| Interacting proteins: P33316 and Q07869 |
Pubmed |
SVM Score :0.62136695 |
| We have previously reported the cloning of rat deoxyuridine triphosphate nucleotidohydrolase ( dUTPase ) cDNA and demonstrated that the full length protein as well as the N terminal 62 amino acid peptide interacts with peroxisome proliferator activated receptor alpha ( PPARalpha ) . 0.62136695^^^ |
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| Interacting proteins: P33316 and Q07869 |
Pubmed |
SVM Score :0.0 |
| In vitro binding assays indicate that rat dUTPase interacts with all three isoforms of mouse PPAR , but not with retinoid 10 receptor and thyroid hormone receptor . ^^^ Full length rat dUTPase prevents PPAR retinoid 10 receptor heterodimerization resulting in an inhibition of PPAR activity in a ligand independent manner . ^^^ The identification of dUTPase as a PPAR interacting protein suggests a possible link between tumorigenic peroxisome proliferators and the enzyme system involved in the maintenance of DNA fidelity . . ^^^ Using a yeast two hybrid system to screen a rat liver cDNA library , we have identified rat deoxyuridine triphosphatase ( dUTPase , EC 3 . 6 . 1 . 23 ) as a PPARalpha interacting protein . ^^^ Interaction of PPARalpha with dUTPase is with the N terminal 62 amino acid segment of rat dUTPase . ^^^ |
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