CD 28 and CTLA 4 , previously mapped to chromosome 3q13 . 3 q 21 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Identification of residues in the 5 domain of CD 80 ( B 7 1 ) implicated in functional interactions with CD 28 and CTLA 4 . ^^^ CD 80 also binds to the CD 28 related molecule CTLA 4 , which is expressed on activated T cells , Recently , additional ligands of CD 28 and CTLA 4 have been described in mice and humans . ^^^ Two hydrophobic residues in the 5 like domain of CD 80 were identified as critical for binding to CD 28 and are also important for the interaction with CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
B 7 1 ( CD 80 ) provides co stimulation for T cell activation by interacting with CD 28 or CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Both extracellular immunoglobin like domains of CD 80 contain residues critical for binding T cell surface receptors CTLA 4 and CD 28 . ^^^ The B 7 related molecules CD 80 and CD 86 are expressed on antigen presenting cells , bind the homologous T cell receptors CD 28 and CTLA 4 , and trigger costimulatory signals important for optimal T cell activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 80 ( B7 / BB 1 ) is a costimulatory molecule that serves as the ligand for two molecules expressed on T lymphocytes , CD 28 and CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 28 and CTLA 4 are structurally related T cell receptors for members of the B 7 ( CD 80 ) gene family , which transmit important costimulatory signals for T cell activation in vitro and in vivo . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Differential effects of CTLA 4 substitutions on the binding of human CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) . ^^^ CTLA 4 expressed on activated T cells binds to CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) molecules present on APC with high avidity and appears to deliver a negative regulatory signal to the T cell . ^^^ We have investigated the kinetics of CTLA 4 binding to CD 80 and CD 86 , together with the effects of selected CTLA 4 mutations on binding activity . ^^^ The dissociation constants ( Kd ) for binding of CTLA 4 Ig to CD 80 and CD 86 transfectants were 8 . 1 and 6 . 7 nM , respectively . ^^^ Surface plasmon resonance was used to determine kinetic parameters of CTLA 4 Ig binding to CD 80 Ig and CD 86 Ig fusion proteins and revealed enhanced association ( ka ) and dissociation ( kd ) rate constants for CD 86 Ig compared with CD 80 Ig . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Conjugation of the T cell receptor ( TCR ) with antigen / MHC proteins must be accompanied by conjugation of T cell counterreceptors ( CD 28 or CTLA 4 ) with costimulatory molecules CD 80 or CD 86 ( B 7 1 or B 7 2 ) on antigen presenting cells ( APC ) to avert T cell anergy , and to provide essential signals for T cell activation and cytokine production . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Anti CD 86 mAb and CTLA 4 Ig , but not anti CD 80 mAb , inhibited the MLR stimulated by SF DC . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The expansion of TIL was partially blocked by the addition of CTLA 4 Ig , which is an inhibitor of costimulatory molecules such as CD 80 and CD 86 , and was almost blocked by the addition of anti ( Fc receptor gamma 2 ) mAb . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
T lymphocyte receptor CTLA 4 binds costimulatory molecules CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) with high avidity and negatively regulates T cell activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Both receptors associate with the counter receptors CD 80 and CD 86 , but the avidity of interaction for CD 28 is about 20 fold lower than for CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 80 antibodies minimally inhibited an allogeneic MLR , whereas CD 86 antibodies and CTLA 4 Ig showed significant inhibition . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4 , a CD 28 homologue expressed on activated T cells , binds with high affinity to the CD 28 ligands , B 7 1 ( CD 80 ) and B 7 2 ( CD 86 ) . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The B 7 receptors , CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) , on the Ag presenting cell ( APC ) , interact with T cell CD 28 or CTLA 4 to deliver a costimulatory signal , which is particularly important for Th 1 activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
T lymphocyte receptors CD 28 and CTLA 4 bind costimulatory molecules CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) on antigen presenting cells and regulate T cell activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Interactions of CD 80 and CD 86 with CD 28 and CTLA 4 . ^^^ Because inhibitors of this interaction may have therapeutic relevance in human autoimmune disease , we investigated the properties of linear peptides derived from conserved regions of CTLA 4 and CD 80 known to be essential for binding . ^^^ Insertion of two residues between the two Ig domains of CD 80 resulted in decreased affinity for CTLA 4 , but a similar mutation in CD 86 was without effect . ^^^ We also identified another asymmetry between CD 80 and CD 86 in that the 5 domain of CD 86 but not that of CD 80 is sufficient for CTLA 4 binding . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Interaction of the CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) molecules on antigen presenting cells with the receptors CD 28 and CTLA 4 on T cells generates signals important in the regulation of immune responses . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The costimulatory signal through CD 80 or CD 86 to its counterreceptor CD 28 or CTLA 4 on T cells has been shown to play an important role in the induction of T cell mediated immunity against tumors . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4 is a costimulation receptor that binds to the same ligands , CD 80 and CD 86 , as CD 28 with high affinity and is transiently expressed on the cell surface of activated T cells . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Expression of CD 28 , CTLA 4 , CD 80 , and CD 86 molecules in patients with autoimmune rheumatic diseases : implications for immunotherapy . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The uses of soluble competitors for CD 28 ( CTLA 4 Ig ) and agonists for the inhibitory receptor CTLA 4 ( CD 80 Ig ) offer therapeutic possibilities to tailor autoimmune responses in nonpathogenic directions . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4Ig fusion protein , that binds to both CD 80 and CD 86 with high affinity and thereby prevents interaction of CD80 / CD86 with CD28 / CTLA 4 , prevents or ameliorates several autoimmune disease in experimental animal models , supporting an importance of this pathway in the development of autoimmune diseases . ^^^ This suggests that the actual regulatory mechanisms of this pathway in autoimmunity is much more complex , because of the existence of two receptors ( CD 28 and CTLA 4 ) and two ligands ( CD 80 and CD 86 ) and the opposite function of CD 28 and CTLA 4 in T cell activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We used a neutralizing antibody to block CTLA 4 interaction with its ligands CD 80 and CD 86 during infection of mice with the nematode , Nippostrongylus brasiliensis . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Mutation of these residues , which are conserved in the CTLA 4 / CD28 family , significantly reduces binding to CD 80 and / or CD 86 , implicating this patch as a ligand binding site . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
