Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Many lines of evidence indicate that cholecystokinin ( CCK ) and its receptors , named CCK 1 R and CCK 2 R , are expressed in the hypothalamo pituitary adrenal ( HPA ) axis , the function of which they acutely stimulate . ^^^ Semiquantitative reverse transcription polymerase chain reaction showed that CCK treatment lowered the expression of CCK 1 R and CCK 2 R mRNAs in the pituitary , but not adrenal gland . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Cholecystokinin , or CCK , is a 33 amino acid peptide , originally considered a gut hormone , that acts via two subtypes of receptors , named CCK 1 R and CCK 2 R . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Although the wide distribution , myriad number of functions , and reported pharmacological heterogeneity of CCK receptors would suggest a large number of receptor subtypes , the application of modern molecular biological techniques has identified two CCK receptors , CCK A receptor ( CCK AR ) and CCK B receptor ( CCK BR ) , that mediate the actions of CCK and gastrin ; gastrin receptors have been found to be identical to CCK BR . ^^^ CCK AR , found predominantly in the GI system and select areas of the CNS , have high affinity for CCK and the nonpeptide antagonist L 364 , 718 , whereas CCK BR , found predominantly in the CNS and select areas of the GI system , have high affinity for CCK and gastrin and the nonpeptide antagonist L 365 , 260 . ^^^ Both CCK AR and CCK BR are highly conserved between species , although there is some tissue specific variation in expression . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To determine the structural basis of CCK A receptor ( CCK AR ) functionally coupled to Gs , a series of chimeric mutants were constructed by replacing exons of human CCK B receptor ( CCK BR ) , from the second to the fifth ( last ) exon , with human CCK AR counterparts . ^^^ However , only the wild type CCK AR and chimeric mutants containing the second exon of CCK AR were able to mediate significantly greater increases in intracellular cAMP content and adenylyl cyclase activity compared with wild type CCK BR . ^^^ A CCK BR mutant was further constructed by replacing five amino acids , Gly Leu Ser Arg ( Arg ) Leu , in the first intracellular loop with the corresponding five CCK AR specific amino acids , Ile Arg Asn Lys ( Arg ) Met . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Thus far , two CCK receptors have been molecularly identified to mediate the actions of CCK and gastrin , CCK A and CCK B receptors ( CCK AR and CCK BR , respectively ) . ^^^ The regulation of CCK AR and CCK BR affinity by guanine nucleotides and the receptor activation of G protein dependent stimulation of phospholipase C and adenylyl cyclase suggested that they were guanine nucleotide binding protein coupled receptors [ G protein coupled receptors ( GPCRs ) ] ; however , the eventual cloning of their cDNAs revealed their heptahelical structure and confirmed their membership in the GPCR superfamily . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Single or double substitutions of the four nonconserved amino acids in the first intracellular loop of the CCK BR were made with their CCK AR counterparts to determine which residues are critical in Gs coupling . ^^^ Single substitution of Ser 82 to Asn , produced maximal cAMP responses comparable with the chimeric CCK BR containing the entire first intracellular loop of the CCK AR . ^^^ Finally , CCK AR reverse mutants were studied to compare them with their corresponding CCK BR mutants that showed increased cAMP responses . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We report here a study of polymorphisms in the CCK pre pro hormone gene ( CCK ) , CCK AR , and CCK BR in DSM 4 panic patients ( n = 99 ) vs controls matched for gender and ethnicity . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Daily energy intake and expenditure were significantly greater in CCK BR ( / ) and CCK AR ( / ) BR ( / ) mice than CCK AR ( / ) and wild type [ CCK AR ( + / + ) BR ( + / + ) ] mice . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We examined the anxiety related behavior of CCK AR , CCK BR , and CCK ARBR gene knockout ( / ) mice in the elevated plus maze . ^^^ CCK AR ( / ) mice showed a significantly higher frequency of open arm entries than wild type and CCK BR ( / ) mice , whereas the percentage open arm entry values in CCK AR ( / ) mice did not differ from those in wild type mice . ^^^ By contrast , CCK BR ( / ) mice showed significantly lower percentage open arm entry values and spent significantly less time in the open arms than wild type and CCK AR ( / ) mice . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
METHODS : CCK AR and CCK BR mRNA expression and cellular distribution in the rat lung were detected by highly sensitive method of in situ reverse transcription polymerase chain reaction ( RT PCR ) and conventional in situ hybridization . ^^^ RESULTS : CCK AR and CCK BR gene positive signals were observed in bronchial epithelial cells , alveolar epithelial cells , pulmonary macrophages and vascular endothelial cells of the rats ' lung by in situ RT PCR . ^^^ By in situ hybridization , however , only the signals of CCK BR but not CCK AR were detected in the lung , and the positive staining was only found in vascular endothelial cells and macrophages . ^^^ CONCLUSION : CCK AR and CCK BR gene were present in pulmonary vascular endothelial cells , macrophages , bronchial epithelial cells and alveolar epithelial cells , which play an important role in mediating the regulatory actions of CCK 8 on these cells . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To confirm the role of CCK AR in the regulation of body temperature , the values of T ( c ) in the CCK AR ( / ) mice were compared with those in CCK B receptor ( CCK BR ) ( / ) , CCK AR ( / ) BR ( / ) , and wild type mice . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
RESULTS : CCK A receptor ( CCK AR ) and CCK B receptor ( CCK BR ) mRNA were detected in rat PIMs and their RT PCR amplified products had a size of approximately 1 . 37 kb and 480 bp , respectively . ^^^ The relative expression of CCK BR mRNA was higher than that of CCK AR mRNA after incubation with LPS for 0 . 5 , 2 , and 6 h . ^^^ Southern blot analysis of RT PCR amplified CCK AR and CCK BR mRNA products using [ gamma 32P ] ATP 5 ' end labelled probe showed specific hybridization bands . ^^^ The specific binding of [ 3H ] CCK 8S to rat PIM membranes was inhibited by unlabelled CCK 8S ( IC 50 = 2 . 3 + / 0 . 8 nmol / L ) , CCK AR specific antagonist CR 1409 ( IC 50 = 0 . 19 + / 0 . 06 micromol / L ) and CCK BR specific antagonist CR 2945 ( IC 50 = 3 . 2 + / 0 . 1 nmol / L ) . ^^^ CONCLUSION : Two types of functional CCK AR and CCK BR existed in rat PIMs and their expression could be upregulated by LPS . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Since the precise mechanism underlying this association has not been elucidated , the role of CCK AR in ethanol ingestion was examined using CCK AR gene deficient ( / ) mice and compared with those of CCK BR ( / ) and wild type mice . ^^^ RESULTS : CCK AR ( / ) mice consumed more ethanol than CCK BR ( / ) and wild type mice , and showed no aversion to high concentrations of ethanol solution . ^^^ D2R expression in the nucleus accumbens was significantly lower in the CCK BR ( / ) mice and was significantly higher in CCK AR ( / ) mice than in wild type mice . ^^^ CONCLUSIONS : Voluntary ingestion of ethanol differed between CCK AR ( / ) and CCK BR ( / ) mice . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The expression of cholecystokinin A receptor ( CCK AR ) and cholecystokinin B receptor ( CCK BR ) mRNA of myocardium in ES rats was examined by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ Gene expression of CCK AR and CCK BR significantly increased in myocardium of ES rats . ^^^ Similar to CCK AR mRNA , the expression of CCK BR mRNA peaked at 2 h and kept a high level at 6 h , but it did not change at the first 0 . 5 h and was stable at a high level at 12 h . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Analysis of the ability of gastrin 17 1 to inhibit 125I gastrin 1 binding demonstrated that gastrin bound to a single class of receptors with a Kd of 0 . 21 + / 0 . 04 nM and a binding capacity of 184 + / 29 fmol / mg protein . 125I Gastrin 1 binding was inhibited by the specific CCK B receptor antagonist L 365 , 260 approximately 40 times more effectively than by the specific CCK A receptor antagonist L 364 , 718 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Devazepide , a potent CCK A receptor antagonist , and L 365 , 260 , a selective CCK B receptor antagonist , have been introduced as pharmacologic tools for differentiating the physiologic roles of CCK A and CCK B receptor subtypes . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Replacement of the amide of compound 4 with a 4 , 5 dihydro 1 , 3 thiazole gives tricyclo [ 3 . 3 . 1 . 1 ( 3 , 7 ) ] dec 2 yl [ 1 [ 4 , 5 dihydro 4 ( phenylmethyl ) 2 thiazolyl ] 2 ( 1H indol 3 yl ) ethyl ] carbamate ( 5 ) , which is selective for the CCK A receptor ( CCK A IC 50 = 125 nM , CCK B IC 50 = 2580 nM , ratio = 21 ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Although these results stress the relative importance of the CCK A receptor in the effects of exogenous CCK 8 administration on feeding , stimulation of the CCK B receptor may still be involved in the control of feeding following the endogenous release of CCK . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Subcutaneously administered selective CCK A receptor antagonist , L 364 , 718 ( 1 mg / kg ) , reversed the inhibitory effect of centrally as well as peripherally administered CCK 8 , but the selective CCK B receptor antagonist , L 365 , 260 ( 1 mg / kg ) , did not . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We studied the behavioral effects of a novel cholecystokinin tetrapeptide ( CCK 4 ) analogue , A 71623 , with full agonist activity and high affinity and selectivity for the CCK A receptor subtype relative to the CCK B receptor . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In contrast , the IC 50 for inhibition of cell growth with two benzodiazepine derived antagonists , the CCK B receptor antagonist L 365 , 260 ( 4 . 6 10 10 ( 5 ) M ) and the CCK A receptor antagonist devazepide ( 1 . 7 10 10 ( 5 ) M ) were two three orders of magnitude greater than those required to inhibit gastrin binding ( 10 ( 8 ) 10 ( 7 ) M ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The cholecystokinin ( CCK ) receptor involved in contraction of guinea pig ileal longitudinal muscle to cholecystokinin is poorly understood ; some studies have suggested that contraction was mediated via a CCK A receptor whereas other studies have implicated CCK B receptors in ileal contraction to CCK . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This paper reviews experiments in which devazepide ( a selective CCK A receptor antagonist ) and L 365 , 260 ( a selective CCK B gastrin receptor antagonist ) have been used . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Compound 9 possesses a selectivity of greater than 500 fold for the pancreatic CCK A receptor over the CCK B receptor . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The effects of systemic treatment with the CCK B receptor antagonist L 365 , 260 , its 3S ( ) enantiomer and the CCK A receptor antagonist devazepide were assessed in the plus maze procedure in mice . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This increase in sensitivity to quinpirole was blocked by pretreatment with the nonselective CCK receptor antagonist proglumide and the preferential CCK A receptor antagonist CR 1409 but not by the preferential CCK B receptor antagonist L 365 , 260 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK A receptor antagonist devazepide but not the CCK B receptor antagonist L 365 , 260 reverses the effects of chronic clozapine and haloperidol on midbrain dopamine neurons . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Administration of 1 100 micrograms / kg i . p . of either the selective CCK A receptor antagonist devazepide ( MK 329 ) or the CCK B receptor antagonist L 365 , 260 alone failed to stimulate a locomotor response in parkinsonian monkeys . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The present report reviews recent evidence obtained in studies using devazepide ( a selective CCK A receptor antagonist ) and L 365 , 260 ( a selective CCK B / gastrin receptor antagonist ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The selective CCK B receptor antagonists CI 988 ( PD 134308 ) and L 365 , 260 produced anxiolytic like effects , whereas MK 329 , a CCK A receptor antagonist , was respectively less potent by factors of 313 and 200 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
L 364 , 718 , an antagonist selective for the CCK A receptor , blocked completely the action of centrally administered CCK , whereas L 365 , 260 , a selective CCK B receptor antagonist , had no effect on the ability of centrally administered CCK to inhibit feeding . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In particular , compounds 2c , 2g , and 2h possess a high affinity for the CCK A receptor subtype coupled with a low affinity for the CCK B subtype . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The inhibitory effect of 10 micrograms / kg ( s . c . ) CCK 8S was prevented by loxiglumide , a mixed type of CCK A and B receptor antagonist , at 1 mg / kg ( intraperitoneal ) and 40 micrograms / rat ( intracerebroventricular , i . c . v . ) ; L 364 , 718 , a CCK A receptor antagonist , at 125 and 250 ng / rat ( i . c . v . ) ; and L 365 , 260 , a CCK B receptor antagonist at 250 ng / rat ( i . c . v . ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK B / gastrin receptor antagonist L 365 , 260 abolished the stimulating effect of cionin on both histamine release and acid secretion , whereas the CCK A receptor antagonist L 364 , 718 only had a faint effect . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Additionally , we utilized 32P labeled cDNA probes of the CCK A receptor and CCK B ( gastrin ) receptor coding regions in order to examine the expression of CCK receptor subtypes in normal rat pancreas at the mRNA level . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK 8 infused intravenously ( 0 . 1 1 microgram . kg 1 . h 1 ) dose dependently increased the occurrence of relaxations while it was reduced by the CCK A receptor antagonist devazepide but not the CCK B antagonist L 365260 , both administered intravenously in a dose range of 0 . 1 100 micrograms / kg . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This effect of CCK 8 could be reversed by devazepide , a CCK A receptor antagonist , at 50 ng and 200 ng and by L 365 , 260 , a CCK B receptor antagonist , at 5 ng administered bilaterally to the nucleus accumbens . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK 8s and A 71623 , a selective CCK A receptor agonist , ( 10 , 25 and 50 ng / kg ) infused bilaterally into the CA , 30 min before ES , significantly reduced this stimulatory effect , while CCK 4 and A 63387 , a selective CCK B receptor agonist ( 10 , 25 and 50 ng / kg ) , had no effect on such a response . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These new analogs were moderately potent antagonists of CCK 8 in the isolated guinea pig gallbladder with exceptional CCK A receptor selectivity as evaluated in membrane preparations from CHO K 1 cells stably transfected with human CCK A and CCK B receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The fact that devazepide is 1000 times more potent as a CCK A receptor antagonist than L 365 , 260 , whereas the two compounds are nearly equipotent at the CCK B receptor subtype , suggests that CCK B rather than CCK A receptors are involved in these effects . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Fifty eight residues were sequentially replaced by the corresponding amino acids from the pharmacologically distinct CCK A receptor subtype . 125I CCK 8 competition binding experiments were performed to compare all mutant CCK B / gastrin receptor constructs with the wild type control . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The affinity of YM 022 for gastrin / CCK B receptor was more than 2 orders of magnitude higher than that for rat pancreatic CCK A receptor and various other receptors , such as benzodiazepine . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This effect of CCK 8 could be reversed by Devazepide , a CCK A receptor antagonist dose dependently at 50 ng and 200 ng , and by L 365 , 260 , a CCK B receptor antagonist at 5 ng and 8 ng administered to the same site . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The selective CCK A receptor antagonist MK 329 reversed the inhibitory effect of the centrally as well as peripherally administered CCK 8 , or of Suc ( Thr 28 , Leu 29 , MePhe 33 ) CCK 7 , whereas the selective CCK B receptor antagonist L 365260 did not . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Since cDNA of both the CCK A receptor ( classical pancreatic CCK receptor ) coding region and the CCK B receptor coding region have recently been cloned and sequenced , we investigated the expression of messenger RNA of these receptors in DSL 6 pancreatic carcinoma . ^^^ In summary , the CCK A receptor mRNA is overexpressed approximately 8 fold and the gastrin ( CCK B ) receptor mRNA is novelly expressed in DSL 6 pancreatic carcinoma as compared to normal rat pancreas . ^^^ The gene overexpression of the CCK A receptor and the novel gene expression of the gastrin ( CCK B ) receptor may be generated by alterations in gene regulation during carcinogenesis , and may play an important role in promoting tumor growth . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
It is concluded that the agonist effect of PD 136 , 450 is mediated via interaction with the gastrin ( CCK B ) receptor in the stomach and the CCK A receptor in the pancreas . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In addition , in ARIP cells , the CCK 8 induced increase in cytosolic calcium was abolished by pretreatment with the selective CCK B receptor antagonist L 365 , 260 but not by the CCK A receptor antagonist L 364 , 718 . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Competition experiments indicated that L 365 , 260 , a selective CCK B ( gastrin ) receptor antagonist , was the most potent displacer of 125I CCK 8 , and no significant displacement of binding was found with the selective CCK A receptor antagonist . ^^^ Growth of PANC 1 cells in culture was stimulated by CCK at a concentration consistent with the Kd , and CCK stimulated growth was inhibited by the CCK B receptor antagonist ( L 365 , 260 ) not the CCK A receptor antagonist ( L 364 , 718 ) . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Neither the CCK A receptor antagonist L 364 , 718 nor the CCK B receptor antagonist L 365 , 260 ( 10 ( 9 ) 10 ( 7 ) moles / kg ) antagonized CCK 8 actions . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Pharmacological analysis using selective agonists and antagonists indicated the expression of the CCK A receptor at birth , whereas the CCK B receptor predominated at postnatal stages . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
MK 329 , a CCK A receptor selective antagonist , at a dose of 20 nmol / kg fully inhibited the action of 20 nmol / kg CCK 8 , while 100 nmol / kg of ( R ) L 365 , 260 , a CCK B selective antagonist , had no effect on the CCK 8 response . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Proglumide ( 1 and 10 mg / kg SC ) and devazepide , ( a selective CCK A receptor antagonist ; 0 . 01 and 1 mg / kg SC ) , as well as caerulein ( 0 . 01 , 0 . 1 and 1 microgram / kg SC ) and CCK 4 ( a selective CCK B receptor agonist ; 25 and 50 micrograms / kg SC ) had no reliable effect . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Furthermore , 10 micrograms / kg of L 365 , 260 , a CCK B receptor antagonist , and 1 mg / kg of devazepide , a CCK A receptor antagonist , even tended to augment the effect of NMDA in the plus maze . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To gain a better understanding of the roles of CCK A and CCK B receptors in spinal nociceptive transmission during inflammation , this study evaluated the effects of intrathecally administered FK 480 ( a CCK A receptor antagonist ) and YM 022 ( a CCK B receptor antagonist ) . ^^^ These data indicate that a CCK B receptor antagonist , but not a CCK A receptor antagonist , produces an antinociceptive effect in the rat formalin test . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK XLR shares approximately 50 % homology at the amino acid level with both the human CCK BR and the peripheral CCK A receptor subtypes . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In man , CCK A receptor mRNA was detected in the brain , stomach , pancreas , and kidney , whereas CCK B receptor mRNA was found in the brain , stomach , and pancreas but not in the kidney . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These compounds displayed micromolar affinities for CCK B rather than CCK A receptor and the obtained results confirm that the 4 ( 3H ) quinazolinone nucleous represent a useful template for the development of selective CCK B receptor ligands . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Both peptides showed higher potency in the PPI assay than in Ca2+ studies . 100nM pentagastrin induced PPI turnover was dose dependently inhibited by the CCK B receptor selective antagonist L 365 , 260 ( IC 50 470nM ) whilst the CCK A receptor antagonist , devazepide , only produced weak partial inhibition ( 18 % at 10 , 000nM ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We examined whether the CCK A and CCK B receptor genes are expressed in the islets and the role of CCK A receptor in insulin secretion . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Evaluation of cholecystokinin , gastrin , CCK A receptor , and CCK B / gastrin receptor gene expressions in gastric cancer . ^^^ In this study , reverse transcription polymerase chain reaction ( RT PCR ) was used to evaluate messenger RNA expression for CCK , gastrin , CCK A receptor , and CCK B / gastrin receptor in surgical specimens of gastric cancers and in normal antrum and body mucosa of the stomach . ^^^ These findings may suggest a greater role for CCK and CCK A receptor than for gastrin and CCK B receptor in gastric cancers . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The binding of labeled CCK 8 was markedly inhibited by CCK 8 and CCK A receptor antagonists , but it was only weakly affected by gastrin and CCK B receptor antagonists . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The antagonist ( 1 microM ) for CCK B receptor , but not CCK A receptor , significantly inhibited the number of GH 3 cells . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The application of modern molecular biological techniques has identified two CCK receptors , CCK A receptor ( CCKAR ) and CCK B / gastrin receptor ( CCKBR ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Binding of 125I BH CCK 8 to the pancreas was inhibited by agonists with the affinities ( dissociation constant ) of CCK ( 0 . 11 nmol / L ) approximately gastrin ( 0 . 15 nmol / L ) and by antagonists with the affinities of CCK B receptor antagonist ( L 365 , 260 , 0 . 18 nmol / L ) > CCK A receptor antagonist ( lorglumide , 8 . 1 nmol / L ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Alligator gallbladder smooth muscle expresses a CCK A receptor subtype , and stomach oxyntic mucosa expresses a distinct receptor subtype , termed CCK B / X because of its similarities to both CCK B and CCK 10 receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The affinity of YF 476 for rat brain gastrin / CCK B receptor was 4100 fold higher than that for rat pancreatic CCK A receptor . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In contrast to Boc CCK 4 , which is 70 fold selective for the CCK B receptor , the modified lysine bearing tetrapeptides were highly potent and selective full agonists at the CCK A receptor . ^^^ Further investigation of the structure activity profile following modification of the substituted phenylurea moiety appended off the lysine revealed that moving certain substituents , e . g . nitro or acetyl , from the 2 or 3 position on the phenyl ring to the 4 position , a relatively minor and subtle structural modification within the tetrapeptide , resulted in loss of CCK A receptor selectivity and development of a trend toward CCK B selectivity . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Porta caval shunted rats displayed an increased CCK A receptor mRNA concentration in the pancreas ( after stimulation with CCK 8s ) and an increased CCK B receptor mRNA concentration in the oxyntic mucosa . ^^^ In conclusion , the porta caval shunting evoked enhancement of the trophic effect of CCK A receptor activation on the pancreas and of CCK B receptor activation on the ECL cells is associated with enhanced expression of CCK A receptor mRNA in the pancreas and of CCK B receptor mRNA in the oxyntic mucosa . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The agonists used were CCK ( 1 30 nmol i . c . v . ) , a CCK A receptor agonist ( SNF 9019 ; 0 . 3 10 nmol i . c . v . ) , and a CCK B receptor agonist ( SNF 9007 ; 0 . 3 10 nmol i . c . v . ) . ^^^ The antagonists used were the CCK A receptor antagonist , L 364 , 718 ( 12 . 5 nmol i . c . v . ) , CCK B receptor antagonist , L 365 , 260 ( 2 . 5 25 nmol i . c . v . ) , and the nonselective opioid receptor antagonist naloxone ( 1 mg / kg s . c . ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To investigate the role of the carboxyl terminus of cholecystokinin ( CCK ) receptors in receptor internalization , the rat wild type ( WT ) CCK A receptor ( WT CCKAR ) and the rat WT CCK B receptor ( WT CCKBR ) were truncated after amino acid residue 399 ( CCKAR Tr 399 ) and 408 ( CCKBR Tr 408 ) , thereby deleting the carboxyl terminal 45 and 44 residues , respectively . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK A receptor agonists A 71378 ( desamino Tyr ( SO3H ) Nle Gly Trp Nle ( N methyl ) Asp Phe NH 2 ) , and A 71623 ( Boc Trp Lys ( epsilon N 2 methylphenylamino carbonyl ) Asp ( N methyl ) Phe NH 2 , as well as the CCK B receptor agonist Suc CCK 4 ( Suc Trp ( N methyl ) Nle Asp Phe NH 2 ) were iontophoretically administered with multibarrel capillaries . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In contrast , CCK A receptor antagonists inhibited the stimulatory effect of G 17 in SIIA cells , whereas CCK B receptor antagonists had no effect . ^^^ Gly G stimulated the growth of AGS and SIIA cells ; neither the CCK B nor the CCK A receptor antagonists blocked this effect . ^^^ Furthermore , Gly G stimulates growth of human gastric cancer cell lines , possibly through a receptor other than the CCK B or CCK A receptor . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Leptin CCK action was blocked by systemic capsaicin at a dose inducing functional ablation of sensory afferent fibers and by devazepide , a CCK A receptor antagonist but not by the CCK B receptor antagonist , L 365 , 260 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK B receptor antagonist L 365 , 260 almost totally blocked MAPK activation in AR42J cells after stimulation with gastrin and glycine extended gastrin and substantially reduced the activation of both kinases by CCK 8 , while the CCK A receptor antagonist L 364 , 718 was much less effective . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The most potent member of this series of eight diastereoisomers , ( 4aS , 5R ) 2 benzyl 5 [ N [ ( tert butoxycarbonyl ) L tryptophyl ] amino ] 1 , 3 dioxoperhydropyrido [ 1 , 2 c ] pyrimidine , displays nanomolar CCK A receptor affinity and higher than 8000 fold potency at the CCK A than at the CCK B receptor . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This effect was blocked by the specific CCK B receptor antagonist D 2 but not by the specific CCK A receptor antagonist L 364 , 718 or by pertussis toxin , indicating that gastrin targets the SRE via specific CCK B receptors through a mechanism independent of Gi . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Pretreatment with the CCK A receptor antagonist MK 329 ( devazepide ; 1 mg / kg and 2 mg / kg i . p . ) reduced the CCK induced increase in c fos expression in the LC / SC by 54 % and 75 % , respectively ; the CCK B receptor antagonist L 365 , 260 had no effect . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK A receptor antagonist MK 329 ( 0 . 1 mg / kg i . p . ) diminished the FLI increase in LC , NTS , AP , and PVN by 39 100 % ; the CCK B receptor antagonist L 365 , 260 reduced the increased FLI in the AP by 54 % . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In this report , we show that the intraperitoneal administration of a CCK B receptor antagonist , PD 135158 ( 0 . 1 mg / kg ) , but not a CCK A receptor antagonist , lorglumide , inhibited hyperlocomotion . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The affinity of ARL 15849 for the CCK A receptor ( Ki = 0 . 034 nM ) is 6 , 600 fold greater than for the CCK B receptor ( Ki = 224 nM ) , whereas CCK 8 and ARL 14294 are nonselective . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Suppression of sham feeding by exogenous CCK 8 or intraintestinal oleate infusion is attenuated by peripheral administration of the CCK A receptor antagonist , devazepide , but not by the CCK B antagonist , L 365260 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To compare the roles of CCK receptors , the effects of the CCK A receptor agonist A 71378 , the CCK A / B receptor agonist CCK 8S and the CCK B receptor agonist BOC CCK 4 on anxiety related behavior and the 5 HT release in the prefrontal cortex were determined . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The gastrin / cholecystokinin ( CCK ) B and CCK A receptor antagonist activities of these compounds were evaluated by investigation of their affinities for human gastrin / CCK B receptors and human CCK A receptors , respectively . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK A receptor is the predominant peripheral CCK receptor subtype and the CCK B receptor is the predominant central CCK receptor . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This tactic yielded a series of monocyclic 2 oxopyrrolidine derivatives 4 with selectivity for CCK A or CCK B receptors and with slightly improved binding affinity at the CCK A receptor subtype with respect to the model 3 oxoindolizidines . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This study was designed to compare the effect of CCK 8 and intraduodenal ( i . d . ) instillation of sodium oleate , or diversion of the pancreatic biliary secretions that are known to release CCK , on the gastric mucosal lesions induced by topical application of 100 % ethanol or acidified aspirin ( ASA ) in rats with or without the pretreatment with a CCK A receptor antagonist , loxiglumide , or with L 365 , 260 to block CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In particular , the data imply a CCK A receptor mechanism in the regulation of individual sensitivity towards ethanol and a CCK B receptor mechanism in the regulation of individual sensitivity towards cocaine . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The simultaneous administration of equimolar doses of a selective CCK A receptor antagonist blocked the effect of CCK , while a CCK B antagonist was ineffective . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The dose range of activity ( 0 . 5 60 micrograms / kg ) together with the evidence that another CCK B receptor antagonist , L 365 , 260 ( 5 micrograms / kg ) increased , while devazepide ( a CCK A receptor antagonist ; 20 micrograms / kg ) decreased non REM sleep and total sleep time , support the original hypothesis that the activity of GV 150013 on sleep progress through CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
However , the binding sites in CCK A receptor seem to be slightly rigid as compared to those in CCK B or gastrin receptor . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Northern blot analysis showed a strong signal for CCK B receptor mRNA in adult pancreas , but no detectable signal for CCK A receptor mRNA . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK A receptor antagonist CR 1409 , but not the CCK B antagonist L 365260 , blocked the vagal response to endogenous CCK stimulation . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The expression of CCK A receptor mRNA and cNOS mRNA was significantly increased in rats treated with CCK 8 and camostate , whereas CCK B receptor mRNA remained unaffected . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We have previously reported that CCK A receptor agonists and CCK B receptor antagonists both enhance memory in an olfactory recognition test . ^^^ Here , we report that the memory enhancing effect of the CCK B receptor antagonist L 365 , 260 ( 1 mg / kg i . p . ) , but not that of the CCK A receptor agonist caerulein ( 0 . 03 mg / kg i . p . ) , was dramatically decreased following a bilateral transection of the perforant path , a principal source of input to the hippocampal formation . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The specific CCK B receptor antagonist L 740 , 093 blocks the gastrin but not the CCK response , indicating that both the CCK B and the CCK A receptor can mediate ICER gene activation . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Under these conditions we observed that the CCK A receptor antagonist , SR 27897 ( 0 . 3 mg kg ( 1 ) ) , but not the CCK B receptor antagonist , L 365260 ( 1 mg kg ( 1 ) ) , increases food intake . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The R enantiomer of 40 , ( R ) 40 ( FR 208419 ) , had 27 fold higher affinity for the CCK A receptor and 8 fold more potent CCK B receptor binding activity than ( S ) 40 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK A receptor antagonist L 364 , 718 was 300 fold more potent than the CCK B receptor antagonist L 365 , 260 at inhibiting CCK 8 induced contraction . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Moreover , CCK , CCK A receptor , and gastrin / CCK B receptor mRNA were measured by reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To test the possibility that cholecystokinin ( CCK ) mediates anorexia induced by IL 1 beta and LPS , mice trained to poke their noses in a hole to obtain a food reward according to a fixed ratio ( 1 reward per 20 actions ) were pretreated with the CCK A receptor antagonist L 364 , 718 ( at 1 mg / kg ) or with the CCK B receptor antagonist L 365 , 260 ( 50 microg / kg ) before being injected with LPS ( 100 microg / kg ) or IL 1 beta ( 20 microg / kg ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The obtained micromolar affinities for CCK A rather than CCK B receptor confirm that the anthranilic acid dimer represents a useful template for the development of selective CCK A receptor ligands . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The effects of cholecystokinin octapeptide ( CCK ( 8 ) ) , the CCK A receptor antagonist , MK 329 , and the CCK B receptor antagonist , L 365 , 260 , microinfused into the paraventricular nucleus of hypothalamus ( PVN ) on colonic motor function was investigated in awake rats , chronically implanted with a microinjection cannula into the PVN and a catheter into the proximal colon . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK 8 induced contraction was blocked by the CCK A receptor antagonists loxiglumide ( IC 50 11 micromol L 1 ) and SR 27897 ( IC 50 74 nmol L 1 ) but not by CCK B receptor antagonists ( 1 micromol L 1 ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK 8 effect , again , could be suppressed by CCK A receptor antagonist devazepide ( 10 nmol / L ) , but partially by CCK B receptor antagonist L 365 , 260 at 10 nmol / L or completely at concentration of 30 nmol / L . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Systemic injection of CCK A receptor antagonists , devazepide ( 0 . 1 and 1 mg / kg , i . p . ) , 30 min before cocaine priming , significantly attenuated cocaine induced reinstatement of CPP , while CCK B receptor antagonist , L 365 , 260 ( 0 . 1 and 1 mg / kg , i . p . ) , did not show a similar effect . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The phorbolester PMA ( 100 nM ) , a protein kinase C activator , downregulated CCK A receptor expression but did not affect CCK B receptor gene transcription . ^^^ Both elevated CCK B and decreased CCK A receptor mRNA expression returned to basal levels 6 h after continuous stimulation . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The pharmacological profile of CCK CHR resembled that of CCK B receptors using agonists ( CCK 8 , CCK 4 , gastrin 17 ) , whereas CCK CHR showed higher affinity for the CCK A receptor antagonist , devazepide , than for the CCK B receptor antagonist , L 365 , 260 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK A receptor antagonist ( L 364 , 718 ) or CCK B receptor antagonist ( L 365 , 260 ) was injected intraperitoneally 15 min before leptin or CCK treatments . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
MK 329 ( 0 . 4 mg / kg , 4 ) , the CCK A receptor antagonist , L 365 , 260 ( 0 . 4 mg / kg , 4 ) , the CCK B receptor antagonist and atropine ( 0 . 2 mg / kg , 4 ) , the M receptor antagonist , did not affect the OT effect on gallbladder motility . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Reverse transcription of meningioma derived RNA into cDNA followed by amplification by the polymerase chain reaction using specific primers for CCK peptide and its CCK A and / B receptor revealed 100 % presence of CCK peptide and CCK B receptors mRNA whereas CCK A receptor was expressed in 66 % of the meningiomas . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Pretreatment with the CCK A receptor antagonist , lorglumide ( 1 microM ) , antagonized the effects of CCK 8s , whereas perfusion with the CCK B preferring agonist CCK 8 nonsulfated ( CCK ns , 1 microM ) did not affect the frequency of sEPSCs . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Those increases were abolished by the CCK A receptor blocker ( lorglumide ) , but not by the CCK B receptor blocker ( itriglumide ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Both the CCK A receptor antagonist lorglumide ( 48 mg kg ( 1 ) , i . v . ) and the CCK B receptor antagonist itriglumide ( 5 . 5 mg kg ( 1 ) , i . v . ) , given separately , prevented the expected increase in pentagastrin and , in addition , reduced the glandular protein synthesis by 16 and 12 % , respectively , below the level of saline treated rats . ^^^ In rats treated with saline only , the glandular protein synthesis was reduced by 22 % by the CCK A receptor antagonist and by 17 % by the CCK B receptor antagonist ; combined , the two antagonists caused no further reduction ( 20 % ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These results suggest that endogenous CCK could play a critical role in mood modulation through CCK A / CCK B receptor stimulation . ^^^ Dysfunctioning of the CCK A / CCK B pathways could be implicated in anxiety and panic attacks . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK interacts with at least two types of receptor called CCK A and CCK B receptors . ^^^ Moreover , selective nonpeptide antagonists have been developed for CCK A and CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The results provide evidence that CCK 8 stimulates the turnover of phosphoinositide and increases InsP 3 labelling in dissociated neonatal rat brain cells , in which both CCK A and CCK B receptors seem to be involved . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Pharmacological experiments using selective CCK A and CCK B receptor antagonists demonstrate that CCK B is the prominent CCK receptor subtype in trigeminal and dorsal root ganglia neurons in the rat , rabbit , and monkey . ^^^ In the rat and rabbit spinal cord , CCK B binding sites are the prominent subtype , whereas in the monkey cord , CCK A is the prominent receptor subtype . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The inhibitory effect of CCK 8 was completely blocked by the selective antagonist for CCK B receptors , ( + ) L 365 , 260 , but not by ( ) L 364 , 718 , which is a selective antagonist for CCK A receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Incubation of nerve sections in the presence of both antagonists produced an additive effect , indicating that both CCK A and CCK B binding sites are transported towards the periphery . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Compounds were assessed in binding assays using homogenated rat pancreatic membranes and bovine striatum as the source of CCK A and CCK B receptors respectively and for anorectic activity after intraperitoneal administration to rats . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Both CCK A and CCK B / gastrin receptors are present on rabbit vagus nerve . ^^^ Under conditions which selectively examined vagal CCK A or CCK B / gastrin receptors , we demonstrated that a number of CCK subtype selective agonists and antagonists possessed similar affinities for the vagal CCK A and B / gastrin receptors as those found on the guinea pig pancreas ( CCK A ) and cerebral cortex ( CCK B ) , respectively . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In the present study , we tested whether this action is mediated by CCK A receptors , CCK B receptors , or both . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Pharmacological responses to CCK are mediated through at least two receptor subtypes termed CCK A and CCK B . ^^^ Using selective antagonists and a behavioural recognition test based on the olfactory discriminative capacities of rats , we found that endogenous CCK acting at CCK A and CCK B receptors modulates olfactory recognition positively and negatively , respectively . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The new compounds were assayed in CCK binding assays using homogenated rat pancreatic membranes and bovine striatum as a source of CCK A and CCK B receptors respectively and in vivo in rats for anorectic activity . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Compounds were assessed in binding assays using homogenated rat pancreatic membranes and bovine striatum as the source of CCK A and CCK B receptors , respectively , and for anorectic activity after intraperitoneal administration to rats . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The effect of caerulein ( 5 micrograms / kg ) was antagonized by devazepide , a CCK A antagonist , at 100 micrograms / kg , but not by a CCK B antagonist L 365 , 260 tested at a wide dose range . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
A series of modifications of the CCK 7 analogue ( des NH 2 ) Tyr ( SO 3 ) Nle Gly Trp Nle Asp Phe NH 2 was prepared and tested for binding to guinea pig CCK A and CCK B receptors and in CCK A mediated functional assays . ^^^ The ( N Me ) Asp 32 and ( N Me ) Leu 31 modifications afforded potent and selective CCK A and CCK B ligands , respectively . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Subtype selective antagonists of the peripheral type ( CCK A ) and the central type ( CCK B ) cholecystokinin ( CCK ) receptors were employed to determine the receptor subtype ( s ) mediating the modulatory actions of CCK on dopamine induced changes in exploratory activity at three sites in the mesolimbic pathway of the rat . ^^^ These data indicate a CCK B pharmacology in the cell body and anterior terminal field , and a CCK A pharmacology in the posterior terminal field , of the mesolimbic dopamine pathway . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This effect was suppressed by the selective CCK B antagonist : L 365 , 260 , but not by the selective CCK A antagonist : MK 329 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To investigate the relative participation of peripheral ( CCK A ) and central ( CCK B ) cholecystokinin ( CCK ) receptors in satiety induced by endogenous CCK , we examined the effect of the CCK A antagonist MK 329 ( 10 315 micrograms / kg ) and the CCK B antagonist L 365260 ( 0 . 1 315 micrograms / kg ) on intake of a 20 % sucrose solution in mildly food deprived mice . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Unexpectedly , the CCK B receptor antagonist , L 365 , 260 , enhanced the response to CCK 8 , an effect diametrically opposite to that produced by CCK A antagonists . ^^^ These observations indicate that CCK A and CCK B receptors mediate quite different , if not opposing , roles in regulating corticotroph secretion . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
H ] pBC 264 , a suitable probe for studying cholecystokinin B receptors : binding characteristics in rodent brains and comparison with [ 3H ] SNF 8702 . [ 3H ] Propionyl Tyr ( SO3H ) gNle mGly Trp ( NMe ) Nle Asp Phe NH 2 ( [ 3H ] pBC 264 ) ( 98 100 Ci / mmol ) , a new peptidase resistant cholecystokinin ( CCK ) agonist that is 1000 fold more potent for CCK B than for CCK A receptors , interacts , with a similar subnanomolar affinity , with a single class of binding sites ( Kd , 0 . 15 0 . 2 nM ) in brain membranes of mouse , rat , guinea pig , and cat , in Tris and Krebs buffers . ^^^ The concentration of CCK A receptors in rodent brain was estimated to be 8 10 fmol / mg of protein , by measurement of the Bmax values of the nonselective agonist [ 3H ] propionyl CCK 8 , with or without 10 nM pBC 264 to saturate CCK B sites . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The response to these peptides was suppressed by pretreatment with a selective antagonist for CCK A receptors , ( ) L 364 , 718 , in a dose related manner , but not with an antagonist for CCK B receptors , ( + ) L 365 , 260 . ^^^ These results indicate that peripheral administration of CCK 8 and ceruletide stimulates the hypothalamo pituitary adrenal axis through the activation of CCK A receptors , but not CCK B receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To determine whether these endocrine responses involve CCK A or CCK B receptors , this experiment investigated the effect of CCK ( 1 microgram / kg ) in pigs ( n = 7 ) pretreated with the CCK A antagonist L 364718 ( 70 microgram / kg ) or the CCK B antagonist L 365260 ( 10 ng / kg and 10 micrograms / kg ) . ^^^ However , the effect of CCK on cortisol secretion does not appear to involve either CCK A or CCK B receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK B and CCK A binding affinities of these analogues are described and their CCK B affinity and selectivity rationalized by consideration of the pK ( a ) values , charge distribution , and geometry of the respective acid mimics . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Based on their relative affinities for cholecystokinin octapeptide ( 26 33 ) ( CCK 8 ) , cholecystokinin tetrapeptide ( 30 33 ) ( CCK 4 ) , desulfated CCK 8 , and gastrin , cholecystokinin ( CCK ) receptors have been classified as CCK A ( alimentary ) and CCK B ( brain ) . ^^^ Selective nonpeptide antagonists of CCK A and CCK B receptors , as well as highly selective CCK A and CCK B peptide agonists , have been described . ^^^ In radioligand binding assays , the IC 50 values for A 71623 and A 70874 were 3 . 7 and 4 . 9 nM in guinea pig pancreas ( CCK A ) and 4500 and 710 nM in cerebral cortex ( CCK B ) , respectively . ^^^ The preferential interaction of these novel CCK 4 analogs with CCK A receptors is in contrast to other CCK 4 based peptides , which are primarily selective for CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To study the interdependence between gastric histamine release and acid secretion , we examined the effects of gastrin ( 1 17 ) [ G ( 1 17 ) ] or cholecystokinin ( 1 33 ) [ CCK ( 1 33 ) ] alone or combined with the gastrin ( CCK B ) antagonist L 365 , 260 or the CCK A antagonist L 364 , 718 in the isolated vascularly perfused rat stomach . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
New ( R ) 4 benzamido 5 oxopentanoic acid derivatives were synthesized by a stereoconservative procedure and evaluated in vitro for their capacity to inhibit the binding of [ 125I ] ( BH ) CCK 8 to either rat peripheral ( CCK A ) or central ( CCK B ) CCK receptors , or the binding of [ 3H ] pentagastrin to rabbit gastric glands , as well as to inhibit , in vivo , the acid secretion induced by pentagastrin infusion in the perfused rat stomach . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The receptor binding activities of these synthetic analogs of CCK 7 and their selectivity for the CCK A and CCK B receptor subtypes were determined using solubilized membrane preparations from rat pancreatic tissue and bovine striatum . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK ) receptors are currently divided into at least two subtypes : a CCK A subtype , responsive to the sulfated form of cholecystokinin octapeptide ( CCK 8 ) and selectively antagonized by L 364 , 718 , and a CCK B subtype , which shares equal affinities for gastrin and CCK 8 . ^^^ The antagonist potencies of L 365 , 260 ( CCK B selective ) and L 364 , 718 ( CCK A selective ) against CCK 8 were also determined . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Peptide analogues were evaluated in a CCK binding assay for affinity for either peripheral ( CCK A ) receptors using homogenated rat pancreatic membranes as the receptor source or for central ( CCK B ) receptors using bovine striatum as the receptor source . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These CCK binding sites displayed a typical CCK B pharmacological profile , established by use of several agonists and antagonists selective for the CCK receptor types , namely compound L 364 , 718 , the Merck CCK antagonist selective for the peripheral CCK receptor ( CCK A ) , and compound L 365 , 260 , the Merck CCK antagonist selective for the central CCK receptor ( CCK B ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
They are significant pharmacological tools for the study of CCK A ( peripheral ) and CCK B ( central ) receptors , their biological actions and their associated intracellular messengers . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Proglumide does not discriminate between CCK A and CCK B ( central type ) receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In homogenate binding studies , L 365 , 260 displayed nanomolar affinity for CCK B receptors in the cerebral cortex of several species including man ( pIC 50 congruent to 8 . 2 ) but showed low affinity for CCK A receptors in the rat pancreas ( pIC 50 congruent to 6 . 3 ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The effects of the selective CCK A antagonist L 365 , 031 and the selective CCK B antagonist L 365 , 260 on morphine analgesia and opiate tolerance and dependence in rats were examined . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Receptors for the brain and gut peptide cholecystokinin ( CCK ) have been classified into two classes , CCK A and CCK B . ^^^ To date , peptide analogues with selectivity for the CCK B receptors have been identified , and selective antagonists for CCK A and CCK B receptors have been reported as well ; until now , there have been no reports of highly selective CCK A agonists . ^^^ The IC 50 values of A 71378 for the pancreatic CCK A , cortical CCK B , and gastrin receptor were 0 . 4 nM , 300 nM , and 1 , 200 nM , respectively . ^^^ The high potency and selectivity of A 71378 for the CCK A over CCK B and gastrin receptors is unprecedented among CCK peptides . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Distinct requirements for activation at CCK A and CCK B / gastrin receptors : studies with a C terminal hydrazide analogue of cholecystokinin tetrapeptide ( 30 33 ) . ^^^ Using 125I Bolton Hunter cholecystokinin octapeptide ( 26 33 ) ( 125I Bolton Hunter CCK 8 ) as the radioligand , A 57696 was found to be selective for cortical CCK B receptors ( IC 50 = 25 nM ) , compared with pancreatic CCK A receptors ( IC 50 = 15 microM ) . ^^^ Stimulatory actions of CCK 8 and A 57696 were reversed by the CCK B selective ( R ) L 365 , 260 ( 100 nM ) , whereas at the same concentration , the CCK A selective ( S ) L 365 , 260 was ineffective . ^^^ Its contrasting functional activities at guinea pig CCK A and CCK B / gastrin receptors in a human tumor cell demonstrate that , in addition to the previously described differences in binding specificity for selective agonists and antagonists , CCK A receptors and CCK B / gastrin receptors have different requirements for activation . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK A receptors have high affinity for sulphated CCK 8 and for MK 329 but low affinity for desulphated CCK 8 and CCK 4 whilst CCK B sites bind MK 329 with low affinity and discriminate poorly between sulphated and desulphated CCK 8 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
