| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.74445254 |
| Moreover , it was found that 125I labeled S100C interacted with annexin 1 in a Ca ( 2+ ) dependent manner . 0.74445254^^^ |
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| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.50861783 |
| This indicates that annexin 1 and S100C form a complex in vivo and that the endosomal localization of this complex is mediated through an interaction of annexin 1 with the endosomal membrane . . 0.50861783^^^ |
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| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.77064437 |
| In control cells , S100A11 was detected on the plasma membrane , where the protein co localized with annexin 1 ( ANXA 1 ) at discrete sites , and found diffusely in the cytoplasm . 0.77064437^^^ |
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| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| Calcium dependent binding of S100C to the N terminal domain of annexin 1 . ^^^ |
|
| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| Structural requirements for annexin 1 S100C complex formation . ^^^ An intracellular ligand for S100C is the Ca2+ / phospholipid binding protein annexin 1 and we show here that complex formation is mediated through unique domains within S100C and annexin 1 . ^^^ Using a proteolytically truncated annexin 1 derivative as well as a number of N terminal annexin 1 peptides in liposome co pelleting and ligand blotting assays we map the S100C binding site to the N terminal 13 residues of annexin 1 . ^^^ Similar analyses employing recombinantly expressed S100C mutants reveal that residues D 91 to 194 in the unique C terminal extension of this S 100 protein are indispensable for annexin 1 binding . ^^^ Interaction between S100C and an N terminal annexin 1 peptide containing a tryptoplan at position 11 can also be monitored by fluorescence emission spectroscopy after tryptophan excitation . ^^^ |
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| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| Calgizzarin is a Ca2+ binding protein of the S 100 family that has been implicated in the regulation of cytoskeletal function through its Ca2+ dependent interaction with annexin 1 . ^^^ |
|
| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| S100A11 , S100A10 , annexin 1 , desmosomal proteins , small proline rich proteins , plasminogen activator inhibitor 2 , and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes . ^^^ |
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| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| Structural basis of the Ca ( 2+ ) dependent association between S100C ( S100A11 ) and its target , the N terminal part of annexin 1 . ^^^ Results : We have solved the crystal structure of a complex of calcium loaded S100C with a synthetic peptide that corresponds to the first 14 residues of the annexin 1 N terminus at 2 . 3 A resolution . ^^^ Our structure can provide a model for a Ca ( 2+ ) regulated annexin 1 S100C heterotetramer , possibly involved in crosslinking membrane surfaces or organising membranes during certain fusion events . . ^^^ |
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| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| The two best characterized complexes are annexin 2 with p 11 and annexin 1 with S100C , the former of which has been implicated in membrane fusion processes . ^^^ We have solved the crystal structures of the complexes of p 11 with annexin 2 N terminus and of S100C with annexin 1 N terminus . ^^^ |
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| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| The physiological target of S100A11 is thought to be annexin 1 , a phospholipid binding protein involved in EGF receptor sorting . ^^^ |
|
| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| Unmasking the annexin 1 interaction from the structure of Apo S100A11 . ^^^ S100A11 is a homodimeric EF hand calcium binding protein that undergoes a calcium induced conformational change and interacts with the phospholipid binding protein annexin 1 to coordinate membrane association . ^^^ This helix arrangement in apo S100A11 partially buries residues in helices 1 ( P 3 , E 11 , A 15 ) , 3 ( V 55 , R 58 , M 59 ) , and 4 ( A 86 , C 87 , S 90 ) and the linker ( A 45 , F 46 ) , which are required for interaction with annexin 1 in the calcium bound state . ^^^ In apo S100A11 , this results in a `` masked ' ' binding surface that prevents annexin 1 binding but is uncovered upon calcium binding . . ^^^ |
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| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| Of these proteins , five typical ones , glutathione S transferase pi ( GST pi ) , voltage dependent anion channel 1 ( VDAC 1 ) , Annexin 1 , Galectin and S100A11 , were further examined by Western blotting , resulting in coincident data with the proteomic evidence . ^^^ |
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| Interacting proteins: P04083 and P31949 |
Pubmed |
SVM Score :0.0 |
| Two dimensional PAGE showed increased expression of 12 proteins , namely glucose regulated protein 75 ( grp 75 ) , calcyclin ( S100A6 ) , degraded cytokeratin 19 , ATP synthase D , ribosomal protein P 0 , degraded cytokeratin 18 ( two spots pI / MW 6 . 03 / 29 . 9 and pI / MW 4 . 66 / 21 . 5 ) , cofilin , annexin A 1 , triose phosphate isomerase , peroxiredoxin 1 , calgizzarin , and profilin . ^^^ |
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