| Sequences within the N terminal receptor activation recognition domain and the C terminal secondary receptor binding domain of beta arrestin 2 conferred strong binding to the C terminus of NHE 5 . ^^^ Full length NHE 5 and beta arrestin 2 also associated in intact cells , as revealed by their coimmunoprecipitation from extracts of transfected CHO cells . ^^^ Moreover , ectopic expression of both proteins caused a redistribution of beta arrestin 2 from the cytoplasm to vesicles containing NHE 5 , and significantly decreased the abundance of the transporter at the cell surface . ^^^ |