However , it has not been established that endogenous CCK causes satiety or whether the response is mediated by peripheral type ( CCK A ) or brain type ( CCK B ) receptors . ^^^ The development of potent and selective antagonists for CCK A ( MK 329 ) and CCK B ( L 365 , 260 ) receptors now allows these issues to be addressed . ^^^ The CCK A antagonist MK 329 and the CCK B antagonist L 365 , 260 increased food intake in partially satiated rats and postponed the onset of satiety ; however , L 365 , 260 was 100 times more potent than MK 329 in increasing feeding and preventing satiety . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
It is suggested that the variable effects of MK 329 on morphine induced and opioid mediated social conflict analgesia may reflect differential , dose dependent effects at CCK B and CCK A sites respectively , a proposal consistent with the 500 fold potency difference observed between the two models . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The exact locus of this interaction , or whether it involves ' peripheral type ' ( CCK A ) or ' central type ' ( CCK B ) receptors is not known . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
However , it remains unclear whether these growth effects are mediated specifically by CCK A receptors , CCK B receptors , or both . ^^^ METHODS : Rats were subcutaneously injected with either ( 1 ) CCK 8 , a nonselective CCK agonist ( 2 . 50 micrograms / kg body wt ) ; ( 2 ) A 71623 , a selective CCK A agonist , tert butyl oxycarbonyl Trp Lys ( epsilon N 2 methylphenylaminocarbonyl ) Asp ( N methyl ) Phe NH 2 ( 1 . 84 micrograms / kg body wt ) ; ( 3 ) SNF 8815 ; a selective CCK B agonist , [ ( 2R , 3S ) beta MePhe 28 , N MeNle 31 ] CCK 26 33 ( 2 . 40 micrograms / kg body wt ) ; or ( 4 ) saline ( control ) for 21 days . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK B antagonist L 365 , 260 inhibited this effect [ concentration inhibiting 50 % of maximal response ( IC 50 ) , 2 10 10 ( 8 ) M ] , whereas the CCK A antagonist L 364 , 718 ( 10 ( 8 ) M ) and the tyrosine kinase inhibitor genistein ( 10 ( 4 ) M ) had no effect . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
It is suggested that centrally applied CCK 8S evokes pepsinogen secretion through the activation of peripheral CCK A and CCK B receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The cyclic analogue 1a has Ki values of 4 . 5 and > 5000 nM at delta and mu opioid receptors , respectively ; and IC 50 values of 1 . 6 and > 10 , 000 nM for CCK A and CCK B receptors , respectively . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Hybrid analogs of the cholecystokinin A ( CCK A ) receptor selective tetrapeptide agonist Boc Trp Lys ( Tac ) Asp MePhe NH 2 ( 1 , A 71623 ) and the CCK B receptor selective antagonists PD 135118 ( 2 ) and CI 988 ( 3 ) were prepared . ^^^ Incorporation of the Lys ( Tac ) side chain into 3 produced the novel agonist analog 7 ( EC 50 = 28 nM in the GPGB ) with excellent affinity for both human CCK A ( IC 50 = 12 nM ) and CCK B ( IC 50 = 17 nM ) receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These studies were undertaken to investigate if CCK A and CCK B receptors were perhaps mediating the mitogenic effects of gastrin on Swiss 3T3 cells . ^^^ Receptor antagonists that inhibit the biological effects and binding of peptides to the CCK A ( L 364 , 718 ( L 18 ) ) and CCK B ( L 365 , 260 ( L 60 ) ) receptors were ineffective toward inhibiting the binding and proliferative effects of gastrin on Swiss 3T3 cells . ^^^ Radiolabeled L 18 and L 60 demonstrated no binding to the cells , indicating that CCK A and CCK B receptors may be absent on Swiss 3T3 cells . ^^^ Possible mRNA expression of CCK A and CCK B receptor subtypes by gastrin responsive rodent intestinal and fibroblast cell lines ( Swiss 3T3 , IEC 6 , CA ) was measured by the methods of Northern blot analysis and reverse transcriptase polymerase chain reaction . mRNA from rat pancreas , AR42J cells , and rat antrum served as positive controls . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Functional studies suggest that guinea pig chief cells have both cholecystokinin A ( CCK A ) and CCK B receptors ( CCK A R and CCK B R , respectively ) . ^^^ These results demonstrate directly for the first time that guinea pig chief cells possess CCK A R and CCK B R . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Cholecystokinin potentiates morphine anticonvulsant action through both CCK A and CCK B receptors . ^^^ We studied the effect of subcutaneous morphine and intracerebroventricularly administered cholecystokinin octapeptide sulphate ester and receptor antagonists CCK A ( MK 329 ) and CCK B ( L 365 , 260 ) on seizures provoked by maximal electroshock in male Sprague Dawley rats . ^^^ Seizures were induced through electrode gel coated ear clip electrodes by a high voltage , high internal resistance constant current generator , 30 minutes after morphine administration and 10 minutes after cholecystokinin 8 SE , CCK A and CCK B infusion . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In an effort to determine whether the CCKA and CCKB receptors may be associated with certain CNS or gastrointestinal diseases , we have localized and compared the human and mouse chromosomal loci encoded by the CCKAR and CCKBR genes . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The duration of MMC disruption and the increase in colonic spike burst frequency after spermidine administration ( 20 mumol ) were significantly reduced by CCK A and CCK B antagonists . ^^^ These results indicate that exogenous polyamines disrupt intestinal MMCs and stimulate colonic motility through a release of CCK acting at CCK A and CCK B receptors and suggest that endogenous polyamines are involved in the postprandial control of intestinal motility . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The behavioral responses induced by BDNL were not significantly blocked by L 365 , 260 , but were suppressed by CI 988 , another selective CCK B antagonist , and by high doses of L 364 , 718 , a selective CCK A antagonist . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
RESULTS : Exogenous CCK significantly reduced food intake in gastrectomized rats ; this was blocked by administration of a CCK A but not a CCK B receptor antagonist . ^^^ Chronic treatment with a CCK A or CCK B receptor antagonist after total gastrectomy in rats significantly increased postoperative food intake and body weight . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These results suggest that 1 ) Both muscularly and neurally located CCK receptors are present on the longitudinal layer of chicken ceca whereas only muscular receptors are present on the circular muscle . 2 ) 5HT2 receptors seem to be involved in the neurally mediated CCK 8s response observed in the longitudinal layer . 3 ) The different potency of CCK 8s , CCK 8ns and CCK 4 to induce contractile effects and of the CCK A and CCK B antagonists to block such effects suggests the existence of two different CCK receptors on the circular layer . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK A and CCK B selective receptor agonists and antagonists modulate olfactory recognition in male rats . ^^^ We have used a behavioural model of olfactory recognition among rats to test this hypothesis and to explore the relationship between CCK A and CCK B receptors and memory retention . ^^^ Systemic injection of CCK 8 , of a selective CCK A agonist , or of non peptide CCK B antagonists ( CI 988 and LY 262691 ) enhanced olfactory recognition . ^^^ CCK A antagonist devazepide on olfactory recognition , these results confirm and extend the hypothesis that there is a balance between CCK A mediated facilitative effects and CCK B mediated inhibitory effects on memory retention . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
All had essentially the same sequence contained within 2 of these clones consisted of 427 amino acids and was 92 % homologous ( 87 % identity ) to the known rat pancreatic CCK A sequence but only 43 % homologous to the gastric CCK B sequence . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We transfected COS cells with cDNA for rat cholecystokinin A ( CCK A ) and different CCK B receptors and measured binding of 125I CCK 8 , [ 3H ] L 364 , 718 and [ 3H ] L 365 , 260 to characterize the different affinity states for each type of CCK receptor . ^^^ Rat CCK A and CCK B receptors , canine CCK B receptors and canine mutant CCK B ( M CCK B ) receptors in which the leucine in position 355 was replaced by valine each existed in three different affinity states for CCK 8 , high affinity , low affinity , and very low affinity . ^^^ In rat CCK A and probably CCK B receptors , most were in the very low affinity state , whereas with canine CCK B and M CCK B receptors , most were in the low affinity state . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Microiontophoretic administration of sulfated CCK octapeptide ( CCK 8S , agonist for CCK A and CCK B receptors ) and the selective CCK B receptor agonists , CCK 4 and unsulfated CCK 8 , inhibited the firing rates of a subpopulation of SNr neurons . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Optimization of this series led to the identification of an azabicyclononane amidine , L 740 , 093 [ N [ ( 3R ) 5 ( 3 azabicyclo [ 3 . 2 . 2 ] nonan 3 yl ) 2 , 3 dihydro 1 methyl 2 oxo 1H 1 , 4 benzodiazepin 3 yl ] N ' ( 3 methylphenyl ) urea ] , that bound with high affinity of CCK B receptors from guinea pig cerebral cortex ( IC 50 of 0 . 1 nM ) and had a CCK B / CCK A receptor selectivity of 16 , 000 . ^^^ In comparison , L 365 , 260 had 85 fold lower affinity ( 8 . 5 nM ) and was only 87 fold selective for CCK B over CCK A receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In addition , the CCK analog [ Boc Tyr ( SO3H ) Nle Gly Trp Nle Asp Phe NH 2 ] ( a mixed CCK A / CCK B agonist ) increased the jump latency and this effect was blocked by MK 329 ( 20 micrograms / kg i . p . ) and by naloxone , but not by the selective CCK B antagonist L 365 , 260 ( 5 mg / kg i . p . ) . ^^^ Taken together , these findings suggest that the potentiating effects of delta agonists on mu mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK A and CCK B receptors and resulting in positive and negative regulation of the endogenous opioid system . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK B antagonist L 365 , 260 ( 10 pmol 1 nmol ) failed to block the gastric vagal afferent response to gastric loads or 100 pmol CCK , while the CCK A antagonist devazepide ( 100 pmol 100 nmol ) competitively and dose dependently attenuated the response to CCK but not to gastric loads . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK A or CCK B . ^^^ Two receptors for cholecystokinin ( CCK ) have been isolated which also bind gastrin : CCK A type and CCK B type , both are coupled to phospholipase C ( PLC ) activation . ^^^ The trophic effect was not blocked by receptor antagonists for CCK A ( L 364 , 718 ) or CCK B ( L 365 , 260 ) . ^^^ The gastrin receptor pharmacology on LoVo cells and the lack of appropriate transcripts suggest that gastrin stimulated growth of these cells by a receptor other than CCK A or CCK B type and there likely exists another receptor for gastrin . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Observed biological activities of substituted phenyl urea / thiourea tetrapeptides as agonists with the cholecystokinin alimentary canal ( CCK A ) receptor , and ( R ) 4 benzamido 5 oxopentanoic acid derivatives with both peripheral ( CCK A ) and the central ( CCK B ) ( brain ) receptors have been shown to be correlated with various physicochemical , e . g . pi , sigma , and structural , e . g . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Pharmacological experiments using CCK or NPY analogs suggest that both subtypes of CCK ( CCK A and CCK B ) and NPY ( Y 1 and Y 2 ) receptor binding sites are expressed by discrete populations of neurons in the nodose ganglion . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In the distal colon , the postprandial response was inhibited by CCK A , CCK B , and 5 HT 2 receptor antagonists , whereas they were inactive in the proximal colon . ^^^ These results suggest that , in rats , CCK 8 is involved in the control of the ileal motor response to feeding through CCK A receptors and in that of the distal colon through both CCK A and CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The antinociceptive activity of SNF 9007 was not a result of the activation of CCK receptors , as treatment with either CCK A or CCK B receptor antagonist was ineffective in blocking SNF 9007 antinociception . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Evidence for expression of CCK A receptors but not CCK B ( gastrin ) receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
FPL 14294 [ 4 ( sulfoxy ) phenylacetyl ( MePhe 6 ) CCK 6 ] is a CCK analog with enhanced metabolic stability that was comparable to CCK 8 in potency to contract isolated gallbladder and in affinity at the CCK A and CCK B receptor . ^^^ Anorectic activity was inhibited by pretreatment with a CCK A antagonist ( MK 329 ) but not by a CCK B antagonist ( L 365 , 260 ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The results showed that ( 1 ) The antagonistic effect of CCK 8 on opioid induced hypotension could be blocked by intrathecal ( 1 . t . ) administration of CCK B antagonist L 365 , 260 at nanogram doses , or by CCK A antagonist devazepide at doses 20 40 times higher than L 365 , 260 , indicating that it was the CCK B receptor which mediates the antiopioid effect . ( 2 ) The depressor effect induced by intrathecal muscimol , a GABA agonist , was blocked neither by naloxone nor by CCK 8 , supporting the notion that CCK 8 is an endogenous opioid antagonist rather than a universal anti hypotension agent . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The present study was performed to ascertain whether the blockade of endogenously released CCK 8 by potent and selective CCK A antagonist devazepide and CCK B antagonist L 365260 would affect opioid analgesia at the spinal cord level . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Derived by reasoned modification of the CCK A selective 3 carboxamido 1 , 4 benzodiazepine , MK 329 , this paper chronicles the development of potent , orally effective compounds in which selectivity for the CCK B receptor subtype was achieved . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK A ) and gastrin ( CCK B ) receptors have been demonstrated in the azaserine induced rat pancreatic carcinoma DSL 6 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The binding sites had high affinity for CCK 8 , CCK 4 , gastrin 1 , and L 365 , 260 ( CCK B antagonist ) , and had low affinity for devazepide ( CCK A antagonist ) , indicating that the binding sites are CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Energy calculations were performed for CCK 8 ( Asp 26 Tyr ( SO 3 ) 27 Met 28 Gly29 Trp 30 Met31 Asp 32 Phe33 NH 2 , 1 ) and [ desaminoTyr ( SO 3 ) 27 , Nle 28 , 31 ] CCK 7 ( 2 ) , which are nonselective ligands of CCK receptors , and for the CCK A selective analog [ desaminoTyr ( SO 3 ) 27 , Nle 28 , 31 , N Me Asp 32 ] CCK 7 ( 3 ) and the CCK B selective analog [ desaminoTyr ( SO 3 ) 27 , Nle 28 , N Me Leu 31 ] CCK 7 ( 4 ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The present study was performed to determine whether these effects are mediated by way of CCK A receptors , CCK B receptors , or both . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The role of cholecystokinin ( CCK ) as a central and peripheral satiety factor was studied using the CCK B ( L 365 , 260 ) and CCK A ( MK 329 ) receptor antagonists in esophageal fistula dogs . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The activity of SR 27897 , a potent and selective CCK A vs CCK B receptor antagonist ( Ki = 0 . 2 nM on guinea pig pancreas vs 2000 nM on rat brain ) was studied on behavioural , electrophysiological and biochemical effects induced by peripheral or central injection of CCK 8S . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The diphenylpyrazolidinone CCK B antagonists , but neither the inactive nor the CCK A selective analog , also decreased the number of spontaneously active A 9 DA cells ; however , none of these compounds produced catalepsy in awake animals . ^^^ These results indicate that the firing of A 9 and A 10 DA neurons is suppressed specifically by antagonism of CCK B , but not CCK A receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Operant feeding was recorded in 18 h deprived pigs after peripheral ( 4 ) or central ( ICV ) administration of saline , the CCK A agonist A 71378 , the CCK B agonist pentagastrin , or pentagastrin vehicle . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Extracellular single unit recording techniques were used to study the effects of the cholecystokinin A ( CCK A ) antagonist , L 364 , 718 , and the CCK B antagonist , PD 134308 , on DA neuronal activity in chloral hydrate anesthetized rats . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK A antagonist completely blocked LH secretion in response to CCK , whereas the CCK B antagonist had no effect . ^^^ To assess whether endogenous CCK , released in response to food intake , stimulates LH secretion , six monkeys were fasted for 1 day and then provided with a normal meal of monkey chow ( i . e . a refeed meal ) the following day , with either no antagonist , CCK A antagonist , or CCK B antagonist administered 30 min before the meal . ^^^ The refeed meal led to a comparable stimulation of LH secretion regardless of whether monkeys received no antagonist ( 3 . 7 + / 0 . 44 LH pulses / 9 h ) , CCK A antagonist ( 3 . 33 + / 0 . 56 LH pulses / 9 h ) , or CCK B antagonist ( 4 . 0 + / 0 . 78 LH pulses / 9 h ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Administration of both CCK A and CCK B receptor antagonists alone resulted in no change in meal size . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The compounds tested were selective CCK B antagonists [ CI 988 ( 0 . 01 1 mg / kg SC ) , L 365 , 260 ( 0 . 004 2 mg / kg IP ) and LY 262 , 691 ( 0 . 001 1 mg / kg SC ) ] , CCK B agonists [ CCK 4 ( 0 . 01 1 mg / kg SC ) and BC 264 ( 0 . 004 1 mg / kg IP ) ] and CCK A antagonists [ devazepide ( 0 . 001 1 mg / kg SC ) and lorglumide ( 0 . 01 1 mg / kg SC ) ] . ^^^ None of these drugs induced the expected behavioural effects , i . e . an anxiolytic like release of the behavioural suppression with CCK B and , possibly , CCK A antagonists and / or a further reduction of lever pressing with CCK B agonists , indicative of an anxiogenic like potential . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In vitro binding studies showed that some derivatives exhibited potent affinity for gastrin CCK B receptor and high selectivity over peripheral CCK ( CCK A ) receptor . ^^^ Structure activity relationship studies of this series suggested that 1 [ ( R ) 2 , 3 dihydro 1 ( 2 , 3 dihydro 1 ( 2 methylphenacyl ) 2 oxo 5 phe nyl 1H 1 , 4 benzodiazepin 3 yl ] 3 ( 3 methylphenyl ) urea ( 35b , YM 022 ) was the optimal compound with IC 50 values of 0 . 17 , 0 . 11 and 150 nM for gastrin , CCK B and CCK A receptors , respectively , and an ED 50 value of 9 . 5 nmol / kg ( i . v . ) in rats . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Male NMRI mice weighing 12 15 g were assigned to six groups ( 10 mice / group ) which were treated with different combinations of 0 . 9 % NaCl , omeprazole , a CCK A antagonist , a CCK B antagonist , loxiglumide , and L 365 , 260 for 10 days each according to different protocols . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
For example , CCK appears to exert its anti opioid actions mainly through the activation of CCK B receptors , whereas its opioid like effects seem to result from the stimulation of CCK A receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK B antagonists suppressed CCK 4 induced calcium mobilization more potently than CCK A antagonist . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The radioligand binding models used in these studies were [ ( 125 ) 1 ] ( BH ) CCK 8 in rat pancreas ( CCK A ) , [ ( 3 ) H ] ( MENLE ( 28 , 31 ) ) cck 8 in guinea pig cerebral cortex ( CCK B ) , and [ ( 3 ) H ] U 69593 ( kappa ( 1 ) ) , [ ( 3 ) H ] DAMGO ( mu ) , and [ ( 3 ) H ] DADLE ( delta ) in guinea pig brain . ^^^ All the title compounds were devoid of significant affinity for both CCK A and CCK B receptors , while some of them bound with nanomolar affinity and high selectivity for kappa opioid receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Both CCK A and CCK B receptor subtypes were visualized in the nucleus of the solitary tract and the area postrema of normal rats , but levels of binding to both of these subtypes were unaffected by the experimental treatments . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
L 364 , 718 ( a CCK A antagonist ) showed a relative selectivity and a high affinity for those receptors located in central tissues , whereas L 365 , 260 ( a CCK B antagonist ) is almost inactive in all studied tissues . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These compounds displayed micromolar affinities for CCK A rather than CCK B receptor and the results have been discussed on the basis of a molecular modelling study . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
RNA were extracted for CCK A and CCK B receptor expression using specific cRNA probes . ^^^ The pig pancreas expresses few CCK A mRNA receptors but a majority of CCK B . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The strategy is exemplified by the design of a selective and high affinity cholecystokinin CCK A antagonist PD 140548 , CCK B antagonist CI 988 ( formerly PD 134308 ) tachykinin NK 1 antagonist PD 154075 and NK 2 antagonist Cam 2291 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
By mapping the distribution of cholecystokinin ( CCK ) receptor types onto an established phylogenetic hypothesis of vertebrate relationships , we tested two hypothesis about the evolution of CCK receptors : ( 1 ) A single CCK receptor type , CCK 10 , is the ancestral receptor , while CCK A and CCK B receptors represent derived receptor types ; ( 2 ) the evolution of two separate CCK receptors is functionally related to the evolution of endothermy . ^^^ Additional competitive inhibition studies showed that the mako CCK 10 receptor has very low affinities for the following nonpeptide agonist and antagonists : A 71623 , L 364 , 718 , A 57696 , A65186 . 72 , Cam 1481 , and SR 27897B ( specific for some mammalian CCK A receptors ) and L 365 , 260 and CI 988 ( specific for some mammalian CCK B receptors ) , confirming the pharmacological differences between the CCK 10 receptor and the CCK A and B receptors . ^^^ CCK A and CCK B , are not part of the suite of characters necessary for evolution of endothermy in fishes . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Interestingly , the dipeptide derivative CI 988 , which has been described as a selective CCK B antagonist , was found to have an antagonist / agonist binding ratio of 1 . 5 for the CCK A receptors in rat pancreas which was sufficiently high for this compound to behave as a full agonist in the amylase assay , although CI 988 did not exhibit agonist activity in the PI assay . ^^^ These results suggest that the effective receptor reserve in the amylase assay is greater than that required to stimulate PI turnover , and that the selective peptoid CCK B antagonist CI 988 has weak agonist activity at CCK A receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Consistent with previous reports , ( S ) configuration at the substituted phenethylamide center , a carboxylic acid and the presence of a phenyl ring were found to be associated with increased affinity at both CCK A and CCK B receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The preparation of the dehydropeptides ( 1 , R = Me ; 2 , R = H ) and the cyclopropylpeptides ( 3 , R = Me ; 4 , R = H ) possessing good binding affinities for the CCK A and CCK B receptors is described . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The overlapping distribution of opioid and cholecystokinin ( CCK ) peptides and their receptors ( mu and delta opioid receptors ; CCK A and CCK B receptors ) in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These two opposing effects were suppressed by the CCK B antagonist PD 134 , 308 , but not by the CCK A antagonist L 364 , 718 and were not prevented by tetrodotoxin , a Na ( + ) channel blocker . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
GW 7854 is a potent mixed CCK A agonist / CCK B antagonist which is orally active in two in vivo models of CCK A mediated agonist activity . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