These libraries were used to screen a blocking monoclonal antibody raised against B 7 1 ( CD 80 ) , a human cell surface antigen that binds two T cell receptors , CD 28 and CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The CTLA 4 ligands CD 80 and CD 86 were simultaneously expressed in most CTLA 4 negative lymphoma cases . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4 ( CD 152 ) , high avidity receptor for CD 80 and CD 86 , is a powerful regulator of T cell activation . ^^^ CTLA 4 ( CD 152 ) , high avidity receptor for CD 80 and CD 86 , is a powerful regulator of T cell activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Blockade of the ligands for CD 28 and CTLA 4 , CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) , revealed distinct and nonoverlapping function . ^^^ These findings suggest complex and distinct roles for CD 28 , CTLA 4 , CD 80 , and CD 86 in T cell costimulation following nucleic acid vaccination . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We found that the accessory cell activity of monocytes during LPS induced T cell proliferation is characterized by the following features : LPS primed monocytes are competent stimulators of T cell proliferation ; interaction of LPS with monocytes during the priming step is dependent on CD 14 and is sensitive to ammonia ; monocyte / T cell interactions are not MHC restricted but are strongly dependent on interactions of CD 28 and / or CTLA 4 on T cells and their ligands CD 80 and / or CD 86 on monocytes . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4 shares important sequence homology with CD 28 and binds to the same ligands , CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) . ^^^ We have developed new monoclonal antibodies against human CTLA 4 and have investigated the in situ expression of CTLA 4 in a wide variety of normal and pathological human tissues expressing CD 80 and CD 86 . ^^^ Interestingly , no or at most scarce expression of CTLA 4 was found in granulomatous lymph nodes , T cell mediated inflammatory diseases , or non Hodgkin ' s lymphomas , regardless of their expression of CD 80 or CD 86 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Immunoliposomes containing monoclonal antibodies ( MAbs ) to the costimulatory molecules CD 28 and CTLA 4 and their counterreceptors B 7 1 ( CD 80 ) and B 7 2 ( CD 86 ) were evaluated for the ability to increase the immune response to recombinant envelope protein rgp 120 of the MN strain of human immunodeficiency virus type 1 ( HIV 1 ) during vaccination . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Following incubation with soluble peptide , CD 80 expression increased , and high levels of CTLA 4 ( CD 152 ) expression were induced . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
A critical test for the hypothesis is whether selective engagement of CTLA 4 receptors by their natural ligands CD 80 and CD 86 enhances or reduces antitumor immunity . ^^^ We report that in syngeneic wild type mice , B7W ( W 88 > A ) , a CD 80 mutant that has lost binding to CD 28 but retained binding to CTLA 4 , can enhance the induction of antitumor cytotoxic T lymphocytes ( CTL ) ; B7Y ( Y 201 > A ) , which binds neither CD 28 nor CTLA 4 , fails to do so . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Co stimulatory molecules B 7 1 ( CD 80 ) / B7 2 ( CD 86 ) and their counter receptors CD28 / CTLA 4 play pivotal roles in T cell activation and immune regulation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Cells expressed high levels of MHC class 2 and production of co stimulatory molecules as evidenced by the binding of a CTLA 4 fusion protein and synthesis of CD 80 transcripts . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Despite the importance of the costimulatory proteins B 7 1 ( CD 80 ) , B 7 2 ( CD 86 ) , and their counterreceptors CD 28 and CTLA 4 ( CD 154 ) in the regulation of T cell proliferation in the adult immunological system , the initial appearance of these proteins during embryonic development has not been investigated . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The role of costimulation in activation for proliferation and cytokine mRNA production of peripheral blood T cells was studied by blocking CD 28 , CTLA 4 , and their ligands CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) . ^^^ RESULTS : The proliferation and the production of type 1 and 2 cytokine mRNA by T cells in response to Der p as well as the control antigens TT and CA was inhibited by simultaneously masking CD 80 and CD 86 using CTLA 4 Ig , a soluble form of CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
To study the prerequisites of functional interactions between malignant B cells and intermingled T cells in B cell non Hodgkin ' s lymphomas ( B NHL ) , we examined the expression of CD 40 , CD 80 and CD 86 and their ligands CD 40 ligand ( CD40L , CD 154 ) , CD 28 and CTLA 4 ( CD 152 ) using immunohistochemistry and confocal laser scanning microscopy . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Positive and negative regulation of human T cell activation mediated by the CTLA 4 / CD28 ligand CD 80 . ^^^ In this study , we have utilized the natural ligand for CD 28 and CTLA 4 ( CD 80 ) to determine under what circumstances positive and negative effects are operative . ^^^ This inhibition is reversed by blocking with both anti CD 80 or Fab fragments of anti CTLA 4 but also requires CD 28 engagement . ^^^ In the absence of intracellular calcium elevation , CTLA 4 was not expressed at the cell surface , and CD 80 acted positively as a costimulator of T cells , via CD 28 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
A chicken homologue of the co stimulating molecule CD 80 which binds to mammalian CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Further , 9 cryosections from MF lesions and 9 from SS lesions were stained for LFA , ICAM 1 , CD 40 , CD 40 ligand , CD 28 , CD 80 , CTLA 4 , CD 86 , FAS , FAS ligand , CLA and CD15s . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We show here that 1 ) F 2 g3p was recognized with anti CTLA 4 mAb but not with anti CD 28 mAb , and 2 ) F 2 g3p bound to CD 80 but not to CD 86 . ^^^ F 2 g3p inhibited the binding of CTLA 4 to CD 80 but not to CD 86 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
