| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Peroxiredoxin 1 ( Prx 1 ) and peroxiredoxin 2 ( Prx 2 ) are found in abundance in the cytoplasm of cells and catalyze the reduction of hydrogen peroxide with the use of electrons provided by thioredoxin . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Many of the identified genes ( e . g . , glutathione S transferase [ MGST 2 ] , thioredoxin reductase beta , and peroxiredoxin 2 ) have been identified as participants in OS responses in the lens and other systems . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Molecular targeting of H ( 2 ) O ( 2 ) by overexpression of peroxiredoxin 2 , a thioredoxin dependent peroxidase , also increased and sustained ERK and MEK activation upon TcR cross linking . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| To protect themselves from these ROSs , the cells have developed both an antioxidant system containing superoxide dismutase 1 ( SOD 1 ) and a redox system including peroxiredoxin 2 ( Prx 2 , thioredoxin peroxidase ) and glutathione peroxidase 1 ( GPx 1 ) : SOD 1 converts superoxide radicals into hydrogen peroxide ( H2O2 ) , and H2O2 is then converted into harmless water ( H2O ) and oxygen ( O 2 ) by Prx 2 and GPx 1 that directly regulate the redox system . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of glutathione S transferase Pi , peroxiredoxin 2 , thioredoxin 2 , and glutaredoxin was elevated whereas that of peroxiredoxin 3 , metallothionein 1F , superoxide dismutase 2 , and thioredoxin reductase 1 was depressed . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Decreases of > or = twofold in GST , superoxide dismutase , aldehyde dehydrogenase , thioredoxin , peroxiredoxin 2 , and peroxiredoxin 6 protein were observed . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Engineering functional artificial hybrid proteins between poplar peroxiredoxin 2 and glutaredoxin or thioredoxin . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Thioredoxin dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein ( BCP ) as a new member of the thiol specific antioxidant protein ( TSA ) / Alkyl hydroperoxide peroxidase C ( AhpC ) family . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Thioredoxin peroxidase 1 ( TxP 1 ) , originally cloned as natural killer enhancing factor B , belongs to a highly conserved antioxidant family . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Of these , four pairs of HPRPs were thioredoxin peroxidase 1 ( TPx 1 ) , TPx 2 , TPx 3 , and the product of human ORF 06 , all of which belong to the peroxiredoxin ( Prx ) family and all of which are involved in the elimination of hydroperoxides . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Thioredoxin peroxidase 1 ( peroxiredoxin 1 ) is increased in thioredoxin 1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone , etoposide , and doxorubicin . ^^^ We report that Trx 1 transfected MCF 7 human breast cancer cells have increased expression of thioredoxin peroxidase 1 ( TrxP 1 ) a peroxiredoxin family member that scavenges H ( 2 ) O ( 2 ) using Trx 1 as a source of reducing equivalents . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Two additional recently described T cell sensitizing egg antigens are Schistosoma mansoni phosphoenolpyruvate carboxykinase ( Sm PEPCK ) and thioredoxin peroxidase 1 ( Sm TPx 1 ) . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Cytosolic thioredoxin peroxidase 1 is essential for the antioxidant defense of yeast with dysfunctional mitochondria . ^^^ The specific role of cytosolic thioredoxin peroxidase 1 ( cTPx 1 ) , encoded by TSA 1 ( thiol specific antioxidant ) , was investigated in the oxidative stress response of Saccharomyces cerevisiae . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| By contrast , a significant reduction was observed in levels of glutathione synthetase ( P < 0 . 01 ) , glutathione S transferase mu 2 ( P < 0 . 01 ) , glutathione S transferase p ( P < 0 . 05 ) , antioxidant protein 2 ( P < 0 . 05 ) , thioredoxin peroxidase 1 ( P < 0 . 05 ) and thioredoxin peroxidase 2 ( P < 0 . 01 ) in DS compared with controls . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Regulation of mitochondrial thioredoxin peroxidase 1 expression by two different pathways : one dependent on cAMP and the other on heme . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Changes in expression of other proteins were also observed in disease states compared to normal tissues , namely translationally controlled tumor protein , thioredoxin peroxidase 1 , glutathione S transferase P , DJ 1 protein , superoxide dismutase ( Cu , Zn ) , and heat shock protein 27 , but these changes are less characteristic , so they do not allow the differentiation between neoplastic and non neoplastic tissues . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Cyclic GMP dependent protein kinase regulates the expression of thioredoxin and thioredoxin peroxidase 1 during hormesis in response to oxidative stress induced apoptosis . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Two additional described T cell sensitizing egg antigens are Schistosoma mansoni phosphoenolpyruvate carboxykinase ( Sm PEPCK ) and thioredoxin peroxidase 1 ( Sm TPx 1 ) . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Interestingly , when glutathione contents in mitochondrial pools were analyzed , all mutants presented lower GSH / GSSG ratios than wild type cells , with the exception of DeltacTPxI strain ( cells in which cytosolic thioredoxin peroxidase 1 gene was disrupted ) that presented higher GSH / GSSG ratio . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Cytosolic thioredoxin peroxidase 1 and 2 are important defenses of yeast against organic hydroperoxide insult : catalases and peroxiredoxins cooperate in the decomposition of H2O2 by yeast . ^^^ The cytosolic thioredoxin peroxidase 2 ( cTPxII / Tsa2p ) from Saccharomyces cerevisiae shares 86 % identity with the relatively well characterized cytosolic thioredoxin peroxidase 1 ( cTPxI / Tsa1p ) . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Using two dimensional gel electrophoresis , mass spectrometry and rat protein database , we successfully identified three distinctly changed proteins named thioredoxin peroxidase 1 , myosin light polypeptide 2 and ubiquitin conjugating enzyme E 2 17 kD , among which ubiquitin conjugating enzyme E 2 17 kD has been documented to be an estrogen related protein , but the other two are first reported to be osteoporosis related proteins in the current study . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| RESULTS : 18 protein spots were differentially expressed as compared with age matched nondemented control brains which were identified as glyceraldehyde 3 phosphate dehydrogenase , uracil DNA glycosylase , human superoxide dismutase , isocitrate dehydrogenase subunit , synaptotagmin 1 , thioredoxin peroxidase 1 , glial fibrillary acidic protein , p 25 alpha , enoyl coenzyme A hydratase short chain 1 , pyridoxine 5 ' phosphate oxidase , Mn superoxide dismutase and alpha enolase , antioxidant protein 2 , ferritin heavy chain , glutamate dehydrogenase precursor , peptidyl prolyl cis trans isomerase A , serum albumin precursor and dihydropyrimidinase related protein 2 . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| TNF ( tumour necrosis factor ) a , which decreases the levels of endogenous GSH , increased the generation of C 16 cer in response to C 6 cer , and this was blocked by exogenous GSH or NAC , or by the overexpression of TPx 1 ( thioredoxin peroxidase 1 ) , an enzyme that reduces the generation of intracellular ROS ( reactive oxygen species ) . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Thioredoxin peroxidase 1 ( TPx 1 ) of the malarial parasite Plasmodium falciparum is a 2 Cys peroxiredoxin involved in the detoxification of reactive oxygen species and as shown here of reactive nitrogen species . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Influences of cytosolic thioredoxin peroxidase 1 and of the mitochondrial functional state . ^^^ First , we demonstrated that cells with this dysfunction rely exclusively on cytosolic thioredoxin peroxidase 1 ( cTPxI ) and its reductant sulfiredoxin , among other antioxidant enzymes tested , to protect them against H2O2 induced death . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| In the presence of thioredoxin , TSA is more active , whereas C170S ( an active mutant of TSA in which cysteine 170 was replaced by a serine ) and open reading frame 6 ( a human antioxidant protein homologous to TSA with only one conserved cysteine residue ) are only slightly affected . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| The presence of thioredoxin peroxidase ( TPx ) , also known as thiol specific antioxidant ( TSA ) , was investigated in neonatal and adult rat islets , and in the beta cell line HIT T 15 . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| This paper presents a characterization of PrxII F at the level of subcellular distribution , activity , and reductive regeneration by mitochondrial thioredoxin and glutaredoxin . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Since one of the mechanisms of the DX antitumor effect has been ascribed to production of ROS , future studies will evaluate the involvement of PrxII and Trx in the chemoresistance of p53Y220S fibroblasts to DX . . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| RNA was extracted for quantitative real time PCR analysis of glutathione peroxidase ( Gpx ) 1 and 4 , glutathione reductase ( Gsr ) , thioredoxin peroxidase 2 ( Prdx 2 ) , thioredoxin ( Txn ) and thioredoxin reductase ( Txnrd ) 1 and 2 gene expression . ^^^ |
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| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Localization of TDPX 1 , a human homologue of the yeast thioredoxin dependent peroxide reductase gene ( TPX ) , to chromosome 13q12 . ^^^ We report here the isolation and regional mapping of a human gene , TDPX 1 , that encodes an enzyme homologous to a yeast thioredoxin dependent peroxide reductase ( thioredoxin peroxidase , TPX ) . ^^^ |
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| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| Using direct sequencing procedures ( Edman degradation ) or matrix assisted laser desorption / ionization mass spectrometry ( MALDI MS ) , these four spots were identified as three new proteins : thioredoxin peroxydase 1 ( TDPX 1 ) , transthyretin ( TTR ) and retinol binding protein ( RBP ) . ^^^ |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and P10599 |
Pubmed |
SVM Score :0.0 |
| NA |
|