New constrained cyclic pseudopeptide cholecystokinin B ( CCK B ) agonists have been designed on the basis of conformational characteristics of the potent and selective CCK B agonist Boc Trp ( NMe ) Nle Asp Phe NH 2 ( Ki = 0 . 8 nM , selectivity ratio CCK A / CCK B > 6000 ) ( Goudreau et al . ^^^ The affinities and selectivities of these compounds for CCK B and CCK A receptors have been determined in vitro by measuring the displacement of [ 3H ] pCCK 8 binding to guinea pig cortex and pancreas membranes , respectively . ^^^ The most potent compound , 8b , N ( cycloamido ) alpha Me ( R ) Trp [ ( 2S ) 2 amino 9 ( ( cycloamido ) carbonyl ) nonanoyl ] Asp Phe NH 2 , has a Ki value of 15 + / 1 nM for guinea pig cortex membranes with a good CCK B selectivity ratio ( CCK A / CCK B = 147 ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Gastrin and cholecystokinin ( CCK ) are gut brain peptides , with multiple functions in the gastrointestinal tract mediated through CCK B gastrin and CCK A receptors . ^^^ The aim of this study was to investigate the distribution and pharmacological characteristics of CCK A and CCK B receptors in the human upper gastrointestinal tract and compare them with those in the rat and dog . ^^^ CCK A receptors were also located in the muscularis propria of antrum , fundus , and gallbladder , whereas CCK B gastrin receptors were only detected in gastric fundic circular muscle . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The identified CCK A and CCK B receptors were specific and of high affinity in the subnanomolar range . ^^^ The rank order of potency of various CCK analogues was : sulfated CCK 8 = L 364 , 718 > > nonsulfated CCK 8 = L 365 , 260 > or = gastrin for CCK A receptors and sulfated CCK 8 > gastrin = nonsulfated CCK 8 > L 365 , 260 > L 364 , 718 for CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
A series of 2 aralkyl 4H pyridothiadiazine 1 , 1 dioxides and 3 aralkylamino 2 aryl 2H pyrido [ 4 , 3 e ] 1 , 2 , 4 thiadiazine 1 , 1 dioxides structurally related to quinazolinone CCK receptor antagonists were synthesized and evaluated as CCK A and CCK B receptor ligands . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
There are two CCK receptors ; both CCK A and CCK B receptors are stimulated by CCK 8 SE . ^^^ The relative importance of the CCK A and CCK B receptors in the somnogenic and hypothermic effects of CCK 8 SE is not well understood . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK induced depolarization was significantly reduced by a CCK A , but not a CCK B , receptor antagonist . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK A and CCK B antagonists , devazepide and L 365260 ( 100 micrograms / kg , i . p . ) , respectively , inhibited the postprandial colonic motor response while only L 365260 reduced the CCK induced stimulation . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These results indicate that CCK A type receptors rather than CCK B receptors may be involved in CCK induced insulin secretion in sheep . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Compounds such as 9d , e and 10d showed high affinity for this receptor ( IC 50 < 2 . 5 nM ) and very good selectivity over CCK A ( CCK A / CCK B > 2000 ) , even as the racemates . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In vitro , AR42J pancreatic acinar carcinoma cells treated with antisense ODN had lower levels of CCK A and CCK B subtype receptor binding than nonsense ODN treated cells . ^^^ In vivo , however , infusions of CCK A mRNA antisense ODN did not alter CCK B receptor binding levels . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Binding affinity for the CCK A vs CCK B receptor showed little dependence on the structure of the C 3 moiety but was affected by the nature of the second substituent at C 3 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
When tested by radioreceptor assay , a synthetic replicate of alligator gastrin 49 exhibited a gastrin like pattern of biological activity on mammalian CCK A and CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These behavioural effects , prevented by the prior i . p . administration of the CCK B antagonist L 365 , 260 but not by the CCK A antagonist L 364 , 718 , were shown to depend on dopaminergic systems , since they were blocked by D 1 ( SCH 23390 , 25 microg / kg i . p . ) or D 2 ( sulpiride , 50 or 100 mg / kg i . p . ) antagonists . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK ) is a 33 amino acid peptide with multiple functions in both the central nervous system ( via CCK B receptors ) and the periphery ( via CCK A receptors ) . ^^^ Compound 6 ( Hpa ( SO3H ) Nle Gly Trp Nle MeAsp Phe NH 2 ) , derived from moving the N methyl group from Phe to Asp , decreased CCK B affinity substantially without affecting CCK A affinity , giving a compound with 6600 fold selectivity for CCK A receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This SAR study led to the identification of tricyclo [ 3 . 3 . 1 . 1 ( 3 , 7 ) ] dec 2 yl [ 1S [ 1 alpha ( S * ) 2 beta ] [ 2 [ ( 2 hydroxycyclohexyl ) amino ] 1 ( 1H indol 3 ylmethyl ) 1 methyl 2 oxoethyl ] carbamate ( CI 1015 , 31 ) with binding affinities of 3 . 0 and 2900 nM for the CCK B and CCK A receptors , respectively . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
At birth lambs received an injection of the CCK A antagonist devazepide ( 0 . 01 or 0 . 1 mg / kg ) , the CCK B antagonist PD 135158 ( 0 . 01 or 0 . 1 mg / kg ) , or saline for the controls ( 1 ml / kg ) . ^^^ The use of a CCK A antagonist , but not a CCK B antagonist , was concluded to prevent the formation of a preferential relationship between the lamb and its mother , most probably by impairing neonatal learning . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
All the compounds were evaluated in vitro towards both CCK B and CCK A receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The compounds were selective for CCK B receptors as they did not bind with high affinity to CCK A receptors expressed in human tumors ( meningiomas or gastroenteropancreatic tumors ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Selective N methylation of a racemic precursor with [ 11C ] iodomethane and subsequent optical resolution of the racemate with HPLC afforded optically pure [ 11C ] L 365 , 260 and [ 11C ] L 365 , 346 , which are selective for CCK B ( central type ) receptors and CCK A ( peripheral type ) receptors , respectively . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
L 740 , 093 exhibited high affinity ( IC 50 0 . 49 nM ) and selectivity ( < 50 % displacement at CCK A sites at 1 microM ) for the human CCK B receptor subtype as estimated from [ 125I ] CCK 8S displacement studies with membranes prepared from hCCK B . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Among the compounds synthesized , 2 [ 3 [ 3 [ N [ 2 ( N methyl N phenylcarbamoylmethoxy ) phenyl ] N ( N meth yl N phenylcarbamoylmethyl ) carbamoylmethyl ] ureido ] phenyl ] acetic acid ( 20i , DA 3934 ) exhibited high affinity for gastrin / CCK B receptors and high selectivity over CCK A receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The present study sought to determine the roles of CCK A and CCK B receptor activation in the PAG in modulating defensive rage behavior . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Measurements were made of the release of cholecystokinin ( CCK ) stimulated by potassium chloride in the hypothalamus after ( a ) gamma irradiation ( 60Co ) , ( b ) treatment with the CCK A and CCK B antagonists L 364 , 718 and L 365 , 260 with and without radiation , ( c ) bilateral abdominal vagotomy , and ( d ) vagotomy with and without radiation and with and without L 364 , 718 . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The stimulation of CCK A or CCK B receptors is implicated in the physical and psychological responses of CCK to stress . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Two types of CCK receptors have been identified : ( 1 ) CCK A receptors are mainly located in the periphery , but are also found in some areas of the CNS ; and ( 2 ) CCK B receptors are widely distributed in the brain . ^^^ It is shown that anxiety like symptoms can only be induced by a selectively acting CCK B agonist , whereas mixed CCK A and B agonists and selective CCK A agonists fail to change behavior in anxiety tests . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Moreover , the affinity of the different compounds towards the cholecystokinin CCK A and CCK B receptors was evaluated . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We detected the expression of mRNA encoding CCK A and CCK B receptors in eight human pancreatic tumour cell lines using reverse transcription polymerase chain reaction ( RT PCR ) , but not by RNase protection assays . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We suggest that effects we have observed correlate with the activation of the CCK A receptors ( CCK 33 , CCK 8 ) or CCK B receptors ( CCK 4 ) . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We therefore investigated , by in situ hybridization , whether CCK A or CCK B receptor mRNA could be detected in normal rat pancreatic islets and in the rat insulinoma cell line , RINm5F . ^^^ The CCK A , but not the CCK B , receptor transcript was detected in both islets and RINm5F cells . ^^^ We conclude that the CCK A , but not the CCK B , receptor subtype is expressed in both normal rat islets and in the rat insulinoma derived cell line RINmS5F . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
High gastrin and cholecystokinin ( CCK ) gene expression in human neuronal , renal , and myogenic stem cell tumors : comparison with CCK A and CCK B receptor contents . ^^^ In addition , CCK A and CCK B receptors were evaluated in the same group of tumors with receptor autoradiography . ^^^ CCK A and CCK B receptors were not frequently found in these tumors , except for leiomyosarcomas . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Using autoradiography , high concentrations of CCK A receptors were detected in the duodenal mucosa , although in the pancreas only CCK B receptors were detected by this method . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
TS 941 had a fivefold lower selectivity than devazepide for pancreatic CCK ( CCK A ) over brain CCK ( CCK B ) receptors but fourfold greater than loxiglumide when IC 50 values for inhibition of [ 125I ] CCK 8 binding in isolated acini and cerebral cortex were compared . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK A , CCK B , neurotensin , somatostatin and VIP receptors were localized by in vitro receptor autoradiography with iodinated radioligands on histological sections of surgical samples of 27 gastric and 25 colonic adenocarcinomas . ^^^ CCK A , CCK B and neurotensin 1 receptors were found in a minority of both tumor types . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
High affinity CCK receptors are divided in two main subtypes : the CCK A ( A for ( A for `` alimentary ' ' ) and the CCK B ( B for `` brain ' ' ) receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK 8 interacts with nanomolar affinities with two different receptors designated CCK A and CCK B . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
This effect was probably due to their similar affinity for both CCK A and CCK B receptors . ^^^ Nonsulfated gastrin derivatives may be preferable because of their CCK B receptor selectivity , hence lower accretion in normal CCK A receptor expressing organs . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Moreover , the results also indicate that distension induced mechanisms involve GRP , 5 HT 3 and CCK A receptors , but not CCK B receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Nonsulfated gastrin derivatives may be preferable because of their CCK B receptor selectivity , and hence , lower accretion in normal CCK A receptor expressing organs . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
A blockade of the CCK A and CCK B receptors by their antagonists led to an increased , an unaffected , or a decreased cell number of the cell lines . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In the present study we investigated the presence of CCK A and CCK B , as well as somatostatin 2 ( SSTR 2 ) receptors by RT PCR , and studied the actions of EGF , CCK and octreotide on DNA synthesis in the human pancreatic adenocarcinoma cell line Capan 2 . ^^^ By means of RT PCR analysis we were able to demonstrate SSTR 2 expression , but not CCK A or CCK B receptor mRNA in Capan 2 cells . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK ) and gastrin exert their effects through two receptors , the CCK A and CCK B receptors . ^^^ Prenatal expression of both CCK A and CCK B receptors in various tissues was analyzed by RT PCR . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In conclusion , CCK 8 blocked ascending contraction elicited by electrical field stimulation of duodenal mucosa by means of simultaneous activation of CCK A and CCK B receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In vitro we found that 1 ) 55 / 70 gastric vagal afferents ( GVAs ) were polymodal , responding to CCK 8 and mechanical stimuli , 13 were mechanoreceptive , and 2 were CCK responsive ; 2 ) sequential or randomized intra arterial injections of CCK 8 ( 0 . 1 200 pmol ) dose dependently increased firing rate and reached the peak rate at 100 pmol ; 3 ) the action was suppressed by CCK A ( Devazepide ) but not by CCK B ( L 365 , 260 ) receptor antagonist ; 4 ) neither antagonist blocked the mechanosensitivity of GVA fibers . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK A antagonist SR 27897B ( 1 mg kg ( 1 ) , i . p . ) reversed the delay induced by 10 mM cefaclor , whereas the CCK B antagonist CI 988 ( 1 mg kg ( 1 ) , i . p . ) had no significant effect . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
At least two different G coupled high affinity receptors have been identified : the CCK A and the CCK B receptors . ^^^ This article reviews the main biological role of CCK , the therapeutic potential of CCK A and CCK B receptor agonists and antagonists and the common compounds from the different families of ligands . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Pancreatic secretory response to feeding in the calf : CCK A receptors , but not CCK B / gastrin receptors are involved . ^^^ The present study was aimed at determining both the role of external stimuli in the outset of the prefeeding phase and the implication of pancreatic CCK A and CCK B / gastrin receptors in the mediation of pancreatic response to feeding . ^^^ The first objective was studied by suppressing external stimuli associated with food intake ( unexpected meal ) and the second by infusing highly specific and potent antagonists of CCK A ( SR 27897 ) and CCK B / gastrin ( PD 135158 ) receptors during the prandial period . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In the present study we investigated the influence of WGA and UEA 1 on CCK 8 induced alpha amylase secretion of the rat pancreatic tumor cell line AR42J , which expresses both CCK A and CCK B receptors . ^^^ The simultaneous application of the lectins with CCK antagonists L 364 , 718 or L 365 , 260 led to a reduction of secretion , but the assignment to CCK A or CCK B receptors was not possible . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Moreover , the cells responded to CCK agonists after adenoviral mediated gene transfer of CCK A or CCK B receptors . ^^^ Quantitative RT PCR indicated that the message levels for CCK A receptors were approximately 30 fold lower than those of CCK B receptors , which were approximately 10 fold lower than those of m 3 Ach receptors . ^^^ In situ hybridization indicated the presence of m 3 Ach receptor and insulin mRNA but not CCK A or CCK B receptor mRNAs in adult human pancreas . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Cellular expression of CCK A and CCK B / gastrin receptors in human gastric mucosa . ^^^ Expression of CCK receptor subtypes was detected in individual cells of the gastric mucosa by reverse transcription ( RT ) PCR in situ , immunohistochemistry and confocal laser scanning microscopy , using antisera against the CCK A or CCK B / gastrin receptor subtype . ^^^ Both CCK A and CCK B receptors were detected in antral and oxyntic mucosa at the mRNA and protein level . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Those present in peripheral system have been termed as CCK A receptors and those present in central nervous system as CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The CCK receptors can be pharmacologically subdivided into two subtypes : CCK A and CCK B . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The amount of mRNA expression of CCK A and CCK B receptors was determined by reverse transcription polymerase chain reaction . ^^^ The results show that CCK A receptors are significantly more expressed in non responders than responders , whereas CCK B receptor expression is similar in both groups . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Neither CCK A nor CCK B receptor mediates amylase release from human pancreatic acini in vitro . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We previously reported genetic variations in the promoter and coding regions of the CCKA receptor ( CCKAR ) , CCKBR , and CCK genes and a possible association between polymorphisms of the CCKAR gene and alcoholism . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Binding of CCK 8 and CCK 58 to CCK A and CCK B receptors and stability to enzymatic digestion were used as independent probes for tertiary structure of the C terminus . ^^^ The effect of tertiary structure on receptor binding at CCK A receptors and CCK B receptors was evaluated using membrane preparations from mouse pancreas and brain . ^^^ RESULTS : CCK 58 was three times more potent than CCK 8 for binding mouse pancreatic membrane CCK A receptors and equipotent to CCK 8 for binding mouse brain CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Most research on the antipsychotic like drug effects of CCK has used CCK or CCK analogues that nonselectively activate both CCK A and CCK B ( CCK 2 ) receptors , which may produce opposite effects . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
No difference was observed in the increase of food intake induced by CCK A and CCK B receptor antagonists in both control and post infected rats . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK peptides exert their action on two distinct receptor subtypes : CCK A ( Alimentary ) now called the CCK1R , mostly expressed peripherally ; and CCK B ( Brain ) , renamed the CCK2R , which is primarily present in the brain . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Evidence on the role of CCK in anxiety related and reward related behaviours in various animal models indicates that CCK B receptors in the basolateral amygdala are important mediators of anxiety related behaviours and that CCK A and CCK B receptors in the nucleus accumbens are important in mediating different aspects of reward related behaviour . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
CCK mediates its effects through interaction with specific receptors subdivided in two subtypes CCK A ( present in the periphery and in few selected brain nuclei ) and CCK B ( the predominant receptor subtype in the brain ) . ^^^ Data showing that CCK A receptors mediate mnemonic while CCK B receptors mediate amnestic effects are also presented . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Our data clearly identified CCK A and CCK B receptor mRNAs in the rat retina and demonstrated that they are functional , stimulating tyrosine phosphorylation pathways . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
A binding assay was used with 125I CCK 8s and dexamethasone stimulated AR42J cells , bearing CCK A as well as CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The possible role of CCK ergic mediation in endotoxin ( LPS ) fever has revealed that while CCK B receptors seem to be involved in the development of fever , the role of CCK A receptors could be more complex . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
To examine the mechanism of this enhanced suppression , we measured the mRNA levels of CCK , CCK A and CCK B receptors in the cerebral cortex and the hypothalamus of young and old male rats . ^^^ The mRNA level of CCK A receptors in the hypothalamus decreased with age , whereas the mRNA levels of CCK B receptors in the hypothalamus and cerebral cortex did not . ^^^ Moreover , the effects of aging on the gene expressions of CCK A and CCK B receptors were different . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Experiments were performed under control conditions , and after pretreatment by gavage feeding with YF 476 , using either a single , low dose of 0 . 3 micromol kg , which would block the CCK B receptors , or a 1000 times higher dose ( 300 micromol kg ) , which would also block the CCK A receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
These novel CCK ligands have shown to act as mixed CCK A / CCK B ligands in a [ 125 ] 1 CCK 8 receptor binding assay . ^^^ The best pyrazoline 5e of this series displayed an IC 50 of 20 and 25 nmol / L for the CCK A , and CCK B receptor , respectively . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Selective CCK A but not CCK B receptor antagonists inhibit HT 29 cell proliferation : synergism with pharmacological levels of melatonin . ^^^ We used HT 29 human colon cancer cells , expressing CCK receptors , to test the antiproliferative effects of several antagonists of CCK A and / or CCK B and their possible synergism with melatonin . ^^^ The following drugs were tested : gastrin ( CCK B agonist ) ; CCK 8s ( CCK A agonist ) ; proglumide ( CCK A plus CCK B antagonist ) ; lorglumide ( CCK A antagonist ) ; PD 135 , 158 ( CCK B antagonist and weak CCK A agonist ) ; devazepide or L 364 , 718 ( CCK A antagonist ) ; L 365 , 260 ( CCK B antagonist ) , and melatonin . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK ) interacts with two types of G protein coupled receptors in the brain : CCK A and CCK B receptors . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
We recently cloned and functionally expressed both the CCKAR and the CCKBR from rat , guinea pig , and human . ^^^ The CCKAR and CCKBR are 48 % homologous and constitute a family of receptors within the guanine nucleotide binding regulatory protein coupled superfamily of receptors . ^^^ Genomic and cDNA library hybridization as well as Northern and Southern hybridization studies among rat , guinea pig , and human species identifies only two members of the CCK receptor family , CCKAR and CCKBR . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The two known receptors mediating the actions of cholecystokinin ( CCK ) and gastrin , CCK type A ( CCKAR ) and CCK type B ( CCKBR ) receptors , are G protein coupled receptors having approximately 50 % amino acid homology . ^^^ Both the CCKAR and CCKBR have high affinity for sulfated CCK peptides , while only the CCKBR has high affinity for gastrin peptides . ^^^ To determine the structural basis for the selectivity of the CCKBR for gastrin , we first constructed a series of CCKB / AR chimeras in which restriction endonuclease defined segments of the CCKBR were replaced with the corresponding segments of the CCKAR . ^^^ This segment could account for 100 of the expected 300 fold lower affinity of gastrin 17 1 observed for the control CCKAR compared to the control CCKBR . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The cholecystokinin ( CCK ) receptor types A and B ( CCKAR and CCKBR ) are G protein coupled receptors with approximately 50 % amino acid identity ; both have high affinity for the sulfated CCK octapeptide ( CCK 8 ) , whereas only the CCKBR has high affinity for gastrin . ^^^ Alanine substitution of the equivalent amino acids in the CCKAR corresponding to each of the five amino acids in ECL 1 and ECL 2 affecting CCK 8 affinity for the CCKBR revealed only two mutations , L103A and F107A , that decreased CCK 8 affinity ( 68 and 2885 fold , respectively ) . ^^^ These data suggest that CCK 8 interacts at multiple contact points in the extracellular domains of CCK receptors and that the CCKAR and CCKBR have distinct binding sites despite their shared high affinity for CCK 8 . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
The responses were not influenced by the pretreatment with L 365 , 260 , a type B CCK receptor ( CCKBR ) antagonist , while they were significantly diminished by pretreatment with MK 329 , a CCKAR antagonist . ^^^ These results demonstrate that neither CCKAR nor CCKBR contributes to the response of the afferent activity of the gastric vagal nerve to a systemic administration of CCK in OLETF rats , suggesting an involvement of novel ( non A , non B ) CCK receptors . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Polymorphisms of the CCK , CCKAR and CCKBR genes : an association with alcoholism study . ^^^ We analyzed genetic variations in the promoter and coding regions of the CCK , CCKA receptor ( CCKAR ) and CCKB receptor ( CCKBR ) genes , and performed association analyses with alcoholism . ^^^ RESULTS : A total of 8 variants in the CCK gene , 11 variants in the CCKAR gene and 9 variants in the CCKBR gene were detected in the present study . ^^^ CONCLUSIONS : Our data suggest that polymorphisms of the CCK , CCKAR and CCKBR genes do not play a major role in alcohol withdrawal symptoms ( even though significant associations were found among polymorphisms at the 388 and 333 loci of the CCKAR gene and hallucinations , the rate was nonsignificant after Bonferroni correction ) . . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
Genomic DNA was analyzed for CCK , CCKAR , and CCKBR ( cholecystokinin B receptor ) polymorphisms by polymerase chain reaction . ^^^ Cases and controls did not differ in CCKAR or CCKBR polymorphisms . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.0
In rat , gastrin and its CCKBR seem responsible for foetal pancreas growth while after birth , CCK was shown to be the most potent trophic factor via occupation of its CCKAR . ^^^ In rodent ' s pancreas , the CCKAR were observed on acinar cells as well as on islet ' s alpha and beta cells ; in six other species , the CCKAR were present only on alpha and beta cells with the CCKBR always present on delta cells . ^^^
Interacting proteins: P32238 and P32239	Pubmed	SVM Score :0.97873388
Further to these , ( 1S trans ) N [ alpha methyl N [ [ ( 2 methylcyclohexyl ) oxy ] carbonyl ] D tryptophyl ] L 3 ( phenylmethyl ) beta alanine ( 28h ) is a mixed CCK A / CCK B ligand with a CCK A binding affinity of IC 50 = 3 . 9 nM and a CCK B binding affinity of IC 50 = 4 . 2 , producing a CCK A / CCK B ratio of unity . 0.97873388^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.97873388