In the present study we examined the expression of CD 40 , CD 40 ligand ( CD40L ) , CD 80 , CD 86 , CD 28 and cytolytic T lymphocyte associated antigen 4 ( CTLA 4 ) on lymphocytes immunohistochemically . ^^^ In vitro kinetics of the expression of CD40L and CTLA 4 by peripheral blood T cells and that of CD 80 and CD 86 by peripheral blood B cells were also investigated by flow cytometry . ^^^ Positive percentage expression of CD40L , CD 28 and CTLA 4 , and CD 40 , CD 80 and CD 86 was calculated for the number of CD3+ and CD19+ cells , respectively . ^^^ Flow cytometric analysis demonstrated that the expression of CD40L and CTLA 4 on T cells , and CD 80 and CD 86 on B cells of peripheral blood was up regulated upon activation . ^^^ While most T cells and B cells expressed CD 28 , and CD 80 and CD 86 , respectively , in gingival tissues , the expression of CD40L and CTLA 4 was lower but highly variable between specimens . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Since the expression of costimulatory molecules has a significant impact on the cytokine profile and proliferation response of T cells , the goal of this study was to characterize the expression of costimulatory molecules ( CD 28 , CTLA 4 ( CD 152 ) , B 7 1 ( CD 80 ) , B 7 2 ( CD 86 ) ) on T cells , monocytes and B cells in WG , and to correlate the findings with clinical parameters such as disease activity , extent and therapy . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
To determine whether antilymphocyte Abs to T cell costimulatory molecules are generated in patients with autoimmune diseases and , if they exist , to clarify the mechanism of their production and pathological roles , we investigated the presence of autoantibodies to CTLA 4 ( CD 152 ) , CD 28 , B 7 1 ( CD 80 ) , and B 7 2 ( CD 86 ) in serum samples obtained from patients with various autoimmune diseases and from normal subjects using recombinant fusion proteins . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Since these two receptors use the same ligands , CD 80 ( B 7 1 ) and CD 86 ( B 7 2 ) , the co ordinate timing of CD 28 and CTLA 4 expression has a major impact on the regulation of immune responses . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Molecular weights of CTLA 4 and CD 80 by sedimentation equilibrium ultracentrifugation . ^^^ We combine several approaches to characterize the molecular weights of the extracellular domains of the glycoproteins CTLA 4 and CD 80 using carbohydrate analysis , electrospray mass spectrometry , size exclusion chromatography , and analytical ultracentrifugation . ^^^ In addition , we have applied a method described previously , using sedimentation equilibrium analysis to calculate the contribution of carbohydrates to the molecular masses of CTLA 4 and CD 80 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Expression of CD 80 and CD 86 on AM , and of CD 28 and CTLA 4 on T cells , was evaluated . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
These mutations in CTLA 4 ablated binding to its natural ligands CD 80 and CD 86 , whereas binding to a conformation dependent anti CTLA 4 monoclonal antibody showed that the 5 domain framework remained correctly folded . ^^^ CTLA 4 displayed on phage bound specifically to immobilized CD 80 Ig and CD 86 Ig and in one step panning enriched 5 , 000 to 2 , 600 fold respectively over wild type phage . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We sought to enhance the protective immune response induced during Mycobacterium bovis BCG infection by administering an antibody that blocks the interaction of CTLA 4 with its ligands , CD 80 and CD 86 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Previously , we found that CTLA4Ig , which blocks the CD28 / CTLA 4 ( CD 152 ) ligands CD 80 and CD 86 , can be used to induce transplantation tolerance to vascularized allografts . ^^^ Here , we show that blockade of CD 152 using an anti CD 152 mAb at the time of transplantation prevents the induction of long term allograft survival by agents that target CD 80 and CD 86 . ^^^ This result , plus experiments using CD 80 deficient mice , suggests a dominant role for CD 80 molecules on donor cells as the relevant ligand for CD 152 . ^^^ The role of CD 80 , CD 86 , and CTLA 4 in alloimmune responses and the induction of long term allograft survival . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
METHODS : Forty six patients with MS and 29 healthy individuals were analyzed by direct 2 color immunofluorescence flow cytometry for expression of CD 80 , CD 86 , CD 28 and CTLA 4 on T and B cells and monocytes . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Although normal alveolar macrophages ( AMs ) did not bear or bore low levels of costimulatory molecules , AMs from sarcoid patients with CD 4 T cell alveolitis upmodulated CD 80 , CD 86 , and CD 72 and expressed high levels of interleukin ( IL ) 15 ; lymphocytes accounting for T cell alveolitis expressed Th 1 type cytokines [ interferon ( IFN ) gamma and / or IL 2 ] and bore high levels of CD 5 and CD 28 but not of CD 152 molecules . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Inhibition of the interaction of T cells with CD 86 , but not CD 80 , at the time of exposure to intranasal Ag prevented the development of unresponsiveness , while selective blockade of CTLA 4 had no effect . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4 ( CD 152 ) , a receptor for the B 7 costimulatory molecules ( CD 80 and CD 86 ) , is considered a fundamental regulator of T cell activation . ^^^ CTLA 4 ( CD 152 ) , a receptor for the B 7 costimulatory molecules ( CD 80 and CD 86 ) , is considered a fundamental regulator of T cell activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
A fusion protein comprising the CTLA 4 extracellular domain joined to a human immunoglobulin heavy chain constant region ( CTLA4Ig ) binds CD 80 and CD 86 with high affinity and inhibits CD80 / CD86 dependent immune responses in vitro and in vivo . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Triggering of human NK cells by CD 80 and CD 86 appeared to be independent of CD 28 and CTLA 4 , at least as determined by the reagents used in the present study , because the expression of these molecules could not be detected on the NK cell lines by either flow cytometry or in redirected lysis assays . ^^^ Thus , human NK cells may use receptors other than CD 28 and CTLA 4 in their interactions with CD 80 and CD 86 molecules . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
