| Interacting proteins: Q7LG56 and P31350 |
Pubmed |
SVM Score :0.0 |
| Amplification of the M 2 gene encoding the small subunit of ribonucleotide reductase ( EC 1 . 17 . 4 . 1 ) was analyzed in a collection of vaccinia virus ( 10 ) isolates selected for resistance to 5 mM hydroxyurea ( HU ) . ^^^ |
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| Interacting proteins: Q7LG56 and P31350 |
Pubmed |
SVM Score :0.0 |
| Here we have isolated a p 53 inducible gene , p53R2 , by using differential display to examine messenger RNAs in a cancer derived human cell line carrying a highly regulated wild type p 53 expression system . p53R2 contains a p 53 binding sequence in intron 1 and encodes a 351 amino acid peptide with striking similarity to the ribonucleotide reductase small subunit ( R 2 ) , which is important in DNA synthesis during cell division . ^^^ Inhibition of endogenous p53R2 expression in cells that have an intact p 53 dependent DNA damage checkpoint reduced ribonucleotide reductase activity , DNA repair and cell survival after exposure to various genotoxins . ^^^ Our results indicate that p53R2 encodes a ribonucleotide reductase that is directly involved in the p 53 checkpoint for repair of damaged DNA . ^^^ The discovery of p53R2 clarifies a relationship between a ribonucleotide reductase activity involved in repair of damaged DNA and tumour suppression by p53 . . ^^^ |
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| Interacting proteins: Q7LG56 and P31350 |
Pubmed |
SVM Score :0.0 |
| The p53R2 gene encodes the p 53 inducible ribonucleotide reductase small subunit 2 homologue , which is part of the p 53 pathway . ^^^ |
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| Interacting proteins: Q7LG56 and P31350 |
Pubmed |
SVM Score :0.0 |
| No significant change in the expression of RRM 2 was observed in either cell line , although both gemcitabine resistant cell lines had an approximate 3 fold increase in p53R2 protein . ^^^ A partial revertant of H 358 G200 cells had reduced levels of RRM 1 protein ( compared with G 200 cells ) , without observed changes in RRM 2 or p53R2 . ^^^ |
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| Interacting proteins: Q7LG56 and P31350 |
Pubmed |
SVM Score :0.0 |
| AIM : p 53 inducible ribonucleotide reductase small subunit 2 ( p53R2 ) encodes a 351 amino acid peptide , which catalyzes conversion of ribonucleoside diphosphates to the corresponding deoxyribonucleotides required for DNA replication and repair . ^^^ |
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| Interacting proteins: Q7LG56 and P31350 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LG56 and P31350 |
Pubmed |
SVM Score :0.0 |
| NA |
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