Further to these , ( 1S trans ) N [ alpha methyl N [ [ ( 2 methylcyclohexyl ) oxy ] carbonyl ] D tryptophyl ] L 3 ( phenylmethyl ) beta alanine ( 28h ) is a mixed CCK A / CCK B ligand with a CCK A binding affinity of IC 50 = 3 . 9 nM and a CCK B binding affinity of IC 50 = 4 . 2 , producing a CCK A / CCK B ratio of unity . 0.97873388^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Many lines of evidence indicate that cholecystokinin ( CCK ) and its receptors , named CCK 1 R and CCK 2 R , are expressed in the hypothalamo pituitary adrenal ( HPA ) axis , the function of which they acutely stimulate . ^^^ Semiquantitative reverse transcription polymerase chain reaction showed that CCK treatment lowered the expression of CCK 1 R and CCK 2 R mRNAs in the pituitary , but not adrenal gland . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cholecystokinin , or CCK , is a 33 amino acid peptide , originally considered a gut hormone , that acts via two subtypes of receptors , named CCK 1 R and CCK 2 R . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Although the wide distribution , myriad number of functions , and reported pharmacological heterogeneity of CCK receptors would suggest a large number of receptor subtypes , the application of modern molecular biological techniques has identified two CCK receptors , CCK A receptor ( CCK AR ) and CCK B receptor ( CCK BR ) , that mediate the actions of CCK and gastrin ; gastrin receptors have been found to be identical to CCK BR . ^^^ CCK AR , found predominantly in the GI system and select areas of the CNS , have high affinity for CCK and the nonpeptide antagonist L 364 , 718 , whereas CCK BR , found predominantly in the CNS and select areas of the GI system , have high affinity for CCK and gastrin and the nonpeptide antagonist L 365 , 260 . ^^^ Both CCK AR and CCK BR are highly conserved between species , although there is some tissue specific variation in expression . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK XLR shares approximately 50 % homology at the amino acid level with both the human CCK BR and the peripheral CCK A receptor subtypes . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To determine the structural basis of CCK A receptor ( CCK AR ) functionally coupled to Gs , a series of chimeric mutants were constructed by replacing exons of human CCK B receptor ( CCK BR ) , from the second to the fifth ( last ) exon , with human CCK AR counterparts . ^^^ However , only the wild type CCK AR and chimeric mutants containing the second exon of CCK AR were able to mediate significantly greater increases in intracellular cAMP content and adenylyl cyclase activity compared with wild type CCK BR . ^^^ A CCK BR mutant was further constructed by replacing five amino acids , Gly Leu Ser Arg ( Arg ) Leu , in the first intracellular loop with the corresponding five CCK AR specific amino acids , Ile Arg Asn Lys ( Arg ) Met . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Thus far , two CCK receptors have been molecularly identified to mediate the actions of CCK and gastrin , CCK A and CCK B receptors ( CCK AR and CCK BR , respectively ) . ^^^ The regulation of CCK AR and CCK BR affinity by guanine nucleotides and the receptor activation of G protein dependent stimulation of phospholipase C and adenylyl cyclase suggested that they were guanine nucleotide binding protein coupled receptors [ G protein coupled receptors ( GPCRs ) ] ; however , the eventual cloning of their cDNAs revealed their heptahelical structure and confirmed their membership in the GPCR superfamily . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Single or double substitutions of the four nonconserved amino acids in the first intracellular loop of the CCK BR were made with their CCK AR counterparts to determine which residues are critical in Gs coupling . ^^^ Single substitution of Ser 82 to Asn , produced maximal cAMP responses comparable with the chimeric CCK BR containing the entire first intracellular loop of the CCK AR . ^^^ Finally , CCK AR reverse mutants were studied to compare them with their corresponding CCK BR mutants that showed increased cAMP responses . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We report here a study of polymorphisms in the CCK pre pro hormone gene ( CCK ) , CCK AR , and CCK BR in DSM 4 panic patients ( n = 99 ) vs controls matched for gender and ethnicity . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Daily energy intake and expenditure were significantly greater in CCK BR ( / ) and CCK AR ( / ) BR ( / ) mice than CCK AR ( / ) and wild type [ CCK AR ( + / + ) BR ( + / + ) ] mice . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We examined the anxiety related behavior of CCK AR , CCK BR , and CCK ARBR gene knockout ( / ) mice in the elevated plus maze . ^^^ CCK AR ( / ) mice showed a significantly higher frequency of open arm entries than wild type and CCK BR ( / ) mice , whereas the percentage open arm entry values in CCK AR ( / ) mice did not differ from those in wild type mice . ^^^ By contrast , CCK BR ( / ) mice showed significantly lower percentage open arm entry values and spent significantly less time in the open arms than wild type and CCK AR ( / ) mice . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
METHODS : CCK AR and CCK BR mRNA expression and cellular distribution in the rat lung were detected by highly sensitive method of in situ reverse transcription polymerase chain reaction ( RT PCR ) and conventional in situ hybridization . ^^^ RESULTS : CCK AR and CCK BR gene positive signals were observed in bronchial epithelial cells , alveolar epithelial cells , pulmonary macrophages and vascular endothelial cells of the rats ' lung by in situ RT PCR . ^^^ By in situ hybridization , however , only the signals of CCK BR but not CCK AR were detected in the lung , and the positive staining was only found in vascular endothelial cells and macrophages . ^^^ CONCLUSION : CCK AR and CCK BR gene were present in pulmonary vascular endothelial cells , macrophages , bronchial epithelial cells and alveolar epithelial cells , which play an important role in mediating the regulatory actions of CCK 8 on these cells . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The expression of cholecystokinin A receptor ( CCK AR ) and cholecystokinin B receptor ( CCK BR ) mRNA of myocardium in ES rats was examined by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ Gene expression of CCK AR and CCK BR significantly increased in myocardium of ES rats . ^^^ Similar to CCK AR mRNA , the expression of CCK BR mRNA peaked at 2 h and kept a high level at 6 h , but it did not change at the first 0 . 5 h and was stable at a high level at 12 h . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These results suggest that endogenous CCK could play a critical role in mood modulation through CCK A / CCK B receptor stimulation . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Pharmacological experiments using selective CCK A and CCK B receptor antagonists demonstrate that CCK B is the prominent CCK receptor subtype in trigeminal and dorsal root ganglia neurons in the rat , rabbit , and monkey . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Analysis of the ability of gastrin 17 1 to inhibit 125I gastrin 1 binding demonstrated that gastrin bound to a single class of receptors with a Kd of 0 . 21 + / 0 . 04 nM and a binding capacity of 184 + / 29 fmol / mg protein . 125I Gastrin 1 binding was inhibited by the specific CCK B receptor antagonist L 365 , 260 approximately 40 times more effectively than by the specific CCK A receptor antagonist L 364 , 718 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To confirm the role of CCK AR in the regulation of body temperature , the values of T ( c ) in the CCK AR ( / ) mice were compared with those in CCK B receptor ( CCK BR ) ( / ) , CCK AR ( / ) BR ( / ) , and wild type mice . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
RESULTS : CCK A receptor ( CCK AR ) and CCK B receptor ( CCK BR ) mRNA were detected in rat PIMs and their RT PCR amplified products had a size of approximately 1 . 37 kb and 480 bp , respectively . ^^^ The relative expression of CCK BR mRNA was higher than that of CCK AR mRNA after incubation with LPS for 0 . 5 , 2 , and 6 h . ^^^ Southern blot analysis of RT PCR amplified CCK AR and CCK BR mRNA products using [ gamma 32P ] ATP 5 ' end labelled probe showed specific hybridization bands . ^^^ The specific binding of [ 3H ] CCK 8S to rat PIM membranes was inhibited by unlabelled CCK 8S ( IC 50 = 2 . 3 + / 0 . 8 nmol / L ) , CCK AR specific antagonist CR 1409 ( IC 50 = 0 . 19 + / 0 . 06 micromol / L ) and CCK BR specific antagonist CR 2945 ( IC 50 = 3 . 2 + / 0 . 1 nmol / L ) . ^^^ CONCLUSION : Two types of functional CCK AR and CCK BR existed in rat PIMs and their expression could be upregulated by LPS . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Since the precise mechanism underlying this association has not been elucidated , the role of CCK AR in ethanol ingestion was examined using CCK AR gene deficient ( / ) mice and compared with those of CCK BR ( / ) and wild type mice . ^^^ RESULTS : CCK AR ( / ) mice consumed more ethanol than CCK BR ( / ) and wild type mice , and showed no aversion to high concentrations of ethanol solution . ^^^ D2R expression in the nucleus accumbens was significantly lower in the CCK BR ( / ) mice and was significantly higher in CCK AR ( / ) mice than in wild type mice . ^^^ CONCLUSIONS : Voluntary ingestion of ethanol differed between CCK AR ( / ) and CCK BR ( / ) mice . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Subcutaneously administered selective CCK A receptor antagonist , L 364 , 718 ( 1 mg / kg ) , reversed the inhibitory effect of centrally as well as peripherally administered CCK 8 , but the selective CCK B receptor antagonist , L 365 , 260 ( 1 mg / kg ) , did not . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We studied the behavioral effects of a novel cholecystokinin tetrapeptide ( CCK 4 ) analogue , A 71623 , with full agonist activity and high affinity and selectivity for the CCK A receptor subtype relative to the CCK B receptor . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In contrast , the IC 50 for inhibition of cell growth with two benzodiazepine derived antagonists , the CCK B receptor antagonist L 365 , 260 ( 4 . 6 10 10 ( 5 ) M ) and the CCK A receptor antagonist devazepide ( 1 . 7 10 10 ( 5 ) M ) were two three orders of magnitude greater than those required to inhibit gastrin binding ( 10 ( 8 ) 10 ( 7 ) M ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Two selective CCK A and CCK B receptor antagonists , L 364 , 718 and L 365 , 260 , respectively , were used to probe further the receptors involved in ileal contraction to this peptide family . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A and CCK B receptor antagonists , devazepide and L 365 , 260 , enhance morphine antinociception only in non acclimated rats exposed to a novel environment . ^^^ Devazepide , a potent CCK A receptor antagonist , and L 365 , 260 , a selective CCK B receptor antagonist , have been introduced as pharmacologic tools for differentiating the physiologic roles of CCK A and CCK B receptor subtypes . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Unexpectedly , the CCK B receptor antagonist , L 365 , 260 , enhanced the response to CCK 8 , an effect diametrically opposite to that produced by CCK A antagonists . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Although these results stress the relative importance of the CCK A receptor in the effects of exogenous CCK 8 administration on feeding , stimulation of the CCK B receptor may still be involved in the control of feeding following the endogenous release of CCK . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Compound 9 possesses a selectivity of greater than 500 fold for the pancreatic CCK A receptor over the CCK B receptor . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The receptor binding activities of these synthetic analogs of CCK 7 and their selectivity for the CCK A and CCK B receptor subtypes were determined using solubilized membrane preparations from rat pancreatic tissue and bovine striatum . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The effects of systemic treatment with the CCK B receptor antagonist L 365 , 260 , its 3S ( ) enantiomer and the CCK A receptor antagonist devazepide were assessed in the plus maze procedure in mice . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This increase in sensitivity to quinpirole was blocked by pretreatment with the nonselective CCK receptor antagonist proglumide and the preferential CCK A receptor antagonist CR 1409 but not by the preferential CCK B receptor antagonist L 365 , 260 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A receptor antagonist devazepide but not the CCK B receptor antagonist L 365 , 260 reverses the effects of chronic clozapine and haloperidol on midbrain dopamine neurons . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We examined the ability of selective CCK A and CCK B receptor antagonists to induce or modulate the locomotor stimulant effects of dopamine agonists in MPTP treated squirrel monkeys . ^^^ Administration of 1 100 micrograms / kg i . p . of either the selective CCK A receptor antagonist devazepide ( MK 329 ) or the CCK B receptor antagonist L 365 , 260 alone failed to stimulate a locomotor response in parkinsonian monkeys . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The selective CCK B receptor antagonists CI 988 ( PD 134308 ) and L 365 , 260 produced anxiolytic like effects , whereas MK 329 , a CCK A receptor antagonist , was respectively less potent by factors of 313 and 200 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
L 364 , 718 , an antagonist selective for the CCK A receptor , blocked completely the action of centrally administered CCK , whereas L 365 , 260 , a selective CCK B receptor antagonist , had no effect on the ability of centrally administered CCK to inhibit feeding . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
According to `` in vitro ' ' binding studies and functional test , nearly all the compounds behaves as CCK antagonists ; moreover some compounds are able to interact differentially with CCK A and CCK B receptor subtype . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The inhibitory effect of 10 micrograms / kg ( s . c . ) CCK 8S was prevented by loxiglumide , a mixed type of CCK A and B receptor antagonist , at 1 mg / kg ( intraperitoneal ) and 40 micrograms / rat ( intracerebroventricular , i . c . v . ) ; L 364 , 718 , a CCK A receptor antagonist , at 125 and 250 ng / rat ( i . c . v . ) ; and L 365 , 260 , a CCK B receptor antagonist at 250 ng / rat ( i . c . v . ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Hybrid analogs of the cholecystokinin A ( CCK A ) receptor selective tetrapeptide agonist Boc Trp Lys ( Tac ) Asp MePhe NH 2 ( 1 , A 71623 ) and the CCK B receptor selective antagonists PD 135118 ( 2 ) and CI 988 ( 3 ) were prepared . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Possible mRNA expression of CCK A and CCK B receptor subtypes by gastrin responsive rodent intestinal and fibroblast cell lines ( Swiss 3T3 , IEC 6 , CA ) was measured by the methods of Northern blot analysis and reverse transcriptase polymerase chain reaction . mRNA from rat pancreas , AR42J cells , and rat antrum served as positive controls . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This effect of CCK 8 could be reversed by devazepide , a CCK A receptor antagonist , at 50 ng and 200 ng and by L 365 , 260 , a CCK B receptor antagonist , at 5 ng administered bilaterally to the nucleus accumbens . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK 8s and A 71623 , a selective CCK A receptor agonist , ( 10 , 25 and 50 ng / kg ) infused bilaterally into the CA , 30 min before ES , significantly reduced this stimulatory effect , while CCK 4 and A 63387 , a selective CCK B receptor agonist ( 10 , 25 and 50 ng / kg ) , had no effect on such a response . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
RESULTS : Exogenous CCK significantly reduced food intake in gastrectomized rats ; this was blocked by administration of a CCK A but not a CCK B receptor antagonist . ^^^ Chronic treatment with a CCK A or CCK B receptor antagonist after total gastrectomy in rats significantly increased postoperative food intake and body weight . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The fact that devazepide is 1000 times more potent as a CCK A receptor antagonist than L 365 , 260 , whereas the two compounds are nearly equipotent at the CCK B receptor subtype , suggests that CCK B rather than CCK A receptors are involved in these effects . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The affinity of YM 022 for gastrin / CCK B receptor was more than 2 orders of magnitude higher than that for rat pancreatic CCK A receptor and various other receptors , such as benzodiazepine . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Microiontophoretic administration of sulfated CCK octapeptide ( CCK 8S , agonist for CCK A and CCK B receptors ) and the selective CCK B receptor agonists , CCK 4 and unsulfated CCK 8 , inhibited the firing rates of a subpopulation of SNr neurons . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This effect of CCK 8 could be reversed by Devazepide , a CCK A receptor antagonist dose dependently at 50 ng and 200 ng , and by L 365 , 260 , a CCK B receptor antagonist at 5 ng and 8 ng administered to the same site . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The antinociceptive activity of SNF 9007 was not a result of the activation of CCK receptors , as treatment with either CCK A or CCK B receptor antagonist was ineffective in blocking SNF 9007 antinociception . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
FPL 14294 [ 4 ( sulfoxy ) phenylacetyl ( MePhe 6 ) CCK 6 ] is a CCK analog with enhanced metabolic stability that was comparable to CCK 8 in potency to contract isolated gallbladder and in affinity at the CCK A and CCK B receptor . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The selective CCK A receptor antagonist MK 329 reversed the inhibitory effect of the centrally as well as peripherally administered CCK 8 , or of Suc ( Thr 28 , Leu 29 , MePhe 33 ) CCK 7 , whereas the selective CCK B receptor antagonist L 365260 did not . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The results showed that ( 1 ) The antagonistic effect of CCK 8 on opioid induced hypotension could be blocked by intrathecal ( 1 . t . ) administration of CCK B antagonist L 365 , 260 at nanogram doses , or by CCK A antagonist devazepide at doses 20 40 times higher than L 365 , 260 , indicating that it was the CCK B receptor which mediates the antiopioid effect . ( 2 ) The depressor effect induced by intrathecal muscimol , a GABA agonist , was blocked neither by naloxone nor by CCK 8 , supporting the notion that CCK 8 is an endogenous opioid antagonist rather than a universal anti hypotension agent . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Since cDNA of both the CCK A receptor ( classical pancreatic CCK receptor ) coding region and the CCK B receptor coding region have recently been cloned and sequenced , we investigated the expression of messenger RNA of these receptors in DSL 6 pancreatic carcinoma . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Derived by reasoned modification of the CCK A selective 3 carboxamido 1 , 4 benzodiazepine , MK 329 , this paper chronicles the development of potent , orally effective compounds in which selectivity for the CCK B receptor subtype was achieved . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In addition , in ARIP cells , the CCK 8 induced increase in cytosolic calcium was abolished by pretreatment with the selective CCK B receptor antagonist L 365 , 260 but not by the CCK A receptor antagonist L 364 , 718 . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Growth of PANC 1 cells in culture was stimulated by CCK at a concentration consistent with the Kd , and CCK stimulated growth was inhibited by the CCK B receptor antagonist ( L 365 , 260 ) not the CCK A receptor antagonist ( L 364 , 718 ) . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Neither the CCK A receptor antagonist L 364 , 718 nor the CCK B receptor antagonist L 365 , 260 ( 10 ( 9 ) 10 ( 7 ) moles / kg ) antagonized CCK 8 actions . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Pharmacological analysis using selective agonists and antagonists indicated the expression of the CCK A receptor at birth , whereas the CCK B receptor predominated at postnatal stages . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The activity of SR 27897 , a potent and selective CCK A vs CCK B receptor antagonist ( Ki = 0 . 2 nM on guinea pig pancreas vs 2000 nM on rat brain ) was studied on behavioural , electrophysiological and biochemical effects induced by peripheral or central injection of CCK 8S . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The receptor subtype mediating this action of CCK was investigated with selective CCK A and CCK B receptor agonists and antagonists . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Proglumide ( 1 and 10 mg / kg SC ) and devazepide , ( a selective CCK A receptor antagonist ; 0 . 01 and 1 mg / kg SC ) , as well as caerulein ( 0 . 01 , 0 . 1 and 1 microgram / kg SC ) and CCK 4 ( a selective CCK B receptor agonist ; 25 and 50 micrograms / kg SC ) had no reliable effect . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Furthermore , 10 micrograms / kg of L 365 , 260 , a CCK B receptor antagonist , and 1 mg / kg of devazepide , a CCK A receptor antagonist , even tended to augment the effect of NMDA in the plus maze . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Administration of both CCK A and CCK B receptor antagonists alone resulted in no change in meal size . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In vitro binding studies showed that some derivatives exhibited potent affinity for gastrin CCK B receptor and high selectivity over peripheral CCK ( CCK A ) receptor . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To gain a better understanding of the roles of CCK A and CCK B receptors in spinal nociceptive transmission during inflammation , this study evaluated the effects of intrathecally administered FK 480 ( a CCK A receptor antagonist ) and YM 022 ( a CCK B receptor antagonist ) . ^^^ These data indicate that a CCK B receptor antagonist , but not a CCK A receptor antagonist , produces an antinociceptive effect in the rat formalin test . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Both CCK A and CCK B receptor subtypes were visualized in the nucleus of the solitary tract and the area postrema of normal rats , but levels of binding to both of these subtypes were unaffected by the experimental treatments . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We have examined the occurrence of CCK A and CCK B receptor mRNA in the brain , digestive tract , pancreas , and kidney of the rat and man by Northern blot and reverse transcribed polymerase chain reaction ( RT PCR ) . ^^^ Northern blot and a PCR technique based on Taq polymerase antibody interaction and using CCK A and CCK B receptor specific primers , followed by Southern blot analysis , were the methods used . ^^^ In man , CCK A receptor mRNA was detected in the brain , stomach , pancreas , and kidney , whereas CCK B receptor mRNA was found in the brain , stomach , and pancreas but not in the kidney . ^^^ Cloning and DNA sequence analysis of the PCR amplified rat and human CCK A and CCK B receptor DNA fragments , which cover the protein encoding regions of the intracellular loop C 3 , showed complete sequence homology as compared with published rat and human sequences . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These compounds displayed micromolar affinities for CCK B rather than CCK A receptor and the obtained results confirm that the 4 ( 3H ) quinazolinone nucleous represent a useful template for the development of selective CCK B receptor ligands . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These compounds displayed micromolar affinities for CCK A rather than CCK B receptor and the results have been discussed on the basis of a molecular modelling study . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
RNA were extracted for CCK A and CCK B receptor expression using specific cRNA probes . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We examined whether the CCK A and CCK B receptor genes are expressed in the islets and the role of CCK A receptor in insulin secretion . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These findings may suggest a greater role for CCK and CCK A receptor than for gastrin and CCK B receptor in gastric cancers . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The binding of labeled CCK 8 was markedly inhibited by CCK 8 and CCK A receptor antagonists , but it was only weakly affected by gastrin and CCK B receptor antagonists . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The antagonist ( 1 microM ) for CCK B receptor , but not CCK A receptor , significantly inhibited the number of GH 3 cells . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Binding of 125I BH CCK 8 to the pancreas was inhibited by agonists with the affinities ( dissociation constant ) of CCK ( 0 . 11 nmol / L ) approximately gastrin ( 0 . 15 nmol / L ) and by antagonists with the affinities of CCK B receptor antagonist ( L 365 , 260 , 0 . 18 nmol / L ) > CCK A receptor antagonist ( lorglumide , 8 . 1 nmol / L ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The affinity of YF 476 for rat brain gastrin / CCK B receptor was 4100 fold higher than that for rat pancreatic CCK A receptor . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In contrast to Boc CCK 4 , which is 70 fold selective for the CCK B receptor , the modified lysine bearing tetrapeptides were highly potent and selective full agonists at the CCK A receptor . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The aim of the present study was to study the expression of CCK A and CCK B receptor mRNA after porta caval shunting . ^^^ Total RNA was isolated from pancreas and oxyntic mucosa for Northern blot analysis of CCK A and CCK B receptor mRNA . ^^^ Porta caval shunted rats displayed an increased CCK A receptor mRNA concentration in the pancreas ( after stimulation with CCK 8s ) and an increased CCK B receptor mRNA concentration in the oxyntic mucosa . ^^^ In conclusion , the porta caval shunting evoked enhancement of the trophic effect of CCK A receptor activation on the pancreas and of CCK B receptor activation on the ECL cells is associated with enhanced expression of CCK A receptor mRNA in the pancreas and of CCK B receptor mRNA in the oxyntic mucosa . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cholecystokinin induced antinociception is not blocked by CCK A or CCK B receptor antagonists . ^^^ The agonists used were CCK ( 1 30 nmol i . c . v . ) , a CCK A receptor agonist ( SNF 9019 ; 0 . 3 10 nmol i . c . v . ) , and a CCK B receptor agonist ( SNF 9007 ; 0 . 3 10 nmol i . c . v . ) . ^^^ The antagonists used were the CCK A receptor antagonist , L 364 , 718 ( 12 . 5 nmol i . c . v . ) , CCK B receptor antagonist , L 365 , 260 ( 2 . 5 25 nmol i . c . v . ) , and the nonselective opioid receptor antagonist naloxone ( 1 mg / kg s . c . ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