These observations suggested that the presence of low levels of CD 80 on monocytes may partially inhibit CD 27 expression due to inefficient delivery of positive signals via CD28 / CD80 interaction , and that the increased levels of CD 80 enhance the inhibition through interactions with CD 152 which is expressed at the highest levels after 48 hr of activation . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
In this study , expression of the co stimulatory ligands B 7 1 ( CD 80 ) and B 7 2 ( CD 86 ) , as well as the receptors CD 28 and CTLA 4 , were quantitated in central nervous system ( CNS ) tissues from mice at various stages of EAE . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Interaction of CTLA 4 ( CD 152 ) with CD 80 or CD 86 inhibits human T cell activation . ^^^ Finally , and importantly , blockade of the interaction of CTLA 4 with its ligands using soluble anti CTLA 4 mAbs , in intact form or as Fab fragments , enhanced T cell activation in several polyclonal or alloantigen specific CD 80 or CD80 / CD86 dependent assays , as measured by cytokine production , cellular proliferation or cytotoxic responses . ^^^ It is concluded that interaction of CTLA 4 with its functional ligands , CD 80 or CD 86 , can down regulate human T cell responses , probably by intracellular signalling events and independent of CD 28 occupancy . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Expression of the costimulator molecules , CD 80 , CD 86 , CD 28 , and CD 152 on lymphocytes from neonates and young children . ^^^ The expression of CD 80 , CD 86 , CD 28 , and CD 152 were examined on peripheral blood lymphocytes from adults , neonates ( cord blood lymphocytes ) and young children ( 2 20 months of age ) . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Expression of costimulatory molecules CD 80 and CD 86 and their receptors CD 28 , CTLA 4 on malignant ascites CD3+ tumour infiltrating lymphocytes ( TIL ) from patients with ovarian and other types of peritoneal carcinomatosis . ^^^ The CD 28 and CTLA 4 molecules on T cells serve as receptors for the CD 80 and CD 86 costimulatory antigens . ^^^ We have examined the frequency of expression of CD 80 ( B7 . 1 ) , CD 86 ( B7 . 2 ) , CD 28 and CTLA 4 surface antigens on TIL isolated from malignant ascites or peritoneal washings of 26 patients with ovarian carcinoma and five patients with non ovarian peritoneal carcinomatosis . ^^^ We have shown that in addition to CD 28 and CTLA 4 , CD3+ intraperitoneal TIL express the costimulatory molecules CD 80 and CD 86 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The present review focuses on the role of two receptor ligand pairs : CD 28 and cytotoxic T lymphocyte associated antigen 4 , which interact with the B 7 ligands ( CD 80 , CD 86 ) ; and CD 40 , which interacts with the CD40L ( CD 154 ) . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We quantitatively measured the number of T cells expressing cell surface activation associated molecules ( CD 69 , CD 25 , CD 122 , HLA DR ) and co stimulatory molecules ( CD 28 , CTLA 4 , CD 80 , CD 86 ) , including a Type 2 T cell marker ( CD 30 ) and CD11b , by flow cytometry of skin and peripheral blood . ^^^ CD 86 , CD 80 , CTLA 4 , CD 30 and CD11b were expressed by less than 23 % of the T cell populations from both the epidermis and dermis . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We determined B lymphocytes ( CD 40 ( + ) ) , T lymphocytes ( CD 3 ( + ) ) , T helper ( CD 4 ( + ) ) , and T suppressor ( CD 8 ( + ) ) cells and the expression of costimulatory signals B7 . 1 ( CD 80 ) and B7 . 2 ( CD 86 ) on B cells and their counter receptors CD 28 and CTLA 4 on T cells by fluorescence activated cell sorting analysis . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
T cell costimulation is provided by ligation of CD 28 with either B7 . 1 ( CD 80 ) or B7 . 2 ( CD 86 ) on antigen presenting cells , and can be inhibited by a soluble form of CTLA 4 ( CTLA 4 Ig ) that binds to both B7 . 1 and B7 . 2 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
In mammals , the classical B 7 molecules expressed on antigen presenting cells , B 7 1 ( CD 80 ) and B 7 2 ( CD 86 ) , bind the structurally related glycoproteins CD 28 and CTLA 4 ( CD 152 ) , generating costimulatory signals that regulate the activation state of T cells . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
No differences in the surface expression of the costimulatory molecules CD 28 , CD 152 or CD 154 was seen between immune and non immune donors after either 24 or 120 h of TSL incubation , nor were differences detected in the expression of the B 7 ligands CD 80 or CD 86 on CD14+ monocytes . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
These data suggest that allergens and irritants may , in part , break peripheral tolerance by their direct effects on keratinocyte costimulatory molecule expression , thereby facilitating interactions with epidermotropic T helper cells via the CD 80 CD28 or CTLA 4 pathways . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4 was shown to be functionally intact by binding to its natural ligands B 7 1 ( CD 80 ) and B 7 2 ( CD 86 ) both in vitro and in situ . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD28 / CTLA 4 interactions with their specific B 7 ligands ( CD 80 and CD 86 ) have decisive roles in antigenic and allogenic responses . ^^^ CTLA 4 was observed in the infiltrating lymphocytes in most of the biopsies , but CD 80 or CD 86 were not . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
This study examined the effects of blockade of the interaction between cytotoxic T lymphocyte antigen 4 ( CTLA 4 ) and its ligands B 7 1 ( CD 80 ) and B 7 2 ( CD 86 ) on the anticryptococcal DTH responses and protection . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
B7 cells could be completely inhibited by blocking CD 80 with CTLA 4 Ig . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 152 ligation by CD 80 on T cells is required for the induction of unresponsiveness by costimulation deficient antigen presentation . ^^^ Proliferation was substantially enhanced by anti CD 80 or anti CD 152 , but was inhibited by anti CD 86 . ^^^ Furthermore , anti CD 80 partially , and anti CD 152 totally protected cloned DO . 11 . 10 T cells from the induction of unresponsiveness following culture with peptide and Chinese hamster ovary H 2 Ad+ CD 80 CD 86 cells . ^^^ The possibility that anti CD 80 liberated CD 28 molecules that were sequestered by the T cell expressed CD 80 , enabling them to coaggregate with TCR : CD 3 complexes was excluded by finding that anti CD 80 and anti CD 152 individually caused maximal enhancement , rather than having additive effects . ^^^ These data suggest that T cell expressed CD 80 has a regulatory function and plays a key role in the induction of unresponsiveness due to costimulation deficient Ag presentation by the ligation of CD 152 on neighboring , or even the same , T cell . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The CTLA 4 receptor ( CD 152 ) on activated T lymphocytes binds B 7 molecules ( CD 80 and CD 86 ) on APC and delivers a signal that inhibits T cell proliferation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
