| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| In contrast to beta arrestin 1 , which is phosphorylated by ERK 1 and ERK 2 , phosphorylation of beta arrestin 2 at Thr 383 is shown to be mediated by casein kinase 2 . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| Further analysis reveals that expression of beta arrestin 2 strengthened CXCR 4 mediated activation of both p 38 MAPK and ERK , and the suppression of beta arrestin 2 expression blocked the activation of two kinases . ^^^ Interestingly , inhibition of p 38 MAPK activation ( but not ERK activation ) by its inhibitors or by expression of a dominant negative mutant of p 38 MAPK effectively blocked the chemotactic effect of beta arrestin 2 . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| These results are the first to demonstrate reciprocal activity of beta arrestin isoforms on a signaling pathway and suggest that physiological levels of beta arrestin 1 may act as `` dominant negative ' ' inhibitors of beta arrestin 2 mediated ERK activation . . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| From coimmunoprecipitation studies , p ERK was found to form stable heterotrimeric complexes with the D 1 dopamine receptor and beta arrestin 2 . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| The biochemical consequences of ERK activation by the G protein and beta arrestin 2 dependent pathways were also distinct . ^^^ G protein mediated ERK activation enhanced the transcription of early growth response 1 , whereas beta arrestin 2 dependent ERK activation did not . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| Gs and beta arrestin mediated pathways to ERK activation could be distinguished with H 89 , an inhibitor of protein kinase A , and beta arrestin 2 small interfering RNA , respectively . ^^^ In contrast , GRK 5 and 6 mediated much less receptor phosphorylation and beta arrestin recruitment , but yet appeared exclusively to support beta arrestin 2 mediated ERK activation . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| The sustainability of interactions between the orexin 1 receptor and beta arrestin 2 is defined by a single C terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation . ^^^ These studies indicate that a single cluster of hydroxy amino acids within the C terminal seven amino acids of the orexin 1 receptor determine the sustainability of interaction with beta arrestin 2 , and indicate an important role of beta arrestin scaffolding in defining the kinetics of orexin 1 receptor mediated ERK MAPK activation . . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| Moreover , ubiquitination patterns and ERK scaffolding of beta arrestin 2 ( K 11 , 12R ) are unimpaired with respect to V2R stimulation . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| Beta arrestin 2 enhances beta 2 adrenergic receptor mediated nuclear translocation of ERK . ^^^ Thus , we have examined the role of beta arrestin 2 in the betaAR mediated ERK signaling pathways . ^^^ However , the activity of nuclear ERK was enhanced by co expression of beta arrestin 2 in beta2AR but not beta1AR expressing cells . ^^^ Pertussis toxin treatment and blockade of Gbetagamma action inhibited beta arrestin 2 enhanced nuclear activation of ERK , suggesting that beta arrestin 2 promotes nuclear ERK localization in a Gbetagamma dependent mechanism upon receptor stimulation . beta2AR containing the carboxyl terminal region of beta1AR lost the beta arrestin 2 promoted nuclear translocation . ^^^ As the carboxyl terminal region is important for beta arrestin binding , these results demonstrate that recruitment of beta arrestin 2 to carboxyl terminal region of beta2AR is important for ERK localization to the nucleus . . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| Beta arrestin 2 modulates the activity of nuclear receptor RAR beta 2 through activation of ERK 2 kinase . ^^^ More importantly , we demonstrate that the induction of PC 12 growth inhibition by Nerve Growth Factor is indeed dependent upon RAR beta 2 transcriptional activation in a beta arrestin 2 and ERK 2 dependent manner . . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| We found that L AP 4 induced a rapid and transient activation of the MAP kinase extracellular signal regulated kinase ( ERK ) through a pathway mediated by dynamin , beta arrestin 2 , and Src . ^^^ |
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| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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