A series of 2 aralkyl 4H pyridothiadiazine 1 , 1 dioxides and 3 aralkylamino 2 aryl 2H pyrido [ 4 , 3 e ] 1 , 2 , 4 thiadiazine 1 , 1 dioxides structurally related to quinazolinone CCK receptor antagonists were synthesized and evaluated as CCK A and CCK B receptor ligands . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To investigate the role of the carboxyl terminus of cholecystokinin ( CCK ) receptors in receptor internalization , the rat wild type ( WT ) CCK A receptor ( WT CCKAR ) and the rat WT CCK B receptor ( WT CCKBR ) were truncated after amino acid residue 399 ( CCKAR Tr 399 ) and 408 ( CCKBR Tr 408 ) , thereby deleting the carboxyl terminal 45 and 44 residues , respectively . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A receptor agonists A 71378 ( desamino Tyr ( SO3H ) Nle Gly Trp Nle ( N methyl ) Asp Phe NH 2 ) , and A 71623 ( Boc Trp Lys ( epsilon N 2 methylphenylamino carbonyl ) Asp ( N methyl ) Phe NH 2 , as well as the CCK B receptor agonist Suc CCK 4 ( Suc Trp ( N methyl ) Nle Asp Phe NH 2 ) were iontophoretically administered with multibarrel capillaries . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In vivo , however , infusions of CCK A mRNA antisense ODN did not alter CCK B receptor binding levels . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Binding affinity for the CCK A vs CCK B receptor showed little dependence on the structure of the C 3 moiety but was affected by the nature of the second substituent at C 3 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In AGS cells , gastrin / CCK B receptor antagonists inhibited the effect of G 17 and competitively antagonized 125I G 17 binding , whereas the CCK preferring ( CCK A ) receptor antagonists had no effect . ^^^ In contrast , CCK A receptor antagonists inhibited the stimulatory effect of G 17 in SIIA cells , whereas CCK B receptor antagonists had no effect . ^^^ CONCLUSIONS : G 17 stimulates proliferation of AGS cells through the CCK B receptor ; however , G 17 mediated growth of SIIA acts through a CCK A like receptor . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Leptin CCK action was blocked by systemic capsaicin at a dose inducing functional ablation of sensory afferent fibers and by devazepide , a CCK A receptor antagonist but not by the CCK B receptor antagonist , L 365 , 260 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK B receptor antagonist L 365 , 260 almost totally blocked MAPK activation in AR42J cells after stimulation with gastrin and glycine extended gastrin and substantially reduced the activation of both kinases by CCK 8 , while the CCK A receptor antagonist L 364 , 718 was much less effective . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The most potent member of this series of eight diastereoisomers , ( 4aS , 5R ) 2 benzyl 5 [ N [ ( tert butoxycarbonyl ) L tryptophyl ] amino ] 1 , 3 dioxoperhydropyrido [ 1 , 2 c ] pyrimidine , displays nanomolar CCK A receptor affinity and higher than 8000 fold potency at the CCK A than at the CCK B receptor . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This effect was blocked by the specific CCK B receptor antagonist D 2 but not by the specific CCK A receptor antagonist L 364 , 718 or by pertussis toxin , indicating that gastrin targets the SRE via specific CCK B receptors through a mechanism independent of Gi . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Pretreatment with the CCK A receptor antagonist MK 329 ( devazepide ; 1 mg / kg and 2 mg / kg i . p . ) reduced the CCK induced increase in c fos expression in the LC / SC by 54 % and 75 % , respectively ; the CCK B receptor antagonist L 365 , 260 had no effect . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A receptor antagonist MK 329 ( 0 . 1 mg / kg i . p . ) diminished the FLI increase in LC , NTS , AP , and PVN by 39 100 % ; the CCK B receptor antagonist L 365 , 260 reduced the increased FLI in the AP by 54 % . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In this report , we show that the intraperitoneal administration of a CCK B receptor antagonist , PD 135158 ( 0 . 1 mg / kg ) , but not a CCK A receptor antagonist , lorglumide , inhibited hyperlocomotion . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The affinity of ARL 15849 for the CCK A receptor ( Ki = 0 . 034 nM ) is 6 , 600 fold greater than for the CCK B receptor ( Ki = 224 nM ) , whereas CCK 8 and ARL 14294 are nonselective . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To compare the roles of CCK receptors , the effects of the CCK A receptor agonist A 71378 , the CCK A / B receptor agonist CCK 8S and the CCK B receptor agonist BOC CCK 4 on anxiety related behavior and the 5 HT release in the prefrontal cortex were determined . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
L 740 , 093 exhibited high affinity ( IC 50 0 . 49 nM ) and selectivity ( < 50 % displacement at CCK A sites at 1 microM ) for the human CCK B receptor subtype as estimated from [ 125I ] CCK 8S displacement studies with membranes prepared from hCCK B . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The present study sought to determine the roles of CCK A and CCK B receptor activation in the PAG in modulating defensive rage behavior . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A receptor is the predominant peripheral CCK receptor subtype and the CCK B receptor is the predominant central CCK receptor . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We therefore investigated , by in situ hybridization , whether CCK A or CCK B receptor mRNA could be detected in normal rat pancreatic islets and in the rat insulinoma cell line , RINm5F . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
High gastrin and cholecystokinin ( CCK ) gene expression in human neuronal , renal , and myogenic stem cell tumors : comparison with CCK A and CCK B receptor contents . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The role of cholecystokinin ( CCK ) , CCK A or CCK B receptor antagonists in the spontaneous preference for drugs of abuse ( alcohol or cocaine ) in naive rats . ^^^ In particular , the data imply a CCK A receptor mechanism in the regulation of individual sensitivity towards ethanol and a CCK B receptor mechanism in the regulation of individual sensitivity towards cocaine . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The dose range of activity ( 0 . 5 60 micrograms / kg ) together with the evidence that another CCK B receptor antagonist , L 365 , 260 ( 5 micrograms / kg ) increased , while devazepide ( a CCK A receptor antagonist ; 20 micrograms / kg ) decreased non REM sleep and total sleep time , support the original hypothesis that the activity of GV 150013 on sleep progress through CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Expressions of CCK A and CCK B receptor messenger RNA ( mRNA ) were studied in human midtrimester fetus ( 14 15 weeks ' gestation ) , infant ( 50 days old ) , and adult pancreas by reverse transcription polymerase chain reaction ( RT PCR ) followed by Southern blot analysis . ^^^ Northern blot analysis showed a strong signal for CCK B receptor mRNA in adult pancreas , but no detectable signal for CCK A receptor mRNA . ^^^ RT PCR / Southern blot analysis also showed CCK A and CCK B receptor mRNA expression in fetal and infant pancreas . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Nonsulfated gastrin derivatives may be preferable because of their CCK B receptor selectivity , hence lower accretion in normal CCK A receptor expressing organs . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The expression of CCK A receptor mRNA and cNOS mRNA was significantly increased in rats treated with CCK 8 and camostate , whereas CCK B receptor mRNA remained unaffected . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We have previously reported that CCK A receptor agonists and CCK B receptor antagonists both enhance memory in an olfactory recognition test . ^^^ Here , we report that the memory enhancing effect of the CCK B receptor antagonist L 365 , 260 ( 1 mg / kg i . p . ) , but not that of the CCK A receptor agonist caerulein ( 0 . 03 mg / kg i . p . ) , was dramatically decreased following a bilateral transection of the perforant path , a principal source of input to the hippocampal formation . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Nonsulfated gastrin derivatives may be preferable because of their CCK B receptor selectivity , and hence , lower accretion in normal CCK A receptor expressing organs . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The specific CCK B receptor antagonist L 740 , 093 blocks the gastrin but not the CCK response , indicating that both the CCK B and the CCK A receptor can mediate ICER gene activation . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We studied the effect of CCK A and CCK B receptor antagonists on food intake during the first period of the dark cycle . ^^^ Under these conditions we observed that the CCK A receptor antagonist , SR 27897 ( 0 . 3 mg kg ( 1 ) ) , but not the CCK B receptor antagonist , L 365260 ( 1 mg kg ( 1 ) ) , increases food intake . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Dual CCK A and CCK B receptor antagonists ( 2 ) . ^^^ The R enantiomer of 40 , ( R ) 40 ( FR 208419 ) , had 27 fold higher affinity for the CCK A receptor and 8 fold more potent CCK B receptor binding activity than ( S ) 40 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A receptor antagonist L 364 , 718 was 300 fold more potent than the CCK B receptor antagonist L 365 , 260 at inhibiting CCK 8 induced contraction . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
By means of RT PCR analysis we were able to demonstrate SSTR 2 expression , but not CCK A or CCK B receptor mRNA in Capan 2 cells . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Moreover , CCK , CCK A receptor , and gastrin / CCK B receptor mRNA were measured by reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To test the possibility that cholecystokinin ( CCK ) mediates anorexia induced by IL 1 beta and LPS , mice trained to poke their noses in a hole to obtain a food reward according to a fixed ratio ( 1 reward per 20 actions ) were pretreated with the CCK A receptor antagonist L 364 , 718 ( at 1 mg / kg ) or with the CCK B receptor antagonist L 365 , 260 ( 50 microg / kg ) before being injected with LPS ( 100 microg / kg ) or IL 1 beta ( 20 microg / kg ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The obtained micromolar affinities for CCK A rather than CCK B receptor confirm that the anthranilic acid dimer represents a useful template for the development of selective CCK A receptor ligands . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The effects of cholecystokinin octapeptide ( CCK ( 8 ) ) , the CCK A receptor antagonist , MK 329 , and the CCK B receptor antagonist , L 365 , 260 , microinfused into the paraventricular nucleus of hypothalamus ( PVN ) on colonic motor function was investigated in awake rats , chronically implanted with a microinjection cannula into the PVN and a catheter into the proximal colon . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This article reviews the main biological role of CCK , the therapeutic potential of CCK A and CCK B receptor agonists and antagonists and the common compounds from the different families of ligands . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Both CCK A and CCK B receptor mRNAs were found in functional lower oesophageal sphincter strips . ^^^ The CCK 8 induced contraction was blocked by the CCK A receptor antagonists loxiglumide ( IC 50 11 micromol L 1 ) and SR 27897 ( IC 50 74 nmol L 1 ) but not by CCK B receptor antagonists ( 1 micromol L 1 ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK 8 effect , again , could be suppressed by CCK A receptor antagonist devazepide ( 10 nmol / L ) , but partially by CCK B receptor antagonist L 365 , 260 at 10 nmol / L or completely at concentration of 30 nmol / L . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In situ hybridization indicated the presence of m 3 Ach receptor and insulin mRNA but not CCK A or CCK B receptor mRNAs in adult human pancreas . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The results show that CCK A receptors are significantly more expressed in non responders than responders , whereas CCK B receptor expression is similar in both groups . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Neither CCK A nor CCK B receptor mediates amylase release from human pancreatic acini in vitro . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Systemic injection of CCK A receptor antagonists , devazepide ( 0 . 1 and 1 mg / kg , i . p . ) , 30 min before cocaine priming , significantly attenuated cocaine induced reinstatement of CPP , while CCK B receptor antagonist , L 365 , 260 ( 0 . 1 and 1 mg / kg , i . p . ) , did not show a similar effect . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
No difference was observed in the increase of food intake induced by CCK A and CCK B receptor antagonists in both control and post infected rats . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This cell line was used to characterize the agonist dependent regulation of CCK A and CCK B receptor gene expression . ^^^ The phorbolester PMA ( 100 nM ) , a protein kinase C activator , downregulated CCK A receptor expression but did not affect CCK B receptor gene transcription . ^^^ CONCLUSION : These results demonstrate that CCK A and CCK B receptor mRNA levels are differentially regulated by their agonists via distinct signal transduction mechanisms in AR42J cells . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The pharmacological profile of CCK CHR resembled that of CCK B receptors using agonists ( CCK 8 , CCK 4 , gastrin 17 ) , whereas CCK CHR showed higher affinity for the CCK A receptor antagonist , devazepide , than for the CCK B receptor antagonist , L 365 , 260 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK A receptor antagonist ( L 364 , 718 ) or CCK B receptor antagonist ( L 365 , 260 ) was injected intraperitoneally 15 min before leptin or CCK treatments . ^^^ CCK 8s induced reduction in the score and WWI was prevented by CCK A , but not by CCK B receptor antagonist , whereas neither antagonist altered the inhibitory effect of leptin on colitis induced injury . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
MK 329 ( 0 . 4 mg / kg , 4 ) , the CCK A receptor antagonist , L 365 , 260 ( 0 . 4 mg / kg , 4 ) , the CCK B receptor antagonist and atropine ( 0 . 2 mg / kg , 4 ) , the M receptor antagonist , did not affect the OT effect on gallbladder motility . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Our data clearly identified CCK A and CCK B receptor mRNAs in the rat retina and demonstrated that they are functional , stimulating tyrosine phosphorylation pathways . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The best pyrazoline 5e of this series displayed an IC 50 of 20 and 25 nmol / L for the CCK A , and CCK B receptor , respectively . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Selective CCK A but not CCK B receptor antagonists inhibit HT 29 cell proliferation : synergism with pharmacological levels of melatonin . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Those increases were abolished by the CCK A receptor blocker ( lorglumide ) , but not by the CCK B receptor blocker ( itriglumide ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Both the CCK A receptor antagonist lorglumide ( 48 mg kg ( 1 ) , i . v . ) and the CCK B receptor antagonist itriglumide ( 5 . 5 mg kg ( 1 ) , i . v . ) , given separately , prevented the expected increase in pentagastrin and , in addition , reduced the glandular protein synthesis by 16 and 12 % , respectively , below the level of saline treated rats . ^^^ In rats treated with saline only , the glandular protein synthesis was reduced by 22 % by the CCK A receptor antagonist and by 17 % by the CCK B receptor antagonist ; combined , the two antagonists caused no further reduction ( 20 % ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK interacts with at least two types of receptor called CCK A and CCK B receptors . ^^^ Moreover , selective nonpeptide antagonists have been developed for CCK A and CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The results provide evidence that CCK 8 stimulates the turnover of phosphoinositide and increases InsP 3 labelling in dissociated neonatal rat brain cells , in which both CCK A and CCK B receptors seem to be involved . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The inhibitory effect of CCK 8 was completely blocked by the selective antagonist for CCK B receptors , ( + ) L 365 , 260 , but not by ( ) L 364 , 718 , which is a selective antagonist for CCK A receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Incubation of nerve sections in the presence of both antagonists produced an additive effect , indicating that both CCK A and CCK B binding sites are transported towards the periphery . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Compounds were assessed in binding assays using homogenated rat pancreatic membranes and bovine striatum as the source of CCK A and CCK B receptors respectively and for anorectic activity after intraperitoneal administration to rats . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Both CCK A and CCK B / gastrin receptors are present on rabbit vagus nerve . ^^^ Under conditions which selectively examined vagal CCK A or CCK B / gastrin receptors , we demonstrated that a number of CCK subtype selective agonists and antagonists possessed similar affinities for the vagal CCK A and B / gastrin receptors as those found on the guinea pig pancreas ( CCK A ) and cerebral cortex ( CCK B ) , respectively . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In the present study , we tested whether this action is mediated by CCK A receptors , CCK B receptors , or both . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Pharmacological responses to CCK are mediated through at least two receptor subtypes termed CCK A and CCK B . ^^^ Using selective antagonists and a behavioural recognition test based on the olfactory discriminative capacities of rats , we found that endogenous CCK acting at CCK A and CCK B receptors modulates olfactory recognition positively and negatively , respectively . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The new compounds were assayed in CCK binding assays using homogenated rat pancreatic membranes and bovine striatum as a source of CCK A and CCK B receptors respectively and in vivo in rats for anorectic activity . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Compounds were assessed in binding assays using homogenated rat pancreatic membranes and bovine striatum as the source of CCK A and CCK B receptors , respectively , and for anorectic activity after intraperitoneal administration to rats . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The effect of caerulein ( 5 micrograms / kg ) was antagonized by devazepide , a CCK A antagonist , at 100 micrograms / kg , but not by a CCK B antagonist L 365 , 260 tested at a wide dose range . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
A series of modifications of the CCK 7 analogue ( des NH 2 ) Tyr ( SO 3 ) Nle Gly Trp Nle Asp Phe NH 2 was prepared and tested for binding to guinea pig CCK A and CCK B receptors and in CCK A mediated functional assays . ^^^ The ( N Me ) Asp 32 and ( N Me ) Leu 31 modifications afforded potent and selective CCK A and CCK B ligands , respectively . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Subtype selective antagonists of the peripheral type ( CCK A ) and the central type ( CCK B ) cholecystokinin ( CCK ) receptors were employed to determine the receptor subtype ( s ) mediating the modulatory actions of CCK on dopamine induced changes in exploratory activity at three sites in the mesolimbic pathway of the rat . ^^^ These data indicate a CCK B pharmacology in the cell body and anterior terminal field , and a CCK A pharmacology in the posterior terminal field , of the mesolimbic dopamine pathway . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This effect was suppressed by the selective CCK B antagonist : L 365 , 260 , but not by the selective CCK A antagonist : MK 329 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To investigate the relative participation of peripheral ( CCK A ) and central ( CCK B ) cholecystokinin ( CCK ) receptors in satiety induced by endogenous CCK , we examined the effect of the CCK A antagonist MK 329 ( 10 315 micrograms / kg ) and the CCK B antagonist L 365260 ( 0 . 1 315 micrograms / kg ) on intake of a 20 % sucrose solution in mildly food deprived mice . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Replacement of the amide of compound 4 with a 4 , 5 dihydro 1 , 3 thiazole gives tricyclo [ 3 . 3 . 1 . 1 ( 3 , 7 ) ] dec 2 yl [ 1 [ 4 , 5 dihydro 4 ( phenylmethyl ) 2 thiazolyl ] 2 ( 1H indol 3 yl ) ethyl ] carbamate ( 5 ) , which is selective for the CCK A receptor ( CCK A IC 50 = 125 nM , CCK B IC 50 = 2580 nM , ratio = 21 ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
H ] pBC 264 , a suitable probe for studying cholecystokinin B receptors : binding characteristics in rodent brains and comparison with [ 3H ] SNF 8702 . [ 3H ] Propionyl Tyr ( SO3H ) gNle mGly Trp ( NMe ) Nle Asp Phe NH 2 ( [ 3H ] pBC 264 ) ( 98 100 Ci / mmol ) , a new peptidase resistant cholecystokinin ( CCK ) agonist that is 1000 fold more potent for CCK B than for CCK A receptors , interacts , with a similar subnanomolar affinity , with a single class of binding sites ( Kd , 0 . 15 0 . 2 nM ) in brain membranes of mouse , rat , guinea pig , and cat , in Tris and Krebs buffers . ^^^ The concentration of CCK A receptors in rodent brain was estimated to be 8 10 fmol / mg of protein , by measurement of the Bmax values of the nonselective agonist [ 3H ] propionyl CCK 8 , with or without 10 nM pBC 264 to saturate CCK B sites . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The response to these peptides was suppressed by pretreatment with a selective antagonist for CCK A receptors , ( ) L 364 , 718 , in a dose related manner , but not with an antagonist for CCK B receptors , ( + ) L 365 , 260 . ^^^ These results indicate that peripheral administration of CCK 8 and ceruletide stimulates the hypothalamo pituitary adrenal axis through the activation of CCK A receptors , but not CCK B receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To determine whether these endocrine responses involve CCK A or CCK B receptors , this experiment investigated the effect of CCK ( 1 microgram / kg ) in pigs ( n = 7 ) pretreated with the CCK A antagonist L 364718 ( 70 microgram / kg ) or the CCK B antagonist L 365260 ( 10 ng / kg and 10 micrograms / kg ) . ^^^ However , the effect of CCK on cortisol secretion does not appear to involve either CCK A or CCK B receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK B and CCK A binding affinities of these analogues are described and their CCK B affinity and selectivity rationalized by consideration of the pK ( a ) values , charge distribution , and geometry of the respective acid mimics . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The introduction of potent cholecystokinin ( CCK ) receptor antagonists , selective for either the CCK A or the CCK B subtype , has provided a great impetus to the study of activity of endogenous CCK in relation to the control of feeding . ^^^ This paper reviews experiments in which devazepide ( a selective CCK A receptor antagonist ) and L 365 , 260 ( a selective CCK B gastrin receptor antagonist ) have been used . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