These findings suggest that interaction of CD 80 and CD 86 with their receptors CD 28 and CTLA 4 selectively promotes cell activation , including proliferation and IgE production in CD40+IL 4 stimulated peripheral blood mononuclear cells from atopic donors . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
On the antigen presenting cell the key players are found in the extended family of B 7 genes comprising cd 80 , cd 86 , B7h / B7RP 1 and B 7 H1 . cd 80 and cd 86 encode proteins that bind to CD 28 and CTLA 4 on T cells . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The crucial role of costimulatory molecules , CD 28 , CTLA 4 , CD 80 and CD 86 , for T cell activation and inhibition has been established . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We have previously shown that blockade of CD 80 costimulation by Y100F Ig , a CTL associated Ag 4 ( CTLA 4 ) Ig mutant that does not bind CD 86 , inhibits the development of lung inflammatory immune responses , but does not affect blood eosinophilia or Ab production . ^^^ Each of those responses was inhibited by treatment with CTLA 4 Ig , which binds both CD 80 and CD 86 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
No differences were noted in the expression of CD 152 or CD 80 , a CD 28 and CD 152 shared ligand . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
An immunoperoxidase technique was used to examine CD 28 , CD 152 , CD 80 and CD 86 positive cells in gingival biopsies from 21 healthy / gingivitis and 26 periodontitis subjects . ^^^ In conclusion , percentages of CD 28 , CD 152 , CD 80 and CD 86 did not reflect differences in clinical status . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Interference with CD 28 , CD 80 , CD 86 or CD 152 in collagen induced arthritis . ^^^ We have investigated interference with co stimulation by administering mAbs towards CD 28 , CD 80 , CD 86 , and CD 152 in mice immunized for the development of collagen induced arthritis ( CIA ) . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
In the present report , we present findings on the gene sequences encoding the nonhuman primate homologues of human CD 80 , CD 86 , their ligands CD 28 and CD 152 , CD 154 , CD 95 , and CD 95 L from rhesus macaques and for phylogenetic analysis from pig tailed macaques , African sooty mangabey monkeys , baboons , and vervets as well as select molecules from the New World aotus and marmoset monkeys . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Engagement of costimulatory molecules such as CD 28 or CD 152 ( CTLA 4 ) on T cells by CD 80 ( B 7 1 ) or CD 86 ( B 7 2 ) dictates the nature of T cell mediated immune responses . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 80 and CD 86 ( also known as B 7 1 and B 7 2 , respectively ) are both ligands for the T cell costimulatory receptors CD 28 and CD 152 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
BACKGROUND : B 7 molecules ( CD 80 , CD 86 ) and their counter receptors , CD 28 and CD 152 ( CTLA 4 ) , play an important role in T cell mediated immune responses . ^^^ However , following the nasal provocation with house dust , not only CD 86 , but also CD 80 , CD 28 , and CD 152 were significantly expressed in allergic patients . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The association of molecules like CD 80 , CD 86 ( co stimulatory molecules ) in monocytes and B cells and CD 30 , CD62L , ALL , CD11a , CD 28 , CD 124 and CD 152 in CD4+ , they have shown to be of particular interest in allergic sufferings . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
ICOS binds to a newly identified ligand on antigen presenting cells different from the CD 152 ligands CD 80 and CD 86 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Sentinel nodes ( SNs ) and non SNs were evaluated by routine pathologic analysis , and a portion of each node was processed for expression of three dendritic markers of activation ( CD 80 , CD 86 , CD 40 ) and their corresponding T cell receptors ( CTLA 4 and CD 28 ) . ^^^ Reverse transcriptase polymerase chain reaction ( RT PCR ) analyses of paired SNs and non SNs demonstrated a marked reduction in semiquantitative expression of CD 80 ( 77 % ) , CD 86 ( 77 % ) , and CD 40 ( 85 % ) , as well as CTLA 4 ( 88 % ) and CD 28 ( 85 % ) in SNs . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4 is a T cell surface molecule that binds to the costimulatory molecules CD 80 and CD 86 on antigen presenting cells and downregulates T cell function . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
A portion of each node was processed for expression of the dendritic markers of activation CD 80 , CD 86 , and CD 40 , and their corresponding T cell receptors CTLA 4 and CD 28 . ^^^ Reverse transcription polymerase chain reaction analyses of corresponding sections of the sentinel and nonsentinel nodes demonstrated a marked reduction in semiquantitative expression of CD 80 ( 77 % ) , CD 86 ( 77 % ) , and CD 40 ( 85 % ) , as well as CTLA 4 ( 88 % ) and CD 28 ( 85 % ) in sentinel as compared to nonsentinel nodes . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4 interacts with the ligands CD 80 and CD 86 on antigen presenting cells ( APC ) , and also directs the assembly of inhibitory signalling complexes that lead to quiescence or anergy . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The similarity of this effect to that reported for selective CTLA 4 blockade suggests that CD 80 is a critical ligand for CTLA 4 in mediating the down regulation of Th 1 responses and CD 8 ( + ) T cell activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Surface expression of CD 25 , CD 28 , CD 40 , CD 54 , CD 80 , CD 86 and CTLA 4 was evaluated on CD 3 , CD 4 , CD 8 , CD 14 and CD 19 PBMC subpopulations by three colour flow cytometry . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Examination of other costimulatory markers in AIM patients showed that CD 80 and CD 152 were not affected . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Upon ligation by CD 80 ( B 7 1 ) or CD 86 ( B 7 2 ) , CD 28 induces T cell proliferation , cytokine production , and effector functions , whereas CTLA 4 signaling inhibits expansion of activated T cells and induces tolerance . ^^^ In contrast to wild type CD 80 , the evolved co stimulatory molecules , termed CD 28 binding protein ( CD28BP ) and CTLA 4 binding protein ( CTLA 4BP ) , selectively bind to CD 28 or CTLA 4 , respectively . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Although new molecules continue to be discovered , the functions of B 7 1 ( CD 80 ) , B 7 2 ( CD 86 ) , CD 28 , cytotoxic T lymphocyte antigen 4 ( CTLA 4 ) , inducible costimulator ( ICOS ) , programmed death 1 ( PD 1 ) , OX 40 ( CD 134 ) and CD 40 ligand ( CD40L , CD 154 ) are now sufficiently understood that immunologists are targeting them to manipulate T cells to slow the progression of autoimmune diseases or treat tumours through the increase in T cell activation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