New ( R ) 4 benzamido 5 oxopentanoic acid derivatives were synthesized by a stereoconservative procedure and evaluated in vitro for their capacity to inhibit the binding of [ 125I ] ( BH ) CCK 8 to either rat peripheral ( CCK A ) or central ( CCK B ) CCK receptors , or the binding of [ 3H ] pentagastrin to rabbit gastric glands , as well as to inhibit , in vivo , the acid secretion induced by pentagastrin infusion in the perfused rat stomach . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK ) receptors are currently divided into at least two subtypes : a CCK A subtype , responsive to the sulfated form of cholecystokinin octapeptide ( CCK 8 ) and selectively antagonized by L 364 , 718 , and a CCK B subtype , which shares equal affinities for gastrin and CCK 8 . ^^^ The antagonist potencies of L 365 , 260 ( CCK B selective ) and L 364 , 718 ( CCK A selective ) against CCK 8 were also determined . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Furthermore , specific CCK receptors have been described , and a distinction drawn between CCK A and CCK B receptors . ^^^ Recently , potent , orally active CCK antagonists , which show a high degree of selectivity for either CCK A or CCK B receptors , have been introduced . ^^^ The present report reviews recent evidence obtained in studies using devazepide ( a selective CCK A receptor antagonist ) and L 365 , 260 ( a selective CCK B / gastrin receptor antagonist ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Based on their relative affinities for cholecystokinin octapeptide ( 26 33 ) ( CCK 8 ) , cholecystokinin tetrapeptide ( 30 33 ) ( CCK 4 ) , desulfated CCK 8 , and gastrin , cholecystokinin ( CCK ) receptors have been classified as CCK A ( alimentary ) and CCK B ( brain ) . ^^^ Selective nonpeptide antagonists of CCK A and CCK B receptors , as well as highly selective CCK A and CCK B peptide agonists , have been described . ^^^ In radioligand binding assays , the IC 50 values for A 71623 and A 70874 were 3 . 7 and 4 . 9 nM in guinea pig pancreas ( CCK A ) and 4500 and 710 nM in cerebral cortex ( CCK B ) , respectively . ^^^ The preferential interaction of these novel CCK 4 analogs with CCK A receptors is in contrast to other CCK 4 based peptides , which are primarily selective for CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To study the interdependence between gastric histamine release and acid secretion , we examined the effects of gastrin ( 1 17 ) [ G ( 1 17 ) ] or cholecystokinin ( 1 33 ) [ CCK ( 1 33 ) ] alone or combined with the gastrin ( CCK B ) antagonist L 365 , 260 or the CCK A antagonist L 364 , 718 in the isolated vascularly perfused rat stomach . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These CCK binding sites displayed a typical CCK B pharmacological profile , established by use of several agonists and antagonists selective for the CCK receptor types , namely compound L 364 , 718 , the Merck CCK antagonist selective for the peripheral CCK receptor ( CCK A ) , and compound L 365 , 260 , the Merck CCK antagonist selective for the central CCK receptor ( CCK B ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
They are significant pharmacological tools for the study of CCK A ( peripheral ) and CCK B ( central ) receptors , their biological actions and their associated intracellular messengers . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Proglumide does not discriminate between CCK A and CCK B ( central type ) receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In homogenate binding studies , L 365 , 260 displayed nanomolar affinity for CCK B receptors in the cerebral cortex of several species including man ( pIC 50 congruent to 8 . 2 ) but showed low affinity for CCK A receptors in the rat pancreas ( pIC 50 congruent to 6 . 3 ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The effects of the selective CCK A antagonist L 365 , 031 and the selective CCK B antagonist L 365 , 260 on morphine analgesia and opiate tolerance and dependence in rats were examined . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Peptide analogues were evaluated in a CCK binding assay for affinity for either peripheral ( CCK A ) receptors using homogenated rat pancreatic membranes as the receptor source or for central ( CCK B ) receptors using bovine striatum as the receptor source . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Receptors for the brain and gut peptide cholecystokinin ( CCK ) have been classified into two classes , CCK A and CCK B . ^^^ To date , peptide analogues with selectivity for the CCK B receptors have been identified , and selective antagonists for CCK A and CCK B receptors have been reported as well ; until now , there have been no reports of highly selective CCK A agonists . ^^^ The IC 50 values of A 71378 for the pancreatic CCK A , cortical CCK B , and gastrin receptor were 0 . 4 nM , 300 nM , and 1 , 200 nM , respectively . ^^^ The high potency and selectivity of A 71378 for the CCK A over CCK B and gastrin receptors is unprecedented among CCK peptides . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Distinct requirements for activation at CCK A and CCK B / gastrin receptors : studies with a C terminal hydrazide analogue of cholecystokinin tetrapeptide ( 30 33 ) . ^^^ Using 125I Bolton Hunter cholecystokinin octapeptide ( 26 33 ) ( 125I Bolton Hunter CCK 8 ) as the radioligand , A 57696 was found to be selective for cortical CCK B receptors ( IC 50 = 25 nM ) , compared with pancreatic CCK A receptors ( IC 50 = 15 microM ) . ^^^ Stimulatory actions of CCK 8 and A 57696 were reversed by the CCK B selective ( R ) L 365 , 260 ( 100 nM ) , whereas at the same concentration , the CCK A selective ( S ) L 365 , 260 was ineffective . ^^^ Its contrasting functional activities at guinea pig CCK A and CCK B / gastrin receptors in a human tumor cell demonstrate that , in addition to the previously described differences in binding specificity for selective agonists and antagonists , CCK A receptors and CCK B / gastrin receptors have different requirements for activation . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK A receptors have high affinity for sulphated CCK 8 and for MK 329 but low affinity for desulphated CCK 8 and CCK 4 whilst CCK B sites bind MK 329 with low affinity and discriminate poorly between sulphated and desulphated CCK 8 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
However , it has not been established that endogenous CCK causes satiety or whether the response is mediated by peripheral type ( CCK A ) or brain type ( CCK B ) receptors . ^^^ The development of potent and selective antagonists for CCK A ( MK 329 ) and CCK B ( L 365 , 260 ) receptors now allows these issues to be addressed . ^^^ The CCK A antagonist MK 329 and the CCK B antagonist L 365 , 260 increased food intake in partially satiated rats and postponed the onset of satiety ; however , L 365 , 260 was 100 times more potent than MK 329 in increasing feeding and preventing satiety . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
It is suggested that the variable effects of MK 329 on morphine induced and opioid mediated social conflict analgesia may reflect differential , dose dependent effects at CCK B and CCK A sites respectively , a proposal consistent with the 500 fold potency difference observed between the two models . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The exact locus of this interaction , or whether it involves ' peripheral type ' ( CCK A ) or ' central type ' ( CCK B ) receptors is not known . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
However , it remains unclear whether these growth effects are mediated specifically by CCK A receptors , CCK B receptors , or both . ^^^ METHODS : Rats were subcutaneously injected with either ( 1 ) CCK 8 , a nonselective CCK agonist ( 2 . 50 micrograms / kg body wt ) ; ( 2 ) A 71623 , a selective CCK A agonist , tert butyl oxycarbonyl Trp Lys ( epsilon N 2 methylphenylaminocarbonyl ) Asp ( N methyl ) Phe NH 2 ( 1 . 84 micrograms / kg body wt ) ; ( 3 ) SNF 8815 ; a selective CCK B agonist , [ ( 2R , 3S ) beta MePhe 28 , N MeNle 31 ] CCK 26 33 ( 2 . 40 micrograms / kg body wt ) ; or ( 4 ) saline ( control ) for 21 days . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK B / gastrin receptor antagonist L 365 , 260 abolished the stimulating effect of cionin on both histamine release and acid secretion , whereas the CCK A receptor antagonist L 364 , 718 only had a faint effect . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK B antagonist L 365 , 260 inhibited this effect [ concentration inhibiting 50 % of maximal response ( IC 50 ) , 2 10 10 ( 8 ) M ] , whereas the CCK A antagonist L 364 , 718 ( 10 ( 8 ) M ) and the tyrosine kinase inhibitor genistein ( 10 ( 4 ) M ) had no effect . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
It has been previously demonstrated that guinea pig pancreas possesses both cholecystokinin A ( CCK A ) receptors and CCK B ( gastrin ) receptors . ^^^ In contrast to guinea pig pancreas , it is not known whether CCK receptors in rat pancreas are CCK A receptors , CCK B ( gastrin ) receptors , or both . ^^^ Thus , in the present study , we characterized CCK receptors in rat pancreas at the receptor and mRNA level . 125I Bolton Hunter labeled CCK octapeptide ( 125I BH CCK 8 ) , the specific CCK A and CCK B ( gastrin ) receptor antagonists L 364 , 718 and L 365 , 260 , and 125I labeled gastrin 1 were utilized to characterize CCK receptors in normal rat pancreas . ^^^ Additionally , we utilized 32P labeled cDNA probes of the CCK A receptor and CCK B ( gastrin ) receptor coding regions in order to examine the expression of CCK receptor subtypes in normal rat pancreas at the mRNA level . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
It is suggested that centrally applied CCK 8S evokes pepsinogen secretion through the activation of peripheral CCK A and CCK B receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The cyclic analogue 1a has Ki values of 4 . 5 and > 5000 nM at delta and mu opioid receptors , respectively ; and IC 50 values of 1 . 6 and > 10 , 000 nM for CCK A and CCK B receptors , respectively . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Functional studies suggest that guinea pig chief cells have both cholecystokinin A ( CCK A ) and CCK B receptors ( CCK A R and CCK B R , respectively ) . ^^^ These results demonstrate directly for the first time that guinea pig chief cells possess CCK A R and CCK B R . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cholecystokinin potentiates morphine anticonvulsant action through both CCK A and CCK B receptors . ^^^ We studied the effect of subcutaneous morphine and intracerebroventricularly administered cholecystokinin octapeptide sulphate ester and receptor antagonists CCK A ( MK 329 ) and CCK B ( L 365 , 260 ) on seizures provoked by maximal electroshock in male Sprague Dawley rats . ^^^ Seizures were induced through electrode gel coated ear clip electrodes by a high voltage , high internal resistance constant current generator , 30 minutes after morphine administration and 10 minutes after cholecystokinin 8 SE , CCK A and CCK B infusion . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK 8 infused intravenously ( 0 . 1 1 microgram . kg 1 . h 1 ) dose dependently increased the occurrence of relaxations while it was reduced by the CCK A receptor antagonist devazepide but not the CCK B antagonist L 365260 , both administered intravenously in a dose range of 0 . 1 100 micrograms / kg . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The duration of MMC disruption and the increase in colonic spike burst frequency after spermidine administration ( 20 mumol ) were significantly reduced by CCK A and CCK B antagonists . ^^^ These results indicate that exogenous polyamines disrupt intestinal MMCs and stimulate colonic motility through a release of CCK acting at CCK A and CCK B receptors and suggest that endogenous polyamines are involved in the postprandial control of intestinal motility . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These results suggest that 1 ) Both muscularly and neurally located CCK receptors are present on the longitudinal layer of chicken ceca whereas only muscular receptors are present on the circular muscle . 2 ) 5HT2 receptors seem to be involved in the neurally mediated CCK 8s response observed in the longitudinal layer . 3 ) The different potency of CCK 8s , CCK 8ns and CCK 4 to induce contractile effects and of the CCK A and CCK B antagonists to block such effects suggests the existence of two different CCK receptors on the circular layer . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK A and CCK B selective receptor agonists and antagonists modulate olfactory recognition in male rats . ^^^ We have used a behavioural model of olfactory recognition among rats to test this hypothesis and to explore the relationship between CCK A and CCK B receptors and memory retention . ^^^ Systemic injection of CCK 8 , of a selective CCK A agonist , or of non peptide CCK B antagonists ( CI 988 and LY 262691 ) enhanced olfactory recognition . ^^^ CCK A antagonist devazepide on olfactory recognition , these results confirm and extend the hypothesis that there is a balance between CCK A mediated facilitative effects and CCK B mediated inhibitory effects on memory retention . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Fifty eight residues were sequentially replaced by the corresponding amino acids from the pharmacologically distinct CCK A receptor subtype . 125I CCK 8 competition binding experiments were performed to compare all mutant CCK B / gastrin receptor constructs with the wild type control . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
All had essentially the same sequence contained within 2 of these clones consisted of 427 amino acids and was 92 % homologous ( 87 % identity ) to the known rat pancreatic CCK A sequence but only 43 % homologous to the gastric CCK B sequence . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We transfected COS cells with cDNA for rat cholecystokinin A ( CCK A ) and different CCK B receptors and measured binding of 125I CCK 8 , [ 3H ] L 364 , 718 and [ 3H ] L 365 , 260 to characterize the different affinity states for each type of CCK receptor . ^^^ Rat CCK A and CCK B receptors , canine CCK B receptors and canine mutant CCK B ( M CCK B ) receptors in which the leucine in position 355 was replaced by valine each existed in three different affinity states for CCK 8 , high affinity , low affinity , and very low affinity . ^^^ In rat CCK A and probably CCK B receptors , most were in the very low affinity state , whereas with canine CCK B and M CCK B receptors , most were in the low affinity state . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The behavioral responses induced by BDNL were not significantly blocked by L 365 , 260 , but were suppressed by CI 988 , another selective CCK B antagonist , and by high doses of L 364 , 718 , a selective CCK A antagonist . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These new analogs were moderately potent antagonists of CCK 8 in the isolated guinea pig gallbladder with exceptional CCK A receptor selectivity as evaluated in membrane preparations from CHO K 1 cells stably transfected with human CCK A and CCK B receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Observed biological activities of substituted phenyl urea / thiourea tetrapeptides as agonists with the cholecystokinin alimentary canal ( CCK A ) receptor , and ( R ) 4 benzamido 5 oxopentanoic acid derivatives with both peripheral ( CCK A ) and the central ( CCK B ) ( brain ) receptors have been shown to be correlated with various physicochemical , e . g . pi , sigma , and structural , e . g . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Pharmacological experiments using CCK or NPY analogs suggest that both subtypes of CCK ( CCK A and CCK B ) and NPY ( Y 1 and Y 2 ) receptor binding sites are expressed by discrete populations of neurons in the nodose ganglion . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In the distal colon , the postprandial response was inhibited by CCK A , CCK B , and 5 HT 2 receptor antagonists , whereas they were inactive in the proximal colon . ^^^ These results suggest that , in rats , CCK 8 is involved in the control of the ileal motor response to feeding through CCK A receptors and in that of the distal colon through both CCK A and CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Optimization of this series led to the identification of an azabicyclononane amidine , L 740 , 093 [ N [ ( 3R ) 5 ( 3 azabicyclo [ 3 . 2 . 2 ] nonan 3 yl ) 2 , 3 dihydro 1 methyl 2 oxo 1H 1 , 4 benzodiazepin 3 yl ] N ' ( 3 methylphenyl ) urea ] , that bound with high affinity of CCK B receptors from guinea pig cerebral cortex ( IC 50 of 0 . 1 nM ) and had a CCK B / CCK A receptor selectivity of 16 , 000 . ^^^ In comparison , L 365 , 260 had 85 fold lower affinity ( 8 . 5 nM ) and was only 87 fold selective for CCK B over CCK A receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In addition , the CCK analog [ Boc Tyr ( SO3H ) Nle Gly Trp Nle Asp Phe NH 2 ] ( a mixed CCK A / CCK B agonist ) increased the jump latency and this effect was blocked by MK 329 ( 20 micrograms / kg i . p . ) and by naloxone , but not by the selective CCK B antagonist L 365 , 260 ( 5 mg / kg i . p . ) . ^^^ Taken together , these findings suggest that the potentiating effects of delta agonists on mu mediated analgesia are due to an increase in the release of endogenous CCK interacting with CCK A and CCK B receptors and resulting in positive and negative regulation of the endogenous opioid system . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK B antagonist L 365 , 260 ( 10 pmol 1 nmol ) failed to block the gastric vagal afferent response to gastric loads or 100 pmol CCK , while the CCK A antagonist devazepide ( 100 pmol 100 nmol ) competitively and dose dependently attenuated the response to CCK but not to gastric loads . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK A or CCK B . ^^^ Two receptors for cholecystokinin ( CCK ) have been isolated which also bind gastrin : CCK A type and CCK B type , both are coupled to phospholipase C ( PLC ) activation . ^^^ The trophic effect was not blocked by receptor antagonists for CCK A ( L 364 , 718 ) or CCK B ( L 365 , 260 ) . ^^^ The gastrin receptor pharmacology on LoVo cells and the lack of appropriate transcripts suggest that gastrin stimulated growth of these cells by a receptor other than CCK A or CCK B type and there likely exists another receptor for gastrin . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The present study was performed to determine whether these effects are mediated by way of CCK A receptors , CCK B receptors , or both . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The role of cholecystokinin ( CCK ) as a central and peripheral satiety factor was studied using the CCK B ( L 365 , 260 ) and CCK A ( MK 329 ) receptor antagonists in esophageal fistula dogs . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The diphenylpyrazolidinone CCK B antagonists , but neither the inactive nor the CCK A selective analog , also decreased the number of spontaneously active A 9 DA cells ; however , none of these compounds produced catalepsy in awake animals . ^^^ These results indicate that the firing of A 9 and A 10 DA neurons is suppressed specifically by antagonism of CCK B , but not CCK A receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Evidence for expression of CCK A receptors but not CCK B ( gastrin ) receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The present study was performed to ascertain whether the blockade of endogenously released CCK 8 by potent and selective CCK A antagonist devazepide and CCK B antagonist L 365260 would affect opioid analgesia at the spinal cord level . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK A ) and gastrin ( CCK B ) receptors have been demonstrated in the azaserine induced rat pancreatic carcinoma DSL 6 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In binding studies , the gastrin receptor antagonist PD 136 , 450 had at least 1000 fold greater affinity for gastrin ( CCK B ) than CCK A receptors . ^^^ It is concluded that the agonist effect of PD 136 , 450 is mediated via interaction with the gastrin ( CCK B ) receptor in the stomach and the CCK A receptor in the pancreas . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The binding sites had high affinity for CCK 8 , CCK 4 , gastrin 1 , and L 365 , 260 ( CCK B antagonist ) , and had low affinity for devazepide ( CCK A antagonist ) , indicating that the binding sites are CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Energy calculations were performed for CCK 8 ( Asp 26 Tyr ( SO 3 ) 27 Met 28 Gly29 Trp 30 Met31 Asp 32 Phe33 NH 2 , 1 ) and [ desaminoTyr ( SO 3 ) 27 , Nle 28 , 31 ] CCK 7 ( 2 ) , which are nonselective ligands of CCK receptors , and for the CCK A selective analog [ desaminoTyr ( SO 3 ) 27 , Nle 28 , 31 , N Me Asp 32 ] CCK 7 ( 3 ) and the CCK B selective analog [ desaminoTyr ( SO 3 ) 27 , Nle 28 , N Me Leu 31 ] CCK 7 ( 4 ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Operant feeding was recorded in 18 h deprived pigs after peripheral ( 4 ) or central ( ICV ) administration of saline , the CCK A agonist A 71378 , the CCK B agonist pentagastrin , or pentagastrin vehicle . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Extracellular single unit recording techniques were used to study the effects of the cholecystokinin A ( CCK A ) antagonist , L 364 , 718 , and the CCK B antagonist , PD 134308 , on DA neuronal activity in chloral hydrate anesthetized rats . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A antagonist completely blocked LH secretion in response to CCK , whereas the CCK B antagonist had no effect . ^^^ To assess whether endogenous CCK , released in response to food intake , stimulates LH secretion , six monkeys were fasted for 1 day and then provided with a normal meal of monkey chow ( i . e . a refeed meal ) the following day , with either no antagonist , CCK A antagonist , or CCK B antagonist administered 30 min before the meal . ^^^ The refeed meal led to a comparable stimulation of LH secretion regardless of whether monkeys received no antagonist ( 3 . 7 + / 0 . 44 LH pulses / 9 h ) , CCK A antagonist ( 3 . 33 + / 0 . 56 LH pulses / 9 h ) , or CCK B antagonist ( 4 . 0 + / 0 . 78 LH pulses / 9 h ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The compounds tested were selective CCK B antagonists [ CI 988 ( 0 . 01 1 mg / kg SC ) , L 365 , 260 ( 0 . 004 2 mg / kg IP ) and LY 262 , 691 ( 0 . 001 1 mg / kg SC ) ] , CCK B agonists [ CCK 4 ( 0 . 01 1 mg / kg SC ) and BC 264 ( 0 . 004 1 mg / kg IP ) ] and CCK A antagonists [ devazepide ( 0 . 001 1 mg / kg SC ) and lorglumide ( 0 . 01 1 mg / kg SC ) ] . ^^^ None of these drugs induced the expected behavioural effects , i . e . an anxiolytic like release of the behavioural suppression with CCK B and , possibly , CCK A antagonists and / or a further reduction of lever pressing with CCK B agonists , indicative of an anxiogenic like potential . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Male NMRI mice weighing 12 15 g were assigned to six groups ( 10 mice / group ) which were treated with different combinations of 0 . 9 % NaCl , omeprazole , a CCK A antagonist , a CCK B antagonist , loxiglumide , and L 365 , 260 for 10 days each according to different protocols . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
For example , CCK appears to exert its anti opioid actions mainly through the activation of CCK B receptors , whereas its opioid like effects seem to result from the stimulation of CCK A receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK B antagonists suppressed CCK 4 induced calcium mobilization more potently than CCK A antagonist . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The radioligand binding models used in these studies were [ ( 125 ) 1 ] ( BH ) CCK 8 in rat pancreas ( CCK A ) , [ ( 3 ) H ] ( MENLE ( 28 , 31 ) ) cck 8 in guinea pig cerebral cortex ( CCK B ) , and [ ( 3 ) H ] U 69593 ( kappa ( 1 ) ) , [ ( 3 ) H ] DAMGO ( mu ) , and [ ( 3 ) H ] DADLE ( delta ) in guinea pig brain . ^^^ All the title compounds were devoid of significant affinity for both CCK A and CCK B receptors , while some of them bound with nanomolar affinity and high selectivity for kappa opioid receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
L 364 , 718 ( a CCK A antagonist ) showed a relative selectivity and a high affinity for those receptors located in central tissues , whereas L 365 , 260 ( a CCK B antagonist ) is almost inactive in all studied tissues . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Both peptides showed higher potency in the PPI assay than in Ca2+ studies . 100nM pentagastrin induced PPI turnover was dose dependently inhibited by the CCK B receptor selective antagonist L 365 , 260 ( IC 50 470nM ) whilst the CCK A receptor antagonist , devazepide , only produced weak partial inhibition ( 18 % at 10 , 000nM ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
By mapping the distribution of cholecystokinin ( CCK ) receptor types onto an established phylogenetic hypothesis of vertebrate relationships , we tested two hypothesis about the evolution of CCK receptors : ( 1 ) A single CCK receptor type , CCK 10 , is the ancestral receptor , while CCK A and CCK B receptors represent derived receptor types ; ( 2 ) the evolution of two separate CCK receptors is functionally related to the evolution of endothermy . ^^^ Additional competitive inhibition studies showed that the mako CCK 10 receptor has very low affinities for the following nonpeptide agonist and antagonists : A 71623 , L 364 , 718 , A 57696 , A65186 . 72 , Cam 1481 , and SR 27897B ( specific for some mammalian CCK A receptors ) and L 365 , 260 and CI 988 ( specific for some mammalian CCK B receptors ) , confirming the pharmacological differences between the CCK 10 receptor and the CCK A and B receptors . ^^^ CCK A and CCK B , are not part of the suite of characters necessary for evolution of endothermy in fishes . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Interestingly , the dipeptide derivative CI 988 , which has been described as a selective CCK B antagonist , was found to have an antagonist / agonist binding ratio of 1 . 5 for the CCK A receptors in rat pancreas which was sufficiently high for this compound to behave as a full agonist in the amylase assay , although CI 988 did not exhibit agonist activity in the PI assay . ^^^ These results suggest that the effective receptor reserve in the amylase assay is greater than that required to stimulate PI turnover , and that the selective peptoid CCK B antagonist CI 988 has weak agonist activity at CCK A receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Consistent with previous reports , ( S ) configuration at the substituted phenethylamide center , a carboxylic acid and the presence of a phenyl ring were found to be associated with increased affinity at both CCK A and CCK B receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The preparation of the dehydropeptides ( 1 , R = Me ; 2 , R = H ) and the cyclopropylpeptides ( 3 , R = Me ; 4 , R = H ) possessing good binding affinities for the CCK A and CCK B receptors is described . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The overlapping distribution of opioid and cholecystokinin ( CCK ) peptides and their receptors ( mu and delta opioid receptors ; CCK A and CCK B receptors ) in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These two opposing effects were suppressed by the CCK B antagonist PD 134 , 308 , but not by the CCK A antagonist L 364 , 718 and were not prevented by tetrodotoxin , a Na ( + ) channel blocker . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
GW 7854 is a potent mixed CCK A agonist / CCK B antagonist which is orally active in two in vivo models of CCK A mediated agonist activity . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The strategy is exemplified by the design of a selective and high affinity cholecystokinin CCK A antagonist PD 140548 , CCK B antagonist CI 988 ( formerly PD 134308 ) tachykinin NK 1 antagonist PD 154075 and NK 2 antagonist Cam 2291 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Gastrin and cholecystokinin ( CCK ) are gut brain peptides , with multiple functions in the gastrointestinal tract mediated through CCK B gastrin and CCK A receptors . ^^^ The aim of this study was to investigate the distribution and pharmacological characteristics of CCK A and CCK B receptors in the human upper gastrointestinal tract and compare them with those in the rat and dog . ^^^ CCK A receptors were also located in the muscularis propria of antrum , fundus , and gallbladder , whereas CCK B gastrin receptors were only detected in gastric fundic circular muscle . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The identified CCK A and CCK B receptors were specific and of high affinity in the subnanomolar range . ^^^ The rank order of potency of various CCK analogues was : sulfated CCK 8 = L 364 , 718 > > nonsulfated CCK 8 = L 365 , 260 > or = gastrin for CCK A receptors and sulfated CCK 8 > gastrin = nonsulfated CCK 8 > L 365 , 260 > L 364 , 718 for CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
There are two CCK receptors ; both CCK A and CCK B receptors are stimulated by CCK 8 SE . ^^^ The relative importance of the CCK A and CCK B receptors in the somnogenic and hypothermic effects of CCK 8 SE is not well understood . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK induced depolarization was significantly reduced by a CCK A , but not a CCK B , receptor antagonist . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK A and CCK B like receptors in the gallbladder and stomach of the alligator ( Alligator mississippiensis ) . ^^^ Alligator gallbladder smooth muscle expresses a CCK A receptor subtype , and stomach oxyntic mucosa expresses a distinct receptor subtype , termed CCK B / X because of its similarities to both CCK B and CCK 10 receptors . ^^^ Both the gallbladder and the stomach binding sites have very low affinities for a panel of nonpeptide receptor agonists and antagonists that are selective for mammalian CCK A and CCK B receptors . ^^^ These results suggest that CCK receptor subtypes diverged from the ancestral CCK 10 receptor in an early amniote , prior to the divergence of mammals and reptiles in vertebrate phylogeny , and that CCK A receptors may have evolved before CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
New constrained cyclic pseudopeptide cholecystokinin B ( CCK B ) agonists have been designed on the basis of conformational characteristics of the potent and selective CCK B agonist Boc Trp ( NMe ) Nle Asp Phe NH 2 ( Ki = 0 . 8 nM , selectivity ratio CCK A / CCK B > 6000 ) ( Goudreau et al . ^^^ The affinities and selectivities of these compounds for CCK B and CCK A receptors have been determined in vitro by measuring the displacement of [ 3H ] pCCK 8 binding to guinea pig cortex and pancreas membranes , respectively . ^^^ The most potent compound , 8b , N ( cycloamido ) alpha Me ( R ) Trp [ ( 2S ) 2 amino 9 ( ( cycloamido ) carbonyl ) nonanoyl ] Asp Phe NH 2 , has a Ki value of 15 + / 1 nM for guinea pig cortex membranes with a good CCK B selectivity ratio ( CCK A / CCK B = 147 ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These behavioural effects , prevented by the prior i . p . administration of the CCK B antagonist L 365 , 260 but not by the CCK A antagonist L 364 , 718 , were shown to depend on dopaminergic systems , since they were blocked by D 1 ( SCH 23390 , 25 microg / kg i . p . ) or D 2 ( sulpiride , 50 or 100 mg / kg i . p . ) antagonists . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK ) is a 33 amino acid peptide with multiple functions in both the central nervous system ( via CCK B receptors ) and the periphery ( via CCK A receptors ) . ^^^ Compound 6 ( Hpa ( SO3H ) Nle Gly Trp Nle MeAsp Phe NH 2 ) , derived from moving the N methyl group from Phe to Asp , decreased CCK B affinity substantially without affecting CCK A affinity , giving a compound with 6600 fold selectivity for CCK A receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This SAR study led to the identification of tricyclo [ 3 . 3 . 1 . 1 ( 3 , 7 ) ] dec 2 yl [ 1S [ 1 alpha ( S * ) 2 beta ] [ 2 [ ( 2 hydroxycyclohexyl ) amino ] 1 ( 1H indol 3 ylmethyl ) 1 methyl 2 oxoethyl ] carbamate ( CI 1015 , 31 ) with binding affinities of 3 . 0 and 2900 nM for the CCK B and CCK A receptors , respectively . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
At birth lambs received an injection of the CCK A antagonist devazepide ( 0 . 01 or 0 . 1 mg / kg ) , the CCK B antagonist PD 135158 ( 0 . 01 or 0 . 1 mg / kg ) , or saline for the controls ( 1 ml / kg ) . ^^^ The use of a CCK A antagonist , but not a CCK B antagonist , was concluded to prevent the formation of a preferential relationship between the lamb and its mother , most probably by impairing neonatal learning . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A and CCK B antagonists , devazepide and L 365260 ( 100 micrograms / kg , i . p . ) , respectively , inhibited the postprandial colonic motor response while only L 365260 reduced the CCK induced stimulation . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
These results indicate that CCK A type receptors rather than CCK B receptors may be involved in CCK induced insulin secretion in sheep . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Compounds such as 9d , e and 10d showed high affinity for this receptor ( IC 50 < 2 . 5 nM ) and very good selectivity over CCK A ( CCK A / CCK B > 2000 ) , even as the racemates . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
When tested by radioreceptor assay , a synthetic replicate of alligator gastrin 49 exhibited a gastrin like pattern of biological activity on mammalian CCK A and CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
All the compounds were evaluated in vitro towards both CCK B and CCK A receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Suppression of sham feeding by exogenous CCK 8 or intraintestinal oleate infusion is attenuated by peripheral administration of the CCK A receptor antagonist , devazepide , but not by the CCK B antagonist , L 365260 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The gastrin / cholecystokinin ( CCK ) B and CCK A receptor antagonist activities of these compounds were evaluated by investigation of their affinities for human gastrin / CCK B receptors and human CCK A receptors , respectively . ^^^ It was found that N methyl N phenyl 2 [ 2 [ N ( N methyl N phenyl carbamoylmethyl ) N [ 2 [ 3 ( 3 methylphenyl ) ureido ] acetyl ] amino ] phenoxy ] acetamide ( 20k , DZ 3514 ) exhibited high affinity for gastrin / CCK B receptors and high selectivity over CCK A receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The compounds were selective for CCK B receptors as they did not bind with high affinity to CCK A receptors expressed in human tumors ( meningiomas or gastroenteropancreatic tumors ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Selective N methylation of a racemic precursor with [ 11C ] iodomethane and subsequent optical resolution of the racemate with HPLC afforded optically pure [ 11C ] L 365 , 260 and [ 11C ] L 365 , 346 , which are selective for CCK B ( central type ) receptors and CCK A ( peripheral type ) receptors , respectively . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This tactic yielded a series of monocyclic 2 oxopyrrolidine derivatives 4 with selectivity for CCK A or CCK B receptors and with slightly improved binding affinity at the CCK A receptor subtype with respect to the model 3 oxoindolizidines . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Among the compounds synthesized , 2 [ 3 [ 3 [ N [ 2 ( N methyl N phenylcarbamoylmethoxy ) phenyl ] N ( N meth yl N phenylcarbamoylmethyl ) carbamoylmethyl ] ureido ] phenyl ] acetic acid ( 20i , DA 3934 ) exhibited high affinity for gastrin / CCK B receptors and high selectivity over CCK A receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Measurements were made of the release of cholecystokinin ( CCK ) stimulated by potassium chloride in the hypothalamus after ( a ) gamma irradiation ( 60Co ) , ( b ) treatment with the CCK A and CCK B antagonists L 364 , 718 and L 365 , 260 with and without radiation , ( c ) bilateral abdominal vagotomy , and ( d ) vagotomy with and without radiation and with and without L 364 , 718 . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The stimulation of CCK A or CCK B receptors is implicated in the physical and psychological responses of CCK to stress . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Two types of CCK receptors have been identified : ( 1 ) CCK A receptors are mainly located in the periphery , but are also found in some areas of the CNS ; and ( 2 ) CCK B receptors are widely distributed in the brain . ^^^ It is shown that anxiety like symptoms can only be induced by a selectively acting CCK B agonist , whereas mixed CCK A and B agonists and selective CCK A agonists fail to change behavior in anxiety tests . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Moreover , the affinity of the different compounds towards the cholecystokinin CCK A and CCK B receptors was evaluated . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We detected the expression of mRNA encoding CCK A and CCK B receptors in eight human pancreatic tumour cell lines using reverse transcription polymerase chain reaction ( RT PCR ) , but not by RNase protection assays . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We suggest that effects we have observed correlate with the activation of the CCK A receptors ( CCK 33 , CCK 8 ) or CCK B receptors ( CCK 4 ) . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
This study was designed to compare the effect of CCK 8 and intraduodenal ( i . d . ) instillation of sodium oleate , or diversion of the pancreatic biliary secretions that are known to release CCK , on the gastric mucosal lesions induced by topical application of 100 % ethanol or acidified aspirin ( ASA ) in rats with or without the pretreatment with a CCK A receptor antagonist , loxiglumide , or with L 365 , 260 to block CCK B receptors . ^^^ Both protection and accompanying hyperemia were completely abolished by blockade of CCK A receptors with loxiglumide , whereas L 365 , 260 , an antagonist of CCK B receptors , had no effect . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Using autoradiography , high concentrations of CCK A receptors were detected in the duodenal mucosa , although in the pancreas only CCK B receptors were detected by this method . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
TS 941 had a fivefold lower selectivity than devazepide for pancreatic CCK ( CCK A ) over brain CCK ( CCK B ) receptors but fourfold greater than loxiglumide when IC 50 values for inhibition of [ 125I ] CCK 8 binding in isolated acini and cerebral cortex were compared . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK A , CCK B , neurotensin , somatostatin and VIP receptors were localized by in vitro receptor autoradiography with iodinated radioligands on histological sections of surgical samples of 27 gastric and 25 colonic adenocarcinomas . ^^^ CCK A , CCK B and neurotensin 1 receptors were found in a minority of both tumor types . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK ) is a multifunctional regulatory peptide , which acts through two main subtypes of receptors , named CCK A and CCK B . ^^^ The simultaneous administration of equimolar doses of a selective CCK A receptor antagonist blocked the effect of CCK , while a CCK B antagonist was ineffective . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
High affinity CCK receptors are divided in two main subtypes : the CCK A ( A for ( A for `` alimentary ' ' ) and the CCK B ( B for `` brain ' ' ) receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK 8 interacts with nanomolar affinities with two different receptors designated CCK A and CCK B . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK acts with three different receptor subtypes termed as CCK A , CCK B , and gastrin receptor , which can be found in peripheral system , brain , and stomach , respectively . ^^^ However , the binding sites in CCK A receptor seem to be slightly rigid as compared to those in CCK B or gastrin receptor . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A receptor antagonist CR 1409 , but not the CCK B antagonist L 365260 , blocked the vagal response to endogenous CCK stimulation . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Moreover , the results also indicate that distension induced mechanisms involve GRP , 5 HT 3 and CCK A receptors , but not CCK B receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
A blockade of the CCK A and CCK B receptors by their antagonists led to an increased , an unaffected , or a decreased cell number of the cell lines . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK ) and gastrin exert their effects through two receptors , the CCK A and CCK B receptors . ^^^ Prenatal expression of both CCK A and CCK B receptors in various tissues was analyzed by RT PCR . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In conclusion , CCK 8 blocked ascending contraction elicited by electrical field stimulation of duodenal mucosa by means of simultaneous activation of CCK A and CCK B receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In vitro we found that 1 ) 55 / 70 gastric vagal afferents ( GVAs ) were polymodal , responding to CCK 8 and mechanical stimuli , 13 were mechanoreceptive , and 2 were CCK responsive ; 2 ) sequential or randomized intra arterial injections of CCK 8 ( 0 . 1 200 pmol ) dose dependently increased firing rate and reached the peak rate at 100 pmol ; 3 ) the action was suppressed by CCK A ( Devazepide ) but not by CCK B ( L 365 , 260 ) receptor antagonist ; 4 ) neither antagonist blocked the mechanosensitivity of GVA fibers . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK A antagonist SR 27897B ( 1 mg kg ( 1 ) , i . p . ) reversed the delay induced by 10 mM cefaclor , whereas the CCK B antagonist CI 988 ( 1 mg kg ( 1 ) , i . p . ) had no significant effect . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Pancreatic secretory response to feeding in the calf : CCK A receptors , but not CCK B / gastrin receptors are involved . ^^^ The present study was aimed at determining both the role of external stimuli in the outset of the prefeeding phase and the implication of pancreatic CCK A and CCK B / gastrin receptors in the mediation of pancreatic response to feeding . ^^^ The first objective was studied by suppressing external stimuli associated with food intake ( unexpected meal ) and the second by infusing highly specific and potent antagonists of CCK A ( SR 27897 ) and CCK B / gastrin ( PD 135158 ) receptors during the prandial period . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In the present study we investigated the influence of WGA and UEA 1 on CCK 8 induced alpha amylase secretion of the rat pancreatic tumor cell line AR42J , which expresses both CCK A and CCK B receptors . ^^^ The simultaneous application of the lectins with CCK antagonists L 364 , 718 or L 365 , 260 led to a reduction of secretion , but the assignment to CCK A or CCK B receptors was not possible . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cellular expression of CCK A and CCK B / gastrin receptors in human gastric mucosa . ^^^ Expression of CCK receptor subtypes was detected in individual cells of the gastric mucosa by reverse transcription ( RT ) PCR in situ , immunohistochemistry and confocal laser scanning microscopy , using antisera against the CCK A or CCK B / gastrin receptor subtype . ^^^ Both CCK A and CCK B receptors were detected in antral and oxyntic mucosa at the mRNA and protein level . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Those present in peripheral system have been termed as CCK A receptors and those present in central nervous system as CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The CCK receptors can be pharmacologically subdivided into two subtypes : CCK A and CCK B . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Binding of CCK 8 and CCK 58 to CCK A and CCK B receptors and stability to enzymatic digestion were used as independent probes for tertiary structure of the C terminus . ^^^ The effect of tertiary structure on receptor binding at CCK A receptors and CCK B receptors was evaluated using membrane preparations from mouse pancreas and brain . ^^^ RESULTS : CCK 58 was three times more potent than CCK 8 for binding mouse pancreatic membrane CCK A receptors and equipotent to CCK 8 for binding mouse brain CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Most research on the antipsychotic like drug effects of CCK has used CCK or CCK analogues that nonselectively activate both CCK A and CCK B ( CCK 2 ) receptors , which may produce opposite effects . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK peptides exert their action on two distinct receptor subtypes : CCK A ( Alimentary ) now called the CCK1R , mostly expressed peripherally ; and CCK B ( Brain ) , renamed the CCK2R , which is primarily present in the brain . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Evidence on the role of CCK in anxiety related and reward related behaviours in various animal models indicates that CCK B receptors in the basolateral amygdala are important mediators of anxiety related behaviours and that CCK A and CCK B receptors in the nucleus accumbens are important in mediating different aspects of reward related behaviour . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
CCK mediates its effects through interaction with specific receptors subdivided in two subtypes CCK A ( present in the periphery and in few selected brain nuclei ) and CCK B ( the predominant receptor subtype in the brain ) . ^^^ Data showing that CCK A receptors mediate mnemonic while CCK B receptors mediate amnestic effects are also presented . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
A binding assay was used with 125I CCK 8s and dexamethasone stimulated AR42J cells , bearing CCK A as well as CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The possible role of CCK ergic mediation in endotoxin ( LPS ) fever has revealed that while CCK B receptors seem to be involved in the development of fever , the role of CCK A receptors could be more complex . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
To examine the mechanism of this enhanced suppression , we measured the mRNA levels of CCK , CCK A and CCK B receptors in the cerebral cortex and the hypothalamus of young and old male rats . ^^^ The mRNA level of CCK A receptors in the hypothalamus decreased with age , whereas the mRNA levels of CCK B receptors in the hypothalamus and cerebral cortex did not . ^^^ Moreover , the effects of aging on the gene expressions of CCK A and CCK B receptors were different . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Experiments were performed under control conditions , and after pretreatment by gavage feeding with YF 476 , using either a single , low dose of 0 . 3 micromol kg , which would block the CCK B receptors , or a 1000 times higher dose ( 300 micromol kg ) , which would also block the CCK A receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Reverse transcription of meningioma derived RNA into cDNA followed by amplification by the polymerase chain reaction using specific primers for CCK peptide and its CCK A and / B receptor revealed 100 % presence of CCK peptide and CCK B receptors mRNA whereas CCK A receptor was expressed in 66 % of the meningiomas . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Pretreatment with the CCK A receptor antagonist , lorglumide ( 1 microM ) , antagonized the effects of CCK 8s , whereas perfusion with the CCK B preferring agonist CCK 8 nonsulfated ( CCK ns , 1 microM ) did not affect the frequency of sEPSCs . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Cholecystokinin ( CCK ) interacts with two types of G protein coupled receptors in the brain : CCK A and CCK B receptors . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In an effort to determine whether the CCKA and CCKB receptors may be associated with certain CNS or gastrointestinal diseases , we have localized and compared the human and mouse chromosomal loci encoded by the CCKAR and CCKBR genes . ^^^ Chromosomal localization of the gastric and brain receptors for cholecystokinin ( CCKAR and CCKBR ) in human and mouse . ^^^ Receptors for cholcystokinin ( CCK ) can be pharmacologically classified into at least two distinct subtypes , CCKAR and CCKBR . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We recently cloned and functionally expressed both the CCKAR and the CCKBR from rat , guinea pig , and human . ^^^ The CCKAR and CCKBR are 48 % homologous and constitute a family of receptors within the guanine nucleotide binding regulatory protein coupled superfamily of receptors . ^^^ Genomic and cDNA library hybridization as well as Northern and Southern hybridization studies among rat , guinea pig , and human species identifies only two members of the CCK receptor family , CCKAR and CCKBR . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The two known receptors mediating the actions of cholecystokinin ( CCK ) and gastrin , CCK type A ( CCKAR ) and CCK type B ( CCKBR ) receptors , are G protein coupled receptors having approximately 50 % amino acid homology . ^^^ Both the CCKAR and CCKBR have high affinity for sulfated CCK peptides , while only the CCKBR has high affinity for gastrin peptides . ^^^ To determine the structural basis for the selectivity of the CCKBR for gastrin , we first constructed a series of CCKB / AR chimeras in which restriction endonuclease defined segments of the CCKBR were replaced with the corresponding segments of the CCKAR . ^^^ This segment could account for 100 of the expected 300 fold lower affinity of gastrin 17 1 observed for the control CCKAR compared to the control CCKBR . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The application of modern molecular biological techniques has identified two CCK receptors , CCK A receptor ( CCKAR ) and CCK B / gastrin receptor ( CCKBR ) . ^^^ The genes of CCKAR and CCKBR consist of five exons interrupted by four introns . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The cholecystokinin ( CCK ) receptor types A and B ( CCKAR and CCKBR ) are G protein coupled receptors with approximately 50 % amino acid identity ; both have high affinity for the sulfated CCK octapeptide ( CCK 8 ) , whereas only the CCKBR has high affinity for gastrin . ^^^ Alanine substitution of the equivalent amino acids in the CCKAR corresponding to each of the five amino acids in ECL 1 and ECL 2 affecting CCK 8 affinity for the CCKBR revealed only two mutations , L103A and F107A , that decreased CCK 8 affinity ( 68 and 2885 fold , respectively ) . ^^^ These data suggest that CCK 8 interacts at multiple contact points in the extracellular domains of CCK receptors and that the CCKAR and CCKBR have distinct binding sites despite their shared high affinity for CCK 8 . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
The responses were not influenced by the pretreatment with L 365 , 260 , a type B CCK receptor ( CCKBR ) antagonist , while they were significantly diminished by pretreatment with MK 329 , a CCKAR antagonist . ^^^ These results demonstrate that neither CCKAR nor CCKBR contributes to the response of the afferent activity of the gastric vagal nerve to a systemic administration of CCK in OLETF rats , suggesting an involvement of novel ( non A , non B ) CCK receptors . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Polymorphisms of the CCK , CCKAR and CCKBR genes : an association with alcoholism study . ^^^ We analyzed genetic variations in the promoter and coding regions of the CCK , CCKA receptor ( CCKAR ) and CCKB receptor ( CCKBR ) genes , and performed association analyses with alcoholism . ^^^ RESULTS : A total of 8 variants in the CCK gene , 11 variants in the CCKAR gene and 9 variants in the CCKBR gene were detected in the present study . ^^^ CONCLUSIONS : Our data suggest that polymorphisms of the CCK , CCKAR and CCKBR genes do not play a major role in alcohol withdrawal symptoms ( even though significant associations were found among polymorphisms at the 388 and 333 loci of the CCKAR gene and hallucinations , the rate was nonsignificant after Bonferroni correction ) . . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
We previously reported genetic variations in the promoter and coding regions of the CCKA receptor ( CCKAR ) , CCKBR , and CCK genes and a possible association between polymorphisms of the CCKAR gene and alcoholism . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
Genomic DNA was analyzed for CCK , CCKAR , and CCKBR ( cholecystokinin B receptor ) polymorphisms by polymerase chain reaction . ^^^ Cases and controls did not differ in CCKAR or CCKBR polymorphisms . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
In rat , gastrin and its CCKBR seem responsible for foetal pancreas growth while after birth , CCK was shown to be the most potent trophic factor via occupation of its CCKAR . ^^^ In rodent ' s pancreas , the CCKAR were observed on acinar cells as well as on islet ' s alpha and beta cells ; in six other species , the CCKAR were present only on alpha and beta cells with the CCKBR always present on delta cells . ^^^
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA
Interacting proteins: P32239 and P32238	Pubmed	SVM Score :0.0
NA