In this study , we have re examined the specificity of CTLA 4 inhibition of MAPKs by using natural ligand with ex vivo purified CD 4 ( + ) T cells deficient in CD 80 and CD 86 ( double knockout ) , or CTLA 4 , CD 80 , and CD 86 ( triple knockout ) . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Inhibition of human T cell proliferation by CTLA 4 utilizes CD 80 and requires CD25+ regulatory T cells . ^^^ CD 28 and CTLA 4 are opposing regulators of T cell activation , triggered by the two ligands CD 80 and CD 86 . ^^^ Using CD 80 and CD 86 molecules expressed on transfected cells , we have identified a major difference between these ligands in that CD 80 transfectants have the ability to inhibit activation of resting human peripheral blood T cells via interaction with CTLA 4 , whereas CD 86 transfectants do not . ^^^ The kinetics of CD 80 CTLA 4 interactions revealed that CTLA 4 inhibition took place within the first 8 h of T cell stimulation , despite there being little measurable CTLA 4 expression on the majority T cells . ^^^ Overall , these data provide evidence that CD 80 and CD 86 differ in their interactions with CTLA 4 and that CD 80 appears to be the preferential inhibitory ligand for CTLA 4 working via a population of CD 4 ( + ) CD 25 ( + ) CTLA 4 ( + ) regulatory T cells . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Role of CD 80 , CD 86 , and CTLA 4 on mouse CD 4 ( + ) T lymphocytes in enhancing cell cycle progression and survival after activation with PMA and ionomycin . ^^^ Cell surface interactions between the T cell costimulatory receptors , CD 28 and cytotoxic T lymphocyte antigen 4 ( CTLA 4 ) , with their cognate ligands , CD 80 and CD 86 , on antigen presenting cells play an important role in T cell activation . ^^^ We show that CD 80 , CD 86 , and CTLA 4 are induced on purified CD 4 ( + ) T cells after in vitro activation with phorbol 12 myristate 13 acetate ( PMA ) and ionomycin , and they play an essential role for proliferation and survival . ^^^ This study reveals a functional role for CD 80 , CD 86 , and CTLA 4 on CD 4 ( + ) T lymphocytes and sheds light on the mechanisms by which these molecules enhance activation and survival with PMA and ionomycin . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Using soluble fusion proteins ( soluble CTLA 4 , CD 28 , and CD 80 ) to block either CD 28 on the surface of T cells or CD 80 on the surface of APCs , it was demonstrated that CD 80 acquisition by T cells is mediated through its receptors , possibly CD 28 interaction . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
High expression of CD 28 , CD 80 , CD 86 , CD 40 , CTLA 4 , CD44v variants , and FasL occurred in alopecia areata resistant mouse spleens . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 4 T cell activation is positively ( CD 28 ) and negatively ( CTLA 4 ) regulated by the costimulatory ligands CD 80 and CD 86 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Fas ligand ( FasL ) , that has the inherent capacities to tether the T cell inhibitor FasL ( CD 95 ligand ) to the surfaces of B 7 ( CD 80 and CD 86 ) positive APC ( via CTLA 4 : B 7 interaction ) , and in so doing , to simultaneously interfere with B 7 to CD 28 T cell activation signals . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We describe an alternative view in which CD 80 is the initial ligand , responsible for maintaining aspects of immune tolerance through interactions with CD 152 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The reduction of CD 80 expression with concomitant increase of CTLA 4 expression alters the course of EAE and may be useful as a monitor in therapy with IFN beta . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
A hexapeptide motif , MYPPPY , which has been supposed to be essential for the interaction with CD 80 , is present in both Woodchuck CD 28 and CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Porins and lipopolysaccharide from Salmonella typhimurium regulate the expression of CD 80 and CD 86 molecules on B cells and macrophages but not CD 28 and CD 152 on T cells . ^^^ RESULTS : Our results show that porins of S . typhimurium increase the expression of CD 86 and the expression of CD 80 both on B lymphocytes and macrophages , while the expression of CD 28 and CD 152 on T lymphocytes was unaltered . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
T cell proliferation was determined with [ 3H ] thymidine incorporation ( CPM ) , and the inhibitory effect of CTLA 4 on T cell proliferation was evaluated by the ratio of CPM for T cells with CHO CD 80 cells to that of T cells with CHO cells ( the CHO CD80 / CHO ratio ) . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 80 and CD 86 expressed on the surface of antigen presenting cells interact with cytotoxic T lymphocyte antigen 4 [ CTLA 4 ( CD 152 ) ] expressed on activated T cells and mediate critical T cell inhibitory signals . ^^^ Co crystallographic structures of both CD 80 and CD 86 bound to CTLA 4 indicate that there is no direct interaction of the C domain of either CD 80 or CD 86 with the CTLA 4 . ^^^ In contrast , previous mutagenesis studies have identified specific amino acids within the C domain of CD 80 that are critical for CTLA 4 binding . ^^^ Our studies further demonstrated that the decreased activation by cells expressing the CD 80 or a chimera containing CD 80 C domain is most likely due to enhanced CTLA 4 binding . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
In addition , hCD 152 hCD59 or pCD 152 hCD59 expression resulted in a significant reduction in T cell activation as the result of CD 152 engagement of porcine CD 86 or murine CD 80 in when Jurkat cells were cocultured with the hCD 152 hCD59 or pCD 152 hCD59 expressing cells . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 80 , CD 86 , CD 28 and Cytotoxic T lymphocyte antigen 4 ( CTLA 4 ) are well known co stimulatory molecules that form the major co stimulatory pathway essential for full activation of T cells . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The aim of the study was to estimate the expression of CTLA 4 ( cytolitic T lymphocyte associated antigen 4 , CD 152 ) , CD 28 , B7 . 1 ( CD 80 ) and CD7 . 2 ( CD 86 ) molecules on peripheral blood cells in patients with Graves ' disease ( GD ) ( n=28 , mean age 15 . 4 ) , in patients with nontoxic nodular goiter ( NTNG ) ( n=28 , mean age 15 . 6 years ) in comparison with sex and age matched healthy control subjects ( n=28 , mean age 15 . 9 years ) . ^^^ The analysis of CD3+ T lymphocytes co expressing CD 152 and CD 28 antigens on peripheral blood revealed increased percentages of CTLA 4 / CD28 positive cells in patients with Graves ' disease ( p < 0 . 004 , p < 0 . 04 ) compared to the controls and euthyroid Graves ' patients , while B7 . 1 ( CD 80 ) and B7 . 2 ( CD 86 ) molecules were detected only in some hyperthyroid patients on activated monocytes . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Interestingly , in the human CD 80 CD152 complex , Pro ( 102 ) of CD 152 restricts the preceding proline to PP ( 2 ) helix in the binding orientation in relation to the shallow binding pocket of CD 80 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Expression of costimulatory molecules ( CD 80 , CD 86 , CD 28 , CD 152 ) , accessory molecules ( TCR alphabeta , TCR gammadelta ) and T cell lineage molecules ( CD4+ , CD8+ ) in PBMC of leprosy patients using Mycobacterium leprae antigen ( MLCWA ) with murabutide and T cell peptide of Trat protein . ^^^ This observation prompted us to study the expression of the costimulatory molecules ( CD 80 , CD 86 , CD 28 , CD 152 ) , other accessory molecules ( TCR alphabeta / gammadelta ) and T cell lineage molecules ( CD4+ and CD8+ ) during constitutive and activated state of peripheral blood mononuclear cells ( PBMC ) derived from normal and leprosy individuals using different formulations of Mycobacterium leprae total cell wall antigen ( MLCWA ) , Trat and MDP BE using flow cytometric analysis . ^^^ An increased surface expression of CD 80 , CD 86 and CD 28 but decreased CD 152 expression was observed when PBMC of normal , BT / TT ( tuberculoid ) and BL / LL ( lepromatous ) patients were stimulated in vitro with MLCWA+MDP BE+Trat peptide using liposomal mode of antigen delivery , while opposite results were obtained with the antigen alone . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We have therefore investigated associations between MS and polymorphisms in the CD 152 ( CTLA 4 ) , CD 28 , CD 80 and CD 86 genes in Australian patients . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
As both CD 28 and CTLA 4 molecules are implicated in the function of Treg , we investigated the ability of their two natural ligands , CD 80 and CD 86 , to influence the Treg suppressive capacity . ^^^ Our data show that CD 80 and CD 86 have opposing functions through CD 28 and CTLA 4 on Treg , an observation that has significant implications for manipulation of immune responses and tolerance in vivo . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The B 7 ligands CD 80 and CD 86 on APCs deliver either costimulatory or inhibitory signals to the T cell when interacting with their counter receptors CD 28 and CD 152 ( CTLA 4 ) on the T cell surface . ^^^ Analysis of the CD 80 CD28 interaction site reveals a well defined interface structurally distinct from that of CD 80 and CD 152 and thus provides valuable information for therapeutic intervention targeted at this pathway , suggesting a general approach for other receptors . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Elevation of plasma soluble T cell costimulatory molecules CTLA 4 , CD 28 and CD 80 in children with allergic asthma . ^^^ BACKGROUND : The surface expression of T cell costimulatory molecules CTLA 4 and CD 28 and their counter ligands , B 7 molecules ( CD 80 , CD 86 ) , is differentially induced for T cell activation and expansion in allergic asthma . ^^^ METHODS : Plasma concentrations of soluble CTLA 4 ( sCTLA 4 ) , CD 28 , CD 80 and CD 86 in 51 children with chronic allergic asthma with or without inhaled corticosteroid treatment , and 22 sex and age matched control subjects were measured by enzyme linked immunosorbent assay . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
This review will discuss the mechanisms of suppression , which include the local secretion of cytokines such as TGF beta and direct cell contact through binding of cell surface molecules such as CTLA 4 on suppressor T cells to CD 80 and CD 86 molecules on effector T cells . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
One of the key costimulatory receptors is CD 80 , which binds the T cell ligands , CD 28 , and CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
This study investigated how CD 80 and CD 86 regulated CD 152 expression in a low responding cardiac transplant model with CD 152 mediated long term graft acceptance . ^^^ Proliferation assays , quantitative ( Q ) real time polymerase chain reaction ( PCR ) , flow cytometric analyses , and fluorescence microscopy were conducted to examine the roles of CD 80 and CD 86 in CD 152 expression . ^^^ A 100 splenic T cells were hyporesponsive to donor specific stimulation , and anti CD 80 , anti CD 86 , or anti CD 152 treatment significantly enhanced the proliferation response of the B10 . ^^^ Proliferation assays and Q PCR revealed that CD 152 inhibited T cell proliferation and , at the same time , decreased CD 152 expression by secluding CD 80 and CD 86 from CD 28 engagement . ^^^ Besides , CD 152 engagement by CD 80 decreased CD 152 mRNA transcription , and CD 152 engagement by CD 86 inhibited surface expression of CD 152 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The best characterized pathway includes CD 28 , its homologue CTLA 4 and their ligands CD 80 and CD 86 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
This work completes the initial structural characterization of the CD 28 CTLA 4 CD 80 CD86 signaling system . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Specifically , the effects of 17beta estradiol on basal and LPS induced surface staining of Class 1 and 2 MHC , as well as CD 40 , CD 80 , CD 86 , CD 152 , CD 28 , CD 8 , CD11b , Fas , FasL , and also ERalpha and ERbeta , were examined in N 9 microglial cells . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The expression and functional roles of costimulatory receptors , CD 28 and cytotoxic T lymphocyte antigen 4 ( CTLA 4 ) , and their ligands , CD 80 and CD 86 , on primary mouse CD 4 ( + ) T cells after activation with different doses of Con A were studied . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD28 / CTLA 4 interactions with their specific B 7 ligands ( CD 80 and CD 86 ) play a decisive role in antigenic and allogenic responses . ^^^ We demonstrated that the combined use of anti CD 80 and anti CD 86 mAbs induced maternal tolerance to the fetus in the abortion prone CBA / J mice , and displayed expansion of the maternal CD 4 ( + ) CD25+ regulatory T cell population and up regulated expression of CTLA 4 , suggesting an active mechanism of regulatory T cells in suppressing maternal rejection to the fetus . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CTLA 4 is an essential protein in the regulation of T cell responses that interacts with two ligands found on the surface of APCs ( CD 80 and CD 86 ) . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Although previous studies have shown that altered B 7 costimulation plays a critical role in UV irradiation induced regulation of immunity , the individual roles of the B 7 receptors ( CD 28 and CTLA 4 ) or the B 7 family members ( CD 80 and CD 86 ) have not been explored . ^^^ Next , we used mice deficient for CD 80 , CD 86 , or both in photocarcinogenesis studies to assess the relative contributions of these CTLA 4 ligands . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Aberrant production of soluble costimulatory molecules CTLA 4 , CD 28 , CD 80 and CD 86 in patients with systemic lupus erythematosus . ^^^ OBJECTIVE : The costimulatory interactions of the B 7 family molecules CD 80 and CD 86 on antigen presenting cells with their T cell counter receptors CD 28 and CTLA 4 modulate T lymphocyte mediated immune responses in a reciprocal manner . ^^^ We investigated the possible aberrant production of soluble ( s ) forms of the T cell costimulatory molecules CD 80 , CD 86 , CD 28 and CTLA 4 in plasma of patients with systemic lupus erythematosus ( SLE ) , an autoimmune disease arising from T lymphocyte dysregulation . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Treatment of cells from CTLA 4 expressing tumor lines with recombinant forms of the CTLA 4 ligands CD 80 and CD 86 induced apoptosis associated with sequential activation of caspase 8 and caspase 3 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The co stimulatory interactions of the B 7 family molecules CD 80 and CD 86 on antigen presenting cells , together with their T cell counter receptors CD 28 and cytotoxic T lymphocyte associated antigen 4 ( CTLA 4 ) , modulate T lymphocyte mediated immune responses in a reciprocal manner . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
In this study , we report the surprising finding that CTLA 4 engagement by soluble antibody or CD 80 potently up regulates lymphocyte function associated antigen 1 ( LFA 1 ) adhesion to intercellular adhesion molecule 1 ( ICAM 1 ) and receptor clustering concurrent with IL 2 inhibition . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
These results indicate that CD 80 and CD 86 mediate distinct signals in previously activated T cells , and demonstrate that CTLA 4 ligation may dominate the outcome of CD 86 mediated costimulation of activated CD4+ T cells . . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The aim of the study was to estimate the expression of cytotoxic T lymphocyte associated antigen 4 ( CTLA 4 , CD 152 ) , CD 28 , B7 . 1 ( CD 80 ) , and B7 . 2 ( CD 86 ) molecules on peripheral blood cells in patients with Graves ' disease ( GD ) ( n = 55 , mean age 15 . 5 + / 5 . 1 years ) and nontoxic nodular goiter ( NTNG ) ( n = 55 , mean age 15 . 2 + / 4 . 5 years ) , in comparison with sex and age matched healthy control subjects ( n = 55 , mean age 15 . 2 + / 3 . 9 years ) . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
The main co stimulatory pathway involves the interaction of CD 80 and CD 86 , expressed on the APCs , with their T cell counter receptor , CD 28 and CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
These cells were found to express CD 29 , CD 44 , CD 90 , CD 95 , CD 105 , CD 166 , and MHC class , but not CD 14 , CD 34 , CD 40 , CD 45 , CD 80 , CD 86 , CD 117 , CD 152 , or MHC class 2 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD 80 cytoplasmic domain controls localization of CD 28 , CTLA 4 , and protein kinase Ctheta in the immunological synapse . ^^^ The binding of costimulatory ligand CD 80 to CD 28 or CTLA 4 on T cells plays an important role in the regulation of the T cell response . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Cytotoxic T lymphocyte antigen 4 ( CTLA 4 ; CD 152 ) is a member of the immunoglobulin gene superfamily with strong homology to the receptor CD 28 with which it shares the ligands CD 80 and CD 86 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
TGF beta accelerated expression of CTLA 4 , and time course studies suggested that CTLA 4 ligation of CD 80 shortly after T cell activation enables TGF beta to induce CD4+CD25 cells to express FoxP 3 and develop suppressor activity . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We generated bivalent CD 28 constructs by fusing the extracellular domains of CTLA 4 or CD 80 with the intracellular domains of CD 28 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Using flow cytometry , the cells were analyzed for the expression of costimulatory molecules , such as CD 80 , CD 86 , and CD 152 ( CTLA 4 ) . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Integration of CD 28 and CTLA 4 function results in differential responses of T cells to CD 80 and CD 86 . ^^^ CD 80 and CD 86 have the capacity to either stimulate or inhibit T cell responses through their receptors CD 28 and cytotoxic T lymphocyte associated antigen 4 ( CTLA 4 ) . ^^^ Once cell division had been initiated , all T cells undergoing cell division expressed CTLA 4 , irrespective of whether CD 80 or CD 86 costimulation was used . ^^^ However , only in the presence of CD 80 was evidence of CTLA 4 engagement and inhibitory function observed . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
We show in this study that reducing Tim 3 signaling during the innate immune response to viral infection in BALB / c mice reduces CD 80 costimulatory molecule expression on mast cells and macrophages and reduces innate CTLA 4 levels in CD4+ T cells , resulting in decreased T regulatory cell populations and increased inflammatory heart disease . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Suppression via CD 80 on Gr 1+CD11b+ myeloid cells was mediated by CD4+CD25+ T regulatory cells and required CD 152 . ^^^ CD 80 knockout or antibody blockade of either CD 80 or CD 152 retarded the growth of 1D8 tumor in mice , suggesting that expression of CD 80 on Gr 1+CD11b+ myeloid cells triggered by 1D8 ovarian carcinoma suppresses antigen specific immunity via CD 152 signaling and CD4+CD25+ T regulatory cells . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
CD4+ T cell populations in the peripheral blood were analysed for the expression of co stimulatory markers CD45RO , CD 70 , CD 80 , CD 86 , CD 137 , CD137L , CD 134 , CD 152 , CD 154 and ICOS . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
Several proteins and mRNAs are up regulated in unstimulated rat CD 4 ( + ) CD 25 ( + ) T cells compared with CD 4 ( + ) CD 25 ( ) T cells , including Foxp 3 , Lag 3 , CD 80 , interleukin 10 ( IL 10 ) and CTLA 4 . ^^^
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA
Interacting proteins: P33681 and P16410	Pubmed	SVM Score :0.0
NA